---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]


## Relevance tier by entity

|Entity|Tier|Description                              |
|:------:|:----:|-----------------------------------------|
|![DLBCL](images/icons/DLBCL_tier2.png) |2   |relevance in DLBCL not firmly established[@reddyGeneticFunctionalDrivers2017]|

## Warnings

<<Warn("The variants reported in this gene in DLBCL failed QC")>>

Mutations in this gene were reported to be inflated in the original results according to [Dreval K](https://www.biorxiv.org/content/10.1101/2023.11.21.567983v1)

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source        |frequency (%)|
|:------:|:--------------:|:-------------:|
|DLBCL |GAMBL genomes |0.38         |
|DLBCL |Schmitz cohort|1.70         |
|DLBCL |Reddy cohort  |1.40         |
|DLBCL |Chapuy cohort |0.43         |



## Mutation pattern and selective pressure estimates

[[include:dnds_ZFX.md]]




[[include:browser_ZFX.md]]

## Expression
![](images/gene_expression/ZFX_by_pathology.svg)
<!-- ORIGIN: reddyGeneticFunctionalDrivers2017 -->
<!-- DLBCL: reddyGeneticFunctionalDrivers2017 -->

[[include:mermaid_ZFX.md]]

## References