---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]


## Relevance tier by entity

|Entity|Tier|Description                              |
|:------:|:----:|-----------------------------------------|
|![DLBCL](images/icons/DLBCL_tier2.png) |2   |relevance in DLBCL not firmly established[@morinMutationalStructuralAnalysis2013]|
|![FL](images/icons/FL_tier2.png)    |2   |relevance in FL not firmly established   [@russler-germainMutationsAssociatedProgression2023]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source        |frequency (%)|
|:------:|:--------------:|:-------------:|
|DLBCL |GAMBL genomes |3.06         |
|DLBCL |Schmitz cohort|6.38         |
|DLBCL |Reddy cohort  |6.61         |
|DLBCL |Chapuy cohort |6.84         |
|FL    |GAMBL genomes |1.39         |

## Mutation pattern and selective pressure estimates

[[include:dnds_SRRM2.md]]



[[include:browser_SRRM2.md]]

## Expression
![](images/gene_expression/SRRM2_by_pathology.svg)
<!-- ORIGIN: morinMutationalStructuralAnalysis2013 -->
<!-- DLBCL: morinMutationalStructuralAnalysis2013 -->
<!-- FL: russler-germainMutationsAssociatedProgression2023b -->

## All Mutations

[RG043](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Morin_2013/RG043.html)

[[include:mermaid_SRRM2.md]]

## References