---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]

## Overview

P2RY8 encodes a G protein–coupled receptor that is expressed on germinal center B cells. Signals through this receptor promote confinement of B cells to the GC niche.[@muppidiLossSignalingGa132014] Downstream signaling through Galpha13 (encoded by GNA13) and S1PR2 is distrupted by mutations of one of these genes in GC lymphomas including the GCB subgroup of DLBCL and BL.[muppidiLossSignalingGa132014] 


## Relevance tier by entity

|Entity|Tier|Description                           |
|:------:|:----:|--------------------------------------|
|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
|![BL](images/icons/BL_tier1.png)    |1   |high-confidence BL gene               [@muppidiLossSignalingGa132014]|
|![DLBCL](images/icons/DLBCL_tier1.png) |1   |high-confidence DLBCL gene            [@lohrDiscoveryPrioritizationSomatic2012]|
|![FL](images/icons/FL_tier2.png)    |2   |relevance in FL not firmly established|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

[[include:DLBCL_P2RY8.md]]
[[include:BL_P2RY8.md]]

## Mutation pattern and selective pressure estimates

[[include:dnds_P2RY8.md]]

[[include:browser_P2RY8.md]]

## Expression
![](images/gene_expression/P2RY8_by_pathology.svg)

[[include:mermaid_P2RY8.md]]

## References


<!-- ORIGIN: lohrDiscoveryPrioritizationSomatic2012a -->
<!-- BL: muppidiLossSignalingGa132014b -->
<!-- DLBCL: lohrDiscoveryPrioritizationSomatic2012a -->