diff --git a/inst/cov/data/phenobarbital_data.csv b/inst/cov/data/phenobarbital_data.csv
new file mode 100644
index 0000000..d32883a
--- /dev/null
+++ b/inst/cov/data/phenobarbital_data.csv
@@ -0,0 +1,745 @@
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diff --git a/inst/cov/data/warfarin_data.csv b/inst/cov/data/warfarin_data.csv
new file mode 100644
index 0000000..ce66cfa
--- /dev/null
+++ b/inst/cov/data/warfarin_data.csv
@@ -0,0 +1,512 @@
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diff --git a/inst/cov/pb/FisherInformation/correlationEstimatesSA.txt b/inst/cov/pb/FisherInformation/correlationEstimatesSA.txt
new file mode 100644
index 0000000..7f896a8
--- /dev/null
+++ b/inst/cov/pb/FisherInformation/correlationEstimatesSA.txt
@@ -0,0 +1,7 @@
+V_pop,1,-0.647912,-0.435907,-0.0992874,-0.0121518,0.0317767,0.00238409
+beta_V_tAPGAR_High,-0.647912,1,0.282449,0.00797906,0.0131849,0.0204614,-0.0137715
+beta_V_tAPGAR_Low,-0.435907,0.282449,1,0.032804,0.0162185,-0.0377099,0.0183612
+k_pop,-0.0992874,0.00797906,0.032804,1,0.0223266,-0.439182,0.0875303
+omega_V,-0.0121518,0.0131849,0.0162185,0.0223266,1,-0.075066,-0.0142108
+omega_k,0.0317767,0.0204614,-0.0377099,-0.439182,-0.075066,1,-0.167853
+b,0.00238409,-0.0137715,0.0183612,0.0875303,-0.0142108,-0.167853,1
diff --git a/inst/cov/pb/FisherInformation/covarianceEstimatesSA.txt b/inst/cov/pb/FisherInformation/covarianceEstimatesSA.txt
new file mode 100644
index 0000000..4f22ecd
--- /dev/null
+++ b/inst/cov/pb/FisherInformation/covarianceEstimatesSA.txt
@@ -0,0 +1,7 @@
+V_pop,0.0056467,-0.00560103,-0.00562705,-0.000379087,-3.56709e-05,0.000164807,1.51502e-06
+beta_V_tAPGAR_High,-0.00560103,0.0132346,0.00558194,4.66395e-05,5.92522e-05,0.000162465,-1.33978e-05
+beta_V_tAPGAR_Low,-0.00562705,0.00558194,0.0295107,0.000286328,0.000108837,-0.00044711,2.66741e-05
+k_pop,-0.000379087,4.66395e-05,0.000286328,0.00258163,4.43143e-05,-0.00154014,3.76102e-05
+omega_V,-3.56709e-05,5.92522e-05,0.000108837,4.43143e-05,0.00152598,-0.000202389,-4.69453e-06
+omega_k,0.000164807,0.000162465,-0.00044711,-0.00154014,-0.000202389,0.00476364,-9.79711e-05
+b,1.51502e-06,-1.33978e-05,2.66741e-05,3.76102e-05,-4.69453e-06,-9.79711e-05,7.15152e-05
diff --git a/inst/cov/pb/IndividualParameters/estimatedIndividualParameters.txt b/inst/cov/pb/IndividualParameters/estimatedIndividualParameters.txt
new file mode 100644
index 0000000..7aac184
--- /dev/null
+++ b/inst/cov/pb/IndividualParameters/estimatedIndividualParameters.txt
@@ -0,0 +1,60 @@
+id,V_SAEM,k_SAEM,V_mean,k_mean,V_mode,k_mode,V_sd,k_sd,WEIGHT,APGAR,tAPGAR
+1,1.36507,0.00450273,1.3446,0.00466268,1.36552,0.00458173,0.0990519,0.000767584,1.4,7,Med
+2,1.23866,0.00437386,1.23165,0.00460192,1.26824,0.00426925,0.0890833,0.000751667,1.5,9,High
+3,1.6821,0.00505469,1.71966,0.00511226,1.69198,0.00509029,0.126212,0.000783286,1.5,6,Med
+4,0.89023,0.00475518,0.911,0.00455246,0.907639,0.00465635,0.0645684,0.000701659,0.9,6,Med
+5,1.84085,0.00506347,1.88133,0.00495185,1.85084,0.00493041,0.140949,0.000816188,1.4,7,Med
+6,1.30114,0.00437466,1.27259,0.00460632,1.30184,0.00448675,0.0866722,0.000634497,1.2,5,Med
+7,1.04565,0.00485025,1.06903,0.00467764,1.05672,0.00483199,0.0845241,0.000679324,1,5,Med
+8,0.970299,0.00514392,0.970992,0.00514736,0.974837,0.00507549,0.0682255,0.000962446,1.2,7,Med
+9,1.19854,0.00411757,1.19733,0.00403461,1.21544,0.00409497,0.0881007,0.000443903,1.4,8,High
+10,1.3769,0.0048506,1.37805,0.00484662,1.38882,0.00483168,0.09917,0.0007317,1.4,7,Med
+11,1.80279,0.00515855,1.84577,0.0050506,1.83575,0.00489009,0.172533,0.000821175,1.2,7,Med
+12,1.36276,0.00439652,1.3975,0.0042596,1.37068,0.00437274,0.101222,0.000421236,1.3,6,Med
+13,0.91407,0.00463514,0.926068,0.00445003,0.917154,0.00467918,0.0652446,0.00072902,1.1,6,Med
+14,0.968937,0.00572103,0.99174,0.00552517,0.981756,0.00562748,0.0622939,0.000407642,1.1,7,Med
+15,1.3392,0.00505013,1.36347,0.0047548,1.37166,0.00477776,0.119671,0.000836597,1.3,7,Med
+16,1.22145,0.00405371,1.19283,0.00443368,1.20382,0.00429512,0.0741338,0.000612968,1.2,9,High
+17,1.03612,0.0045483,1.03995,0.00465647,1.04292,0.00452619,0.0535836,0.000779155,1.1,5,Med
+18,1.074,0.00638388,1.07805,0.00629808,1.08859,0.00628585,0.0839612,0.000350779,1,5,Med
+19,1.0813,0.00471885,1.07154,0.00499549,1.08935,0.00481758,0.0866937,0.000803975,1,1,Low
+20,1.07193,0.00516801,1.08486,0.00502455,1.0895,0.00495601,0.0664833,0.000811289,1.2,6,Med
+21,1.63102,0.0047654,1.62867,0.00463639,1.63167,0.00479216,0.155145,0.000623158,1.8,7,Med
+22,1.37482,0.00480672,1.39178,0.00498105,1.38735,0.00480865,0.10744,0.00089797,1.5,8,High
+23,2.72362,0.00568031,2.69069,0.00576692,2.71723,0.00557442,0.195654,0.000974405,3.1,3,Low
+24,3.53858,0.00539914,3.43387,0.00555631,3.48289,0.0054334,0.249054,0.000707746,3.2,2,Low
+25,1.06391,0.00386967,1.04797,0.0041991,1.05384,0.0041458,0.0414753,0.000593862,0.7,1,Low
+26,2.98731,0.00481891,2.95843,0.00488103,2.91446,0.00498772,0.236784,0.000828262,3.5,9,High
+27,1.354,0.00519834,1.37521,0.00507132,1.37845,0.00499655,0.127487,0.00091705,1.9,5,Med
+28,3.32997,0.00501016,3.42084,0.00492941,3.36217,0.00480582,0.373534,0.000923345,3.2,9,High
+29,0.985641,0.00469107,1.01877,0.00471696,1.01585,0.00475799,0.101668,0.000898363,1,7,Med
