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ClinVarRCV_functional_data.xsd
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<xs:schema version="2.0;" xmlns:xs="http://www.w3.org/2001/XMLSchema">
<xs:element name="ReleaseSet" type="ReleaseType"/>
<xs:element name="ClinVarSet" type="PublicSetType">
<xs:annotation>
<xs:documentation>The ClinVarSet is used to group the aggregate record (RCV accession)
with the submissions underlying it (SCV accessions) </xs:documentation>
</xs:annotation>
</xs:element>
<xs:element name="ClinVarAssertion" type="MeasureTraitType"/>
<xs:annotation>
<xs:documentation>The ClinVarAssertion is the package of data as received from the
submitter. During integration with other submissions, the content may have been
mapped to controlled values. </xs:documentation>
</xs:annotation>
<xs:element name="ReferenceClinVarAssertion" type="ReferenceAssertionType"/>
<xs:simpleType name="typeStatus">
<xs:restriction base="xs:string">
<xs:enumeration value="current"/>
<xs:enumeration value="completed and retired"/>
<xs:enumeration value="delete"/>
<xs:enumeration value="in development"/>
<xs:enumeration value="reclassified"/>
<xs:enumeration value="reject"/>
<xs:enumeration value="secondary"/>
<xs:enumeration value="suppressed"/>
<xs:enumeration value="under review"/>
</xs:restriction>
</xs:simpleType>
<xs:complexType name="MeasureType">
<xs:sequence>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Name" type="SetElementSetType"/>
<xs:element maxOccurs="1" minOccurs="0" name="CanonicalSPDI" type="xs:string"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Symbol" type="SetElementSetType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="AttributeSet">
<xs:complexType>
<xs:sequence>
<xs:element maxOccurs="1" minOccurs="1" name="Attribute">
<xs:complexType>
<xs:simpleContent>
<xs:extension base="AttributeType">
<xs:attribute name="Type" use="required">
<xs:simpleType>
<xs:restriction base="xs:string">
<xs:enumeration value="HGVS, genomic, top level"/>
<xs:enumeration
value="HGVS, genomic, top level, previous"/>
<xs:enumeration
value="HGVS, genomic, top level, other"/>
<xs:enumeration value="HGVS, genomic, RefSeqGene"/>
<xs:enumeration value="HGVS, genomic, LRG"/>
<xs:enumeration value="HGVS, genomic"/>
<xs:enumeration value="HGVS, coding, RefSeq"/>
<xs:enumeration value="HGVS, coding, LRG"/>
<xs:enumeration value="HGVS, coding"/>
<!--for HGVS expressions provided by submitters that are not completely qualified with
accession and version-->
<xs:enumeration value="HGVS, incomplete"/>
<xs:enumeration value="HGVS, previous"/>
<xs:enumeration value="HGVS, protein"/>
<xs:enumeration value="HGVS, protein, RefSeq"/>
<xs:enumeration value="HGVS, non-coding"/>
<xs:enumeration value="HGVS, non-validated"/>
<xs:enumeration value="HGVS, RNA"/>
<xs:enumeration value="HGVS, legacy"/>
<xs:enumeration value="HGVS, uncertain"/>
<xs:enumeration value="HGVS"/>
<xs:enumeration value="NonHGVS"/>
<xs:enumeration value="Location"/>
<xs:enumeration value="MiscellaneousDescription"/>
<xs:enumeration value="Description"/>
<xs:enumeration value="FunctionalConsequence"/>
<xs:enumeration value="MolecularConsequence"/>
<xs:enumeration value="ProteinChange1LetterCode"/>
<xs:enumeration value="ProteinChange3LetterCode"/>
<xs:enumeration value="ActivityLevel"/>
<xs:enumeration value="GlobalMinorAlleleFrequency"/>
<xs:enumeration value="AlleleFrequency"/>
<xs:enumeration value="Suspect"/>
<xs:enumeration value="Allelic Variant, previous"/>
<xs:enumeration value="acceptor splice site"/>
<xs:enumeration value="donor splice site"/>
<xs:enumeration value="nucleotide change"/>
<xs:enumeration value="protein change, historical"/>
<xs:enumeration value="transcript variant"/>
<xs:enumeration value="AbsoluteCopyNumber"/>
<xs:enumeration value="ReferenceCopyNumber"/>
<xs:enumeration value="CopyNumberTuple"/>
<xs:enumeration value="COSMIC"/>
<xs:enumeration value="SubmitterVariantId"/>
<xs:enumeration value="ISCNCoordinates"/>
</xs:restriction>
</xs:simpleType>
</xs:attribute>
<xs:attribute name="Change" use="optional"/>
<xs:attribute name="Accession" type="xs:string"
use="optional"/>
<xs:attribute name="Version" type="xs:positiveInteger"
use="optional"/>
<xs:attribute name="MANESelect" type="xs:boolean"
use="optional"/>
<xs:attribute name="MANEPlusClinical" type="xs:boolean"
use="optional"/>
</xs:extension>
</xs:simpleContent>
</xs:complexType>
</xs:element>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Citation"
