---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]


## Relevance tier by entity

|Entity|Tier|Description                           |
|:------:|:----:|--------------------------------------|
|![BL](images/icons/BL_tier2.png)    |2   |relevance in BL not firmly established[@paneaWholeGenomeLandscape2019]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source               |frequency (%)|
|:------:|:---------------------:|:-------------:|
|BL    |GAMBL genomes+capture| 3.0         |
|BL    |Thomas cohort        | 0.8         |
|BL    |Panea cohort         |10.9         |

## Mutation pattern and selective pressure estimates

[[include:dnds_PLCG2.md]]




## PLCG2 Hotspots

| Chromosome |Coordinate (hg19) | ref>alt | HGVSp | 
 | :---:| :---: | :--: | :---: |
| chr16 | 81819719 | C>A | T42N |

[[include:browser_PLCG2.md]]

## Expression
![](images/gene_expression/PLCG2_by_pathology.svg)
<!-- ORIGIN: paneaWholeGenomeLandscape2019 -->
<!-- BL: paneaWholeGenomeLandscape2019 -->

[[include:mermaid_PLCG2.md]]

## References