+30,1.90815,0.00469364,1.90892,0.00491507,1.94594,0.00472863,0.204962,0.00068543,1.8,8,High
+31,1.22709,0.00490806,1.21215,0.00511139,1.21756,0.00479711,0.115942,0.000824596,1.4,8,High
+32,4.96601,0.00507385,4.87568,0.00503065,4.94262,0.00499475,0.365989,0.000746195,3.6,9,High
+33,1.5253,0.00472151,1.50948,0.00477455,1.53975,0.00467739,0.12416,0.000946615,1.7,8,High
+34,1.54524,0.00470046,1.52716,0.00478211,1.52388,0.0048086,0.134443,0.000899913,1.7,4,Med
+35,1.80226,0.00476678,1.87218,0.00474843,1.86638,0.00458585,0.179566,0.000891753,2.5,5,Med
+36,1.41707,0.00542492,1.42152,0.00546417,1.41391,0.00558791,0.111035,0.000448293,1.5,5,Med
+37,1.21583,0.00454308,1.21562,0.00449646,1.22542,0.00464353,0.0634087,0.000652584,1.2,9,High
+38,1.42374,0.00503918,1.43182,0.00508952,1.43821,0.00500464,0.0938143,0.000409346,1.3,8,High
+39,1.88371,0.00516055,1.86076,0.00525898,1.85515,0.00524287,0.148936,0.000584956,1.9,10,High
+40,1.36948,0.00497986,1.37473,0.00493004,1.37889,0.00479692,0.120757,0.000990846,1.1,3,Low
+41,1.86093,0.00485832,1.84917,0.00476156,1.86596,0.00484356,0.118248,0.000771871,1.7,7,Med
+42,4.19461,0.00596577,4.17058,0.00588161,4.27871,0.00541521,0.286496,0.00105831,2.8,9,High
+43,0.836117,0.00480345,0.824381,0.00495039,0.837975,0.0047933,0.0755358,0.000821687,0.9,1,Low
+44,1.49596,0.00466369,1.45836,0.00466319,1.48172,0.00470082,0.114864,0.000463702,1.4,7,Med
+45,0.938179,0.00453504,0.92598,0.00473575,0.938387,0.00464707,0.0644822,0.000700612,0.8,2,Low
+46,1.10517,0.00477249,1.10879,0.00477912,1.1257,0.00479537,0.11451,0.000827035,1.1,8,High
+47,2.27986,0.00490235,2.2725,0.00487477,2.29154,0.00484686,0.234556,0.000944721,2.6,9,High
+48,0.725826,0.00338584,0.727778,0.00344076,0.709853,0.00363822,0.0439024,0.000428403,0.7,8,High
+49,1.40904,0.00452594,1.39116,0.00483219,1.41252,0.004618,0.0849743,0.000668962,1.3,8,High
+50,0.884347,0.00530195,0.882162,0.00517182,0.89538,0.00491303,0.0450933,0.00106172,1.1,6,Med
+51,1.11976,0.00435061,1.14044,0.00423379,1.12879,0.00429352,0.0737652,0.000765667,0.9,9,High
+52,0.749937,0.0055283,0.748929,0.00574792,0.741763,0.00584408,0.047788,0.000872427,0.9,7,Med
+53,1.51642,0.0045936,1.50994,0.00474449,1.53568,0.00456475,0.127226,0.00109609,1.7,8,High
+54,1.38003,0.00475195,1.38743,0.00445518,1.38124,0.00467501,0.075496,0.000667736,1.8,8,High
+55,1.56763,0.00487203,1.55777,0.00484869,1.57469,0.00486167,0.201176,0.000770133,1.1,4,Med
+56,0.690686,0.00479029,0.694776,0.00482393,0.692031,0.00474518,0.0621356,0.000859716,0.6,4,Med
+57,1.98954,0.00502514,1.99814,0.00496364,1.99014,0.00498249,0.137482,0.000736982,2.1,6,Med
+58,1.21562,0.00499815,1.20255,0.00501633,1.22259,0.00496959,0.093285,0.000741269,1.4,8,High
+59,0.96167,0.00467771,0.969286,0.00463854,0.976577,0.00460034,0.0761073,0.000866162,1.1,6,Med
diff --git a/inst/cov/pb/IndividualParameters/estimatedRandomEffects.txt b/inst/cov/pb/IndividualParameters/estimatedRandomEffects.txt
new file mode 100644
index 0000000..40f2657
--- /dev/null
+++ b/inst/cov/pb/IndividualParameters/estimatedRandomEffects.txt
@@ -0,0 +1,60 @@
+id,eta_V_SAEM,eta_k_SAEM,eta_V_mean,eta_k_mean,eta_V_mode,eta_k_mode,eta_V_sd,eta_k_sd,WEIGHT,APGAR,tAPGAR
+1,0.0889532,-0.0732039,0.0726794,-0.043725,0.0908758,-0.0462315,0.0746714,0.178475,1.4,7,Med
+2,-0.273014,-0.101827,-0.275453,-0.0551755,-0.243606,-0.11687,0.0714567,0.163694,1.5,9,High
+3,0.298849,0.0455526,0.318751,0.0516244,0.305241,0.0590254,0.0739476,0.153573,1.5,6,Med
+4,-0.336945,-0.0140647,-0.316397,-0.064412,-0.317567,-0.0300765,0.0712033,0.153402,0.9,6,Med
+5,0.38979,0.0504285,0.408511,0.0183559,0.394979,0.0271139,0.0750348,0.160766,1.4,7,Med
+6,0.0422678,-0.10057,0.0181382,-0.0504928,0.043121,-0.0671799,0.0668564,0.139345,1.2,5,Med
+7,-0.176119,0.00559015,-0.157004,-0.0360943,-0.165489,0.00694914,0.0785078,0.145783,1,5,Med
+8,-0.252185,0.0632649,-0.25254,0.0515662,-0.246144,0.0561136,0.0697793,0.196942,1.2,7,Med
+9,-0.305943,-0.149024,-0.30385,-0.179655,-0.286133,-0.158549,0.0735623,0.112934,1.4,8,High
+10,0.0990451,0.00582259,0.0974394,-0.00158811,0.107799,0.00688479,0.0716391,0.152962,1.4,7,Med
+11,0.365531,0.0670761,0.387828,0.0382643,0.386793,0.0189021,0.0943022,0.160349,1.2,7,Med
+12,0.0878584,-0.0845335,0.111395,-0.123992,0.0946519,-0.0929202,0.0725854,0.0985337,1.3,6,Med
+13,-0.31216,-0.0390774,-0.300066,-0.088659,-0.307138,-0.0251868,0.073018,0.163204,1.1,6,Med
+14,-0.252475,0.181669,-0.230905,0.138234,-0.239071,0.159353,0.0623661,0.0748375,1.1,7,Med
+15,0.0678552,0.0442651,0.085409,-0.0244879,0.0953652,-0.00433679,0.0898102,0.175319,1.3,7,Med
+16,-0.286659,-0.172342,-0.306834,-0.0886189,-0.29574,-0.11083,0.0621496,0.138583,1.2,9,High
+17,-0.186425,-0.0593193,-0.182845,-0.0445817,-0.178636,-0.0584296,0.0523858,0.172602,1.1,5,Med
+18,-0.149229,0.292797,-0.14854,0.270389,-0.135771,0.269991,0.0779559,0.0555785,1,5,Med
+19,-0.277014,-0.0289622,-0.282805,0.0276625,-0.263025,0.00396264,0.081386,0.157847,1,1,Low
+20,-0.151623,0.0728385,-0.141106,0.0331147,-0.134942,0.0322916,0.0619082,0.160618,1.2,6,Med
+21,0.266473,-0.00868031,0.262477,-0.0432221,0.268944,-0.00132736,0.0968281,0.132539,1.8,7,Med
+22,-0.169213,-0.00859959,-0.153623,0.0214533,-0.153838,0.00210688,0.0770543,0.177591,1.5,8,High
