---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]



## Relevance tier by entity

|Entity|Tier|Description                              |
|:------:|:----:|-----------------------------------------|
|![DLBCL](images/icons/DLBCL_tier2.png) |3   |Retired, failed QC[@reddyGeneticFunctionalDrivers2017]|

## Warnings

<<Warn("The variants reported in this gene in DLBCL failed QC")>>

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source        |frequency (%)|
|:------:|:--------------:|:-------------:|
|DLBCL |GAMBL genomes |1.53         |
|DLBCL |Schmitz cohort|2.34         |
|DLBCL |Reddy cohort  |0.80         |
|DLBCL |Chapuy cohort |0.43         |

## Mutation pattern and selective pressure estimates

[[include:dnds_SYK.md]]



[[include:browser_SYK.md]]

## Expression
![](images/gene_expression/SYK_by_pathology.svg)
<!-- ORIGIN: reddyGeneticFunctionalDrivers2017 -->
<!-- DLBCL: reddyGeneticFunctionalDrivers2017 -->

## All Mutations

[Reddy_2079T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2079T.html)
[Reddy_2228T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2228T.html)
[Reddy_2261T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2261T.html)
[Reddy_2599T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2599T.html)
[Reddy_2761T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2761T.html)
[Reddy_2766T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2766T.html)
[Reddy_2874T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2874T.html)
[Reddy_2922T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2922T.html)
[Reddy_3610T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3610T.html)
[Reddy_3627T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3627T.html)
[Reddy_3637T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3637T.html)
[Reddy_3698T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3698T.html)
[Reddy_683T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_683T.html)

[[include:mermaid_SYK.md]]

## References