UBR5
[[TOC]]
Mutations in this gene were first described in DLBCL in 2013[@zhangGeneticHeterogeneityDiffuse2013] and by the same group in a subsequent study.[@reddyGeneticFunctionalDrivers2017] It remains in Tier 2 because other exome and genome-wide studies of DLBCL did not reproduce this observation.
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence PMBL/cHL/GZL gene |
 |
2 | relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013] |
 |
1 | high-confidence MCL gene [@pararajalingamCodingNoncodingDrivers2020] |
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 3.63 |
| DLBCL | Schmitz cohort | 5.53 |
| DLBCL | Reddy cohort | 3.20 |
| DLBCL | Chapuy cohort | 5.13 |
| MCL | GAMBL genomes | 9.00 |
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