LYN
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LYN mutations have been reported in DLBCL but the rate is relatively rare in most cohorts. The mutation pattern in DLBCL and FL implies the preferential accumulation of inactivating mutations. Without further support, this gene may be migrated to Tier 2.
| Entity | Tier | Description |
|---|---|---|
 |
2 | low-confidence DLBCL gene[@chapuyMolecularSubtypesDiffuse2018] |
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 2.29 |
| DLBCL | Schmitz cohort | 1.70 |
| DLBCL | Reddy cohort | 1.30 |
| DLBCL | Chapuy cohort | 5.56 |
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 1.641 | 0.000 |
| DLBCL | No | No | 10.031 | 17.456 |
| FL | No | No | 0.000 | 0.000 |
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