type="CitationType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="XRef" type="XrefType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Comment"
type="CommentType"/>
</xs:sequence>
</xs:complexType>
</xs:element>
<xs:element maxOccurs="1" minOccurs="0" name="AlleleFrequencyList">
<xs:complexType>
<xs:sequence>
<xs:element maxOccurs="unbounded" minOccurs="1" name="AlleleFrequency">
<xs:complexType>
<xs:attribute name="Value" type="xs:double"/>
<xs:attribute name="Source" type="xs:string"/>
<xs:attribute name="URL" type="xs:anyURI" use="optional"/>
</xs:complexType>
</xs:element>
</xs:sequence>
</xs:complexType>
</xs:element>
<xs:element maxOccurs="1" minOccurs="0" name="GlobalMinorAlleleFrequency">
<xs:complexType>
<xs:attribute name="Value" type="xs:double"/>
<xs:attribute name="Source" type="xs:string"/>
<xs:attribute name="MinorAllele" type="xs:string" use="optional"/>
<xs:attribute name="URL" type="xs:anyURI" use="optional"/>
</xs:complexType>
</xs:element>
<xs:element maxOccurs="2" minOccurs="0" name="CytogeneticLocation" type="xs:string">
<xs:annotation>
<xs:documentation>Cytogenetic location is maintained independent of
sequence location.</xs:documentation>
</xs:annotation>
</xs:element>
<xs:element maxOccurs="unbounded" minOccurs="0" name="SequenceLocation"
type="SequenceLocationType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="MeasureRelationship">
<xs:annotation>
<xs:documentation>MeasureRelationship is used to represent relationships between
the type of measure being represented, and other object. This can be
gene/variant, protein/gene, etc., as in when a variation is reported to be
within a gene. </xs:documentation>
</xs:annotation>
<xs:complexType>
<xs:sequence>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Name"
type="SetElementSetType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Symbol"
type="SetElementSetType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="AttributeSet">
<xs:complexType>
<xs:sequence>
<xs:element maxOccurs="1" minOccurs="1" name="Attribute">
<xs:complexType>
<xs:simpleContent>
<xs:extension base="AttributeType">
<xs:attribute name="Type" use="required">
<xs:simpleType>
<xs:restriction base="xs:string">
<xs:enumeration value="HGVS"/>
<xs:enumeration value="genotype"/>
<xs:enumeration value="Haploinsufficiency"/>
<xs:enumeration value="Triplosensitivity"/>
<xs:enumeration value="gene relationships"/>
</xs:restriction>
</xs:simpleType>
</xs:attribute>
</xs:extension>
</xs:simpleContent>
</xs:complexType>
</xs:element>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Citation"
type="CitationType"/>
</xs:sequence>
</xs:complexType>
</xs:element>
<xs:element maxOccurs="unbounded" minOccurs="0" name="SequenceLocation"
type="SequenceLocationType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Citation"
type="CitationType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="XRef" type="XrefType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Comment"
type="CommentType"/>
</xs:sequence>
<xs:attribute name="Type" use="required">
<xs:simpleType>
<xs:restriction base="xs:string">
<xs:enumeration value="variant in gene"/>
<xs:enumeration value="co-occurring variant"/>
<xs:enumeration value="within single gene"/>
<xs:enumeration value="within multiple genes by overlap"/>
<xs:enumeration value="genes overlapped by variant"/>
<xs:enumeration value="near gene, upstream"/>
<xs:enumeration value="near gene, downstream"/>
<xs:enumeration value="asserted, but not computed"/>
</xs:restriction>
</xs:simpleType>
</xs:attribute>
<xs:attributeGroup ref="CVIdentifiers"/>
</xs:complexType>
</xs:element>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Citation" type="CitationType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="XRef" type="XrefType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Comment" type="CommentType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Source" type="DataSourceType"/>
</xs:sequence>
<xs:attribute name="Type" use="required">
<xs:simpleType>
<xs:restriction base="xs:string">
<xs:enumeration value="Gene"/>
<xs:enumeration value="Variation"/>
<xs:enumeration value="Insertion"/>
<xs:enumeration value="Deletion"/>
<xs:enumeration value="single nucleotide variant"/>
<xs:enumeration value="Indel"/>
<xs:enumeration value="Duplication"/>
<xs:enumeration value="Tandem duplication"/>
<xs:enumeration value="Structural variant"/>
<xs:enumeration value="copy number gain"/>
<xs:enumeration value="copy number loss"/>
