---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
nocite: |
  @reichelFlowSortingExome2015, @schmitzGeneticsPathogenesisDiffuse2018, 
---
[[_TOC_]]

## Overview
WEE1 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus. 


## Relevance tier by entity

[[include:tables/table1_WEE1.md]]

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

### DLBCL
[[include:tables/DLBCL_WEE1.md]]

## Mutation pattern and selective pressure estimates

[[include:tables/dnds_WEE1.md]]

## aSHM regions

|chr_name|hg19_start|hg19_end|region                                                                                     |regulatory_comment|
|:--------:|:----------:|:--------:|:-------------------------------------------------------------------------------------------:|:------------------:|
|chr11   |9595246   |9599502 |[intron](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr11%3A9595246%2D9599502)|NA                |



## WEE1 Hotspots

| Chromosome |Coordinate (hg19) | ref>alt | HGVSp | 
 | :---:| :---: | :--: | :---: |
| chr11 | 9595762 | G>C | L94F |
| chr11 | 9595887 | G>A | S136N |
| chr11 | 9595888 | C>G | S136R |
| chr11 | 9595889 | T>G | S137A |

[[include:tables/browser_WEE1.md]]

## Expression
![](images/gene_expression/WEE1_by_pathology.svg)
<!-- ORIGIN: reichelFlowSortingExome2015a -->
<!-- PMBL: reichelFlowSortingExome2015a -->
<!-- DLBCL: schmitzGeneticsPathogenesisDiffuse2018a -->

[[include:tables/mermaid_WEE1.md]]

## References