---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]


## Relevance tier by entity

|Entity|Tier|Description               |
|:------:|:----:|--------------------------|
|![BL](images/icons/BL_tier1.png)    |1   |high-confidence BL gene   [@loveGeneticLandscapeMutations2012]|
|![DLBCL](images/icons/DLBCL_tier1.png) |1   |high-confidence DLBCL gene[@reddyGeneticFunctionalDrivers2017; @chapuyMolecularSubtypesDiffuse2018]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

[[include:DLBCL_PTEN.md]]
[[include:BL_PTEN.md]]

## Mutation pattern and selective pressure estimates

[[include:dnds_PTEN.md]]

[[include:browser_PTEN.md]]

## Expression
![](images/gene_expression/PTEN_by_pathology.svg)
<!-- ORIGIN: loveGeneticLandscapeMutations2012 -->
<!-- BL: loveGeneticLandscapeMutations2012 -->

[[include:mermaid_PTEN.md]]

## References