---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]

## Overview
Mutations in this gene are relatively rare in DLBCL overall but show a pattern of inactivation. 


## Relevance tier by entity

|Entity|Tier|Description                           |
|:------:|:----:|--------------------------------------|
|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established[@sarkozyMutationalLandscapeGray2021]|
|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene[@spinaGeneticsNodalMarginal2016]|
|![BL](images/icons/BL_tier2.png)    |2   |relevance in BL not firmly established[@schmitzBurkittLymphomaPathogenesis2012]|
|![DLBCL](images/icons/DLBCL_tier2.png) |2  |relevance in DLBCL not firmly established           |

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source               |frequency (%)|
|:------:|:---------------------:|:-------------:|
|BL    |GAMBL genomes+capture|6.24         |
|BL    |Thomas cohort        |  NA         |
|BL    |Panea cohort         |  NA         |
|DLBCL |GAMBL genomes        |2.10         |
|DLBCL |Schmitz cohort       |5.74         |
|DLBCL |Reddy cohort         |3.60         |
|DLBCL |Chapuy cohort        |4.27         |

## Mutation pattern and selective pressure estimates

[[include:dnds_NCOR2.md]]



[[include:browser_NCOR2.md]]

## Expression
![](images/gene_expression/NCOR2_by_pathology.svg)

<!-- FLAGGED FOR TIER 2 -->
<!-- ORIGIN: schmitzBurkittLymphomaPathogenesis2012 -->
<!-- MZL: spinaGeneticsNodalMarginal2016b -->
<!-- BL: schmitzBurkittLymphomaPathogenesis2012 -->
<!-- BL: schmitzBurkittLymphomaPathogenesis2012 -->

[[include:mermaid_NCOR2.md]]

## References
<!-- PMBL: sarkozyMutationalLandscapeGray2021a -->