From fa9e6c42bf567b9d0246d451932772f87ddfcb4a Mon Sep 17 00:00:00 2001 From: RJSheppard Date: Fri, 28 Jun 2024 11:43:46 +0100 Subject: [PATCH 01/11] Added parameters csv file that contains falciparum and vivax specific parameter sets. These are now selected in the get_parameters() function by specificying parasite == "falciparum" or "vivax". The functions then selects the parasite-specific values and combines then withe the non-parasite specific values. In order to allow the vivax code to run without full functionality, we have included additional falciparum parameters in the vivax parameter set. These will be removed in the following stages. Added tests to check parameters are behaving as expected. --- R/parameters.R | 469 +++++++++++++++++-------------- data-raw/parasite_parameters.R | 9 + data-raw/parasite_parameters.csv | 119 ++++++++ data/parasite_parameters.rda | Bin 0 -> 1168 bytes tests/testthat/test-vivax.R | 26 ++ 5 files changed, 413 insertions(+), 210 deletions(-) create mode 100644 data-raw/parasite_parameters.R create mode 100644 data-raw/parasite_parameters.csv create mode 100644 data/parasite_parameters.rda create mode 100644 tests/testthat/test-vivax.R diff --git a/R/parameters.R b/R/parameters.R index 90ad4842..f9ea33da 100644 --- a/R/parameters.R +++ b/R/parameters.R @@ -1,13 +1,26 @@ #' @title Get model parameters #' @description #' get_parameters creates a named list of parameters for use in the model. These -#' parameters are passed to process functions. These parameters are explained in +#' parameters are passed to process functions. The default parameters, which +#' are for Plasmodium falciparum, are explained in #' "The US President's Malaria Initiative, Plasmodium falciparum transmission #' and mortality: A modelling study." #' +#' Plasmodium vivax specific parameters are explained in +#' "Mathematical modelling of the impact of expanding levels of malaria control +#' interventions on Plasmodium vivax." by White, Michael T., et al. with parameter +#' values found in "Accelerating towards P. vivax elimination with a novel +#' serological test-and-treat strategy: a modelling case study in Brazil" by +#' Nekkab, Narimane T.,et al. or online repository. +#' #' @param overrides a named list of parameter values to use instead of defaults +#' @param parasite Plasmodium parasite species ("falciparum" or "vivax"); default = "falciparum" +#' #' The parameters are defined below. #' +#' parasite parameter +#' * parasite - parasite species (falciparum or vivax); default = "falciparum" +#' #' initial state proportions: #' #' * s_proportion - the proportion of `human_population` that begin as susceptible; default = 0.420433246 @@ -24,7 +37,14 @@ #' * dd - the delay for humans to move from state D to A; default = 5 #' * dt - the delay for humans to move from state Tr to S; default = 5 #' * da - the delay for humans to move from state A to U; default = 195 -#' * du - the delay for humans to move from state U to S; default = 110 +#' * du - the delay for humans to move from state U to S (p.f only); default = 110 +#' +#' duration of pcr detectable infection: du (p.v only): +#' +#' * dpcr_max - Maximum duration of subpatent infection: default = 70 +#' * dpcr_min - Minimum duration of subpatent infection: default = 10 +#' * kpcr - Shape parameter: default = 4.602 +#' * apcr50 - Scale parameter: default = 9.9 #' #' human demography parameters: #' @@ -35,33 +55,37 @@ #' #' initial immunity values: #' -#' * init_icm - the immunity from clinical disease at birth; default = 0 -#' * init_ivm - the immunity from severe disease at birth; default = 0 -#' * init_ib - the initial pre-erythrocitic immunity; default = 0 +#' * init_ib - the initial pre-erythrocitic immunity (p.f only); default = 0 +#' * init_iaa - the initial acquired anti-parasite immunity (p.v only): default = 0 +#' * init_iam - the initial anti-parasite immunity at birth (p.v only); default = 0 #' * init_ica - the initial acquired immunity from clinical disease; default = 0 -#' * init_iva - the initial acquired immunity from severe disease; default = 0 -#' * init_id - the initial acquired immunity to detectability; default = 0 +#' * init_icm - the initial clinical immunity at birth; default = 0 +#' * init_iva - the initial acquired immunity from severe disease (p.f only); default = 0 +#' * init_ivm - the initial severe immunity from severe disease at birth (p.f only); default = 0 +#' * init_id - the initial acquired immunity to lm detectability (p.f only); default = 0 #' #' immunity decay rates: #' -#' * rm - decay rate for maternal immunity to clinical disease; default = 67.6952 -#' * rvm - decay rate for maternal immunity to severe disease; default = 76.8365 -#' * rb - decay rate for acquired pre-erythrocytic immunity; default = 3650 +#' * rb - decay rate for acquired pre-erythrocytic immunity (p.f only); default = 3650 +#' * ra - decay rate for acquired anti-parasite immunity (p.v only); default = 3650 #' * rc - decay rate for acquired immunity to clinical disease; default = 10950 -#' * rva - decay rate for acquired immunity to severe disease; default = 10950 -#' * rid - decay rate for acquired immunity to detectability; default = 3650 +#' * rva - decay rate for acquired immunity to severe disease (p.f only); default = 10950 +#' * rm - decay rate for maternal immunity to clinical disease (or p.v: maternal clinical and anti-parasite immunities); default = 67.6952 +#' * rvm - decay rate for maternal immunity to severe disease (p.f only); default = 76.8365 +#' * rid - decay rate for acquired immunity to lm-detectability (p.f only); default = 3650 #' #' immunity boost grace periods: #' -#' * ub - period in which pre-erythrocytic immunity cannot be boosted; default = 7.2 +#' * ub - period in which pre-erythrocytic immunity cannot be boosted (p.f only); default = 7.2 +#' * ua - period in which anti-parasite immunity cannot be boosted (p.v only); default = 9.44512 #' * uc - period in which clinical immunity cannot be boosted; default = 6.06 -#' * uv - period in which severe immunity cannot be boosted; default = 11.4321 -#' * ud - period in which immunity to detectability cannot be boosted; default = 9.44512 +#' * uv - period in which severe immunity cannot be boosted (p.f only); default = 11.4321 +#' * ud - period in which immunity to detectability cannot be boosted (p.f only); default = 9.44512 #' #' maternal immunity parameters: #' -#' * pcm - new-born clinical immunity relative to mother's; default = 0.774368 -#' * pvm - new-born severe immunity relative to mother's; default = 0.195768 +#' * pcm - new-born clinical immunity (or p.v: clinical and anti-parasite immunities) relative to mother's; default = 0.774368 +#' * pvm - new-born severe immunity relative to mother's (p.f only); default = 0.195768 #' #' unique biting rate: #' @@ -71,14 +95,17 @@ #' * n_heterogeneity_groups - number discretised groups for heterogeneity, used #' for sampling mothers; default = 5 #' -#' probability of pre-erythrocytic infection: +#' probability of pre-erythrocytic infection (p.f only): #' #' * b0 - maximum probability due to no immunity; default = 0.59 #' * b1 - maximum reduction due to immunity; default = 0.5 #' * ib0 - scale parameter; default = 43.9 #' * kb - shape parameter; default = 2.16 +#' +#' probability of pre-erythrocytic infection (p.v only): +#' * b - probability of pre-erythrocytic infection: default = 0.5 #' -#' probability of detection by light-microscopy when asymptomatic: +#' probability of detection by light-microscopy when asymptomatic (p.f only): #' #' * fd0 - time-scale at which immunity changes with age; default = 0.007055 #' * ad - scale parameter relating age to immunity; default = 7993.5 @@ -87,6 +114,13 @@ #' * id0 - scale parameter; default = 1.577533 #' * kd - shape parameter; default = 0.476614 #' +#' probability of patent infection due to anti-parasite immunity (p.v only): +#' +#' * phi0lm - maximum probability due to no immunity; default = 0.8918 +#' * phi1lm - maximum reduction due to immunity; default = 0.00482170890334156 +#' * ic0lm - scale parameter; default = 27.52 +#' * kclm - shape parameter; default = 2.403 +#' #' probability of clinical infection: #' #' * phi0 - maximum probability due to no immunity; default = 0.792 @@ -94,7 +128,7 @@ #' * ic0 - scale parameter; default = 18.02366 #' * kc - shape parameter; default = 2.36949 #' -#' probability of severe infection: +#' probability of severe infection (p.f only): #' #' * theta0 - maximum probability due to no immunity; default = 0.0749886 #' * theta1 - maximum reduction due to immunity; default = 0.0001191 @@ -107,6 +141,7 @@ #' infectivity towards mosquitoes: #' #' * cd - infectivity of clinically diseased humans towards mosquitoes; default = 0.068 +#' * ca - infectivity of asymptomatic humans towards mosquitoes (p.v only); default = 0.1 #' * gamma1 - parameter for infectivity of asymptomatic humans; default = 1.82425 #' * cu - infectivity of sub-patent infection; default = 0.0062 #' * ct - infectivity of treated infection; default = 0.021896 @@ -156,6 +191,13 @@ #' * delay_gam - lag from parasites to infectious gametocytes; default = 12.5 #' * dem - extrinsic incubation period in mosquito population model; default = 10 #' +#' hypnozoite parameters (p.v only): +#' +#' * f - hypnozoite relapse rate; default = 0.024 +#' * gammal - hypnozoite batch clearance rate; default = 0.0026 +#' * init_hyp - initial hypnozoite batch number; default = 0 +#' * kmax - maximum number of hypnozoite batches for use in the equilibrium solution; default = 10 +#' #' treatment parameters: #' please set treatment parameters with the convenience functions #' \code{\link{set_drugs}} and \code{\link{set_clinical_treatment}} @@ -166,6 +208,9 @@ #' model prophylaxis for each drug; default = turned off #' * drug_prophylaxis_scale - a vector of scale parameters for weibull curves to #' model prophylaxis for each drug; default = turned off +#' * drug_hypnozoite_efficacy - a vector of efficacies targeting hypnozoites; default = turned off +#' * drug_hypnozoite_prophylaxis_shape - a vector of shape parameters for weibull curves to model prophylaxis against hypnozoite batch formation (days); default = turned off +#' * drug_hypnozoite_prophylaxis_scale - a vector of scale parameters for weibull curves to model prophylaxis against hypnozoite batch formation (days); default = turned off #' * clinical_treatment_drugs - a vector of drugs that are available for #' clinically diseased (these values refer to the index in drug_* parameters); default = NULL, NULL, NULL #' * clinical_treatment_coverage - a vector of coverage values for each drug; default = NULL, NULL, NULL @@ -235,6 +280,8 @@ #' * incidence_rendering_min_ages - the minimum ages for incidence #' outputs (includes asymptomatic microscopy +); default = turned off #' * incidence_rendering_max_ages - the corresponding max ages; default = turned off +#' * patent_incidence_rendering_min_ages - the minimum ages for patent incidence outputs (LM detectable), (p.v only); default = turned off +#' * patent_incidence_rendering_max_ages - the corresponding max ages (p.v only); default = turned off #' * clinical_incidence_rendering_min_ages - the minimum ages for clinical incidence outputs (symptomatic); default = 0 #' * clinical_incidence_rendering_max_ages - the corresponding max ages; default = 1825 #' * severe_incidence_rendering_min_ages - the minimum ages for severe incidence @@ -243,7 +290,30 @@ #' * prevalence_rendering_min_ages - the minimum ages for clinical prevalence #' outputs; default = 730 #' * prevalence_rendering_max_ages - the corresponding max ages; default = 3650 -#' +#' * n_with_hypnozoites_rendering_min_ages - the minimum ages for number with hypnozoites outputs (p.v only); default = numeric(0) +#' * n_with_hypnozoites_rendering_max_ages - the corresponding max ages; default = numeric(0) +#' +#' * ib_rendering_min_ages - the minimum ages for blood immunity outputs (p.f only); default = numeric(0) +#' * ib_rendering_max_ages - the corresponding max ages; default = numeric(0) +#' * id_rendering_min_ages - the minimum ages for acquired detectability immunity (p.f); default = numeric(0) +#' * id_rendering_max_ages - the corresponding max ages; default = numeric(0) +#' * iaa_rendering_min_ages - the minimum ages for antiparasite immunity (p.v only); default = numeric(0) +#' * iam_rendering_max_ages - the corresponding max ages; default = numeric(0) +#' * ica_rendering_min_ages - the minimum ages for acquired clinical immunity outputs; default = numeric(0) +#' * ica_rendering_max_ages - the corresponding max ages; default = numeric(0) +#' * iva_rendering_min_ages - the minimum ages for acquired severe immunity outputs (p.f only); default = numeric(0) +#' * iva_rendering_max_ages - the corresponding max ages; default = numeric(0) +#' * idm_rendering_min_ages - the minimum ages for maternal antiparasite immunity outputs (p.v only); default = numeric(0) +#' * idm_rendering_max_ages - the corresponding max ages; default = numeric(0) +#' * icm_rendering_min_ages - the minimum ages for maternal clinical immunity outputs; default = numeric(0) +#' * icm_rendering_max_ages - the corresponding max ages; default = numeric(0) +#' * ivm_rendering_min_ages - the minimum ages for maternal severe immunity outputs (p.f only); default = numeric(0) +#' * ivm_rendering_max_ages - the corresponding max ages; default = numeric(0) +#' * hypnozoites_rendering_min_ages - the minimum ages average hypnozoite batches outputs (p.v only); default = numeric(0) +#' * hypnozoites_rendering_max_ages - the corresponding max ages; default = numeric(0) +#' * n_with_hypnozoites_rendering_min_ages - the minimum ages average hypnozoite batches outputs (p.v only); default = numeric(0) +#' * n_with_hypnozoites_rendering_max_ages - the corresponding max ages; default = numeric(0) +#' #' miscellaneous: #' #' * mosquito_limit - the maximum number of mosquitoes to allow for in the @@ -259,200 +329,179 @@ #' rates; default = TRUE #' #' @export -get_parameters <- function(overrides = list()) { - parameters <- list( - # initial state proportions - s_proportion = 0.420433246, - d_proportion = 0.007215064, - a_proportion = 0.439323667, - u_proportion = 0.133028023, - t_proportion = 0, - # human fixed state transitions - dd = 5, - dt = 5, - da = 195, - du = 110, - # human demography parameters - human_population = 100, - average_age = 7663, - custom_demography = FALSE, +get_parameters <- function(overrides = list(), parasite = "falciparum") { + + if(!parasite %in% c("falciparum","vivax")){stop("parasite must be 'falciparum' or 'vivax'")} + + parameters <- c( + # human fixed state transitions # initial immunities - init_ica = 0, - init_iva = 0, - init_icm = 0, - init_ivm = 0, - init_id = 0, - init_ib = 0, # immunity decay rates - rm = 67.6952, - rvm = 76.8365, - rb = 10 * 365, - rc = 30 * 365, - rva = 30 * 365, - rid = 10 * 365, # immunity boost grace periods - ub = 7.2, - uc = 6.06, - uv = 11.4321, - ud = 9.44512, # maternal immunity parameters - pcm = .774368, - pvm = .195768, - # unique biting rate - a0 = 8 * 365, - rho = .85, - sigma_squared = 1.67, - n_heterogeneity_groups = 5, - enable_heterogeneity = TRUE, - # blood immunity parameters - b0 = 0.59, - b1 = 0.5, - ib0 = 43.9, - kb = 2.16, - # asymptomatic immunity to lm detection parameters - fd0 = 0.007055, - ad = 21.9 * 365, - gammad= 4.8183, - d1 = 0.160527, - id0 = 1.577533, - kd = .476614, - # clinical immunity parameters - phi0 = .792, - phi1 = .00074, - ic0 = 18.02366, - kc = 2.36949, - # severe disease immunity parameters - theta0 = .0749886, - theta1 = .0001191, - kv = 2.00048, - fv0 = 0.141195, - av = 2493.41, - gammav = 2.91282, - iv0 = 1.09629, + # probability of pre-erythrocytic infection/blood immunity + # probability of asymptomatic detection (p.f only) + # probability of patent infection (due to anti-parasite immunity, p.v only) + # probability of clinical infection + # probability of severe infection (p.f only) # infectivity towards mosquitos - cd = 0.068, - gamma1= 1.82425, - cu = 0.0062, - ct = 0.021896, - # mosquito fixed state transitions (inc. mortality) - del = 6.64, - dl = 3.72, - dpl = .643, - me = .0338, - ml = .0348, - mup = .249, - mum = .132, - # species-specific vector biology (default is An. gambiae s.s) - species = 'gamb', - species_proportions = 1, - blood_meal_rates = 1/3, - Q0 = .92, - foraging_time = .69, - beta = 21.2, - total_M = 1000, - init_foim= 0, - # carrying capacity parameters - g0 = 2, - g = c(.3, .6, .9), - h = c(.1, .4, .7), - gamma = 13.25, - model_seasonality = FALSE, - rainfall_floor = 0.001, - # flexible carrying capacity - carrying_capacity = FALSE, - carrying_capacity_timesteps = NULL, - carrying_capacity_values = NULL, - # parasite incubation delays - de = 12, - delay_gam = 12.5, - dem = 10, - # treatment parameters - drug_efficacy = numeric(0), - drug_rel_c = numeric(0), - drug_prophylaxis_shape = numeric(0), - drug_prophylaxis_scale = numeric(0), - clinical_treatment_drugs = list(), - clinical_treatment_timesteps = list(), - clinical_treatment_coverages = list(), - # MDA - mda = FALSE, - mda_drug = 0, - mda_timesteps = NULL, - mda_coverages = NULL, - mda_min_ages = -1, - mda_max_ages = -1, - smc = FALSE, - smc_drug = 0, - smc_timesteps = NULL, - smc_coverages = NULL, - smc_min_ages = -1, - smc_max_ages = -1, - # PMC - pmc = FALSE, - pmc_drug = 0, - pmc_timesteps = NULL, - pmc_coverages = NULL, - pcs_ages = -1, - # bed nets - bednets = FALSE, - phi_bednets = .85, - k0 = .699, - # indoor spraying - spraying = FALSE, - phi_indoors = .90, - # pev - pev = FALSE, - pev_doses = c(0, 1.5 * 30, 3 * 30), - # tbv - tbv = FALSE, - tbv_mt = 35, - tbv_md = 46.7, - tbv_ma = 3.6, - tbv_mu = 0.8, - tbv_k = 0.9, - tbv_tau = 22, - tbv_rho = .7, - tbv_ds = 45, - tbv_dl = 591, - tbv_tra_mu = 12.63, - tbv_gamma1 = 2.5, - tbv_gamma2 = .06, - tbv_timesteps = NULL, - tbv_coverages = NULL, - tbv_ages = NULL, - # antimalarial resistance - antimalarial_resistance = FALSE, - antimalarial_resistance_drug = NULL, - antimalarial_resistance_timesteps = NULL, - artemisinin_resistance_proportion = NULL, - partner_drug_resistance_proportion = NULL, - slow_parasite_clearance_probability = NULL, - early_treatment_failure_probability = NULL, - late_clinical_failure_probability = NULL, - late_parasitological_failure_probability = NULL, - reinfection_during_prophylaxis_probability = NULL, - dt_slow_parasite_clearance = NULL, - # rendering - prevalence_rendering_min_ages = 2 * 365, - prevalence_rendering_max_ages = 10 * 365, - incidence_rendering_min_ages = numeric(0), - incidence_rendering_max_ages = numeric(0), - clinical_incidence_rendering_min_ages = numeric(0), - clinical_incidence_rendering_max_ages = numeric(0), - severe_prevalence_rendering_min_ages = numeric(0), - severe_prevalence_rendering_max_ages = numeric(0), - severe_incidence_rendering_min_ages = numeric(0), - severe_incidence_rendering_max_ages = numeric(0), - age_group_rendering_min_ages = numeric(0), - age_group_rendering_max_ages = numeric(0), - # misc - mosquito_limit = 100 * 1000, - individual_mosquitoes = FALSE, - human_population_timesteps = 0, - r_tol = 1e-4, - a_tol = 1e-4, - ode_max_steps = 1e6, - progress_bar = FALSE + # parasite incubation periods + # hypnozoite parameters (p.v only) + parasite_parameters[[parasite]], + + list( + # parasite + parasite = parasite, + # initial state proportions + s_proportion = 0.420433246, + d_proportion = 0.007215064, + a_proportion = 0.439323667, + u_proportion = 0.133028023, + t_proportion = 0, + # human demography parameters + human_population = 100, + average_age = 7663, + custom_demography = FALSE, + # unique biting rate + a0 = 8 * 365, + rho = .85, + sigma_squared = 1.67, + n_heterogeneity_groups = 5, + enable_heterogeneity = TRUE, + # mosquito fixed state transitions (inc. mortality) + del = 6.64, + dl = 3.72, + dpl = .643, + me = .0338, + ml = .0348, + mup = .249, + mum = .132, + # species-specific vector biology (default is An. gambiae s.s) + species = 'gamb', + species_proportions = 1, + blood_meal_rates = 1/3, + Q0 = .92, + foraging_time = .69, + beta = 21.2, + total_M = 1000, + init_foim= 0, + # carrying capacity parameters + g0 = 2, + g = c(.3, .6, .9), + h = c(.1, .4, .7), + gamma = 13.25, + model_seasonality = FALSE, + rainfall_floor = 0.001, + # flexible carrying capacity + carrying_capacity = FALSE, + carrying_capacity_timesteps = NULL, + carrying_capacity_values = NULL, + # treatment parameters + drug_efficacy = numeric(0), + drug_rel_c = numeric(0), + drug_prophylaxis_shape = numeric(0), + drug_prophylaxis_scale = numeric(0), + clinical_treatment_drugs = list(), + clinical_treatment_timesteps = list(), + clinical_treatment_coverages = list(), + # MDA + mda = FALSE, + mda_drug = 0, + mda_timesteps = NULL, + mda_coverages = NULL, + mda_min_ages = -1, + mda_max_ages = -1, + smc = FALSE, + smc_drug = 0, + smc_timesteps = NULL, + smc_coverages = NULL, + smc_min_ages = -1, + smc_max_ages = -1, + # PMC + pmc = FALSE, + pmc_drug = 0, + pmc_timesteps = NULL, + pmc_coverages = NULL, + pcs_ages = -1, + # bed nets + bednets = FALSE, + phi_bednets = .85, + k0 = .699, + # indoor spraying + spraying = FALSE, + phi_indoors = .90, + # pev + pev = FALSE, + pev_doses = c(0, 1.5 * 30, 3 * 30), + # tbv + tbv = FALSE, + tbv_mt = 35, + tbv_md = 46.7, + tbv_ma = 3.6, + tbv_mu = 0.8, + tbv_k = 0.9, + tbv_tau = 22, + tbv_rho = .7, + tbv_ds = 45, + tbv_dl = 591, + tbv_tra_mu = 12.63, + tbv_gamma1 = 2.5, + tbv_gamma2 = .06, + tbv_timesteps = NULL, + tbv_coverages = NULL, + tbv_ages = NULL, + # antimalarial resistance + antimalarial_resistance = FALSE, + antimalarial_resistance_drug = NULL, + antimalarial_resistance_timesteps = NULL, + artemisinin_resistance_proportion = NULL, + partner_drug_resistance_proportion = NULL, + slow_parasite_clearance_probability = NULL, + early_treatment_failure_probability = NULL, + late_clinical_failure_probability = NULL, + late_parasitological_failure_probability = NULL, + reinfection_during_prophylaxis_probability = NULL, + dt_slow_parasite_clearance = NULL, + # rendering + age_group_rendering_min_ages = numeric(0), + age_group_rendering_max_ages = numeric(0), + incidence_rendering_min_ages = numeric(0), + incidence_rendering_max_ages = numeric(0), + patent_incidence_rendering_min_ages = numeric(0), + patent_incidence_rendering_max_ages = numeric(0), + clinical_incidence_rendering_min_ages = numeric(0), + clinical_incidence_rendering_max_ages = numeric(0), + severe_incidence_rendering_min_ages = numeric(0), + severe_incidence_rendering_max_ages = numeric(0), + prevalence_rendering_min_ages = 2 * 365, + prevalence_rendering_max_ages = 10 * 365, + ib_rendering_min_ages = numeric(0), + ib_rendering_max_ages = numeric(0), + id_rendering_min_ages = numeric(0), + id_rendering_max_ages = numeric(0), + ica_rendering_min_ages = numeric(0), + ica_rendering_max_ages = numeric(0), + iva_rendering_min_ages = numeric(0), + iva_rendering_max_ages = numeric(0), + idm_rendering_min_ages = numeric(0), + idm_rendering_max_ages = numeric(0), + icm_rendering_min_ages = numeric(0), + icm_rendering_max_ages = numeric(0), + ivm_rendering_min_ages = numeric(0), + ivm_rendering_max_ages = numeric(0), + hypnozoites_rendering_min_ages = numeric(0), + hypnozoites_rendering_max_ages = numeric(0), + n_with_hypnozoites_rendering_min_ages = numeric(0), + n_with_hypnozoites_rendering_max_ages = numeric(0), + # misc + mosquito_limit = 100 * 1000, + individual_mosquitoes = FALSE, + human_population_timesteps = 0, + r_tol = 1e-4, + a_tol = 1e-4, + ode_max_steps = 1e6, + progress_bar = FALSE + ) ) # Override parameters with any client specified ones diff --git a/data-raw/parasite_parameters.R b/data-raw/parasite_parameters.R new file mode 100644 index 00000000..65b5c71b --- /dev/null +++ b/data-raw/parasite_parameters.R @@ -0,0 +1,9 @@ +## code to prepare parasite parameters +parasite_csv <- read.csv("data-raw/parasite_parameters.csv") +parasite_parameters <- lapply(unique(parasite_csv$parasite), function(x){ + parameters <- as.list(parasite_csv[parasite_csv$parasite==x,c("default")]) + names(parameters) <- parasite_csv[parasite_csv$parasite==x,c("parameter")] + return(parameters) +}) +names(parasite_parameters) <- unique(parasite_csv$parasite) +usethis::use_data(parasite_parameters, overwrite = TRUE) \ No newline at end of file diff --git a/data-raw/parasite_parameters.csv b/data-raw/parasite_parameters.csv new file mode 100644 index 00000000..b05e8995 --- /dev/null +++ b/data-raw/parasite_parameters.csv @@ -0,0 +1,119 @@ +parasite,parameter,default,reference +falciparum,dd,5, +falciparum,dt,5, +falciparum,da,195, +falciparum,du,110, +falciparum,init_ib,0, +falciparum,init_ica,0, +falciparum,init_iva,0, +falciparum,init_icm,0, +falciparum,init_ivm,0, +falciparum,init_id,0, +falciparum,rb,3650, +falciparum,rc,10950, +falciparum,rva,10950, +falciparum,rid,3650, +falciparum,rm,67.6952, +falciparum,rvm,76.8365, +falciparum,ub,7.2, +falciparum,uc,6.06, +falciparum,uv,11.4321, +falciparum,ud,9.44512, +falciparum,pcm,0.774368, +falciparum,pvm,0.195768, +falciparum,b0,0.59, +falciparum,b1,0.5, +falciparum,ib0,43.9, +falciparum,kb,2.16, +falciparum,fd0,0.007055, +falciparum,ad,7993.5, +falciparum,gammad,4.9183, +falciparum,d1,0.160527, +falciparum,id0,1.577533, +falciparum,kd,0.476614, +falciparum,phi0,0.792, +falciparum,phi1,0.00074, +falciparum,ic0,18.02366, +falciparum,kc,2.36949, +falciparum,theta0,0.0749886, +falciparum,theta1,0.0001191, +falciparum,iv0,1.09629, +falciparum,kv,2.00048, +falciparum,fv0,0.141195, +falciparum,av,2493.41, +falciparum,gammav,2.91282, +falciparum,cd,0.068, +falciparum,gamma1,1.82425, +falciparum,cu,0.0062, +falciparum,ct,0.021896, +falciparum,de,12, +falciparum,delay_gam,12.5, +falciparum,dem,10, +vivax,dd,5, +vivax,dt,1, +vivax,da,10, +vivax,dpcr_max,70, +vivax,dpcr_min,10, +vivax,kpcr,4.602, +vivax,apcr50,9.9, +vivax,init_iaa,0, +vivax,init_iam,0, +vivax,init_ica,0, +vivax,init_icm,0, +vivax,ra,3650, +vivax,rc,10950, +vivax,rm,35.148, +vivax,ua,19.77, +vivax,uc,7.85, +vivax,pcm,0.421, +vivax,b,0.5, +vivax,philm_min,0.0043, +vivax,philm_max,0.8918, +vivax,klm,2.403, +vivax,alm50,27.52, +vivax,phi0,0.8605, +vivax,phi1,0.020918070889018, +vivax,ic0,11.538, +vivax,kc,2.25, +vivax,cd,0.8, +vivax,ca,0.1, +vivax,cu,0.035, +vivax,ct,0.4, +vivax,de,10, +vivax,delay_gam,0, +vivax,dem,8.4, +vivax,f,0.02439024, +vivax,gammal,0.002610966, +vivax,init_hyp,0, +vivax,kmax,10 +vivax,du,110,to_be_removed +vivax,init_iva,0,to_be_removed +vivax,init_ivm,0,to_be_removed +vivax,init_ib,0,to_be_removed +vivax,init_id,0,to_be_removed +vivax,ub,7.2,to_be_removed +vivax,uv,11.4321,to_be_removed +vivax,ud,9.44512,to_be_removed +vivax,pvm,0.195768,to_be_removed +vivax,rvm,76.8365,to_be_removed +vivax,rb,3650,to_be_removed +vivax,rva,10950,to_be_removed +vivax,rid,3650,to_be_removed +vivax,b0,0.59,to_be_removed +vivax,b1,0.5,to_be_removed +vivax,ib0,43.9,to_be_removed +vivax,kb,2.16,to_be_removed +vivax,theta0,0.0749886,to_be_removed +vivax,theta1,0.0001191,to_be_removed +vivax,iv0,1.09629,to_be_removed +vivax,kv,2.00048,to_be_removed +vivax,fv0,0.141195,to_be_removed +vivax,av,2493.41,to_be_removed +vivax,gammav,2.91282,to_be_removed +vivax,gamma1,1.82425,to_be_removed +vivax,fd0,0.007055,to_be_removed +vivax,ad,7993.5,to_be_removed +vivax,gammad,4.9183,to_be_removed +vivax,d1,0.160527,to_be_removed +vivax,id0,1.577533,to_be_removed +vivax,kd,0.476614,to_be_removed diff --git a/data/parasite_parameters.rda b/data/parasite_parameters.rda new file mode 100644 index 0000000000000000000000000000000000000000..8ba53c5177aea74b4c0844c9a6652acceb886824 GIT binary patch literal 1168 zcmV;B1aJF7T4*^jL0KkKS-LZk#{dMsfB*mad_~>ufA8nteOUkhe|2^||NQ><{^q}@ zy7PPgeLK(tzFxo*02nn?!g?S8Gynhq9-sgNLqGrk000Jn02%-Q8UO&(Kxk;l+K2!R z13<~327u7S($913=I+XaS%!F*M1L z&;vjK8Uq3vF*0PrVFo~G8fej>iII>R0LWwjG^Cmu27m)V0B8ZBpa1{>0004?0iXZ? z000000000ah?7GoPg7*dYI#jPPbR0S>7)Z`8UPJFO{u03Xv956k5CMQA)13jO#!BW z$TDDq$ul62LJTG$ZpO8=Z-nEF(Z{1+4bkP@&?F?B0@wnG!a%B)_A9|4RR%z_E+pb% zCP^>@2^-FX=Q&yqBuQoUgLpof28>cYL$jop)fWs3Lk$)f{L`43YeA%)f2+%MDp7p>&HA5i?R81%~ zCmXfK#x)m`7{%S=kRzF<1kq^g=Zr>#XC#D#&k?|*B(xe*Sj5?EsmjE2t&JJj*f~m_ z5?YN3?6!0vB#x*wHYJ>vEh{Hs0xiTOm=YGOU=XYfeG7_k!ZZrB9ApV{$hk>}WC|=H zB+LTD83A&@ltxJ)J$^J{rI%9Ba5L`X1F{7M9fo9+X$KvMvodyz!T{``<1>!qjzQUn z4NX%dikR}xPS1o?xME)_{GfaTE%0cac8joWc?;8kKR{RG9;`=%b!S+2YiAlKhS$%K>#Vt z1VljL;f!c|QUs7-Z{58v*YLg#gu#76QjccA-@bse^5ZX{4hWF|CJ2c6@M0Y-_jgpO zXMm7~NHcOKCK%AUgg1ev+>&^fa7$0DP@+;Nb*m##``xB6CMggYv&1{#mW?5vQdStJ zWd>#l1&Je8v1~z8B$7hNkfH~YXicdArd(#ahy&YPgIAvO9&!g{<=JwU^t_xiLgMWu zv<3=5!E(&bK+F}FRxmKZZ+4Q!l%ifS$lsR&lgAv&G4d|&M$R^H|47tpM{8!FLE(LU z0!bpPrB2k4VUn1@WR>)NC{-nv_^cP?hQm8(7ATAo3{`{!HbS&{l8I6m#o@prQdrKve|~@pmLsg$WCzIUH~;miTr6 literal 0 HcmV?d00001 diff --git a/tests/testthat/test-vivax.R b/tests/testthat/test-vivax.R new file mode 100644 index 00000000..09a5e6ae --- /dev/null +++ b/tests/testthat/test-vivax.R @@ -0,0 +1,26 @@ +test_that('Test falciparum switch produces same', { + parameters_def <- get_parameters() + parameters_fal <- get_parameters(parasite = "falciparum") + expect_identical(parameters_def, parameters_fal) +}) + +test_that('Test vivax model runs', { + vivax_parameters <- get_parameters(parasite = "vivax") + sim_res <- run_simulation(timesteps = 100, parameters = vivax_parameters) + expect_equal(nrow(sim_res), 100) +}) + +test_that('Test parasite = vivax sets parameters$parasite to vivax', { + vivax_parameters <- get_parameters(parasite = "vivax") + expect_identical(vivax_parameters$parasite, "vivax") +}) + +test_that('Test difference between falciparum and vivax parameter lists', { + falciparum_parameters <- get_parameters(parasite = "falciparum") + vivax_parameters <- get_parameters(parasite = "vivax") + + expect_true(all(names(falciparum_parameters)[!names(falciparum_parameters) %in% names(vivax_parameters)] %in% + c("du","rvm","rva","rb","b0","b1","ib0","kb","theta0","theta1","kv","fv0","av","gammav","iv0","fd0","ad","gammad","d1","id0","kd","ub","uv","gamma1","pvm","init_ivm","init_ib","init_iva"))) + expect_true(all(names(vivax_parameters[!names(vivax_parameters) %in% names(falciparum_parameters)]) %in% + c("dpcr_max","dpcr_min","kpcr","apcr50","init_iaa","init_iam","ra","ua","b","philm_min","philm_max","klm","alm50","ca","f","gammal","init_hyp","kmax"))) +}) From ba93c32142aa4e2ccd13c045c29e979d560c377d Mon Sep 17 00:00:00 2001 From: RJSheppard Date: Fri, 28 Jun 2024 12:24:03 +0100 Subject: [PATCH 02/11] Committing the revised parameter function documentation. --- man/get_parameters.Rd | 121 ++++++++++++++++++++++++++++++++++-------- 1 file changed, 99 insertions(+), 22 deletions(-) diff --git a/man/get_parameters.Rd b/man/get_parameters.Rd index fe4fb259..d4098b40 100644 --- a/man/get_parameters.Rd +++ b/man/get_parameters.Rd @@ -4,12 +4,20 @@ \alias{get_parameters} \title{Get model parameters} \usage{ -get_parameters(overrides = list()) +get_parameters(overrides = list(), parasite = "falciparum") } \arguments{ -\item{overrides}{a named list of parameter values to use instead of defaults +\item{overrides}{a named list of parameter values to use instead of defaults} + +\item{parasite}{Plasmodium parasite species ("falciparum" or "vivax"); default = "falciparum" + The parameters are defined below. +parasite parameter +\itemize{ +\item parasite - parasite species (falciparum or vivax); default = "falciparum" +} + initial state proportions: \itemize{ \item s_proportion - the proportion of \code{human_population} that begin as susceptible; default = 0.420433246 @@ -27,7 +35,15 @@ human fixed state transitions: \item dd - the delay for humans to move from state D to A; default = 5 \item dt - the delay for humans to move from state Tr to S; default = 5 \item da - the delay for humans to move from state A to U; default = 195 -\item du - the delay for humans to move from state U to S; default = 110 +\item du - the delay for humans to move from state U to S (p.f only); default = 110 +} + +duration of pcr detectable infection: du (p.v only): +\itemize{ +\item dpcr_max - Maximum duration of subpatent infection: default = 70 +\item dpcr_min - Minimum duration of subpatent infection: default = 10 +\item kpcr - Shape parameter: default = 4.602 +\item apcr50 - Scale parameter: default = 9.9 } human demography parameters: @@ -40,36 +56,40 @@ if custom_demography is FALSE; default = 7663 initial immunity values: \itemize{ -\item init_icm - the immunity from clinical disease at birth; default = 0 -\item init_ivm - the immunity from severe disease at birth; default = 0 -\item init_ib - the initial pre-erythrocitic immunity; default = 0 +\item init_ib - the initial pre-erythrocitic immunity (p.f only); default = 0 +\item init_iaa - the initial acquired anti-parasite immunity (p.v only): default = 0 +\item init_iam - the initial anti-parasite immunity at birth (p.v only); default = 0 \item init_ica - the initial acquired immunity from clinical disease; default = 0 -\item init_iva - the initial acquired immunity from severe disease; default = 0 -\item init_id - the initial acquired immunity to detectability; default = 0 +\item init_icm - the initial clinical immunity at birth; default = 0 +\item init_iva - the initial acquired immunity from severe disease (p.f only); default = 0 +\item init_ivm - the initial severe immunity from severe disease at birth (p.f only); default = 0 +\item