---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]


## Relevance tier by entity

|Entity|Tier|Description               |
|:------:|:----:|--------------------------|
|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene[@spinaGeneticsNodalMarginal2016]|
|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
|![DLBCL](images/icons/DLBCL_tier1.png) |2   |low-confidence DLBCL gene|
|![FL](images/icons/FL_tier1.png)    |1   |high-confidence FL gene   |

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source        |frequency (%)|
|:------:|:--------------:|:-------------:|
|DLBCL |GAMBL genomes |5.54         |
|DLBCL |Schmitz cohort|7.66         |
|DLBCL |Reddy cohort  |5.21         |
|DLBCL |Chapuy cohort |5.56         |
|FL    |GAMBL genomes |3.70         |

## Mutation pattern and selective pressure estimates

[[include:dnds_PTPRD.md]]




## PTPRD Hotspots

| Chromosome |Coordinate (hg19) | ref>alt | HGVSp | 
 | :---:| :---: | :--: | :---: |
| chr9 | 8376670 | T>G | Q1481H |

[[include:browser_PTPRD.md]]

## Expression
![](images/gene_expression/PTPRD_by_pathology.svg)
<!-- ORIGIN: spinaGeneticsNodalMarginal2016b -->
<!-- MZL: spinaGeneticsNodalMarginal2016b -->

[[include:mermaid_PTPRD.md]]

## References