<xs:enumeration value="protein only"/>
<xs:enumeration value="Microsatellite"/>
<xs:enumeration value="fusion"/>
<xs:enumeration value="Inversion"/>
<xs:enumeration value="Translocation"/>
<xs:enumeration value="QTL"/>
<xs:enumeration value="Complex"/>
</xs:restriction>
</xs:simpleType>
</xs:attribute>
<xs:attributeGroup ref="CVIdentifiers"/>
</xs:complexType>
<xs:complexType name="XrefType">
<xs:annotation>
<xs:documentation>This structure is used to represent how an object described in the
submission relates to objects in other databases. </xs:documentation>
</xs:annotation>
<xs:attribute name="DB" type="xs:string" use="required">
<xs:annotation>
<xs:documentation>The name of the database. When there is an overlap with sequence
databases, that name is used.</xs:documentation>
</xs:annotation>
</xs:attribute>
<xs:attribute name="ID" type="xs:string" use="required">
<xs:annotation>
<xs:documentation>The identifier used by the database. Being exported as a
string even though internally the database has rules for defining which
datases use integer identifers.</xs:documentation>
</xs:annotation>
</xs:attribute>
<xs:attribute name="Type" type="xs:string" use="optional">
<xs:annotation>
<xs:documentation>Used to differentiate between different types of identifers
that a database may provide.</xs:documentation>
</xs:annotation>
</xs:attribute>
<xs:attribute name="URL" type="xs:anyURI" use="optional"/>
<xs:attribute default="current" name="Status" type="typeStatus" use="optional"/>
</xs:complexType>
<xs:complexType name="CitationType">
<xs:sequence>
<xs:element maxOccurs="unbounded" minOccurs="0" name="ID">
<xs:complexType>
<xs:simpleContent>
<xs:extension base="xs:string">
<xs:attribute name="Source" type="xs:string" use="required">
<xs:annotation>
<xs:documentation>If there is an identifier, what database
provides it.</xs:documentation>
</xs:annotation>
</xs:attribute>
</xs:extension>
</xs:simpleContent>
</xs:complexType>
</xs:element>
<xs:element maxOccurs="1" minOccurs="0" name="URL" type="xs:anyURI"/>
<xs:element maxOccurs="1" minOccurs="0" name="CitationText" type="xs:string"/>
</xs:sequence>
<xs:attribute name="Type" type="xs:string" use="optional">
<xs:annotation>
<xs:documentation>This maintained distinct from publication types in PubMed and
established by GTR curators. The default is 'general'.</xs:documentation>
</xs:annotation>
</xs:attribute>
<xs:attribute name="Abbrev" type="xs:string" use="optional">
<xs:annotation>
<xs:documentation>Corresponds to the abbreviation reported by
GTR.</xs:documentation>
</xs:annotation>
</xs:attribute>
</xs:complexType>
<xs:complexType name="CommentType">
<xs:annotation>
<xs:documentation>A structure to support reporting unformatted content.
</xs:documentation>
</xs:annotation>
<xs:simpleContent>
<xs:extension base="xs:string">
<xs:attribute name="DataSource" type="xs:string"/>
<xs:attribute name="Type" type="CommentTypeList"/>
</xs:extension>
</xs:simpleContent>
</xs:complexType>
<xs:complexType name="DataSourceType">
<xs:attribute name="DataSource" type="xs:string" use="required">
<xs:annotation>
<xs:documentation>A standard term for the source of the
information</xs:documentation>
</xs:annotation>
</xs:attribute>
<xs:attribute name="ID" type="xs:string" use="optional">
<xs:annotation>
<xs:documentation>The identifier used by the data source</xs:documentation>
</xs:annotation>
</xs:attribute>
<xs:attribute name="SourceType" use="optional">
<xs:annotation>
<xs:documentation>Controlled terms to categorize the source of the
information</xs:documentation>
</xs:annotation>
<xs:simpleType>
<xs:restriction base="xs:string">
<xs:enumeration value="laboratory"/>
<xs:enumeration value="locus-specific database (LSDB)"/>
<xs:enumeration value="consortium"/>
<xs:enumeration value="resource"/>
<xs:enumeration value="patient registry"/>
<xs:enumeration value="other"/>
</xs:restriction>
</xs:simpleType>
</xs:attribute>
</xs:complexType>
<xs:complexType name="PublicSetType">
<xs:sequence>
<xs:element default="current" maxOccurs="1" minOccurs="1" name="RecordStatus">
<xs:simpleType>
<xs:restriction base="xs:string">
<xs:enumeration value="current"/>
<xs:enumeration value="replaced"/>
<xs:enumeration value="deleted"/>
<xs:enumeration value="previous"/>
</xs:restriction>
</xs:simpleType>
</xs:element>
<xs:element maxOccurs="1" minOccurs="0" name="ReplacedBy" type="xs:string"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Replaces" type="xs:string"/>