+23,0.645646,0.161013,0.638538,0.169689,0.651005,0.149879,0.0728982,0.168566,3.1,3,Low
+24,0.908832,0.115272,0.88251,0.138346,0.899254,0.124255,0.0713464,0.129475,3.2,2,Low
+25,-0.292107,-0.217187,-0.302538,-0.143957,-0.29617,-0.146214,0.0395071,0.147234,0.7,1,Low
+26,0.605163,-0.0128711,0.600212,0.00257728,0.588449,0.0386698,0.0802233,0.170679,3.5,9,High
+27,0.079961,0.0705278,0.0935741,0.0387287,0.100304,0.0404379,0.0940524,0.183384,1.9,5,Med
+28,0.710166,0.0316529,0.742568,0.00871231,0.731351,0.00151964,0.110931,0.192855,3.2,9,High
+29,-0.239373,-0.0304589,-0.206981,-0.0340052,-0.204928,-0.00848361,0.0990519,0.181235,1,7,Med
+30,0.157033,-0.0255281,0.159462,0.0143843,0.184507,-0.0146744,0.108604,0.138613,1.8,8,High
+31,-0.283947,0.00718304,-0.293454,0.0496942,-0.284384,-0.000294747,0.0963636,0.166077,1.4,8,High
+32,1.11616,0.040031,1.10011,0.0360944,1.11666,0.0400786,0.0770605,0.150084,3.6,9,High
+33,-0.0651804,-0.0208583,-0.0729126,-0.0252667,-0.0496166,-0.0255698,0.0834029,0.204365,1.7,8,High
+34,0.213464,-0.0293972,0.198773,-0.0213208,0.200603,0.00209658,0.0898587,0.190196,1.7,4,Med
+35,0.365489,-0.0187217,0.401731,-0.027004,0.403344,-0.045333,0.0977774,0.179296,2.5,5,Med
+36,0.127942,0.129343,0.127953,0.126406,0.125699,0.152296,0.0794003,0.0845266,1.5,5,Med
+37,-0.292933,-0.057286,-0.287323,-0.0751272,-0.277955,-0.0328346,0.0517306,0.141102,1.2,9,High
+38,-0.133683,0.0530762,-0.124431,0.0556004,-0.117839,0.0420563,0.0654573,0.0812033,1.3,8,High
+39,0.146013,0.0746865,0.136538,0.085326,0.136731,0.0885594,0.0802211,0.112982,1.9,10,High
+40,-0.0407484,0.0276321,-0.0340675,0.00745074,-0.027327,-0.000334993,0.085531,0.1973,1.1,3,Low
+41,0.399999,0.00709871,0.391999,-0.0207645,0.403118,0.00934112,0.0647646,0.161564,1.7,7,Med
+42,0.946346,0.20657,0.944458,0.186499,0.972416,0.120903,0.0687624,0.187367,2.8,9,High
+43,-0.535873,-0.0126244,-0.545912,0.0173665,-0.525374,-0.00108929,0.0914706,0.16677,0.9,1,Low
+44,0.179993,-0.0254146,0.153471,-0.0335694,0.172546,-0.0205712,0.0803606,0.0997795,1.4,7,Med
+45,-0.419447,-0.066625,-0.427929,-0.0237553,-0.4122,-0.0320716,0.0695434,0.14457,0.8,2,Low
+46,-0.390733,-0.0204809,-0.383357,-0.0189974,-0.362832,-0.000657966,0.104293,0.173456,1.1,8,High
+47,0.335064,0.00285871,0.334219,-0.0019725,0.347987,0.0100219,0.104738,0.186622,2.6,9,High
+48,-0.806607,-0.351102,-0.800897,-0.340278,-0.823934,-0.276814,0.0623941,0.123585,0.7,8,High
+49,-0.144899,-0.0664602,-0.152995,-0.00251842,-0.135863,-0.0383465,0.0618932,0.138031,1.3,8,High
+50,-0.344024,0.093339,-0.347346,0.0538998,-0.331165,0.0235817,0.0511819,0.20582,1.1,6,Med
+51,-0.374539,-0.103806,-0.35195,-0.141882,-0.36009,-0.111203,0.0654728,0.184052,0.9,9,High
+52,-0.509145,0.13856,-0.511818,0.169167,-0.519384,0.19712,0.0641487,0.150612,0.9,7,Med
+53,-0.070534,-0.0530169,-0.0726886,-0.0348276,-0.0522601,-0.0499444,0.083752,0.211892,1.7,8,High
+54,-0.164461,-0.0181261,-0.155248,-0.0851636,-0.158255,-0.0260781,0.0539236,0.147044,1.8,8,High
+55,0.224624,8.13076e-05,0.214054,-0.00259102,0.233398,0.0130731,0.131793,0.162701,1.1,4,Med
+56,-0.593988,-0.00920932,-0.588808,-0.0103186,-0.588783,-0.0111799,0.089271,0.176412,0.6,4,Med
+57,0.465882,0.0402655,0.469121,0.0225516,0.467547,0.0376207,0.0704244,0.151388,2.1,6,Med
+58,-0.292143,0.0301801,-0.299679,0.0331685,-0.280267,0.0350274,0.075211,0.15113,1.4,8,High
+59,-0.260521,-0.0309933,-0.254932,-0.0510545,-0.24436,-0.0421778,0.0784758,0.185206,1.1,6,Med
diff --git a/inst/cov/pb/IndividualParameters/simulatedIndividualParameters.txt b/inst/cov/pb/IndividualParameters/simulatedIndividualParameters.txt
new file mode 100644
index 0000000..f30d177
--- /dev/null
+++ b/inst/cov/pb/IndividualParameters/simulatedIndividualParameters.txt
@@ -0,0 +1,591 @@
+rep,id,V,k,WEIGHT,APGAR,tAPGAR
+1,1,1.43402,0.00430085,1.4,7,Med
+2,1,1.44354,0.00518855,1.4,7,Med
+3,1,1.42435,0.00406735,1.4,7,Med
+4,1,1.16665,0.00558739,1.4,7,Med
+5,1,1.30794,0.00558078,1.4,7,Med
+6,1,1.18038,0.00569842,1.4,7,Med
+7,1,1.40722,0.00531767,1.4,7,Med
+8,1,1.39115,0.00351815,1.4,7,Med
+9,1,1.29304,0.00452603,1.4,7,Med
+10,1,1.41479,0.00398897,1.4,7,Med
+1,2,1.06315,0.00478736,1.5,9,High
+2,2,1.18111,0.00349778,1.5,9,High
+3,2,1.28789,0.00497486,1.5,9,High
+4,2,1.21266,0.0044337,1.5,9,High
+5,2,1.37057,0.00436739,1.5,9,High
+6,2,1.217,0.00371453,1.5,9,High
+7,2,1.16339,0.00517519,1.5,9,High
+8,2,1.1444,0.00519771,1.5,9,High
+9,2,1.13593,0.00571889,1.5,9,High
+10,2,1.27293,0.00420215,1.5,9,High
+1,3,1.63743,0.00564198,1.5,6,Med
+2,3,1.65007,0.00589452,1.5,6,Med
+3,3,1.61784,0.00629807,1.5,6,Med
+4,3,1.59454,0.00485899,1.5,6,Med
+5,3,1.66354,0.0053981,1.5,6,Med
+6,3,1.67281,0.00432221,1.5,6,Med
+7,3,1.5942,0.00565747,1.5,6,Med
+8,3,1.79224,0.00373831,1.5,6,Med
+9,3,1.89904,0.00479305,1.5,6,Med
+10,3,1.77934,0.00561235,1.5,6,Med
+1,4,0.856883,0.00398642,0.9,6,Med
+2,4,0.94745,0.00460603,0.9,6,Med
+3,4,0.85974,0.00526347,0.9,6,Med
+4,4,0.916478,0.00384101,0.9,6,Med
+5,4,0.995,0.00408662,0.9,6,Med
+6,4,0.890392,0.00470944,0.9,6,Med
+7,4,0.810623,0.00533088,0.9,6,Med
+8,4,0.996623,0.00384021,0.9,6,Med
+9,4,0.969795,0.0041652,0.9,6,Med
+10,4,0.892837,0.00471414,0.9,6,Med
+1,5,1.92127,0.00450982,1.4,7,Med
+2,5,2.04467,0.00512033,1.4,7,Med
+3,5,1.87536,0.00554947,1.4,7,Med
+4,5,2.03344,0.00379288,1.4,7,Med
