---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]


## Relevance tier by entity

|Entity|Tier|Description                              |
|:------:|:----:|-----------------------------------------|
|![BL](images/icons/BL_tier1.png)    |1 | aSHM target and high-confidence BL gene   [@grandeGenomewideDiscoverySomatic2019]|
|![DLBCL](images/icons/DLBCL_tier2.png) |1 | aSHM target and high-confidence DLBCL gene|


## Mutation incidence in large patient cohorts (GAMBL reanalysis)

[[include:DLBCL_TCL1A.md]]
[[include:BL_TCL1A.md]]

## Mutation pattern and selective pressure estimates

[[include:dnds_TCL1A.md]]

## aSHM regions

|chr_name|hg19_start|hg19_end|region                                                                                    |regulatory_comment|
|:--------:|:----------:|:--------:|:------------------------------------------------------------------------------------------:|:------------------:|
|chr14   |96179535  |96180366|[TSS](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr14%3A96179535%2D96180366)|active_promoter   |



[[include:browser_TCL1A.md]]

## Expression
![](images/gene_expression/TCL1A_by_pathology.svg)

[[include:mermaid_TCL1A.md]]

## References

<!-- ORIGIN: grandeGenomewideDiscoverySomatic2019 -->
<!-- BL: grandeGenomewideDiscoverySomatic2019 -->