---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]


## Relevance tier by entity

|Entity|Tier|Description                           |
|:------:|:----:|--------------------------------------|
|![BL](images/icons/BL_tier2.png)    |2 | aSHM target; Although recurrent, the relevance of mutations in BL is tenuous [@paneaWholeGenomeLandscape2019]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source               |frequency (%)|
|:------:|:---------------------:|:-------------:|
|BL    |GAMBL genomes+capture|0.23         |
|BL    |Thomas cohort        |0.40         |
|BL    |Panea cohort         |  NA         |

## Mutation pattern and selective pressure estimates

[[include:dnds_RNF144B.md]]

## aSHM regions

|chr_name|hg19_start|hg19_end|region                                                                                   |regulatory_comment|
|:--------:|:----------:|:--------:|:-----------------------------------------------------------------------------------------:|:------------------:|
|chr6    |25861094  |25868788|[TSS](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr6%3A25861094%2D25868788)|NA                |



[[include:browser_RNF144B.md]]

## Expression
![](images/gene_expression/RNF144B_by_pathology.svg)
<!-- ORIGIN: paneaWholeGenomeLandscape2019 -->
<!-- BL: paneaWholeGenomeLandscape2019 -->

[[include:mermaid_RNF144B.md]]

## References