+5,5,1.85428,0.00567761,1.4,7,Med
+6,5,1.76669,0.00387938,1.4,7,Med
+7,5,2.15389,0.00452073,1.4,7,Med
+8,5,2.1646,0.00396229,1.4,7,Med
+9,5,1.96004,0.0052661,1.4,7,Med
+10,5,1.8211,0.00486031,1.4,7,Med
+1,6,1.31894,0.00458769,1.2,5,Med
+2,6,1.2054,0.00463669,1.2,5,Med
+3,6,1.3687,0.00490408,1.2,5,Med
+4,6,1.19669,0.00445888,1.2,5,Med
+5,6,1.15741,0.00584706,1.2,5,Med
+6,6,1.34941,0.00452642,1.2,5,Med
+7,6,1.30183,0.00379039,1.2,5,Med
+8,6,1.36302,0.00396159,1.2,5,Med
+9,6,1.2519,0.00404664,1.2,5,Med
+10,6,1.26,0.00430772,1.2,5,Med
+1,7,1.01504,0.00480345,1,5,Med
+2,7,0.987367,0.00602617,1,5,Med
+3,7,1.10077,0.0035081,1,5,Med
+4,7,1.00873,0.0051883,1,5,Med
+5,7,1.03325,0.00356778,1,5,Med
+6,7,0.988094,0.00462005,1,5,Med
+7,7,0.957005,0.00497255,1,5,Med
+8,7,1.17732,0.00474189,1,5,Med
+9,7,0.892118,0.00596693,1,5,Med
+10,7,1.0708,0.00443324,1,5,Med
+1,8,1.05472,0.00423242,1.2,7,Med
+2,8,0.871392,0.00509222,1.2,7,Med
+3,8,1.11413,0.00506291,1.2,7,Med
+4,8,0.906944,0.00474245,1.2,7,Med
+5,8,1.00162,0.00518277,1.2,7,Med
+6,8,1.0276,0.00632609,1.2,7,Med
+7,8,0.998964,0.00493847,1.2,7,Med
+8,8,1.01467,0.00587819,1.2,7,Med
+9,8,0.88637,0.00465668,1.2,7,Med
+10,8,0.939679,0.00491258,1.2,7,Med
+1,9,1.28052,0.00325429,1.4,8,High
+2,9,1.10633,0.0039202,1.4,8,High
+3,9,1.1917,0.00363103,1.4,8,High
+4,9,1.11379,0.00383408,1.4,8,High
+5,9,1.14061,0.00479276,1.4,8,High
+6,9,1.33771,0.00360347,1.4,8,High
+7,9,1.18744,0.00424402,1.4,8,High
+8,9,1.07585,0.00425117,1.4,8,High
+9,9,1.18295,0.00449972,1.4,8,High
+10,9,1.26049,0.00433603,1.4,8,High
+1,10,1.5892,0.00436113,1.4,7,Med
+2,10,1.23043,0.00552474,1.4,7,Med
+3,10,1.40011,0.00520465,1.4,7,Med
+4,10,1.33513,0.00455253,1.4,7,Med
+5,10,1.60497,0.00342343,1.4,7,Med
+6,10,1.38128,0.00486136,1.4,7,Med
+7,10,1.31195,0.00435808,1.4,7,Med
+8,10,1.27278,0.00571058,1.4,7,Med
+9,10,1.26265,0.00604965,1.4,7,Med
+10,10,1.29136,0.00541112,1.4,7,Med
+1,11,1.76096,0.00654886,1.2,7,Med
+2,11,1.81408,0.0056004,1.2,7,Med
+3,11,2.04439,0.00472308,1.2,7,Med
+4,11,1.6752,0.00563854,1.2,7,Med
+5,11,1.82028,0.00556086,1.2,7,Med
+6,11,1.55972,0.00503855,1.2,7,Med
+7,11,2.25003,0.00375682,1.2,7,Med
+8,11,1.78844,0.00534893,1.2,7,Med
+9,11,1.78813,0.00457,1.2,7,Med
+10,11,1.98428,0.00510177,1.2,7,Med
+1,12,1.44947,0.00456266,1.3,6,Med
+2,12,1.30851,0.00469414,1.3,6,Med
+3,12,1.36565,0.00412822,1.3,6,Med
+4,12,1.46422,0.00387675,1.3,6,Med
+5,12,1.30468,0.00481993,1.3,6,Med
+6,12,1.52041,0.00392947,1.3,6,Med
+7,12,1.36013,0.00433219,1.3,6,Med
+8,12,1.35461,0.00417247,1.3,6,Med
+9,12,1.47422,0.00374272,1.3,6,Med
+10,12,1.65104,0.00356284,1.3,6,Med
+1,13,0.729092,0.00511191,1.1,6,Med
+2,13,1.00941,0.00314678,1.1,6,Med
+3,13,0.740785,0.00728829,1.1,6,Med
+4,13,1.03988,0.00462367,1.1,6,Med
+5,13,0.973902,0.00408929,1.1,6,Med
+6,13,0.794326,0.00323765,1.1,6,Med
+7,13,0.882748,0.00505525,1.1,6,Med
+8,13,1.0325,0.00336162,1.1,6,Med
+9,13,0.884189,0.00475201,1.1,6,Med
+10,13,0.963388,0.00454162,1.1,6,Med
+1,14,0.995617,0.00476716,1.1,7,Med
+2,14,1.07307,0.00506015,1.1,7,Med
+3,14,0.986245,0.00524375,1.1,7,Med
+4,14,0.913177,0.00612099,1.1,7,Med
+5,14,0.996586,0.00560972,1.1,7,Med
+6,14,0.972998,0.00548711,1.1,7,Med
+7,14,1.00834,0.00588224,1.1,7,Med
+8,14,0.992734,0.00542314,1.1,7,Med
+9,14,0.896399,0.00581425,1.1,7,Med
+10,14,1.01335,0.00586861,1.1,7,Med
+1,15,1.48444,0.00558257,1.3,7,Med
+2,15,1.4609,0.00455576,1.3,7,Med
+3,15,1.48525,0.00466278,1.3,7,Med
+4,15,1.37412,0.00519794,1.3,7,Med
+5,15,1.21238,0.00487389,1.3,7,Med
+6,15,1.20643,0.00376654,1.3,7,Med
+7,15,1.28065,0.00459023,1.3,7,Med
+8,15,1.42711,0.0042965,1.3,7,Med
+9,15,1.33861,0.00484788,1.3,7,Med
+10,15,1.38595,0.00463773,1.3,7,Med
+1,16,1.34758,0.003355,1.2,9,High
+2,16,1.19508,0.00417023,1.2,9,High
+3,16,1.14489,0.00432617,1.2,9,High
+4,16,1.18166,0.00428757,1.2,9,High
+5,16,1.03601,0.0043076,1.2,9,High
+6,16,1.16847,0.00409646,1.2,9,High
+7,16,1.15756,0.00487119,1.2,9,High
+8,16,1.18732,0.00439697,1.2,9,High
+9,16,0.988167,0.00407582,1.2,9,High
+10,16,1.24242,0.00440579,1.2,9,High
+1,17,1.10052,0.00387389,1.1,5,Med
+2,17,1.0565,0.00571835,1.1,5,Med
+3,17,1.03713,0.0047076,1.1,5,Med
+4,17,1.05989,0.00425775,1.1,5,Med
+5,17,1.03413,0.00427568,1.1,5,Med
+6,17,1.03358,0.00390672,1.1,5,Med
+7,17,1.12379,0.00451478,1.1,5,Med
+8,17,1.00277,0.00492941,1.1,5,Med
+9,17,1.10211,0.00462905,1.1,5,Med
+10,17,1.02769,0.00650516,1.1,5,Med
+1,18,1.16593,0.00591942,1,5,Med
+2,18,1.0853,0.0067316,1,5,Med
+3,18,1.17197,0.00583604,1,5,Med
+4,18,0.93911,0.0067764,1,5,Med
+5,18,0.925204,0.00693823,1,5,Med
+6,18,1.07812,0.006567,1,5,Med
+7,18,0.951464,0.006567,1,5,Med
+8,18,1.19916,0.00590673,1,5,Med
+9,18,1.25222,0.00590673,1,5,Med
+10,18,1.08547,0.00644029,1,5,Med
+1,19,1.04325,0.00547988,1,1,Low
+2,19,1.16357,0.00391872,1,1,Low
+3,19,1.09562,0.00549577,1,1,Low
+4,19,1.02994,0.00520011,1,1,Low
+5,19,1.13091,0.00473794,1,1,Low
+6,19,1.15795,0.00416285,1,1,Low
+7,19,0.966617,0.00563581,1,1,Low
+8,19,1.07286,0.00583048,1,1,Low
+9,19,1.13494,0.00392984,1,1,Low
+10,19,0.977425,0.00507513,1,1,Low
+1,20,1.15917,0.0038772,1.2,6,Med
+2,20,0.948175,0.00555792,1.2,6,Med
+3,20,1.10723,0.00472416,1.2,6,Med
+4,20,1.09704,0.00440753,1.2,6,Med
+5,20,1.13394,0.00352105,1.2,6,Med
+6,20,1.10289,0.00631867,1.2,6,Med
