---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]

## Overview

Mutations in this gene were first described in DLBCL and FL in 2021 by Hübschmann et al.[@hubschmannMutationalMechanismsShaping2021]


## Relevance tier by entity

|Entity|Tier|Description                              |
|:------:|:----:|-----------------------------------------|
|![DLBCL](images/icons/DLBCL_tier2.png) |2   |relevance in DLBCL not firmly established[@hubschmannMutationalMechanismsShaping2021]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source        |frequency (%)|
|:------:|:--------------:|:-------------:|
|DLBCL |GAMBL genomes |0.38         |
|DLBCL |Schmitz cohort|0.21         |
|DLBCL |Reddy cohort  |0.30         |
|DLBCL |Chapuy cohort |0.85         |

## Mutation pattern and selective pressure estimates

[[include:dnds_PNPO.md]]


[[include:browser_PNPO.md]]

## Expression
![](images/gene_expression/PNPO_by_pathology.svg)

## All Mutations

[SP192997](https://www.bcgsc.ca/downloads/morinlab/GAMBL/MALY/SP192997.html)
[SP116610](https://www.bcgsc.ca/downloads/morinlab/GAMBL/MALY/SP116610.html)

[[include:mermaid_PNPO.md]]

## References


<!-- ORIGIN: hubschmannMutationalMechanismsShaping2021b -->
<!-- DLBCL: hubschmannMutationalMechanismsShaping2021b -->