---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]



## Relevance tier by entity

|Entity|Tier|Description                              |
|:------:|:----:|-----------------------------------------|
|![BL](images/icons/BL_tier1.png)    |1   |high-confidence BL gene                  [@thomasGeneticSubgroupsInform2023]|
|![DLBCL](images/icons/DLBCL_tier2.png) |3   |Retired, Failed QC[@reddyGeneticFunctionalDrivers2017]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

[[include:DLBCL_PHF6.md]]
[[include:BL_PHF6.md]]

## Mutation pattern and selective pressure estimates

[[include:dnds_PHF6.md]]


[[include:browser_PHF6.md]]

## Expression
![](images/gene_expression/PHF6_by_pathology.svg)
<!-- ORIGIN: reddyGeneticFunctionalDrivers2017 -->
<!-- BL: thomasGeneticSubgroupsInform2023 -->
<!-- DLBCL: reddyGeneticFunctionalDrivers2017 -->

## All Mutations

[Reddy_2135T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2135T.html)
[Reddy_2190T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2190T.html)
[Reddy_2191T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2191T.html)
[Reddy_2470T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2470T.html)
[Reddy_2475T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2475T.html)
[Reddy_2482T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2482T.html)
[Reddy_2628T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2628T.html)
[Reddy_2764T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2764T.html)
[Reddy_2778T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2778T.html)
[Reddy_2788T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2788T.html)
[Reddy_3403T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3403T.html)
[Reddy_3422T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3422T.html)
[Reddy_3508T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3508T.html)
[Reddy_3548T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3548T.html)
[Reddy_3557T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3557T.html)
[Reddy_3603T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3603T.html)
[Reddy_3725T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3725T.html)
[Reddy_3955T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3955T.html)
[Reddy_823T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_823T.html)

[[include:mermaid_PHF6.md]]

## References