---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---

[[_TOC_]]


## Relevance tier by entity

|Entity|Tier|Description               |
|:------:|:----:|--------------------------|
|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene[@jardinRecurrentMutationsExportin2016]|
|![DLBCL](images/icons/DLBCL_tier1.png) |1   |high-confidence DLBCL gene[@mareschalWholeExomeSequencing2016; @reddyGeneticFunctionalDrivers2017]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

[[include:DLBCL_XPO1.md]]

## Mutation pattern and selective pressure estimates

[[include:dnds_XPO1.md]]

## XPO1 Hotspots

| Chromosome |Coordinate (hg19) | ref>alt | HGVSp | 
 | :---:| :---: | :--: | :---: |
| chr2 | 61719471 | T>C | E571G |
| chr2 | 61719472 | C>T | E571K |

[[include:browser_XPO1.md]]

## Expression
![](images/gene_expression/XPO1_by_pathology.svg)
<!-- ORIGIN: mareschalWholeExomeSequencing2016 -->
<!-- DLBCL: mareschalWholeExomeSequencing2016 -->
<!-- PMBL: jardinRecurrentMutationsExportin2016a -->

[[include:mermaid_XPO1.md]]

## References