<xs:element maxOccurs="1" minOccurs="0" name="Title" type="xs:string">
<xs:annotation>
<xs:documentation>The title is contructed from the concatenation of the
description of the variation and the phenotype. In the database it is
extracted from the title of RCV accession</xs:documentation>
</xs:annotation>
</xs:element>
<xs:element maxOccurs="1" minOccurs="0" ref="ReferenceClinVarAssertion">
<xs:annotation>
<xs:documentation> This element is not required becuase the PublicSetType
is also used for SCV Accessions which do not have an RCV
</xs:documentation>
</xs:annotation>
</xs:element>
<xs:element maxOccurs="unbounded" minOccurs="1" ref="ClinVarAssertion"/>
<xs:element minOccurs="0" name="DeletedSCVList">
<xs:complexType>
<xs:sequence>
<xs:element maxOccurs="unbounded" minOccurs="1" name="SCV"
type="typeDeletedSCV"/>
</xs:sequence>
</xs:complexType>
</xs:element>
</xs:sequence>
<xs:attributeGroup ref="CVIdentifiers"/>
</xs:complexType>
<xs:complexType name="typeDeletedSCV">
<xs:annotation>
<xs:documentation>A structure to support reporting of an accession, its version, the
date is was deleted and description of deletion</xs:documentation>
</xs:annotation>
<xs:sequence>
<xs:element maxOccurs="1" minOccurs="1" name="Accession">
<xs:complexType>
<xs:simpleContent>
<xs:extension base="xs:string">
<xs:attribute name="Version" type="xs:nonNegativeInteger" use="required"/>
<xs:attribute name="DateDeleted" type="xs:date" use="required"/>
</xs:extension>
</xs:simpleContent>
</xs:complexType>
</xs:element>
<xs:element maxOccurs="1" minOccurs="0" name="Description" type="xs:string"/>
</xs:sequence>
</xs:complexType>
<xs:complexType name="ReleaseType">
<xs:sequence>
<xs:element maxOccurs="unbounded" minOccurs="1" ref="ClinVarSet">
<xs:annotation>
<xs:documentation>Top-level element to bundle the reports of
ClinVarSets.</xs:documentation>
</xs:annotation>
</xs:element>
</xs:sequence>
<xs:attribute name="Type" type="xs:string" use="required"/>
<xs:attribute name="Dated" type="xs:date" use="required"/>
</xs:complexType>
<xs:complexType name="MeasureTraitType">
<xs:sequence>
<xs:element maxOccurs="1" minOccurs="1" name="ClinVarSubmissionID">
<xs:complexType>
<xs:attribute name="submitter" type="xs:string" use="optional"/>
<xs:attribute name="title" type="xs:string" use="optional"/>
<xs:attribute name="localKey" type="xs:string" use="required">
<xs:annotation>
<xs:documentation>Of primary use to submitters, to facilitate
identification of records corresponding to their submissions.
If not provided by a submitter, NCBI generates. If provided by
submitter, that is represented in localKeyIsSubmitted.
</xs:documentation>
</xs:annotation>
</xs:attribute>
<xs:attribute name="submittedAssembly" type="xs:string" use="optional"/>
<xs:attribute name="submitterDate" type="xs:date" use="optional"/>
<xs:attribute name="localKeyIsSubmitted" use="optional"/>
</xs:complexType>
</xs:element>
<xs:element maxOccurs="1" minOccurs="1" name="ClinVarAccession">
<xs:complexType>
<xs:attribute name="Acc" type="xs:string" use="required"/>
<xs:attribute name="Version" type="xs:integer" use="required"/>
<xs:attribute name="Type" use="required">
<xs:annotation>
<xs:documentation>RCV accessions aggregate data from each submission.
Each submission is assigned an accession of beginning with 'SCV'
</xs:documentation>
</xs:annotation>
<xs:simpleType>
<xs:restriction base="xs:string">
<xs:enumeration value="RCV"/>
<xs:enumeration value="SCV"/>
</xs:restriction>
</xs:simpleType>
</xs:attribute>
<xs:attribute name="OrgID" type="xs:int" use="optional"/>
<xs:attribute name="OrgAbbreviation" type="xs:string" use="optional"/>
<xs:attribute name="DateUpdated" type="xs:date">
<xs:annotation>
<xs:documentation>The date that the latest update to the submitted
record became public in ClinVar. </xs:documentation>
</xs:annotation>
</xs:attribute>
<xs:attribute name="DateCreated" type="xs:date" use="optional">
<xs:annotation>
<xs:documentation>DateCreated is the date when the record first became
public in ClinVar. </xs:documentation>
</xs:annotation>
</xs:attribute>
<xs:attribute fixed="primary" name="OrgType" type="xs:string" use="optional"/>
<xs:attribute name="OrganizationCategory" type="xs:string" use="optional"/>
</xs:complexType>
</xs:element>
<xs:element maxOccurs="1" minOccurs="0" name="AdditionalSubmitters">
<xs:annotation>
<xs:documentation>Optional element used only if there are multiple submitters.
When there are multiple, each is listed in this element.