+7,20,1.03883,0.00472468,1.2,6,Med
+8,20,1.13813,0.00459236,1.2,6,Med
+9,20,1.01497,0.00581719,1.2,6,Med
+10,20,0.997637,0.00623155,1.2,6,Med
+1,21,1.74909,0.0039214,1.8,7,Med
+2,21,1.60071,0.00478415,1.8,7,Med
+3,21,1.76967,0.00401544,1.8,7,Med
+4,21,1.6946,0.00476987,1.8,7,Med
+5,21,1.46675,0.00478625,1.8,7,Med
+6,21,1.85256,0.00428127,1.8,7,Med
+7,21,1.32604,0.00611587,1.8,7,Med
+8,21,1.60339,0.00417599,1.8,7,Med
+9,21,1.57224,0.00545826,1.8,7,Med
+10,21,1.78793,0.00383009,1.8,7,Med
+1,22,1.44793,0.00406581,1.5,8,High
+2,22,1.53459,0.00579128,1.5,8,High
+3,22,1.40407,0.00535543,1.5,8,High
+4,22,1.31337,0.00436825,1.5,8,High
+5,22,1.31936,0.00357171,1.5,8,High
+6,22,1.28275,0.00430078,1.5,8,High
+7,22,1.39507,0.00615468,1.5,8,High
+8,22,1.31745,0.00614835,1.5,8,High
+9,22,1.22582,0.00734382,1.5,8,High
+10,22,1.28607,0.0051226,1.5,8,High
+1,23,2.70419,0.00516399,3.1,3,Low
+2,23,2.38421,0.00538887,3.1,3,Low
+3,23,2.83159,0.0053806,3.1,3,Low
+4,23,2.98069,0.00499181,3.1,3,Low
+5,23,2.92681,0.00520288,3.1,3,Low
+6,23,2.65325,0.00637134,3.1,3,Low
+7,23,2.39136,0.00819805,3.1,3,Low
+8,23,2.67525,0.00629653,3.1,3,Low
+9,23,2.69348,0.0058216,3.1,3,Low
+10,23,2.55897,0.00681741,3.1,3,Low
+1,24,3.8094,0.00596645,3.2,2,Low
+2,24,3.48393,0.00619727,3.2,2,Low
+3,24,3.07979,0.0053586,3.2,2,Low
+4,24,3.3984,0.0053523,3.2,2,Low
+5,24,3.17518,0.00613229,3.2,2,Low
+6,24,3.2979,0.00594029,3.2,2,Low
+7,24,3.62199,0.00522223,3.2,2,Low
+8,24,3.30604,0.00486328,3.2,2,Low
+9,24,3.20736,0.00696021,3.2,2,Low
+10,24,3.39914,0.00632509,3.2,2,Low
+1,25,1.08207,0.00501218,0.7,1,Low
+2,25,1.00633,0.00411811,0.7,1,Low
+3,25,1.08051,0.00441079,0.7,1,Low
+4,25,1.06997,0.00400748,0.7,1,Low
+5,25,1.06426,0.00307338,0.7,1,Low
+6,25,1.06292,0.00361452,0.7,1,Low
+7,25,0.959568,0.0047734,0.7,1,Low
+8,25,1.00092,0.00501304,0.7,1,Low
+9,25,1.04143,0.0044396,0.7,1,Low
+10,25,1.10997,0.00318601,0.7,1,Low
+1,26,3.06523,0.0057461,3.5,9,High
+2,26,2.73777,0.00530428,3.5,9,High
+3,26,2.80204,0.00548725,3.5,9,High
+4,26,2.8791,0.00455485,3.5,9,High
+5,26,2.98209,0.00424707,3.5,9,High
+6,26,3.03692,0.00391918,3.5,9,High
+7,26,2.52967,0.00537003,3.5,9,High
+8,26,2.51165,0.00591973,3.5,9,High
+9,26,2.745,0.00471288,3.5,9,High
+10,26,3.04118,0.00351538,3.5,9,High
+1,27,1.46642,0.00436015,1.9,5,Med
+2,27,1.349,0.00526736,1.9,5,Med
+3,27,1.40176,0.00408882,1.9,5,Med
+4,27,1.2611,0.00578382,1.9,5,Med
+5,27,1.35908,0.00531789,1.9,5,Med
+6,27,1.71243,0.0041792,1.9,5,Med
+7,27,1.4209,0.00467767,1.9,5,Med
+8,27,1.49548,0.00416351,1.9,5,Med
+9,27,1.21315,0.00750668,1.9,5,Med
+10,27,1.39735,0.00461985,1.9,5,Med
+1,28,2.81775,0.00555665,3.2,9,High
+2,28,3.4835,0.00487655,3.2,9,High
+3,28,3.78455,0.00520173,3.2,9,High
+4,28,3.84696,0.00377666,3.2,9,High
+5,28,3.49814,0.00430067,3.2,9,High
+6,28,2.78173,0.00657323,3.2,9,High
+7,28,3.49677,0.00542036,3.2,9,High
+8,28,3.44802,0.0062661,3.2,9,High
+9,28,3.23679,0.0052087,3.2,9,High
+10,28,3.44012,0.00619086,3.2,9,High
+1,29,1.05033,0.00336561,1,7,Med
+2,29,0.982575,0.00498667,1,7,Med
+3,29,0.958756,0.00417924,1,7,Med
+4,29,0.937571,0.00453318,1,7,Med
+5,29,0.840995,0.00543478,1,7,Med
+6,29,1.02887,0.00526258,1,7,Med
+7,29,0.991329,0.00625651,1,7,Med
+8,29,1.05279,0.00439381,1,7,Med
+9,29,0.961791,0.00443529,1,7,Med
+10,29,1.09635,0.00473036,1,7,Med
+1,30,1.94956,0.00503259,1.8,8,High
+2,30,1.54312,0.00496771,1.8,8,High
+3,30,1.5755,0.00513151,1.8,8,High
+4,30,1.93141,0.00474559,1.8,8,High
+5,30,2.0311,0.00520802,1.8,8,High
+6,30,1.68034,0.00492875,1.8,8,High
+7,30,1.85369,0.00550676,1.8,8,High
+8,30,1.92208,0.00499871,1.8,8,High
+9,30,1.61047,0.00638856,1.8,8,High
+10,30,2.13341,0.00488463,1.8,8,High
+1,31,1.34008,0.00592433,1.4,8,High
+2,31,1.3885,0.00389843,1.4,8,High
+3,31,1.18802,0.00661311,1.4,8,High
+4,31,1.12291,0.00480386,1.4,8,High
+5,31,1.0204,0.00550426,1.4,8,High
+6,31,1.32147,0.00538598,1.4,8,High
+7,31,1.02381,0.00426267,1.4,8,High
+8,31,1.27287,0.00527043,1.4,8,High
+9,31,1.24843,0.00429936,1.4,8,High
+10,31,1.29604,0.00562319,1.4,8,High
+1,32,4.5616,0.00393196,3.6,9,High
+2,32,4.9279,0.00440648,3.6,9,High
+3,32,4.89482,0.0040919,3.6,9,High
+4,32,4.31946,0.00500113,3.6,9,High
+5,32,5.57385,0.0046663,3.6,9,High
+6,32,4.74471,0.00547061,3.6,9,High
+7,32,4.79757,0.00497097,3.6,9,High
+8,32,4.74486,0.00652915,3.6,9,High
+9,32,4.97198,0.00567132,3.6,9,High
+10,32,5.21272,0.00396676,3.6,9,High
+1,33,1.80942,0.00404194,1.7,8,High
+2,33,1.52077,0.00412081,1.7,8,High
+3,33,1.45889,0.0051307,1.7,8,High
+4,33,1.50972,0.00529144,1.7,8,High
+5,33,1.5244,0.004485,1.7,8,High
+6,33,1.42033,0.00579301,1.7,8,High
+7,33,1.32989,0.00780792,1.7,8,High
+8,33,1.6624,0.00418031,1.7,8,High
+9,33,1.29365,0.00537039,1.7,8,High
+10,33,1.70468,0.00342493,1.7,8,High
+1,34,1.40384,0.00439751,1.7,4,Med
+2,34,1.61001,0.00622218,1.7,4,Med
+3,34,1.36087,0.005911,1.7,4,Med
+4,34,1.44171,0.00415317,1.7,4,Med
+5,34,1.7604,0.00439205,1.7,4,Med
+6,34,1.50331,0.00477392,1.7,4,Med
+7,34,1.66007,0.00392373,1.7,4,Med
+8,34,1.70778,0.00449939,1.7,4,Med
+9,34,1.66825,0.00352082,1.7,4,Med
+10,34,1.275,0.00357541,1.7,4,Med
+1,35,1.72871,0.00484962,2.5,5,Med
+2,35,1.73782,0.00553705,2.5,5,Med
+3,35,2.17598,0.00420442,2.5,5,Med
+4,35,1.75373,0.00547487,2.5,5,Med
+5,35,1.86982,0.00458887,2.5,5,Med
