---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]

## Overview
S1PR2 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus.


## Relevance tier by entity

|Entity|Tier|Description                           |
|:------:|:----:|--------------------------------------|
|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
|![BL](images/icons/BL_tier2.png)    |2 | aSHM target; Although recurrent, the relevance of mutations in BL is tenuous [@muppidiLossSignalingGa132014]|
|![DLBCL](images/icons/DLBCL_tier1.png) |1 | aSHM target and high-confidence DLBCL gene            [@morinFrequentMutationHistonemodifying2011; @lohrDiscoveryPrioritizationSomatic2012; @morinMutationalStructuralAnalysis2013]|
|![FL](images/icons/FL_tier1.png)    |1 | aSHM target and high-confidence FL gene               |

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

[[include:DLBCL_S1PR2.md]]
[[include:FL_S1PR2.md]]
[[include:BL_S1PR2.md]]

## Mutation pattern and selective pressure estimates

[[include:dnds_S1PR2.md]]

## aSHM regions

|chr_name|hg19_start|hg19_end|region                                                                                    |regulatory_comment|
|:--------:|:----------:|:--------:|:------------------------------------------------------------------------------------------:|:------------------:|
|chr19   |10340142  |10341764|[TSS](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr19%3A10340142%2D10341764)|active_promoter   |


[[include:browser_S1PR2.md]]

## Expression
![](images/gene_expression/S1PR2_by_pathology.svg)
<!-- ORIGIN: 21796119 -->
<!-- BL: muppidiLossSignalingGa132014b -->
<!-- DLBCL: morinFrequentMutationHistonemodifying2011 -->

[[include:mermaid_S1PR2.md]]

## References