---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
# SEL1L3

## Relevance tier by entity

|Entity|Tier|Description                              |
|:------:|:----:|-----------------------------------------|
|![DLBCL](images/icons/DLBCL_tier2.png) |2 | aSHM target; Although recurrent, the relevance of mutations in DLBCL is tenuous |

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source        |frequency (%)|
|:------:|:--------------:|:-------------:|
|DLBCL |GAMBL genomes |5.16         |
|DLBCL |Schmitz cohort|4.04         |
|DLBCL |Reddy cohort  |2.20         |
|DLBCL |Chapuy cohort |  NA         |

## Mutation pattern and selective pressure estimates

[[include:dnds_SEL1L3.md]]

## aSHM regions

|chr_name|hg19_start|hg19_end|region                                                                                   |regulatory_comment|
|:--------:|:----------:|:--------:|:-----------------------------------------------------------------------------------------:|:------------------:|
|chr4    |25861094  |25868788|[TSS](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr4%3A25861094%2D25868788)|NA                |


[[include:browser_SEL1L3.md]]

## Expression
![](images/gene_expression/SEL1L3_by_pathology.svg)
<!-- ORIGIN: Unknown -->

[[include:mermaid_SEL1L3.md]]

## References