+6,35,2.03008,0.00417386,2.5,5,Med
+7,35,1.82832,0.00443912,2.5,5,Med
+8,35,1.97293,0.00576994,2.5,5,Med
+9,35,1.80029,0.00376832,2.5,5,Med
+10,35,1.88987,0.00401418,2.5,5,Med
+1,36,1.30888,0.00591561,1.5,5,Med
+2,36,1.62809,0.00429111,1.5,5,Med
+3,36,1.45084,0.00557707,1.5,5,Med
+4,36,1.42223,0.00519452,1.5,5,Med
+5,36,1.44192,0.00537106,1.5,5,Med
+6,36,1.48832,0.00516344,1.5,5,Med
+7,36,1.27498,0.00579692,1.5,5,Med
+8,36,1.33719,0.00563268,1.5,5,Med
+9,36,1.43744,0.00573317,1.5,5,Med
+10,36,1.3869,0.00545221,1.5,5,Med
+1,37,1.14318,0.0041136,1.2,9,High
+2,37,1.22603,0.00499331,1.2,9,High
+3,37,1.25269,0.00463674,1.2,9,High
+4,37,1.20066,0.0042596,1.2,9,High
+5,37,1.13341,0.0051065,1.2,9,High
+6,37,1.19166,0.00372417,1.2,9,High
+7,37,1.24961,0.00463906,1.2,9,High
+8,37,1.25152,0.00472451,1.2,9,High
+9,37,1.2892,0.00418817,1.2,9,High
+10,37,1.36922,0.00364349,1.2,9,High
+1,38,1.38814,0.00549547,1.3,8,High
+2,38,1.56468,0.00471879,1.3,8,High
+3,38,1.50771,0.00512858,1.3,8,High
+4,38,1.28619,0.00575359,1.3,8,High
+5,38,1.40119,0.00532724,1.3,8,High
+6,38,1.4722,0.00469315,1.3,8,High
+7,38,1.34448,0.00571422,1.3,8,High
+8,38,1.41701,0.00520304,1.3,8,High
+9,38,1.27144,0.00582007,1.3,8,High
+10,38,1.55892,0.00471485,1.3,8,High
+1,39,1.78567,0.00555864,1.9,10,High
+2,39,1.8296,0.00489526,1.9,10,High
+3,39,1.79829,0.00531933,1.9,10,High
+4,39,2.06205,0.00473824,1.9,10,High
+5,39,1.78098,0.00606555,1.9,10,High
+6,39,1.53739,0.00667803,1.9,10,High
+7,39,1.65213,0.00553441,1.9,10,High
+8,39,1.75864,0.00568592,1.9,10,High
+9,39,1.96209,0.00527759,1.9,10,High
+10,39,2.06554,0.00471909,1.9,10,High
+1,40,1.43147,0.00512688,1.1,3,Low
+2,40,1.16317,0.00422652,1.1,3,Low
+3,40,1.26982,0.00465554,1.1,3,Low
+4,40,1.31799,0.00376774,1.1,3,Low
+5,40,1.28891,0.00466145,1.1,3,Low
+6,40,1.41954,0.00481679,1.1,3,Low
+7,40,1.39434,0.00508502,1.1,3,Low
+8,40,1.6202,0.00369659,1.1,3,Low
+9,40,1.45118,0.00549865,1.1,3,Low
+10,40,1.33283,0.00532767,1.1,3,Low
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+2,41,1.97511,0.0067026,1.7,7,Med
+3,41,1.88895,0.00388258,1.7,7,Med
+4,41,1.74316,0.00431669,1.7,7,Med
+5,41,1.96928,0.00508807,1.7,7,Med
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+7,41,1.97536,0.00548479,1.7,7,Med
+8,41,1.7486,0.00508428,1.7,7,Med
+9,41,1.69623,0.00488147,1.7,7,Med
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+4,42,4.53372,0.00591594,2.8,9,High
+5,42,4.069,0.00574314,2.8,9,High
+6,42,4.3614,0.00702277,2.8,9,High
+7,42,4.08403,0.00601651,2.8,9,High
+8,42,3.76077,0.00697897,2.8,9,High
+9,42,4.54242,0.00360672,2.8,9,High
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+5,43,0.918826,0.00526328,0.9,1,Low
+6,43,0.759701,0.00490341,0.9,1,Low
+7,43,0.827351,0.00475877,0.9,1,Low
+8,43,0.827966,0.00510146,0.9,1,Low
+9,43,0.745786,0.00619156,0.9,1,Low
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+4,44,1.47569,0.00381004,1.4,7,Med
+5,44,1.54745,0.00451733,1.4,7,Med
+6,44,1.42625,0.00486492,1.4,7,Med
+7,44,1.45053,0.0049446,1.4,7,Med
+8,44,1.41957,0.0041696,1.4,7,Med
+9,44,1.4856,0.00477801,1.4,7,Med
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+3,45,0.866929,0.00502587,0.8,2,Low
+4,45,1.07633,0.00395138,0.8,2,Low
+5,45,0.940076,0.00456061,0.8,2,Low
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+7,45,0.952567,0.00509197,0.8,2,Low
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+9,45,0.878122,0.00397662,0.8,2,Low
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+4,46,0.925758,0.0041005,1.1,8,High
+5,46,1.09886,0.00573755,1.1,8,High
+6,46,1.00166,0.00457504,1.1,8,High
+7,46,1.10305,0.00400894,1.1,8,High
+8,46,1.20964,0.00446239,1.1,8,High
+9,46,0.900958,0.00338688,1.1,8,High
+10,46,1.01038,0.00523378,1.1,8,High
+1,47,2.2291,0.00485264,2.6,9,High
+2,47,2.23681,0.00530187,2.6,9,High
+3,47,2.4493,0.00517069,2.6,9,High
+4,47,1.83919,0.00569094,2.6,9,High
+5,47,2.22921,0.00543821,2.6,9,High
+6,47,2.40716,0.00402952,2.6,9,High
+7,47,2.20016,0.00747639,2.6,9,High
+8,47,2.25634,0.00479367,2.6,9,High
+9,47,2.30578,0.00392144,2.6,9,High
+10,47,2.52926,0.00534738,2.6,9,High
+1,48,0.652578,0.00358965,0.7,8,High
+2,48,0.776446,0.00313951,0.7,8,High
+3,48,0.708211,0.0038736,0.7,8,High
+4,48,0.772221,0.00333009,0.7,8,High
+5,48,0.733486,0.00332225,0.7,8,High
+6,48,0.752232,0.003248,0.7,8,High
+7,48,0.729271,0.00355129,0.7,8,High
+8,48,0.779875,0.00317208,0.7,8,High
+9,48,0.585271,0.00420359,0.7,8,High
+10,48,0.756814,0.00313104,0.7,8,High
+1,49,1.51947,0.0043539,1.3,8,High
+2,49,1.40534,0.00457144,1.3,8,High
+3,49,1.40534,0.00442604,1.3,8,High
+4,49,1.40838,0.00445897,1.3,8,High
+5,49,1.38989,0.00550058,1.3,8,High
+6,49,1.27747,0.0047967,1.3,8,High
+7,49,1.38658,0.00576701,1.3,8,High
+8,49,1.46982,0.00486816,1.3,8,High
+9,49,1.4465,0.00471709,1.3,8,High
+10,49,1.3854,0.0050337,1.3,8,High
+1,50,0.906907,0.00555871,1.1,6,Med
+2,50,0.904139,0.00525971,1.1,6,Med
+3,50,0.836497,0.00553706,1.1,6,Med
+4,50,0.877889,0.00462613,1.1,6,Med
+5,50,0.908601,0.00395689,1.1,6,Med
+6,50,0.897479,0.00330605,1.1,6,Med
+7,50,0.797256,0.00505711,1.1,6,Med
+8,50,0.836367,0.00456196,1.1,6,Med
+9,50,0.814895,0.00751092,1.1,6,Med
+10,50,0.946638,0.00503133,1.1,6,Med
+1,51,1.17218,0.00281149,0.9,9,High
+2,51,1.19554,0.00355795,0.9,9,High
