--- bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true --- [[_TOC_]] ## Relevance tier by entity |Entity|Tier|Description | |:------:|:----:|-----------------------------------------| |![DLBCL](images/icons/DLBCL_tier2.png) |2 | aSHM target; Although recurrent, the relevance of mutations in DLBCL is tenuous [@arthurGenomewideDiscoverySomatic2018]| ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |Entity|source |frequency (%)| |:------:|:--------------:|:-------------:| |DLBCL |GAMBL genomes |1.15 | |DLBCL |Schmitz cohort|1.28 | |DLBCL |Reddy cohort |1.30 | |DLBCL |Chapuy cohort |0.85 | ## Mutation pattern and selective pressure estimates [[include:dnds_LPP.md]] ## aSHM regions |chr_name|hg19_start|hg19_end |region |regulatory_comment| |:--------:|:----------:|:---------:|:------------------------------------------------------------------------------------------------:|:------------------:| |chr3 |187771678 |187801626|[TSS-1](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr3%3A187771678%2D187801626) |NA | |chr3 |187801627 |187813568|[TSS-2](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr3%3A187801627%2D187813568) |NA | |chr3 |187813569 |187955254|[TSS-3](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr3%3A187813569%2D187955254) |NA | |chr3 |187955255 |187969220|[TSS-4](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr3%3A187955255%2D187969220) |NA | |chr3 |188261523 |188327097|[TSS-5](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr3%3A188261523%2D188327097) |NA | |chr3 |188377178 |188401951|[intron-1](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr3%3A188377178%2D188401951)|NA | |chr3 |188401952 |188461879|[intron-2](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr3%3A188401952%2D188461879)|NA | |chr3 |188461880 |188474683|[intron-3](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr3%3A188461880%2D188474683)|NA | |chr3 |188474684 |188491248|[intron-4](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr3%3A188474684%2D188491248)|NA | [[include:browser_LPP.md]] ## Expression ![](images/gene_expression/LPP_by_pathology.svg) [[include:mermaid_LPP.md]] ## References