---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]


## Relevance tier by entity

|Entity|Tier|Description                              |
|:------:|:----:|-----------------------------------------|
|![DLBCL](images/icons/DLBCL_tier2.png) |2   |relevance in DLBCL not firmly established[@hubschmannMutationalMechanismsShaping2021]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source        |frequency (%)|
|:------:|:--------------:|:-------------:|
|DLBCL |GAMBL genomes |1.34         |
|DLBCL |Schmitz cohort|1.49         |
|DLBCL |Reddy cohort  |0.90         |
|DLBCL |Chapuy cohort |1.28         |

## Mutation pattern and selective pressure estimates

[[include:dnds_TRAF6.md]]


## TRAF6 Hotspots

| Chromosome |Coordinate (hg19) | ref>alt | HGVSp | 
 | :---:| :---: | :--: | :---: |
| chr11 | 36511924 | C>A | E345* |
| chr11 | 36511915 | G>A | Q348* |
| chr11 | 36511893 | C>T | W355* |
| chr11 | 36511892 | C>T | W355* |

[[include:browser_TRAF6.md]]

## Expression
![](images/gene_expression/TRAF6_by_pathology.svg)
<!-- ORIGIN: hubschmannMutationalMechanismsShaping2021b -->
<!-- DLBCL: hubschmannMutationalMechanismsShaping2021b -->

## All Mutations

[SP116630](https://www.bcgsc.ca/downloads/morinlab/GAMBL/MALY/SP116630.html)
[SP193005](https://www.bcgsc.ca/downloads/morinlab/GAMBL/MALY/SP193005.html)
[SP193312](https://www.bcgsc.ca/downloads/morinlab/GAMBL/MALY/SP193312.html)
[SP59456](https://www.bcgsc.ca/downloads/morinlab/GAMBL/MALY/SP59456.html)

[[include:mermaid_TRAF6.md]]

## References