NCOR2
Mutations in this gene are relatively rare in DLBCL overall but show a pattern of inactivation. Without further support, this gene may be migrated to Tier 2.
| Entity | Tier | Description |
|---|---|---|
 |
2 | relevance in PMBL/cHL/GZL not firmly established |
 |
1 | high-confidence MZL gene |
 |
2 | relevance in BL not firmly established |
 |
1 | high-confidence DLBCL gene |
| Entity | source | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 6.24 |
| BL | Thomas cohort | NA |
| BL | Panea cohort | NA |
| DLBCL | GAMBL genomes | 2.10 |
| DLBCL | Schmitz cohort | 5.74 |
| DLBCL | Reddy cohort | 3.60 |
| DLBCL | Chapuy cohort | 4.27 |
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 0.551 | 0.000 |
| DLBCL | No | No | 1.376 | 4.613 |
| FL | No | No | 0.985 | 0.000 |
Note
First described in BL in 2022 by Burkhardt B
| Chromosome | Coordinate (hg19) | ref>alt | HGVSp |
|---|
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
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