---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]



## Relevance tier by entity

|Entity|Tier|Description               |
|:------:|:----:|--------------------------|
|![DLBCL](images/icons/DLBCL_tier1.png) |1   |high-confidence DLBCL gene[@morinMutationalStructuralAnalysis2013; @reddyGeneticFunctionalDrivers2017; @arthurGenomewideDiscoverySomatic2018]|
|![MCL](images/icons/MCL_tier1.png)   |1   |high-confidence MCL gene  [@zhangGenomicLandscapeMantle2014]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

[[include:DLBCL_RB1.md]]

## Mutation pattern and selective pressure estimates

[[include:dnds_RB1.md]]

[[include:browser_RB1.md]]

## Expression
![](images/gene_expression/RB1_by_pathology.svg)
<!-- ORIGIN: morinMutationalStructuralAnalysis2013 -->
<!-- DLBCL: morinMutationalStructuralAnalysis2013 -->
<!-- MCL: zhangGenomicLandscapeMantle2014 -->

[[include:mermaid_RB1.md]]

## References