Bug/maternal immunity sampling #279
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…he function now calculates the maternally-acquired immunity to severe disease (birth_ivm) using the acquired immunity to severe disease (iva) rather than the acquired immunity to clinical disease (ica)
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For reference, papers do not explicitly state which acquired immunity to use. But this change would make malariasimulation consistent with the previous model |
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And the equilibrium |
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The sample_maternal_immunity() function (in mortality_processes.R), which samples and assigns maternally-inherited immunity to clinical (icm) and severe (ivm) disease for a Bitset of target individuals (in practice those who have died and are being re-born into the population) currently calculates the maternally-inherited immunity to clinical and severe disease as follows:
I think maternally inherited immunity to severe disease (birth_ivm) should presumably be calculated using the mothers acquired immunity to severe disease variables$iva), so have amended the calculation for maternally-inherited immunity to severe disease to the following:
birth_ivm <- variables$iva$get_values(mothers) * parameters$pvm