---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---

[[_TOC_]]



## Relevance tier by entity

|Entity|Tier|Description                           |
|:------:|:----:|--------------------------------------|
|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene[@spinaGeneticsNodalMarginal2016] |
|![DLBCL](images/icons/DLBCL_tier1.png) |1   |high-confidence DLBCL gene[@morinFrequentMutationHistonemodifying2011]            |
|![FL](images/icons/FL_tier1.png)    |1   |high-confidence FL gene[@cheungAcquiredTNFRSF14Mutations2010]               |

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

[[include:DLBCL_TNFRSF14.md]]
[[include:FL_TNFRSF14.md]]

## Mutation pattern and selective pressure estimates

[[include:dnds_TNFRSF14.md]]

## TNFRSF14 Hotspots

| Chromosome |Coordinate (hg19) | ref>alt | HGVSp | 
 | :---:| :---: | :--: | :---: |
| chr1 | 2488104 | A>G | M1? |
| chr1 | 2488105 | T>C | M1? |
| chr1 | 2488105 | T>G | M1? |
| chr1 | 2488106 | G>A | M1? |
| chr1 | 2488107 | G>T | E2* |
| chr1 | 2488123 | G>A | W7* |
| chr1 | 2488124 | G>A | W7* |
| chr1 | 2488132 | C>A | P10H |
| chr1 | 2488138 | G>A | W12* |
| chr1 | 2488139 | G>A | W12* |
| chr1 | 2488152 | A>T | K17* |
| chr1 | 2488156 | C>A | T18N |

[[include:browser_TNFRSF14.md]]

## Expression
![](images/gene_expression/TNFRSF14_by_pathology.svg)


<!-- ORIGIN: cheungAcquiredTNFRSF14Mutations2010a @cheungAcquiredTNFRSF14Mutations2010a -->
<!-- FL: cheungAcquiredTNFRSF14Mutations2010a -->
<!-- MZL: spinaGeneticsNodalMarginal2016b @spinaGeneticsNodalMarginal2016b -->
<!-- DLBCL: morinFrequentMutationHistonemodifying2011 -->

[[include:mermaid_TNFRSF14.md]]

# References