init_id - the initial acquired immunity to lm detectability (p.f only); default = 0 } immunity decay rates: \itemize{ -\item rm - decay rate for maternal immunity to clinical disease; default = 67.6952 -\item rvm - decay rate for maternal immunity to severe disease; default = 76.8365 -\item rb - decay rate for acquired pre-erythrocytic immunity; default = 3650 +\item rb - decay rate for acquired pre-erythrocytic immunity (p.f only); default = 3650 +\item ra - decay rate for acquired anti-parasite immunity (p.v only); default = 3650 \item rc - decay rate for acquired immunity to clinical disease; default = 10950 -\item rva - decay rate for acquired immunity to severe disease; default = 10950 -\item rid - decay rate for acquired immunity to detectability; default = 3650 +\item rva - decay rate for acquired immunity to severe disease (p.f only); default = 10950 +\item rm - decay rate for maternal immunity to clinical disease (or p.v: maternal clinical and anti-parasite immunities); default = 67.6952 +\item rvm - decay rate for maternal immunity to severe disease (p.f only); default = 76.8365 +\item rid - decay rate for acquired immunity to lm-detectability (p.f only); default = 3650 } immunity boost grace periods: \itemize{ -\item ub - period in which pre-erythrocytic immunity cannot be boosted; default = 7.2 +\item ub - period in which pre-erythrocytic immunity cannot be boosted (p.f only); default = 7.2 +\item ua - period in which anti-parasite immunity cannot be boosted (p.v only); default = 9.44512 \item uc - period in which clinical immunity cannot be boosted; default = 6.06 -\item uv - period in which severe immunity cannot be boosted; default = 11.4321 -\item ud - period in which immunity to detectability cannot be boosted; default = 9.44512 +\item uv - period in which severe immunity cannot be boosted (p.f only); default = 11.4321 +\item ud - period in which immunity to detectability cannot be boosted (p.f only); default = 9.44512 } maternal immunity parameters: \itemize{ -\item pcm - new-born clinical immunity relative to mother's; default = 0.774368 -\item pvm - new-born severe immunity relative to mother's; default = 0.195768 +\item pcm - new-born clinical immunity (or p.v: clinical and anti-parasite immunities) relative to mother's; default = 0.774368 +\item pvm - new-born severe immunity relative to mother's (p.f only); default = 0.195768 } unique biting rate: @@ -81,7 +101,7 @@ unique biting rate: for sampling mothers; default = 5 } -probability of pre-erythrocytic infection: +probability of pre-erythrocytic infection (p.f only): \itemize{ \item b0 - maximum probability due to no immunity; default = 0.59 \item b1 - maximum reduction due to immunity; default = 0.5 @@ -89,7 +109,12 @@ probability of pre-erythrocytic infection: \item kb - shape parameter; default = 2.16 } -probability of detection by light-microscopy when asymptomatic: +probability of pre-erythrocytic infection (p.v only): +\itemize{ +\item b - probability of pre-erythrocytic infection: default = 0.5 +} + +probability of detection by light-microscopy when asymptomatic (p.f only): \itemize{ \item fd0 - time-scale at which immunity changes with age; default = 0.007055 \item ad - scale parameter relating age to immunity; default = 7993.5 @@ -99,6 +124,14 @@ probability of detection by light-microscopy when asymptomatic: \item kd - shape parameter; default = 0.476614 } +probability of patent infection due to anti-parasite immunity (p.v only): +\itemize{ +\item phi0lm - maximum probability due to no immunity; default = 0.8918 +\item phi1lm - maximum reduction due to immunity; default = 0.00482170890334156 +\item ic0lm - scale parameter; default = 27.52 +\item kclm - shape parameter; default = 2.403 +} + probability of clinical infection: \itemize{ \item phi0 - maximum probability due to no immunity; default = 0.792 @@ -107,7 +140,7 @@ probability of clinical infection: \item kc - shape parameter; default = 2.36949 } -probability of severe infection: +probability of severe infection (p.f only): \itemize{ \item theta0 - maximum probability due to no immunity; default = 0.0749886 \item theta1 - maximum reduction due to immunity; default = 0.0001191 @@ -121,6 +154,7 @@ probability of severe infection: infectivity towards mosquitoes: \itemize{ \item cd - infectivity of clinically diseased humans towards mosquitoes; default = 0.068 +\item ca - infectivity of asymptomatic humans towards mosquitoes (p.v only); default = 0.1 \item gamma1 - parameter for infectivity of asymptomatic humans; default = 1.82425 \item cu - infectivity of sub-patent infection; default = 0.0062 \item ct - infectivity of treated infection; default = 0.021896 @@ -175,6 +209,14 @@ parasite incubation periods: \item dem - extrinsic incubation period in mosquito population model; default = 10 } +hypnozoite parameters (p.v only): +\itemize{ +\item f - hypnozoite relapse rate; default = 0.024 +\item gammal - hypnozoite batch clearance rate; default = 0.0026 +\item init_hyp - initial hypnozoite batch number; default = 0 +\item kmax - maximum number of hypnozoite batches for use in the equilibrium solution; default = 10 +} + treatment parameters: please set treatment parameters with the convenience functions \code{\link{set_drugs}} and \code{\link{set_clinical_treatment}} @@ -185,6 +227,9 @@ please set treatment parameters with the convenience functions model prophylaxis for each drug; default = turned off \item drug_prophylaxis_scale - a vector of scale parameters for weibull curves to model prophylaxis for each drug; default = turned off +\item drug_hypnozoite_efficacy - a vector of efficacies targeting hypnozoites; default = turned off +\item drug_hypnozoite_prophylaxis_shape - a vector of shape parameters for weibull curves to model prophylaxis against hypnozoite batch formation (days); default = turned off +\item drug_hypnozoite_prophylaxis_scale - a vector of scale parameters for weibull curves to model prophylaxis against hypnozoite batch formation (days); default = turned off \item clinical_treatment_drugs - a vector of drugs that are available for clinically diseased (these values refer to the index in drug_* parameters); default = NULL, NULL, NULL \item clinical_treatment_coverage - a vector of coverage values for each drug; default = NULL, NULL, NULL @@ -258,6 +303,8 @@ Please set rendered age groups using the convenience function \item incidence_rendering_min_ages - the minimum ages for incidence outputs (includes asymptomatic microscopy +); default = turned off \item incidence_rendering_max_ages - the corresponding max ages; default = turned off +\item patent_incidence_rendering_min_ages - the minimum ages for patent incidence outputs (LM detectable), (p.v only); default = turned off +\item patent_incidence_rendering_max_ages - the corresponding max ages (p.v only); default = turned off \item clinical_incidence_rendering_min_ages - the minimum ages for clinical incidence outputs (symptomatic); default = 0 \item clinical_incidence_rendering_max_ages - the corresponding max ages; default = 1825 \item severe_incidence_rendering_min_ages - the minimum ages for severe incidence @@ -266,6 +313,28 @@ outputs; default = turned off \item prevalence_rendering_min_ages - the minimum ages for clinical prevalence outputs; default = 730 \item prevalence_rendering_max_ages - the corresponding max ages; default = 3650 +\item n_with_hypnozoites_rendering_min_ages - the minimum ages for number with hypnozoites outputs (p.v only); default = numeric(0) +\item n_with_hypnozoites_rendering_max_ages - the corresponding max ages; default = numeric(0) +\item ib_rendering_min_ages - the minimum ages for blood immunity outputs (p.f only); default = numeric(0) +\item ib_rendering_max_ages - the corresponding max ages; default = numeric(0) +\item id_rendering_min_ages - the minimum ages for acquired detectability immunity (p.f); default = numeric(0) +\item id_rendering_max_ages - the corresponding max ages; default = numeric(0) +\item iaa_rendering_min_ages - the minimum ages for antiparasite immunity (p.v only); default = numeric(0) +\item iam_rendering_max_ages - the corresponding max ages; default = numeric(0) +\item ica_rendering_min_ages - the minimum ages for acquired clinical immunity outputs; default = numeric(0) +\item ica_rendering_max_ages - the corresponding max ages; default = numeric(0) +\item iva_rendering_min_ages - the minimum ages for acquired severe immunity outputs (p.f only); default = numeric(0) +\item iva_rendering_max_ages - the corresponding max ages; default = numeric(0) +\item idm_rendering_min_ages - the minimum ages for maternal antiparasite immunity outputs (p.v only); default = numeric(0) +\item idm_rendering_max_ages - the corresponding max ages; default = numeric(0) +\item icm_rendering_min_ages - the minimum ages for maternal clinical immunity outputs; default = numeric(0) +\item icm_rendering_max_ages - the corresponding max ages; default = numeric(0) +\item ivm_rendering_min_ages - the minimum ages for maternal severe immunity outputs (p.f only); default = numeric(0) +\item ivm_rendering_max_ages - the corresponding max ages; default = numeric(0) +\item hypnozoites_rendering_min_ages - the minimum ages average hypnozoite batches outputs (p.v only); default = numeric(0) +\item hypnozoites_rendering_max_ages - the corresponding max ages; default = numeric(0) +\item n_with_hypnozoites_rendering_min_ages - the minimum ages average hypnozoite batches outputs (p.v only); default = numeric(0) +\item n_with_hypnozoites_rendering_max_ages - the corresponding max ages; default = numeric(0) } miscellaneous: @@ -285,7 +354,15 @@ rates; default = TRUE } \description{ get_parameters creates a named list of parameters for use in the model. These -parameters are passed to process functions. These parameters are explained in +parameters are passed to process functions. The default parameters, which +are for Plasmodium falciparum, are explained in "The US President's Malaria Initiative, Plasmodium falciparum transmission and mortality: A modelling study." + +Plasmodium vivax specific parameters are explained in +"Mathematical modelling of the impact of expanding levels of malaria control +interventions on Plasmodium vivax." by White, Michael T., et al. with parameter +values found in "Accelerating towards P. vivax elimination with a novel +serological test-and-treat strategy: a modelling case study in Brazil" by +Nekkab, Narimane T.,et al. or online repository. } From 7db7a3b1321724038f16e4818f07e31d4682bd77 Mon Sep 17 00:00:00 2001 From: RJSheppard Date: Tue, 9 Jul 2024 12:02:41 +0100 Subject: [PATCH 03/11] Added parameter file to package --- data/parasite_parameters.rda | Bin 1168 -> 1184 bytes 1 file changed, 0 insertions(+), 0 deletions(-) diff --git a/data/parasite_parameters.rda b/data/parasite_parameters.rda index 8ba53c5177aea74b4c0844c9a6652acceb886824..8b006cf8b1a210ba36c6bb7d412a476dac7afb36 100644 GIT binary patch delta 1125 zcmV-r1e*Jh37`oMLRx4!F+o`-Q(1}LbD@zAD1T4_Kq7)vQJ_(#L(*+SLr+sp8hTGi z^l2FeLF!~bQW%VY0BsNr2AMP%gK7XCrkZK$3`0Ql(3*Olr|O$bD1ZRaGz^*mXblWa zGGsIW&;SO2z=n)WnJ}0^kQxS>G-zUEWCnmT82}&vGz|kLfEois6HJ*605kvrpfDk$ z6B8y(CJfu@Zb7?~LXpbUmU2$5eXe*lppO${cKN%{$Ux?Q8f0mqpfu2W znlu_2G|)5#AjzhlkPQH7pa9X4pu{mUGyrL=Fj?Kcsx+`b-1oKb;w*{O_v`v+~Xne+7%X zH*kmp=D$*G$fe@ID&A)sOFJ&I^ki=|TD^AvXP5H}d;^WMdE9*Sb}I0=+2kaZj!sfY z6burK)BuEb!$1Lva-E`yP*oEk3iMN1 z(o;E`O{JPyJfq2-rfgubX1Pt{f0e7RDzvDg6=yAxZj1}N)eJz4fe9uF3sOV?g@7~K zTqE!a&|IwpK$q@L3k-&kAeg{f!JshMB{8Is9!KRlX{ppXKpfma!Wso8LmNpvf(T^W zY8>KH2x?F_1VIE6hR6*?!+=dxcc+POeqLcRp7R{6dLvt~(n8U#6W9{Xf1gntZPWp) z`%QVcCbutc`Cq$bpEKtm8S+Gmy<-fE!U{>1i5Nw!&vJ7j{>kghH>QK0+Z=+}RUI-d z3=?!p!#S0*377-GEK(r|K+a_FE*7sC2{hN&2*lT!;X$Eu$3=FvLRL5AZ57t__{>z; z8{{Dl90{Yl^wMe=?=&R2f664^5~87+7&N2odhdjzwYMa?{Zf^3!D<$yo#FArsLoVa zBr@Kx>q46L2NaaCmTsim2?hldxq4p`R!S(Kx+p7w-5L{YNGzCHZ0v$Bu)*Kj#opQ^ zbP!?~X>N>LL6#Q_&Zg`bSOyqvxFlr@)y)hT!v_&1t)#AEvx)SWe?p_UAmE$b_9kq3 zr)OFC5VM7{k*o}94o2dzW7jvti~H^Yw+SAe^PfIO z1<{IjM~EW_y)lHneW$bj_T}j delta 1109 zcmV-b1giU>36Kd6LRx4!F+o`-Q(3w*k;jn^C@EgR5&#%ARKj{705kvq03M(K14BRn z00006fB+f*02%-Q(?Dow$l8dJ$S8jT00ThKGH3yyG%+;EkkA7_02%`V8Zk0t!eItL zXc}nIp^1@@8UV;-05qhU8U}y^Kmcd~p`ZW&00001paGx&0000000000B#4tkC{I&l z%4&H{Jx?a5sp+HxX&L|xJx!^m5NO0bMvqVogCUxOLrnpufXFgngUK@>k3xS8CLwOd zwX|=9-`Y?!sPm+uw2p78pXipDNgiJ=W99kqO9!ZSgdY!B1MtbZW z>mSI>a6W*;6BChtARt6U{+fS$*|H!A&@cp^^}s?kLm>!MO(-=d8@0y9H5ZZ?#ognO zBblZI(P-=Ej7EfKB!q;|5x}D)v>H-a#Mx}A%EWW6jTzY3IZB-pT8#!qjzQUn4NX%dikR}xPS1o? zxME)_{GfaTE%0cac8joWc?;8kKRGAU_k&W%mhS0;o*#Edr}0D zU~k>MF4yqB4TQmcLQ;=r!QZ}sv-0CFpbiL;044~C`S4;LEcbU*sb_$YhDbAVCMFor zxr8@?rreTvmT*f?tWcs-Cv~eMQ2X7cFeWJw7_-DX;FgUco>G5S7^h_hW(Wm|BUZ6& zK~p4>LdcM!2a;$_sQ{*2X1a(2+gyWJp7S1Z2V~{ha+dVGoHIh=?IpAZ3P8bf%+5f} z6_-{pFu`wjlEsvwUNOkumjaW=9Lh2BF7HOpHgNw))N4m;W}rdgeSHE+BCDlN)R1A4 zn80L}^nEB*C6<5qtQX{l!#ijeD2x&eRfGdJLbP#7$|aggfHQP~qTQLA1f`NwG4juD zRUKd!WTPt=&>9BffM3xv2o>$JO}IeYaC;Mia5l#n_RirPz}`17Y*Kt9rme{?&(_y8 zeTM%$Zlp5%vc3F$^cHM6oUfF++d4OFR2l!nRqfT-RkkR$U zt*`bu%`MBLox?<(FWg!k)J@YIK-Zg{q@kQM=N)gU8=zTJWfen6YYu5h%QXidd|~m- zvoYR{_!+U$`b=|%AahU1B?-NQ@I3epodtx@IuQ@!CO-?1KTGmm1jYx9dW7M@>{l8I b6m#o@prR20MnF{s5Ak;-Q-ui&qd6RKic8nt From 2e30e83dece7f9b23db8d6c2aca66b379a501030 Mon Sep 17 00:00:00 2001 From: RJSheppard Date: Tue, 9 Jul 2024 17:23:34 +0100 Subject: [PATCH 04/11] Adding reference to parasite parameters object so that it will work with profiling/benchmarking --- R/parameters.R | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/R/parameters.R b/R/parameters.R index f9ea33da..95e7f776 100644 --- a/R/parameters.R +++ b/R/parameters.R @@ -347,7 +347,7 @@ get_parameters <- function(overrides = list(), parasite = "falciparum") { # infectivity towards mosquitos # parasite incubation periods # hypnozoite parameters (p.v only) - parasite_parameters[[parasite]], + malariasimulation::parasite_parameters[[parasite]], list( # parasite From a32f27c42ed7f6c34bce4474a4abb54218432434 Mon Sep 17 00:00:00 2001 From: RJSheppard Date: Wed, 10 Jul 2024 15:55:12 +0100 Subject: [PATCH 05/11] Replaced falciparum/vivax parameter comparison test that compares precise differences. --- tests/testthat/test-vivax.R | 24 +++++++++++++++++++----- 1 file changed, 19 insertions(+), 5 deletions(-) diff --git a/tests/testthat/test-vivax.R b/tests/testthat/test-vivax.R index 09a5e6ae..c15dbeda 100644 --- a/tests/testthat/test-vivax.R +++ b/tests/testthat/test-vivax.R @@ -19,8 +19,22 @@ test_that('Test difference between falciparum and vivax parameter lists', { falciparum_parameters <- get_parameters(parasite = "falciparum") vivax_parameters <- get_parameters(parasite = "vivax") - expect_true(all(names(falciparum_parameters)[!names(falciparum_parameters) %in% names(vivax_parameters)] %in% - c("du","rvm","rva","rb","b0","b1","ib0","kb","theta0","theta1","kv","fv0","av","gammav","iv0","fd0","ad","gammad","d1","id0","kd","ub","uv","gamma1","pvm","init_ivm","init_ib","init_iva"))) - expect_true(all(names(vivax_parameters[!names(vivax_parameters) %in% names(falciparum_parameters)]) %in% - c("dpcr_max","dpcr_min","kpcr","apcr50","init_iaa","init_iam","ra","ua","b","philm_min","philm_max","klm","alm50","ca","f","gammal","init_hyp","kmax"))) -}) + in_falciparum_not_vivax <- setdiff(names(falciparum_parameters), names(vivax_parameters)) + in_vivax_not_falciparum <- setdiff(names(vivax_parameters), names(falciparum_parameters)) + + expect_identical( + in_falciparum_not_vivax, + character(0) + ) + + expect_identical( + sort(in_vivax_not_falciparum), + c("dpcr_max", "dpcr_min", "k_pcr", "apcr50", # human sub-patent state delay + "init_iaa", "init_iam", "ra", "ua", # antiparasite immunity parameters) + "b", # probability of infection given an infectious bite + "philm_min", "philm_max", "klm", "alm50", # probability of light-microscopy detectable infection parameters + "ca", # light-microscopy detectable infection infectivity towards mosquitos + "f", "gammal", "init_hyp", "kmax" # hypnozoite parameters + ) + ) +}) \ No newline at end of file From 289dafafd926919149e39e9f6e51517e3581a864 Mon Sep 17 00:00:00 2001 From: RJSheppard Date: Wed, 10 Jul 2024 16:11:27 +0100 Subject: [PATCH 06/11] Swapped sort in vivax parameter test for ordered character vector and corrected parameter label. --- tests/testthat/test-vivax.R | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/tests/testthat/test-vivax.R b/tests/testthat/test-vivax.R index c15dbeda..a3b49124 100644 --- a/tests/testthat/test-vivax.R +++ b/tests/testthat/test-vivax.R @@ -28,8 +28,8 @@ test_that('Test difference between falciparum and vivax parameter lists', { ) expect_identical( - sort(in_vivax_not_falciparum), - c("dpcr_max", "dpcr_min", "k_pcr", "apcr50", # human sub-patent state delay + in_vivax_not_falciparum, + c("dpcr_max", "dpcr_min", "kpcr", "apcr50", # human sub-patent state delay "init_iaa", "init_iam", "ra", "ua", # antiparasite immunity parameters) "b", # probability of infection given an infectious bite "philm_min", "philm_max", "klm", "alm50", # probability of light-microscopy detectable infection parameters From 3701f3607666264a7885f717a51ac36aeab2a127 Mon Sep 17 00:00:00 2001 From: RJSheppard Date: Tue, 16 Jul 2024 14:27:16 +0100 Subject: [PATCH 07/11] Corrected an incorrect parameter (gammad) which I'm likely to have miscopied. --- data-raw/parasite_parameters.csv | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/data-raw/parasite_parameters.csv b/data-raw/parasite_parameters.csv index b05e8995..4a927371 100644 --- a/data-raw/parasite_parameters.csv +++ b/data-raw/parasite_parameters.csv @@ -27,7 +27,7 @@ falciparum,ib0,43.9, falciparum,kb,2.16, falciparum,fd0,0.007055, falciparum,ad,7993.5, -falciparum,gammad,4.9183, +falciparum,gammad,4.8183, falciparum,d1,0.160527, falciparum,id0,1.577533, falciparum,kd,0.476614, @@ -113,7 +113,7 @@ vivax,gammav,2.91282,to_be_removed vivax,gamma1,1.82425,to_be_removed vivax,fd0,0.007055,to_be_removed vivax,ad,7993.5,to_be_removed -vivax,gammad,4.9183,to_be_removed +vivax,gammad,4.8183,to_be_removed vivax,d1,0.160527,to_be_removed vivax,id0,1.577533,to_be_removed vivax,kd,0.476614,to_be_removed From 648e8701b583b49b28eb2eab73daea05be9025c9 Mon Sep 17 00:00:00 2001 From: RJSheppard Date: Tue, 30 Jul 2024 09:57:40 +0100 Subject: [PATCH 08/11] Added link to online repository for parameters. Removed patent incidence rendering. --- R/parameters.R | 16 +++++++--------- 1 file changed, 7 insertions(+), 9 deletions(-) diff --git a/R/parameters.R b/R/parameters.R index 95e7f776..9fed04d0 100644 --- a/R/parameters.R +++ b/R/parameters.R @@ -11,7 +11,8 @@ #' interventions on Plasmodium vivax." by White, Michael T., et al. with parameter #' values found in "Accelerating towards P. vivax elimination with a novel #' serological test-and-treat strategy: a modelling case study in Brazil" by -#' Nekkab, Narimane T.,et al. or online repository. +#' Nekkab, Narimane T.,et al. or online repository: +#' https://github.com/MWhite-InstitutPasteur/Pvivax_TQ_IBM. #' #' @param overrides a named list of parameter values to use instead of defaults #' @param parasite Plasmodium parasite species ("falciparum" or "vivax"); default = "falciparum" @@ -280,8 +281,6 @@ #' * incidence_rendering_min_ages - the minimum ages for incidence #' outputs (includes asymptomatic microscopy +); default = turned off #' * incidence_rendering_max_ages - the corresponding max ages; default = turned off -#' * patent_incidence_rendering_min_ages - the minimum ages for patent incidence outputs (LM detectable), (p.v only); default = turned off -#' * patent_incidence_rendering_max_ages - the corresponding max ages (p.v only); default = turned off #' * clinical_incidence_rendering_min_ages - the minimum ages for clinical incidence outputs (symptomatic); default = 0 #' * clinical_incidence_rendering_max_ages - the corresponding max ages; default = 1825 #' * severe_incidence_rendering_min_ages - the minimum ages for severe incidence @@ -293,6 +292,8 @@ #' * n_with_hypnozoites_rendering_min_ages - the minimum ages for number with hypnozoites outputs (p.v only); default = numeric(0) #' * n_with_hypnozoites_rendering_max_ages - the corresponding max ages; default = numeric(0) #' +#' Age structured mean immunity (/hyponozoite) rendering: +#' #' * ib_rendering_min_ages - the minimum ages for blood immunity outputs (p.f only); default = numeric(0) #' * ib_rendering_max_ages - the corresponding max ages; default = numeric(0) #' * id_rendering_min_ages - the minimum ages for acquired detectability immunity (p.f); default = numeric(0) @@ -311,8 +312,6 @@ #' * ivm_rendering_max_ages - the corresponding max ages; default = numeric(0) #' * hypnozoites_rendering_min_ages - the minimum ages average hypnozoite batches outputs (p.v only); default = numeric(0) #' * hypnozoites_rendering_max_ages - the corresponding max ages; default = numeric(0) -#' * n_with_hypnozoites_rendering_min_ages - the minimum ages average hypnozoite batches outputs (p.v only); default = numeric(0) -#' * n_with_hypnozoites_rendering_max_ages - the corresponding max ages; default = numeric(0) #' #' miscellaneous: #' @@ -467,14 +466,15 @@ get_parameters <- function(overrides = list(), parasite = "falciparum") { age_group_rendering_max_ages = numeric(0), incidence_rendering_min_ages = numeric(0), incidence_rendering_max_ages = numeric(0), - patent_incidence_rendering_min_ages = numeric(0), - patent_incidence_rendering_max_ages = numeric(0), clinical_incidence_rendering_min_ages = numeric(0), clinical_incidence_rendering_max_ages = numeric(0), severe_incidence_rendering_min_ages = numeric(0), severe_incidence_rendering_max_ages = numeric(0), prevalence_rendering_min_ages = 2 * 365, prevalence_rendering_max_ages = 10 * 365, + n_with_hypnozoites_rendering_min_ages = numeric(0), + n_with_hypnozoites_rendering_max_ages = numeric(0), + # age structured average immunity (/hypnozoite) rendering ib_rendering_min_ages = numeric(0), ib_rendering_max_ages = numeric(0), id_rendering_min_ages = numeric(0), @@ -491,8 +491,6 @@ get_parameters <- function(overrides = list(), parasite = "falciparum") { ivm_rendering_max_ages = numeric(0), hypnozoites_rendering_min_ages = numeric(0), hypnozoites_rendering_max_ages = numeric(0), - n_with_hypnozoites_rendering_min_ages = numeric(0), - n_with_hypnozoites_rendering_max_ages = numeric(0), # misc mosquito_limit = 100 * 1000, individual_mosquitoes = FALSE, From 188998853a9b4a6a6feeb9b011e453ae8f762c37 Mon Sep 17 00:00:00 2001 From: RJSheppard Date: Tue, 30 Jul 2024 09:58:27 +0100 Subject: [PATCH 09/11] Added revised documentation. --- man/get_parameters.Rd | 11 ++++++----- 1 file changed, 6 insertions(+), 5 deletions(-) diff --git a/man/get_parameters.Rd b/man/get_parameters.Rd index d4098b40..882440a7 100644 --- a/man/get_parameters.Rd +++ b/man/get_parameters.Rd @@ -303,8 +303,6 @@ Please set rendered age groups using the convenience function \item incidence_rendering_min_ages - the minimum ages for incidence outputs (includes asymptomatic microscopy +); default = turned off \item incidence_rendering_max_ages - the corresponding max ages; default = turned off -\item patent_incidence_rendering_min_ages - the minimum ages for patent incidence outputs (LM detectable), (p.v only); default = turned off -\item patent_incidence_rendering_max_ages - the corresponding max ages (p.v only); default = turned off \item clinical_incidence_rendering_min_ages - the minimum ages for clinical incidence outputs (symptomatic); default = 0 \item clinical_incidence_rendering_max_ages - the corresponding max ages; default = 1825 \item severe_incidence_rendering_min_ages - the minimum ages for severe incidence @@ -315,6 +313,10 @@ outputs; default = 730 \item prevalence_rendering_max_ages - the corresponding max ages; default = 3650 \item n_with_hypnozoites_rendering_min_ages - the minimum ages for number with hypnozoites outputs (p.v only); default = numeric(0) \item n_with_hypnozoites_rendering_max_ages - the corresponding max ages; default = numeric(0) +} + +Age structured mean immunity (/hyponozoite) rendering: +\itemize{ \item ib_rendering_min_ages - the minimum ages for blood immunity outputs (p.f only); default = numeric(0) \item ib_rendering_max_ages - the corresponding max ages; default = numeric(0) \item id_rendering_min_ages - the minimum ages for acquired detectability immunity (p.f); default = numeric(0) @@ -333,8 +335,6 @@ outputs; default = 730 \item ivm_rendering_max_ages - the corresponding max ages; default = numeric(0) \item hypnozoites_rendering_min_ages - the minimum ages average hypnozoite batches outputs (p.v only); default = numeric(0) \item hypnozoites_rendering_max_ages - the corresponding max ages; default = numeric(0) -\item n_with_hypnozoites_rendering_min_ages - the minimum ages average hypnozoite batches outputs (p.v only); default = numeric(0) -\item n_with_hypnozoites_rendering_max_ages - the corresponding max ages; default = numeric(0) } miscellaneous: @@ -364,5 +364,6 @@ Plasmodium vivax specific parameters are explained in interventions on Plasmodium vivax." by White, Michael T., et