</xs:documentation>
</xs:annotation>
<xs:complexType>
<xs:sequence>
<xs:element maxOccurs="unbounded" minOccurs="1" name="SubmitterDescription"
type="SubmitterType"/>
</xs:sequence>
</xs:complexType>
</xs:element>
<xs:element default="current" maxOccurs="1" minOccurs="1" name="RecordStatus">
<xs:simpleType>
<xs:restriction base="xs:string">
<xs:enumeration value="current"/>
<xs:enumeration value="replaced"/>
<xs:enumeration value="removed"/>
</xs:restriction>
</xs:simpleType>
</xs:element>
<xs:choice>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Replaces" type="xs:string"/>
<xs:element minOccurs="0" name="ReplacedList">
<xs:annotation>
<xs:documentation> The list of SCV accessions this SCV record has
replaced. </xs:documentation>
</xs:annotation>
<xs:complexType>
<xs:sequence>
<xs:element maxOccurs="unbounded" minOccurs="1" name="Replaced"
type="typeRecordHistory"/>
</xs:sequence>
</xs:complexType>
</xs:element>
</xs:choice>
<xs:element minOccurs="1" name="Classification" type="ClassificationTypeSCV"/>
<xs:element name="Assertion" type="AssertionTypeSCV"/>
<xs:element minOccurs="0" name="ExternalID" type="XrefType">
<xs:annotation>
<xs:documentation>XrefType is used to identify data source(s) and their
identifiers. Optional because not all sources have an ID specific to
the assertion. </xs:documentation>
</xs:annotation>
</xs:element>
<xs:element maxOccurs="unbounded" minOccurs="0" name="AttributeSet">
<xs:annotation>
<xs:documentation>AttributeSet is a package to represent a unit of information,
the source(s) of that unit, identifiers representing that unit, and
comments. </xs:documentation>
</xs:annotation>
<xs:complexType>
<xs:sequence>
<xs:element name="Attribute">
<xs:complexType>
<xs:simpleContent>
<xs:extension base="AttributeType">
<xs:attribute name="Type" use="required">
<xs:simpleType>
<xs:restriction base="xs:string">
<xs:enumeration value="ModeOfInheritance"/>
<xs:enumeration value="Penetrance"/>
<xs:enumeration value="AgeOfOnset"/>
<xs:enumeration value="Severity"/>
<xs:enumeration value="ClassificationHistory"/>
<xs:enumeration value="SeverityDescription"/>
<xs:enumeration value="AssertionMethod"/>
</xs:restriction>
</xs:simpleType>
</xs:attribute>
</xs:extension>
</xs:simpleContent>
</xs:complexType>
</xs:element>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Citation"
type="CitationType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="XRef" type="XrefType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Comment"
type="CommentType"/>
</xs:sequence>
</xs:complexType>
</xs:element>
<xs:element maxOccurs="unbounded" name="ObservedIn" type="SCVObservationSet"/>
<xs:choice maxOccurs="1" minOccurs="1">
<xs:element maxOccurs="1" minOccurs="1" name="MeasureSet" type="MeasureSetType"/>
<xs:element maxOccurs="1" minOccurs="1" name="GenotypeSet" type="GenotypeSetType"/>
</xs:choice>
<xs:element maxOccurs="1" minOccurs="1" name="TraitSet" type="ClinAsserTraitSetType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Citation" type="CitationType"/>
<xs:element maxOccurs="1" minOccurs="0" name="StudyName" type="xs:string"/>
<xs:element maxOccurs="1" minOccurs="0" name="StudyDescription" type="xs:string"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Comment" type="CommentType"/>
</xs:sequence>
<xs:attribute name="DateCreated" type="xs:date">
<xs:annotation>
<xs:documentation>DateCreated is the date when the record first became public in
ClinVar. </xs:documentation>
</xs:annotation>
</xs:attribute>
<xs:attribute name="DateLastUpdated" type="xs:date">
<xs:annotation>
<xs:documentation>The date that the latest update to the submitted record became
public in ClinVar. </xs:documentation>
</xs:annotation>
</xs:attribute>
<xs:attribute name="SubmissionDate" type="xs:date"/>
<xs:attribute name="SubmissionName" type="xs:string" use="optional"/>
<xs:attribute name="FDARecognizedDatabase" type="xs:boolean" use="optional"/>
<xs:attributeGroup ref="CVIdentifiers"/>
</xs:complexType>
<xs:complexType name="ReferenceAssertionType">
<xs:sequence>
<xs:element maxOccurs="1" minOccurs="1" name="ClinVarAccession">
<xs:complexType>
<xs:attribute name="Acc" type="xs:string" use="required">
<xs:annotation>
<xs:documentation>The accession assigned by ClinVar.</xs:documentation>
</xs:annotation>
</xs:attribute>
<xs:attribute name="Version" type="xs:integer" use="required">
<xs:annotation>
<xs:documentation>A new version of an SCV accession is assigned with an
update from the submitter. A new version of an RCV accession
is assigned when the set of ClinVarAssertions is changed,
either by a change in version or by addition of a new
submission.</xs:documentation>
</xs:annotation>
</xs:attribute>
<xs:attribute name="Type" use="required">
<xs:simpleType>
<xs:restriction base="xs:string">
<xs:enumeration value="RCV"/>
</xs:restriction>
</xs:simpleType>
</xs:attribute>
<xs:attribute name="DateUpdated" type="xs:date"/>
<xs:attribute name="DateCreated" type="xs:date"/>
</xs:complexType>
</xs:element>
<xs:element default="current" maxOccurs="1" minOccurs="1" name="RecordStatus">
<xs:simpleType>
<xs:restriction base="xs:string">
<xs:enumeration value="current"/>
<xs:enumeration value="replaced"/>
<xs:enumeration value="removed"/>
</xs:restriction>
</xs:simpleType>
</xs:element>
<xs:element name="Classifications" type="ClassificationType">
<xs:annotation>
<xs:documentation>Used to bundle different types of Classifications (germline, oncogenic, somatic clinical impact).</xs:documentation>
</xs:annotation>
</xs:element>
<xs:element name="Assertion" type="AssertionTypeRCV"/>
<xs:element minOccurs="0" name="ExternalID" type="XrefType">
<xs:annotation>
<xs:documentation>Represents the public identifier a source may have for this
record. </xs:documentation>
</xs:annotation>
</xs:element>
<xs:element maxOccurs="unbounded" minOccurs="0" name="AttributeSet">
<xs:annotation>
<xs:documentation>Many concepts in the database are represented by what ClinVar
terms an AttributeSet, which is an open-ended structure providing the
equivalent of a type of information, the value(s) for that data type,
submitter(s), free text comment(s) describing that attribute, identifier(s)
for that attribute, and citation(s) related to that attribute.
