---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]


## Relevance tier by entity

|Entity|Tier|Description                           |
|:------:|:----:|--------------------------------------|
|![DLBCL](images/icons/DLBCL_tier1.png) |1   |high-confidence DLBCL gene            [@morinFrequentMutationHistonemodifying2011; @zhangGeneticHeterogeneityDiffuse2013; @morinMutationalStructuralAnalysis2013]|
|![FL](images/icons/FL_tier2.png)    |2   |relevance in FL not firmly established[@morinFrequentMutationHistonemodifying2011]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

[[include:DLBCL_TMEM30A.md]]
[[include:FL_TMEM30A.md]]

## Mutation pattern and selective pressure estimates

[[include:dnds_TMEM30A.md]]


## TMEM30A Hotspots

| Chromosome |Coordinate (hg19) | ref>alt | HGVSp | 
 | :---:| :---: | :--: | :---: |
| chr6 | 75969072 | G>A | R226* |
| chr6 | 75965985 | G>A | R307* |
| chr6 | 75965975 | A>T | M310K |

[[include:browser_TMEM30A.md]]

## Expression
![](images/gene_expression/TMEM30A_by_pathology.svg)
<!-- ORIGIN: morinFrequentMutationHistonemodifying2011 -->
<!-- DLBCL: morinFrequentMutationHistonemodifying2011 -->
<!-- FL: morinFrequentMutationHistonemodifying2011 -->
[[include:mermaid_TMEM30A.md]]

## References