---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]


## Relevance tier by entity

|Entity|Tier|Description                           |
|:------:|:----:|--------------------------------------|
|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
|![DLBCL](images/icons/DLBCL_tier1.png) |1   |high-confidence DLBCL gene            [@schmitzGeneticsPathogenesisDiffuse2018]|
|![FL](images/icons/FL_tier2.png)    |2   |relevance in FL not firmly established[@hubschmannMutationalMechanismsShaping2021]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source        |frequency (%)|
|:------:|:--------------:|:-------------:|
|DLBCL |GAMBL genomes |2.68         |
|DLBCL |Schmitz cohort|7.66         |
|DLBCL |Reddy cohort  |6.61         |
|DLBCL |Chapuy cohort |6.41         |
|FL    |GAMBL genomes |3.00         |

## Mutation pattern and selective pressure estimates

[[include:dnds_PRKDC.md]]




[[include:browser_PRKDC.md]]

## Expression
![](images/gene_expression/PRKDC_by_pathology.svg)
<!-- ORIGIN: schmitzGeneticsPathogenesisDiffuse2018a -->
<!-- DLBCL: schmitzGeneticsPathogenesisDiffuse2018a -->
<!-- FL: hubschmannMutationalMechanismsShaping2021b -->

## All Mutations

[SP192833](https://www.bcgsc.ca/downloads/morinlab/GAMBL/MALY/SP192833.html)
[SP116701](https://www.bcgsc.ca/downloads/morinlab/GAMBL/MALY/SP116701.html)
[SP59304](https://www.bcgsc.ca/downloads/morinlab/GAMBL/MALY/SP59304.html)
[SP192765](https://www.bcgsc.ca/downloads/morinlab/GAMBL/MALY/SP192765.html)
[SP194065](https://www.bcgsc.ca/downloads/morinlab/GAMBL/MALY/SP194065.html)
[SP116720](https://www.bcgsc.ca/downloads/morinlab/GAMBL/MALY/SP116720.html)

[[include:mermaid_PRKDC.md]]

## References