</xs:documentation>
</xs:annotation>
<xs:complexType>
<xs:sequence>
<xs:element name="Attribute">
<xs:complexType>
<xs:simpleContent>
<xs:extension base="AttributeType">
<xs:attribute name="Type" use="required">
<xs:simpleType>
<xs:restriction base="xs:string">
<xs:enumeration value="ModeOfInheritance"/>
<xs:enumeration value="Penetrance"/>
<xs:enumeration value="AgeOfOnset"/>
</xs:restriction>
</xs:simpleType>
</xs:attribute>
</xs:extension>
</xs:simpleContent>
</xs:complexType>
</xs:element>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Citation"
type="CitationType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="XRef" type="XrefType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Comment"
type="CommentType"/>
</xs:sequence>
</xs:complexType>
</xs:element>
<xs:element maxOccurs="unbounded" minOccurs="0" name="ObservedIn" type="ObservationSet"/>
<xs:choice maxOccurs="1" minOccurs="1">
<xs:element maxOccurs="1" minOccurs="1" name="MeasureSet" type="MeasureSetType"/>
<xs:element maxOccurs="1" minOccurs="1" name="GenotypeSet" type="GenotypeSetType"/>
</xs:choice>
<xs:element maxOccurs="1" minOccurs="1" name="TraitSet" type="TraitSetType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Citation" type="CitationType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Comment" type="CommentType"/>
</xs:sequence>
<xs:attribute name="DateCreated" type="xs:date">
<xs:annotation>
<xs:documentation>The date that the latest update to the submitted record became
public in ClinVar.</xs:documentation>
</xs:annotation>
</xs:attribute>
<xs:attribute name="DateLastUpdated" type="xs:date">
<xs:annotation>
<xs:documentation>The date the record was last updated in the public database. The
update may be a change to one of the submitted records (SCVs) or annotation
added to the aggregate record by NCBI staff. This date is independent of a
version change; annotated added by NCBI may change without representing a change
in the version</xs:documentation>
</xs:annotation>
</xs:attribute>
<xs:attribute name="SubmissionDate" type="xs:date"/>
<xs:attributeGroup ref="CVIdentifiers"/>
</xs:complexType>
<xs:complexType name="MeasureSetAttributeSet">
<xs:sequence>
<xs:element maxOccurs="1" minOccurs="1" name="Attribute">
<xs:complexType>
<xs:simpleContent>
<xs:extension base="AttributeType">
<xs:attribute name="Type" use="required">
<xs:annotation>
<xs:documentation>MGG-2713 added HGVS, Description, and
MolecularConsequence for AttributeType because they are in
the submission xsd. Skipping Location, which is also in the
submission xsd. In the current set of submissions, (March
2017) only HGVS is used. djh</xs:documentation>
</xs:annotation>
<xs:simpleType>
<xs:restriction base="xs:string">
<xs:enumeration value="Description"/>
<xs:enumeration value="MolecularConsequence"/>
<xs:enumeration value="HGVS"/>
<xs:enumeration value="HGVS, genomic, top level"/>
<xs:enumeration value="HGVS, genomic, top level, previous"/>
<xs:enumeration value="HGVS, genomic, top level, other"/>
<xs:enumeration value="HGVS, genomic, RefSeqGene"/>
<xs:enumeration value="HGVS, genomic, LRG"/>
<xs:enumeration value="HGVS, coding, RefSeq"/>
<xs:enumeration value="HGVS, coding, LRG"/>
<xs:enumeration value="HGVS, coding"/>
<xs:enumeration value="HGVS, RNA"/>
<xs:enumeration value="HGVS, previous"/>
<xs:enumeration value="HGVS, protein"/>
<xs:enumeration value="HGVS, protein, RefSeq"/>
<xs:enumeration value="HGVS, nucleotide"/>
<xs:enumeration value="HGVS, non-validated"/>
<xs:enumeration value="HGVS, legacy"/>
<xs:enumeration value="HGVS, uncertain"/>
<xs:enumeration value="FunctionalConsequence"/>
<xs:enumeration value="ISCNCoordinates"/>
<xs:enumeration value="SubmitterVariantId"/>
</xs:restriction>
</xs:simpleType>
</xs:attribute>
<xs:attribute name="Change" use="optional"/>
<xs:attribute name="MANESelect" type="xs:boolean" use="optional"/>
<xs:attribute name="MANEPlusClinical" type="xs:boolean" use="optional"/>
</xs:extension>
</xs:simpleContent>
</xs:complexType>
</xs:element>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Citation" type="CitationType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="XRef" type="XrefType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Comment" type="CommentType"/>
</xs:sequence>
</xs:complexType>
<xs:complexType name="MeasureSetType">
<xs:sequence>
<xs:element maxOccurs="unbounded" minOccurs="1" name="Measure" type="MeasureType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Name" type="SetElementSetType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Symbol" type="SetElementSetType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="AttributeSet"
