---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]

## Overview

Due to [minimal support](RET#representative-mutation) in the original primary data, [low expression in BL](RET#ret-expression) and very few mutations reported in subsequent studies, this gene is very unlikely to be relevant in BL. 



## Relevance tier by entity

|Entity|Tier|Description                           |
|:------:|:----:|--------------------------------------|
|![BL](images/icons/BL_tier2.png)    |3   |Retired, Failed QC[@loveGeneticLandscapeMutations2012]|

## Warnings

<<Warn("The variants reported in this gene failed QC")>>

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source               |frequency (%)|
|:------:|:---------------------:|:-------------:|
|BL    |GAMBL genomes+capture|2.31         |
|BL    |Thomas cohort        |  NA         |
|BL    |Panea cohort         |  NA         |

## Mutation pattern and selective pressure estimates

[[include:dnds_RET.md]]




[[include:browser_RET.md]]

## Expression
![](images/gene_expression/RET_by_pathology.svg)
<!-- ORIGIN: loveGeneticLandscapeMutations2012 -->
<!-- BL: loveGeneticLandscapeMutations2012 -->

## Representative Mutation

![](primary/Love_RET_42930092.png)
**Rating**
&starf; &star; &star; &star; &star;


[[include:mermaid_RET.md]]

## References