---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
nocite: |
  @arthurGenomewideDiscoverySomatic2018, @zhangGeneticHeterogeneityDiffuse2013, @schmitzGeneticsPathogenesisDiffuse2018, 
---
[[_TOC_]]

## Overview
OSBPL10 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus.


## Relevance tier by entity

[[include:tables/table1_OSBPL10.md]]

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

### DLBCL
[[include:tables/DLBCL_OSBPL10.md]]

## Mutation pattern and selective pressure estimates

[[include:tables/dnds_OSBPL10.md]]

## aSHM regions

|chr_name|hg19_start|hg19_end|region                                                                                     |regulatory_comment|
|:--------:|:----------:|:--------:|:-------------------------------------------------------------------------------------------:|:------------------:|
|chr3    |32020518  |32024930|[TSS-1](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr3%3A32020518%2D32024930)|active_promoter   |


[[include:tables/browser_OSBPL10.md]]

## Expression
![](images/gene_expression/OSBPL10_by_pathology.svg)
<!-- ORIGIN: arthurGenomewideDiscoverySomatic2018 -->
<!-- DLBCL: arthurGenomewideDiscoverySomatic2018 -->

[[include:tables/mermaid_OSBPL10.md]]

## References