+3,51,1.10774,0.00413173,0.9,9,High
+4,51,1.0905,0.00403637,0.9,9,High
+5,51,1.14484,0.00500858,0.9,9,High
+6,51,1.00927,0.00584736,0.9,9,High
+7,51,1.26555,0.00373299,0.9,9,High
+8,51,1.23127,0.00378081,0.9,9,High
+9,51,1.1632,0.0039046,0.9,9,High
+10,51,1.15455,0.00467337,0.9,9,High
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+2,52,0.668455,0.0065069,0.9,7,Med
+3,52,0.69181,0.00535058,0.9,7,Med
+4,52,0.733289,0.00573261,0.9,7,Med
+5,52,0.820015,0.00502839,0.9,7,Med
+6,52,0.848794,0.00405806,0.9,7,Med
+7,52,0.770622,0.00477202,0.9,7,Med
+8,52,0.769927,0.00590108,0.9,7,Med
+9,52,0.730501,0.00566339,0.9,7,Med
+10,52,0.74719,0.00599287,0.9,7,Med
+1,53,1.6102,0.00555916,1.7,8,High
+2,53,1.38222,0.00351541,1.7,8,High
+3,53,1.49302,0.00468331,1.7,8,High
+4,53,1.43491,0.00496942,1.7,8,High
+5,53,1.40859,0.00430079,1.7,8,High
+6,53,1.40578,0.00403837,1.7,8,High
+7,53,1.32848,0.00450369,1.7,8,High
+8,53,1.55288,0.00556963,1.7,8,High
+9,53,1.35358,0.00510279,1.7,8,High
+10,53,1.38599,0.00410671,1.7,8,High
+1,54,1.27052,0.00504491,1.8,8,High
+2,54,1.37269,0.00421083,1.8,8,High
+3,54,1.38994,0.00467388,1.8,8,High
+4,54,1.45409,0.0039114,1.8,8,High
+5,54,1.41622,0.00403542,1.8,8,High
+6,54,1.25788,0.00474756,1.8,8,High
+7,54,1.41308,0.00408813,1.8,8,High
+8,54,1.31205,0.00523731,1.8,8,High
+9,54,1.31081,0.00459868,1.8,8,High
+10,54,1.49369,0.00447223,1.8,8,High
+1,55,1.61591,0.00381981,1.1,4,Med
+2,55,1.85926,0.00501073,1.1,4,Med
+3,55,1.68373,0.00563928,1.1,4,Med
+4,55,1.75449,0.00621892,1.1,4,Med
+5,55,1.58676,0.00396616,1.1,4,Med
+6,55,1.33328,0.003925,1.1,4,Med
+7,55,1.24773,0.00574426,1.1,4,Med
+8,55,1.7854,0.00407625,1.1,4,Med
+9,55,1.74244,0.00321633,1.1,4,Med
+10,55,1.51987,0.00544468,1.1,4,Med
+1,56,0.715181,0.00487808,0.6,4,Med
+2,56,0.675356,0.0055922,0.6,4,Med
+3,56,0.707571,0.003771,0.6,4,Med
+4,56,0.687987,0.00481087,0.6,4,Med
+5,56,0.779703,0.00490148,0.6,4,Med
+6,56,0.634995,0.0073004,0.6,4,Med
+7,56,0.705203,0.00412683,0.6,4,Med
+8,56,0.704506,0.00377748,0.6,4,Med
+9,56,0.692623,0.00334558,0.6,4,Med
+10,56,0.62219,0.00513195,0.6,4,Med
+1,57,2.05355,0.00506732,2.1,6,Med
+2,57,1.79508,0.00650743,2.1,6,Med
+3,57,1.88581,0.00567852,2.1,6,Med
+4,57,2.30992,0.00461063,2.1,6,Med
+5,57,1.94856,0.00391646,2.1,6,Med
+6,57,2.01023,0.00522503,2.1,6,Med
+7,57,1.9884,0.00461867,2.1,6,Med
+8,57,1.84997,0.0040422,2.1,6,Med
+9,57,1.95828,0.00526436,2.1,6,Med
+10,57,1.89855,0.00542709,2.1,6,Med
+1,58,1.25352,0.00385262,1.4,8,High
+2,58,1.12754,0.00579711,1.4,8,High
+3,58,1.3412,0.00549364,1.4,8,High
+4,58,1.15977,0.00551374,1.4,8,High
+5,58,1.21736,0.00381103,1.4,8,High
+6,58,1.13522,0.00479525,1.4,8,High
+7,58,1.21841,0.0052969,1.4,8,High
+8,58,1.19758,0.00413793,1.4,8,High
+9,58,1.22512,0.00509666,1.4,8,High
+10,58,1.41006,0.00479535,1.4,8,High
+1,59,0.967937,0.00526406,1.1,6,Med
+2,59,0.967469,0.00462731,1.1,6,Med
+3,59,0.923978,0.00414916,1.1,6,Med
+4,59,1.02275,0.004177,1.1,6,Med
+5,59,0.919,0.00509081,1.1,6,Med
+6,59,0.809576,0.00687798,1.1,6,Med
+7,59,0.996659,0.00525425,1.1,6,Med
+8,59,0.912912,0.00316911,1.1,6,Med
+9,59,0.981204,0.00373821,1.1,6,Med
+10,59,1.01957,0.00441722,1.1,6,Med
diff --git a/inst/cov/pb/IndividualParameters/simulatedRandomEffects.txt b/inst/cov/pb/IndividualParameters/simulatedRandomEffects.txt
new file mode 100644
index 0000000..104fe9f
--- /dev/null
+++ b/inst/cov/pb/IndividualParameters/simulatedRandomEffects.txt
@@ -0,0 +1,591 @@
+rep,id,eta_V,eta_k,WEIGHT,APGAR,tAPGAR
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+3,1,0.13306,-0.165317,1.4,7,Med
+4,1,-0.0665232,0.152204,1.4,7,Med
+5,1,0.0477986,0.151019,1.4,7,Med
+6,1,-0.0548225,0.17188,1.4,7,Med
+7,1,0.120957,0.102727,1.4,7,Med
+8,1,0.109473,-0.310373,1.4,7,Med
+9,1,0.0363386,-0.0584636,1.4,7,Med
+10,1,0.126326,-0.184776,1.4,7,Med
+1,2,-0.420003,-0.00233067,1.5,9,High
+2,2,-0.314783,-0.31618,1.5,9,High
+3,2,-0.228233,0.0360876,1.5,9,High
+4,2,-0.288418,-0.0790747,1.5,9,High
+5,2,-0.166007,-0.0941427,1.5,9,High
+6,2,-0.28485,-0.256058,1.5,9,High
+7,2,-0.3299,0.0755662,1.5,9,High
+8,2,-0.346355,0.0799097,1.5,9,High
+9,2,-0.353782,0.175466,1.5,9,High
+10,2,-0.239911,-0.132714,1.5,9,High
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+2,3,0.280158,0.205713,1.5,6,Med
+3,3,0.260436,0.271935,1.5,6,Med
+4,3,0.245928,0.0125208,1.5,6,Med
+5,3,0.28829,0.117738,1.5,6,Med
+6,3,0.293849,-0.104542,1.5,6,Med
+7,3,0.245716,0.164668,1.5,6,Med
+8,3,0.36281,-0.249675,1.5,6,Med
+9,3,0.420691,-0.00114267,1.5,6,Med
+10,3,0.355585,0.15666,1.5,6,Med
+1,4,-0.375112,-0.185415,0.9,6,Med
+2,4,-0.274639,-0.0409435,0.9,6,Med
+3,4,-0.371784,0.0924806,0.9,6,Med
+4,4,-0.307875,-0.222574,0.9,6,Med
+5,4,-0.225671,-0.160591,0.9,6,Med
+6,4,-0.336752,-0.0187392,0.9,6,Med
+7,4,-0.430611,0.105206,0.9,6,Med
+8,4,-0.224041,-0.222783,0.9,6,Med
+9,4,-0.251329,-0.141544,0.9,6,Med
+10,4,-0.33401,-0.0177418,0.9,6,Med
+1,5,0.432329,-0.0620527,1.4,7,Med
+2,5,0.49458,0.0649106,1.4,7,Med
+3,5,0.408144,0.145394,1.4,7,Med
+4,5,0.489069,-0.235184,1.4,7,Med
+5,5,0.396836,0.168221,1.4,7,Med
+6,5,0.348447,-0.212635,1.4,7,Med
+7,5,0.546616,-0.0596346,1.4,7,Med
+8,5,0.551579,-0.191486,1.4,7,Med
+9,5,0.452304,0.0929819,1.4,7,Med
+10,5,0.378785,0.0127938,1.4,7,Med
+1,6,0.0561728,-0.0449333,1.2,5,Med
+2,6,-0.0338482,-0.0343087,1.2,5,Med
