---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]



## Relevance tier by entity

|Entity|Tier|Description               |
|:------:|:----:|--------------------------|
|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene[@rossiCodingGenomeSplenic2012]|
|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene[@tiacciPervasiveMutationsJAKSTAT2018]|
|![BL](images/icons/BL_tier1.png)    |1   |high-confidence BL gene   [@wildaInactivationARFMDM2p53Pathway2004]|
|![DLBCL](images/icons/DLBCL_tier1.png) |1   |high-confidence DLBCL gene[@lohrDiscoveryPrioritizationSomatic2012]|
|![FL](images/icons/FL_tier1.png)    |1   |high-confidence FL gene   [@morinFrequentMutationHistonemodifying2011]|
|![MCL](images/icons/MCL_tier1.png)   |1   |high-confidence MCL gene  [@beaLandscapeSomaticMutations2013]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

[[include:DLBCL_TP53.md]]
[[include:FL_TP53.md]]
[[include:BL_TP53.md]]

## Mutation pattern and selective pressure estimates

[[include:dnds_TP53.md]]

[[include:browser_TP53.md]]

## Expression
![](images/gene_expression/TP53_by_pathology.svg)


<!-- ORIGIN: wildaInactivationARFMDM2p53Pathway2004 -->
<!-- BL: wildaInactivationARFMDM2p53Pathway2004 -->
<!-- FL: morinFrequentMutationHistonemodifying2011 -->
<!-- BL: wildaInactivationARFMDM2p53Pathway2004 -->
<!-- MCL: beaLandscapeSomaticMutations2013 -->
<!-- MZL: rossiCodingGenomeSplenic2012c -->
<!-- PMBL: tiacciPervasiveMutationsJAKSTAT2018b -->

[[include:mermaid_TP53.md]]

## References