---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]



## Relevance tier by entity

|Entity|Tier|Description                              |
|:------:|:----:|-----------------------------------------|
|![MZL](images/icons/MZL_tier2.png)|2|relevance in MZL not firmly established[@rossiCodingGenomeSplenic2012]|
|![DLBCL](images/icons/DLBCL_tier2.png) |3   |Retired, Failed QC[@reddyGeneticFunctionalDrivers2017]|

## Warnings

<<Warn("The variants reported in this gene in DLBCL failed QC")>>

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source        |frequency (%)|
|:------:|:--------------:|:-------------:|
|DLBCL |GAMBL genomes |2.68         |
|DLBCL |Schmitz cohort|3.40         |
|DLBCL |Reddy cohort  |1.20         |
|DLBCL |Chapuy cohort |1.28         |

## Mutation pattern and selective pressure estimates

[[include:dnds_WAC.md]]




[[include:browser_WAC.md]]

## Expression
![](images/gene_expression/WAC_by_pathology.svg)
<!-- ORIGIN: rossiCodingGenomeSplenic2012c -->
<!-- DLBCL: reddyGeneticFunctionalDrivers2017 -->
<!-- MZL: rossiCodingGenomeSplenic2012c -->

## All Mutations

[Reddy_2232T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2232T.html)
[Reddy_2619T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2619T.html)
[Reddy_2698T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2698T.html)
[Reddy_2769T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2769T.html)
[Reddy_2791T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2791T.html)
[Reddy_2892T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2892T.html)
[Reddy_2898T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2898T.html)
[Reddy_2919T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2919T.html)
[Reddy_2931T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2931T.html)
[Reddy_2933T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2933T.html)
[Reddy_2934T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2934T.html)
[Reddy_2936T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2936T.html)
[Reddy_2953T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2953T.html)
[Reddy_2999T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2999T.html)
[Reddy_3456T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3456T.html)
[Reddy_3480T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3480T.html)
[Reddy_3653T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3653T.html)
[Reddy_3704T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3704T.html)
[Reddy_3721T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3721T.html)
[Reddy_3750T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3750T.html)
[Reddy_3758T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3758T.html)
[Reddy_3977T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3977T.html)

[[include:mermaid_WAC.md]]

## References