---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]


## Relevance tier by entity

|Entity|Tier|Description               |
|:------:|:----:|--------------------------|
|![DLBCL](images/icons/DLBCL_tier1.png) |1   |high-confidence DLBCL gene[@lohrDiscoveryPrioritizationSomatic2012; @zhangGeneticHeterogeneityDiffuse2013; @reddyGeneticFunctionalDrivers2017]|
|![FL](images/icons/FL_tier1.png)    |1   |high-confidence FL gene   [@krysiakRecurrentSomaticMutations2017]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

[[include:DLBCL_POU2F2.md]]
[[include:FL_POU2F2.md]]

## Mutation pattern and selective pressure estimates

[[include:dnds_POU2F2.md]]

## POU2F2 Hotspots

| Chromosome |Coordinate (hg19) | ref>alt | HGVSp | 
 | :---:| :---: | :--: | :---: |
| chr19 | 42600031 | C>G | Q238H |
| chr19 | 42600031 | C>A | Q238H |
| chr19 | 42600030 | T>C | T239A |
| chr19 | 42600030 | T>A | T239S |

[[include:browser_POU2F2.md]]

## Expression
![](images/gene_expression/POU2F2_by_pathology.svg)
<!-- ORIGIN: zhangGeneticHeterogeneityDiffuse2013 -->
<!-- DLBCL: zhangGeneticHeterogeneityDiffuse2013 -->
<!-- FL: krysiakRecurrentSomaticMutations2017b -->

[[include:mermaid_POU2F2.md]]

## References