--- bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true nocite: | @pasqualucciHypermutationMultipleProtooncogenes2001, --- # RHOH ## Relevance tier by entity |Entity|Tier|Description | |:------:|:----:|-----------------------------------------| |![DLBCL](images/icons/DLBCL_tier2.png) |2 | aSHM target; Although recurrent, the relevance of mutations in DLBCL is tenuous [@pasqualucciHypermutationMultipleProtooncogenes2001]| ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |Entity|source |frequency (%)| |:------:|:--------------:|:-------------:| |DLBCL |GAMBL genomes |1.15 | |DLBCL |Schmitz cohort|0.43 | |DLBCL |Reddy cohort |0.10 | |DLBCL |Chapuy cohort | NA | ## Mutation pattern and selective pressure estimates [[include:dnds_RHOH.md]] ## aSHM regions |chr_name|hg19_start|hg19_end|region |regulatory_comment| |:--------:|:----------:|:--------:|:-----------------------------------------------------------------------------------------:|:------------------:| |chr4 |40193105 |40204231|[TSS](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr4%3A40193105%2D40204231)|active_promoter | [[include:browser_RHOH.md]] ## Expression ![](images/gene_expression/RHOH_by_pathology.svg) <!-- ORIGIN: pasqualucciHypermutationMultipleProtooncogenes2001a --> <!-- DLBCL: pasqualucciHypermutationMultipleProtooncogenes2001a --> ## References