al. with parameter values found in "Accelerating towards P. vivax elimination with a novel serological test-and-treat strategy: a modelling case study in Brazil" by -Nekkab, Narimane T.,et al. or online repository. +Nekkab, Narimane T.,et al. or online repository: +https://github.com/MWhite-InstitutPasteur/Pvivax_TQ_IBM. } From 8e95304a6628f4b0ba26b0c18636acc9cc81a05b Mon Sep 17 00:00:00 2001 From: RJSheppard Date: Fri, 2 Aug 2024 16:16:05 +0100 Subject: [PATCH 10/11] Corrected mislabeled parameters and parameter values. Created Pvivax parameter sets object and selection within set_parameter_draw function. The data object is currently wrong and will need updating, but should work within the framework designed. --- R/parameters.R | 17 +- data-raw/parameter_draws.R | 61 +- ...meter_draws.csv => parameter_draws_pf.csv} | 0 data-raw/parameter_draws_pv.csv | 1001 +++++++++++++++++ data/parameter_draws_pf.rda | Bin 0 -> 183792 bytes data/parameter_draws_pv.rda | Bin 0 -> 95122 bytes man/get_parameters.Rd | 10 +- 7 files changed, 1068 insertions(+), 21 deletions(-) rename data-raw/{parameter_draws.csv => parameter_draws_pf.csv} (100%) create mode 100644 data-raw/parameter_draws_pv.csv create mode 100644 data/parameter_draws_pf.rda create mode 100644 data/parameter_draws_pv.rda diff --git a/R/parameters.R b/R/parameters.R index 9fed04d0..d0fdfede 100644 --- a/R/parameters.R +++ b/R/parameters.R @@ -78,7 +78,7 @@ #' immunity boost grace periods: #' #' * ub - period in which pre-erythrocytic immunity cannot be boosted (p.f only); default = 7.2 -#' * ua - period in which anti-parasite immunity cannot be boosted (p.v only); default = 9.44512 +#' * ua - period in which anti-parasite immunity cannot be boosted (p.v only); default = 19.77 #' * uc - period in which clinical immunity cannot be boosted; default = 6.06 #' * uv - period in which severe immunity cannot be boosted (p.f only); default = 11.4321 #' * ud - period in which immunity to detectability cannot be boosted (p.f only); default = 9.44512 @@ -117,10 +117,10 @@ #' #' probability of patent infection due to anti-parasite immunity (p.v only): #' -#' * phi0lm - maximum probability due to no immunity; default = 0.8918 -#' * phi1lm - maximum reduction due to immunity; default = 0.00482170890334156 -#' * ic0lm - scale parameter; default = 27.52 -#' * kclm - shape parameter; default = 2.403 +#' * philm_max - maximum probability due to no immunity; default = 0.8918 +#' * philm_min - maximum reduction due to immunity; default = 0.0043 +#' * alm50 - scale parameter; default = 27.52 +#' * klm - shape parameter; default = 2.403 #' #' probability of clinical infection: #' @@ -609,6 +609,13 @@ parameterise_total_M <- function(parameters, total_M) { #' #' @export set_parameter_draw <- function(parameters, draw){ + + if(parameters$parasite == "falciparum"){ + parameter_draws <- parameter_draws_pf + } else if (parameters$parasite == "vivax"){ + parameter_draws <- parameter_draws_pv + } + if(draw > 1000 || draw < 1){ stop("draw must be an integer between 1 and 1000") } diff --git a/data-raw/parameter_draws.R b/data-raw/parameter_draws.R index 2935f3ab..610a12cc 100644 --- a/data-raw/parameter_draws.R +++ b/data-raw/parameter_draws.R @@ -1,15 +1,54 @@ -## code to prepare parameter draws +## code to prepare parameter draws: pf +pd_pf <- read.csv("data-raw/parameter_draws_pf.csv") -pd <- read.csv("data-raw/parameter_draws.csv") +# Split individual draws_pf into a list of named parameter lists +draws_pf <- 1:max(pd_pf$draw) +parameter_draws_pf <- list() +for(draw in draws_pf){ + pars <- as.list(pd_pf[pd_pf$draw == draw, "value"]) + names(pars) <- pd_pf[pd_pf$draw == draw, "parameter"] + parameter_draws_pf[[draw]] <- pars +} +names(parameter_draws_pf) <- draws_pf + +usethis::use_data(parameter_draws_pf, overwrite = TRUE) + +## code to prepare parameter draws: pv +## this dataset does not match the default parameters, but the code should still be functional. +pd_pv <- read.csv("data-raw/parameter_draws_pv.csv") |> + tibble::rownames_to_column(var = "draw") |> + dplyr::mutate(sigma_squared = sig_het) |> + dplyr::select(-sig_het) |> + tidyr::pivot_longer(cols = !draw, names_to = "parameter", values_to = "value") |> + dplyr::mutate(parameter = dplyr::case_when( + parameter == "u_par" ~ "ua", + parameter == "phi_LM_max" ~ "philm_max", + parameter == "phi_LM_min" ~ "philm_min", + parameter == "A_LM_50pc" ~ "alm50", + parameter == "K_LM" ~ "klm", + parameter == "u_clin" ~ "ud", + parameter == "phi_D_max" ~ "ua", + parameter == "phi_D_min" ~ "ua", + parameter == "A_D_50pc" ~ "ic0", + parameter == "K_D" ~ "kc", + parameter == "A_d_PCR_50pc" ~ "apcr50", + parameter == "K_d_PCR" ~ "kpcr", + parameter == "d_PCR_max" ~ "dpcr_max", + parameter == "d_LM" ~ "da", + parameter == "P_MI" ~ "pcm", + parameter == "d_MI" ~ "rm", + parameter == "sigma_squared" ~ parameter + )) |> + as.data.frame() -# Split individual draws into a list of named parameter lists -draws <- 1:max(pd$draw) -parameter_draws <- list() -for(draw in draws){ - pars <- as.list(pd[pd$draw == draw, "value"]) - names(pars) <- pd[pd$draw == draw, "parameter"] - parameter_draws[[draw]] <- pars +# Split individual draws_pf into a list of named parameter lists +draws_pv <- 1:max(pd_pv$draw) +parameter_draws_pv <- list() +for(draw in draws_pv){ + pars <- as.list(pd_pv[pd_pv$draw == draw, "value"]) + names(pars) <- pd_pv[pd_pv$draw == draw, "parameter"] + parameter_draws_pv[[draw]] <- pars } -names(parameter_draws) <- draws +names(parameter_draws_pv) <- draws_pv -usethis::use_data(parameter_draws, overwrite = TRUE) +usethis::use_data(parameter_draws_pv, overwrite = TRUE) diff --git a/data-raw/parameter_draws.csv b/data-raw/parameter_draws_pf.csv similarity index 100% rename from data-raw/parameter_draws.csv rename to data-raw/parameter_draws_pf.csv diff --git a/data-raw/parameter_draws_pv.csv b/data-raw/parameter_draws_pv.csv new file mode 100644 index 00000000..f75ee2c3 --- /dev/null +++ b/data-raw/parameter_draws_pv.csv @@ -0,0 +1,1001 @@ +"u_par","phi_LM_max","phi_LM_min","A_LM_50pc","K_LM","u_clin","phi_D_max","phi_D_min","A_D_50pc","K_D","A_d_PCR_50pc","K_d_PCR","d_PCR_max","d_LM","P_MI","d_MI","sig_het" +46.5395,0.944231,0.0122627,18.247,3.72678,4.50074,0.971775,0.00523084,23.2866,3.90737,14.6828,4.88214,51.806,18.0504,0.350776,46.4141,1.57779 +40.5749,0.906438,0.0156893,19.1449,3.92828,4.2751,0.975524,0.00323,22.063,4.28012,11.3159,4.62718,57.4076,19.6247,0.407246,30.1973,1.49431 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z;&$#IPG9{2J4bZ!ZzwG1u|tbpGle|yO{cJkpRTJh*;`k~2kia=v=AsnNXep!nvUPH zAf*H9fn>QVFxpc5_N@7<=$!dMee&zyT-F~ICtaG-(UP)EOx=l{uv7{Sev0z`kO|Zs zIA5!8qVWBci`u=pHfubLeTK(CeUZ zPSqYL*fTDf;?=Ehtzmu~8ROHge2h2?V(-w^&{)4HS)i%o})nIb3pdzE12$hnZ4A%1KO14_b5wt{mqCJJOBRy7SHM@h<+*}?*}Z*X--%HI2}EMw1MV**J0N8S4s-W`S-q5Cmx zP3zpLn8$wxMPlphviS{Bt~w2A!4Q7Xd4P%GU%tav-R+l>`KY3}IP^en1_!vblh+#h zumIMfopYtfXdom{7Lv^;YItc!=n16tvJYT#zytp61PQHYH=#>FGrlFBxa_$Y6|0|r zWY6JVKUn|)T6UipysA9h>lf%LA`AYE^j74%caCcoYok;AddCjdjBfPxk6T%PU$v9n3Gam@H&7eesKimW8_9 z=dPH{mI8;O2z9bgmXLh4=GBu^?kgNuI|U)?2nN;1uW}S9FDqbVjkIynKq!{)TOon~ z5EOJcsaCK-1^LWC3{x5s(t(23KsDyhIG1`Wm09 z17Vn@*YyG3*?AkE;>Z`pfN-mId9z_N6#$%mym1~fMvo!9B0CjQvgTv~fErUQ-q}MT z2F9um_7b&r;LOGua=qpRkXbW&woVPI5y5dq?Skz1C~!W_`iP}yzDL{Jko9v)s6q{IxJ)lbs@HRX=7+EbhUj;Fe#|l2ZyzPgkC!kdkVlFLfVXHH>6=5ZNQSaE zC2gCf@#;ncF$bf&I%A&Wy8l)k{FbnZ#&1?2=8G34CBk{jRM_r}L*O#2E40yFi_l#7 z(Q-ivuN4Xz#40=sDI+d|2pc&Ya_=Gm7B3yDz4skA`MdO=I zg56PAP|hIq4FPd3P^xNJt252KB((-(;tsd2*%1%~L`!Q)*ORU;ojey0-!_~FzSpGy zT2Tr3<2H+iC%o!>zUE`{(g31Qr}n#rcwf!Vdg`s@hNFag*rGKMk9`ua1LoDj+M){i z5pa3aqQw;c0G{b|=g>reFQ$^(YhOYjfOGP2Irn!qQBROKk>}yqr5SFQ(-ATSFuY!b z_f>94wAIHgOHj;mfB@XuzBf}CScH+`_%n+HKu|7Wbxp17nUGrkNyNNu)w;E%*~jKm zizl9gM{B8qxh;SZpm@jM)e77~E_VTgUz` Date: Mon, 2 Sep 2024 10:08:34 +0100 Subject: [PATCH 11/11] Added a stop function to prevent use of vivax parameter draws for now. --- R/parameters.R | 1 + 1 file changed, 1 insertion(+) diff --git a/R/parameters.R b/R/parameters.R index d0fdfede..aa1d3a28 100644 --- a/R/parameters.R +++ b/R/parameters.R @@ -613,6 +613,7 @@ set_parameter_draw <- function(parameters, draw){ if(parameters$parasite == "falciparum"){ parameter_draws <- parameter_draws_pf } else if (parameters$parasite == "vivax"){ + stop("P. vivax parameter draws are not functional yet!") parameter_draws <- parameter_draws_pv }