---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
nocite: |
  @zhangGeneticHeterogeneityDiffuse2013, @rossiCodingGenomeSplenic2012, 
---
[[_TOC_]]


## Relevance tier by entity

[[include:tables/table1_TRRAP.md]]

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source        |frequency (%)|
|:------:|:--------------:|:-------------:|
|DLBCL |GAMBL genomes |2.87         |
|DLBCL |Schmitz cohort|8.94         |
|DLBCL |Reddy cohort  |3.50         |
|DLBCL |Chapuy cohort |5.98         |

## Mutation pattern and selective pressure estimates

[[include:tables/dnds_TRRAP.md]]




## TRRAP Hotspots

| Chromosome |Coordinate (hg19) | ref>alt | HGVSp | 
 | :---:| :---: | :--: | :---: |
| chr7 | 98509802 | C>T | S722F |

[[include:tables/browser_TRRAP.md]]

## Expression
![](images/gene_expression/TRRAP_by_pathology.svg)
<!-- ORIGIN: rossiCodingGenomeSplenic2012c -->
<!-- DLBCL: parryWholeExomeSequencing2013 -->
<!-- MZL: rossiCodingGenomeSplenic2012c -->

[[include:tables/mermaid_TRRAP.md]]

## References