TET2

TET2

History

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timeline
    title Publication timing
      2017-05-01 : Albuquerque : DLBCL
      2019-09-26 : Panea : BL

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Relevance tier by entity

Entity	Tier	Description
	2	relevance in BL not firmly established
	1	high-confidence DLBCL gene

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
BL	GAMBL genomes+capture	5.31
BL	Thomas cohort	5.10
BL	Panea cohort	10.90
DLBCL	GAMBL genomes	5.54
DLBCL	Schmitz cohort	11.70
DLBCL	Reddy cohort	7.41
DLBCL	Chapuy cohort	5.98

Mutation pattern and selective pressure estimates

Entity	aSHM	Significant selection	dN/dS (missense)	dN/dS (nonsense)
BL	No	Yes	1.516	25.932
DLBCL	No	Yes	0.663	12.181
FL	No	No	0.892	10.949

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

TET2 Expression

References

1. Albuquerque MA, Grande BM, Ritch EJ, Pararajalingam P, Jessa S, Krzywinski M, Grewal JK, Shah SP, Boutros PC, Morin RD. Enhancing knowledge discovery from cancer genomics data with Galaxy. Gigascience. 2017 May 1;6(5):1–13. PMCID: PMC5437943
2. Panea R, Love C, Shingleton JR, Reddy A, Bailey J, Moormann A, Otieno J, Ong’echa J, Oduor C, Schroêder K, Masalu N, Chao N, Agajanian M, Major M, Fedoriw Y, Richards K, Rymkiewicz G, Miles R, Alobeid B, Bhagat G, Flowers C, Ondrejka S, Hsi E, Choi W, Au-Yeung R, Hartmann W, Lenz G, Meyerson H, Lin YY, Zhuang Y, Luftig M, Waldrop A, Dave T, Thakkar D, Sahay H, Li G, Palus B, Seshadri V, Kim S, Gascoyne R, Levy S, Mukhopadhyay M, Dunson D, Dave S. The whole genome landscape of Burkitt lymphoma subtypes. Blood. 2019;