---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
# IL16

## Overview
The IL16 gene, which encodes a pro-inflammatory cytokine, plays a role in immune responses. IL-16 is highly expressed in the activated B-cell-like (ABC) subtype of DLBCL compared to the germinal center B-cell-like (GCB) subtype. The role of mutations in lymphomagenesis is not understood. Overall, the mutation rate of IL16 is relatively low in DLBCL. *Without further support, this gene may be migrated to Tier 2.* 

## Relevance tier by entity

|Entity|Tier|Description               |
|:------:|:----:|--------------------------|
|![DLBCL](images/icons/DLBCL_tier1.png) |1   |high-confidence DLBCL gene|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source        |frequency (%)|
|:------:|:--------------:|:-------------:|
|DLBCL |GAMBL genomes |2.29         |
|DLBCL |Schmitz cohort|3.83         |
|DLBCL |Reddy cohort  |2.80         |
|DLBCL |Chapuy cohort |5.13         |

## Mutation pattern and selective pressure estimates

[[include:dnds_IL16.md]]



[[include:browser_IL16.md]]

## Expression
![](images/gene_expression/IL16_by_pathology.svg)

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## References