---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]


## Relevance tier by entity

|Entity|Tier|Description                           |
|:------:|:----:|--------------------------------------|
|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene[@yanBCRTLRSignaling2012]|
|![DLBCL](images/icons/DLBCL_tier1.png) |1   |high-confidence DLBCL gene            [@ngoOncogenicallyActiveMYD882011]|
|![FL](images/icons/FL_tier2.png)    |2   |relevance in FL not firmly established|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

[[include:DLBCL_MYD88.md]]
[[include:FL_MYD88.md]]

## Mutation pattern and selective pressure estimates

[[include:dnds_MYD88.md]]

## MYD88 Hotspots

| Chromosome |Coordinate (hg19) | ref>alt | HGVSp | 
 | :---:| :---: | :--: | :---: |
| chr3 | 38182641 | T>C | L265P |

[[include:browser_MYD88.md]]

## Expression
![](images/gene_expression/MYD88_by_pathology.svg)
<!-- ORIGIN: yanBCRTLRSignaling2012a -->
<!-- DLBCL: ngoOncogenicallyActiveMYD882011a -->
<!-- MZL: yanBCRTLRSignaling2012a -->

[[include:mermaid_MYD88.md]]

## References