---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]




## Relevance tier by entity

|Entity|Tier|Description                           |
|:------:|:----:|--------------------------------------|
|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene[@ohgamiSTAT3MutationsAre2014]|
|![DLBCL](images/icons/DLBCL_tier1.png) |1   |high-confidence DLBCL gene            [@lohrDiscoveryPrioritizationSomatic2012; @morinFrequentMutationHistonemodifying2011; @reddyGeneticFunctionalDrivers2017]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

[[include:DLBCL_STAT3.md]]

## Mutation pattern and selective pressure estimates

[[include:dnds_STAT3.md]]

## STAT3 Hotspots

| Chromosome |Coordinate (hg19) | ref>alt | HGVSp | 
 | :---:| :---: | :--: | :---: |
| chr17 | 40475330 | C>T | D566N |
| chr17 | 40475325 | A>T | N567K |
| chr17 | 40475318 | C>T | D570N |
| chr17 | 40475317 | T>C | D570G |

[[include:browser_STAT3.md]]

## Expression
![](images/gene_expression/STAT3_by_pathology.svg)
<!-- ORIGIN: ohgamiSTAT3MutationsAre2014 -->
<!-- DLBCL: ohgamiSTAT3MutationsAre2014 -->

[[include:mermaid_STAT3.md]]

## References