type="MeasureSetAttributeSet"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Citation" type="CitationType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="XRef" type="XrefType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Comment" type="CommentType"/>
</xs:sequence>
<xs:attribute name="Type" use="required">
<xs:simpleType>
<xs:restriction base="xs:string">
<xs:enumeration value="Gene"/>
<xs:enumeration value="Variant"/>
<xs:enumeration value="gene-variant"/>
<xs:enumeration value="OMIM record"/>
<xs:enumeration value="Haplotype"/>
<xs:enumeration value="Haplotype, single variant"/>
<!--for complex variants with phase unknown or not reported-->
<xs:enumeration value="Phase unknown"/>
<!--for complex variants on different named chromosomes (i.e. not homologs)-->
<xs:enumeration value="Distinct chromosomes"/>
<xs:enumeration value="CompoundHeterozygote"/>
<xs:enumeration value="Diplotype"/>
</xs:restriction>
</xs:simpleType>
</xs:attribute>
<xs:attribute name="NumberOfChromosomes" type="xs:positiveInteger" use="optional"/>
<xs:attributeGroup ref="VCV"/>
<xs:attributeGroup ref="CVIdentifiers"/>
</xs:complexType>
<xs:complexType name="GenotypeSetType">
<xs:sequence>
<xs:element maxOccurs="unbounded" minOccurs="1" name="MeasureSet" type="MeasureSetType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Name" type="SetElementSetType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Symbol" type="SetElementSetType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="AttributeSet"
type="MeasureSetAttributeSet"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Citation" type="CitationType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="XRef" type="XrefType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Comment" type="CommentType"/>
</xs:sequence>
<xs:attribute name="Type" use="required">
<xs:simpleType>
<xs:restriction base="xs:string">
<xs:enumeration value="CompoundHeterozygote"/>
<xs:enumeration value="Diplotype"/>
</xs:restriction>
</xs:simpleType>
</xs:attribute>
<xs:attributeGroup ref="VCV"/>
<xs:attributeGroup ref="CVIdentifiers"/>
</xs:complexType>
<xs:complexType name="TraitSetType">
<xs:sequence>
<xs:element maxOccurs="unbounded" minOccurs="1" name="Trait" type="TraitType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Name" type="SetElementSetType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Symbol" type="SetElementSetType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="AttributeSet">
<xs:complexType>
<xs:sequence>
<xs:element maxOccurs="1" minOccurs="1" name="Attribute">
<xs:complexType>
<xs:simpleContent>
<xs:extension base="AttributeType">
<xs:attribute name="Type" type="xs:string" use="required"/>
</xs:extension>
</xs:simpleContent>
</xs:complexType>
</xs:element>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Citation"
type="CitationType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="XRef" type="XrefType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Comment"
type="CommentType">
<xs:annotation>
<xs:documentation>table_type = 38</xs:documentation>
</xs:annotation>
</xs:element>
</xs:sequence>
</xs:complexType>
</xs:element>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Citation" type="CitationType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="XRef" type="XrefType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Comment" type="CommentType"/>
</xs:sequence>
<xs:attribute name="Type" use="required">
<xs:simpleType>
<xs:restriction base="xs:string">
<xs:enumeration value="Disease"/>
<xs:enumeration value="DrugResponse"/>
<xs:enumeration value="Finding"/>
<xs:enumeration value="PhenotypeInstruction"/>
<xs:enumeration value="TraitChoice"/>
</xs:restriction>
</xs:simpleType>
</xs:attribute>
<xs:attributeGroup ref="CVIdentifiers"/>
</xs:complexType>
<xs:complexType name="TraitType">
<xs:sequence>
<xs:element maxOccurs="unbounded" minOccurs="1" name="Name" type="SetElementSetType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Symbol" type="SetElementSetType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="AttributeSet">
<xs:complexType>
<xs:sequence>
<xs:element maxOccurs="1" minOccurs="1" name="Attribute">
<xs:complexType>
<xs:simpleContent>
<xs:extension base="AttributeType">
<xs:attribute name="Type" type="xs:string" use="required"/>
</xs:extension>
</xs:simpleContent>
</xs:complexType>
</xs:element>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Citation"
type="CitationType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="XRef" type="XrefType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Comment"
type="CommentType"/>
</xs:sequence>
</xs:complexType>
</xs:element>
<xs:element maxOccurs="unbounded" minOccurs="0" name="TraitRelationship">
<xs:complexType>
<xs:sequence>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Name"
