---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]

## Overview
PIM2 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus.



## Relevance tier by entity

|Entity|Tier|Description               |
|:------:|:----:|--------------------------|
|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene[@reichelFlowSortingExome2015]|
|![DLBCL](images/icons/DLBCL_tier1.png) |1 | aSHM target and high-confidence DLBCL gene[@reddyGeneticFunctionalDrivers2017; @schmitzGeneticsPathogenesisDiffuse2018; @arthurGenomewideDiscoverySomatic2018]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

[[include:DLBCL_PIM2.md]]

## Mutation pattern and selective pressure estimates

[[include:dnds_PIM2.md]]

## aSHM regions

|chr_name|hg19_start|hg19_end|region                                                                                   |regulatory_comment|
|:--------:|:----------:|:--------:|:-----------------------------------------------------------------------------------------:|:------------------:|
|chrX    |48774756  |48776255|[TSS](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chrX%3A48774756%2D48776255)|active_promoter   |


[[include:browser_PIM2.md]]

## Expression
![](images/gene_expression/PIM2_by_pathology.svg)
<!-- ORIGIN: reichelFlowSortingExome2015a -->
<!-- DLBCL: arthurGenomewideDiscoverySomatic2018 -->
<!-- PMBL: reichelFlowSortingExome2015a -->

[[include:mermaid_PIM2.md]]

## References