---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]

## Overview
ZFP36L1 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus.


## Relevance tier by entity

|Entity|Tier|Description                           |
|:------:|:----:|--------------------------------------|
|![MCL](images/icons/MCL_tier2.png)|2|relevance in MCL not firmly established|
|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene[@reichelFlowSortingExome2015]|
|![BL](images/icons/BL_tier2.png)    |2 | aSHM target; Although recurrent, the relevance of mutations in BL is tenuous [@paneaWholeGenomeLandscape2019]|
|![DLBCL](images/icons/DLBCL_tier1.png) |1 | aSHM target and high-confidence DLBCL gene            [@morinFrequentMutationHistonemodifying2011]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

[[include:DLBCL_ZFP36L1.md]]
[[include:BL_ZFP36L1.md]]

## Mutation pattern and selective pressure estimates

[[include:dnds_ZFP36L1.md]]

## aSHM regions

|chr_name|hg19_start|hg19_end|region                                                                                    |regulatory_comment|
|:--------:|:----------:|:--------:|:------------------------------------------------------------------------------------------:|:------------------:|
|chr14   |69257848  |69259739|[TSS](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr14%3A69257848%2D69259739)|active_promoter   |


[[include:browser_ZFP36L1.md]]

## Expression
![](images/gene_expression/ZFP36L1_by_pathology.svg)

[[include:mermaid_ZFP36L1.md]]

## References

<!-- DLBCL: morinFrequentMutationHistonemodifying2011 -->
<!-- PMBL: reichelFlowSortingExome2015a -->
<!-- BL: paneaWholeGenomeLandscape2019 -->
<!-- ORIGIN: morinFrequentMutationHistonemodifying2011 -->