type="SetElementSetType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Symbol"
type="SetElementSetType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="AttributeSet">
<xs:complexType>
<xs:sequence>
<xs:element maxOccurs="1" minOccurs="1" name="Attribute">
<xs:complexType>
<xs:simpleContent>
<xs:extension base="AttributeType">
<xs:attribute name="Type" type="xs:string"
use="required"/>
</xs:extension>
</xs:simpleContent>
</xs:complexType>
</xs:element>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Citation"
type="CitationType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="XRef"
type="XrefType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Comment"
type="CommentType"/>
</xs:sequence>
</xs:complexType>
</xs:element>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Citation"
type="CitationType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="XRef" type="XrefType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Source"
type="DataSourceType"/>
</xs:sequence>
<xs:attribute name="Type" use="required">
<xs:simpleType>
<xs:restriction base="xs:string">
<xs:enumeration value="phenocopy"/>
<xs:enumeration value="Subphenotype"/>
<xs:enumeration value="DrugResponseAndDisease"/>
<xs:enumeration value="co-occurring condition"/>
<xs:enumeration value="Finding member"/>
</xs:restriction>
</xs:simpleType>
</xs:attribute>
<xs:attributeGroup ref="CVIdentifiers"/>
</xs:complexType>
</xs:element>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Citation" type="CitationType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="XRef" type="XrefType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Comment" type="CommentType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Source" type="DataSourceType"/>
</xs:sequence>
<xs:attribute name="Type" use="required">
<xs:simpleType>
<xs:restriction base="xs:string">
<xs:enumeration value="Disease"/>
<xs:enumeration value="DrugResponse"/>
<xs:enumeration value="BloodGroup"/>
<xs:enumeration value="Finding"/>
<xs:enumeration value="NamedProteinVariant"/>
<xs:enumeration value="PhenotypeInstruction"/>
</xs:restriction>
</xs:simpleType>
</xs:attribute>
<xs:attributeGroup ref="CVIdentifiers"/>
</xs:complexType>
<xs:complexType name="ClinAsserTraitSetType">
<xs:sequence>
<xs:element maxOccurs="unbounded" minOccurs="1" name="Trait" type="ClinAsserTraitType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Name" type="SetElementSetType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Symbol" type="SetElementSetType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="AttributeSet">
<xs:complexType>
<xs:sequence>
<xs:element maxOccurs="1" minOccurs="1" name="Attribute">
<xs:complexType>
<xs:simpleContent>
<xs:extension base="AttributeType">
<xs:attribute name="Type" type="xs:string" use="required"/>
</xs:extension>
</xs:simpleContent>
</xs:complexType>
</xs:element>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Citation"
type="CitationType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="XRef" type="XrefType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Comment"
type="CommentType">
<xs:annotation>
<xs:documentation>table_type = 38</xs:documentation>
</xs:annotation>
</xs:element>
</xs:sequence>
</xs:complexType>
</xs:element>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Citation" type="CitationType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="XRef" type="XrefType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Comment" type="CommentType"/>
</xs:sequence>
<xs:attribute name="Type" use="required">
<xs:simpleType>
<xs:restriction base="xs:string">
<xs:enumeration value="Disease"/>
<xs:enumeration value="DrugResponse"/>
<xs:enumeration value="Finding"/>
<xs:enumeration value="PhenotypeInstruction"/>
<xs:enumeration value="TraitChoice"/>
</xs:restriction>
</xs:simpleType>
</xs:attribute>
<xs:attribute name="DateLastEvaluated" type="xs:date"/>
<xs:attributeGroup ref="CVIdentifiers"/>
<xs:attribute name="multipleConditionExplanation" type="xs:string" use="optional"/>
</xs:complexType>
<xs:simpleType name="ClinicalFeaturesAffectedStatusType">
<xs:restriction base="xs:string">
<xs:enumeration value="present"/>
<xs:enumeration value="absent"/>
<xs:enumeration value="not tested"/>
</xs:restriction>
</xs:simpleType>
<xs:complexType name="ClinAsserTraitType">
<xs:sequence>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Name" type="SetElementSetType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="Symbol" type="SetElementSetType"/>
<xs:element maxOccurs="unbounded" minOccurs="0" name="AttributeSet">
<xs:complexType>
<xs:sequence>
<xs:element maxOccurs="1" minOccurs="1" name="Attribute">
<xs:complexType>
<xs:simpleContent>