---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
nocite: |
  @lohrDiscoveryPrioritizationSomatic2012, 
---
[[_TOC_]]


## Relevance tier by entity

[[include:tables/table1_PCLO.md]]

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source        |frequency (%)|
|:------:|:--------------:|:-------------:|
|DLBCL |GAMBL genomes |16.44        |
|DLBCL |Schmitz cohort|21.28        |
|DLBCL |Reddy cohort  |15.12        |
|DLBCL |Chapuy cohort |23.08        |
|FL    |GAMBL genomes | 9.24        |

## Mutation pattern and selective pressure estimates

[[include:tables/dnds_PCLO.md]]


## PCLO Hotspots

| Chromosome |Coordinate (hg19) | ref>alt | HGVSp | 
 | :---:| :---: | :--: | :---: |
| chr7 | 82585303 | G>T | L1656I |
| chr7 | 82585302 | A>G | L1656P |
| chr7 | 82544727 | T>C | K4192R |

[[include:tables/browser_PCLO.md]]

## Expression
![](images/gene_expression/PCLO_by_pathology.svg)

[[include:tables/mermaid_PCLO.md]]

## References


<!-- ORIGIN: lohrDiscoveryPrioritizationSomatic2012a -->
<!-- DLBCL: lohrDiscoveryPrioritizationSomatic2012a -->