---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]

## Overview

Mutations in this gene were first described in DLBCL in 2013[@zhangGeneticHeterogeneityDiffuse2013] and by the same group in a subsequent study.[@reddyGeneticFunctionalDrivers2017] It remains in Tier 2 because other exome and genome-wide studies of DLBCL did not reproduce this observation. 



## Relevance tier by entity

|Entity|Tier|Description                              |
|:------:|:----:|-----------------------------------------|
|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
|![DLBCL](images/icons/DLBCL_tier2.png) |2   |relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]|
|![MCL](images/icons/MCL_tier1.png)   |1   |high-confidence MCL gene                 [@pararajalingamCodingNoncodingDrivers2020]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source        |frequency (%)|
|:------:|:--------------:|:-------------:|
|DLBCL |GAMBL genomes |3.63         |
|DLBCL |Schmitz cohort|5.53         |
|DLBCL |Reddy cohort  |3.20         |
|DLBCL |Chapuy cohort |5.13         |
|MCL   |GAMBL genomes |9.00         |

## Mutation pattern and selective pressure estimates

[[include:dnds_UBR5.md]]




[[include:browser_UBR5.md]]

## Expression
![](images/gene_expression/UBR5_by_pathology.svg)
<!-- ORIGIN: zhangGeneticHeterogeneityDiffuse2013 -->
<!-- DLBCL: zhangGeneticHeterogeneityDiffuse2013 -->
<!-- MCL: pararajalingamCodingNoncodingDrivers2020 -->

[[include:mermaid_UBR5.md]]

## References