+3,6,0.0931994,0.0217581,1.2,5,Med
+4,6,-0.0411006,-0.0734107,1.2,5,Med
+5,6,-0.0744743,0.19763,1.2,5,Med
+6,6,0.0790117,-0.0583769,1.2,5,Med
+7,6,0.0431112,-0.235839,1.2,5,Med
+8,6,0.0890454,-0.191663,1.2,5,Med
+9,6,0.00400263,-0.170421,1.2,5,Med
+10,6,0.0104498,-0.107901,1.2,5,Med
+1,7,-0.205727,0.00102476,1,5,Med
+2,7,-0.233372,0.227802,1,5,Med
+3,7,-0.124646,-0.313234,1,5,Med
+4,7,-0.211965,0.0780978,1,5,Med
+5,7,-0.187949,-0.296366,1,5,Med
+6,7,-0.232636,-0.0379026,1,5,Med
+7,7,-0.264605,0.0356232,1,5,Med
+8,7,-0.0574172,-0.011873,1,5,Med
+9,7,-0.334816,0.217924,1,5,Med
+10,7,-0.152252,-0.0791777,1,5,Med
+1,8,-0.16738,-0.125536,1.2,7,Med
+2,8,-0.358322,0.0594053,1.2,7,Med
+3,8,-0.112586,0.0536319,1.2,7,Med
+4,8,-0.318333,-0.0117559,1.2,7,Med
+5,8,-0.219042,0.0770301,1.2,7,Med
+6,8,-0.193429,0.276374,1.2,7,Med
+7,8,-0.221695,0.0287467,1.2,7,Med
+8,8,-0.206092,0.20294,1.2,7,Med
+9,8,-0.341279,-0.0300064,1.2,7,Med
+10,8,-0.282876,0.0234897,1.2,7,Med
+1,9,-0.233969,-0.388333,1.4,8,High
+2,9,-0.38019,-0.202167,1.4,8,High
+3,9,-0.305853,-0.278794,1.4,8,High
+4,9,-0.373472,-0.22438,1.4,8,High
+5,9,-0.349671,-0.00120167,1.4,8,High
+6,9,-0.190281,-0.286411,1.4,8,High
+7,9,-0.30944,-0.122798,1.4,8,High
+8,9,-0.408122,-0.121116,1.4,8,High
+9,9,-0.313225,-0.0642932,1.4,8,High
+10,9,-0.249737,-0.101351,1.4,8,High
+1,10,0.242574,-0.0955781,1.4,7,Med
+2,10,-0.013296,0.140927,1.4,7,Med
+3,10,0.115893,0.0812429,1.4,7,Med
+4,10,0.0683736,-0.0526258,1.4,7,Med
+5,10,0.252445,-0.337667,1.4,7,Med
+6,10,0.10235,0.0130089,1.4,7,Med
+7,10,0.0508578,-0.0962783,1.4,7,Med
+8,10,0.0205474,0.174012,1.4,7,Med
+9,10,0.0125566,0.231692,1.4,7,Med
+10,10,0.0350346,0.120147,1.4,7,Med
+1,11,0.345199,0.310982,1.2,7,Med
+2,11,0.374918,0.154528,1.2,7,Med
+3,11,0.494441,-0.0158478,1.2,7,Med
+4,11,0.295275,0.161315,1.2,7,Med
+5,11,0.378333,0.147443,1.2,7,Med
+6,11,0.22385,0.0488083,1.2,7,Med
+7,11,0.590284,-0.244735,1.2,7,Med
+8,11,0.360683,0.108588,1.2,7,Med
+9,11,0.360514,-0.0487953,1.2,7,Med
+10,11,0.464596,0.0612787,1.2,7,Med
+1,12,0.15054,-0.0504024,1.3,6,Med
+2,12,0.0482282,-0.0219937,1.3,6,Med
+3,12,0.0909732,-0.150462,1.3,6,Med
+4,12,0.160665,-0.213312,1.3,6,Med
+5,12,0.0452967,0.00445005,1.3,6,Med
+6,12,0.198322,-0.199806,1.3,6,Med
+7,12,0.0869238,-0.102235,1.3,6,Med
+8,12,0.082858,-0.1398,1.3,6,Med
+9,12,0.167473,-0.248496,1.3,6,Med
+10,12,0.280749,-0.297751,1.3,6,Med
+1,13,-0.536613,0.0632638,1.1,6,Med
+2,13,-0.211295,-0.42193,1.1,6,Med
+3,13,-0.520703,0.41796,1.1,6,Med
+4,13,-0.181551,-0.0371213,1.1,6,Med
+5,13,-0.247103,-0.159937,1.1,6,Med
+6,13,-0.45092,-0.39346,1.1,6,Med
+7,13,-0.345373,0.0521182,1.1,6,Med
+8,13,-0.188677,-0.355886,1.1,6,Med
+9,13,-0.343742,-0.00974109,1.1,6,Med
+10,13,-0.257957,-0.0550259,1.1,6,Med
+1,14,-0.225051,-0.00655845,1.1,7,Med
+2,14,-0.150132,0.0530867,1.1,7,Med
+3,14,-0.234508,0.0887285,1.1,7,Med
+4,14,-0.311484,0.243416,1.1,7,Med
+5,14,-0.224078,0.156192,1.1,7,Med
+6,14,-0.248032,0.134093,1.1,7,Med
+7,14,-0.212355,0.203629,1.1,7,Med
+8,14,-0.227951,0.122367,1.1,7,Med
+9,14,-0.330028,0.192003,1.1,7,Med
+10,14,-0.207394,0.201308,1.1,7,Med
+1,15,0.174379,0.15134,1.3,7,Med
+2,15,0.158396,-0.0519172,1.3,7,Med
+3,15,0.174922,-0.0286978,1.3,7,Med
+4,15,0.0971523,0.0799534,1.3,7,Med
+5,15,-0.0280702,0.0155825,1.3,7,Med
+6,15,-0.0329891,-0.242151,1.3,7,Med
+7,15,0.0267096,-0.0443796,1.3,7,Med
+8,15,0.13499,-0.110508,1.3,7,Med
+9,15,0.0709717,0.0102317,1.3,7,Med
+10,15,0.105725,-0.0340834,1.3,7,Med
+1,16,-0.182924,-0.357858,1.2,9,High
+2,16,-0.303021,-0.140337,1.2,9,High
+3,16,-0.34593,-0.103627,1.2,9,High
+4,16,-0.314313,-0.112588,1.2,9,High
+5,16,-0.445862,-0.107928,1.2,9,High
+6,16,-0.325543,-0.158186,1.2,9,High
+7,16,-0.334921,0.0150294,1.2,9,High
+8,16,-0.30954,-0.0873931,1.2,9,High
+9,16,-0.49314,-0.163238,1.2,9,High
+10,16,-0.264179,-0.0853897,1.2,9,High
+1,17,-0.124874,-0.214049,1.1,5,Med
+2,17,-0.165698,0.175371,1.1,5,Med
+3,17,-0.184204,-0.0191314,1.1,5,Med
+4,17,-0.162498,-0.119569,1.1,5,Med
+5,17,-0.187093,-0.115366,1.1,5,Med
+6,17,-0.187628,-0.20561,1.1,5,Med
+7,17,-0.103948,-0.0609522,1.1,5,Med
+8,17,-0.217892,0.0269098,1.1,5,Med
+9,17,-0.123435,-0.0359578,1.1,5,Med
+10,17,-0.19334,0.304286,1.1,5,Med
+1,18,-0.0671357,0.209929,1,5,Med
+2,18,-0.138804,0.338503,1,5,Med
+3,18,-0.0619748,0.195744,1,5,Med
+4,18,-0.283481,0.345136,1,5,Med
+5,18,-0.298399,0.368737,1,5,Med
+6,18,-0.145443,0.313748,1,5,Med
+7,18,-0.270411,0.313748,1,5,Med
+8,18,-0.0390392,0.207783,1,5,Med
+9,18,0.00425834,0.207783,1,5,Med
+10,18,-0.138649,0.294265,1,5,Med
+1,19,-0.306262,0.132775,1,1,Low
+2,19,-0.197115,-0.202544,1,1,Low
+3,19,-0.257284,0.135669,1,1,Low
+4,19,-0.319107,0.0803704,1,1,Low
+5,19,-0.225589,-0.0127074,1,1,Low
+6,19,-0.201959,-0.14211,1,1,Low
+7,19,-0.38256,0.160832,1,1,Low
+8,19,-0.278283,0.194791,1,1,Low
+9,19,-0.222025,-0.19971,1,1,Low
+10,19,-0.371441,0.0560436,1,1,Low
+1,20,-0.0729579,-0.213197,1.2,6,Med
+2,20,-0.273874,0.146916,1.2,6,Med
+3,20,-0.118793,-0.01562,1.2,6,Med
+4,20,-0.128044,-0.0849945,1.2,6,Med
+5,20,-0.0949584,-0.30955,1.2,6,Med
+6,20,-0.122725,0.275199,1.2,6,Med
+7,20,-0.182564,-0.0155095,1.2,6,Med
+8,20,-0.0912702,-0.0439153,1.2,6,Med
+9,20,-0.205798,0.192509,1.2,6,Med
+10,20,-0.223024,0.261317,1.2,6,Med
+1,21,0.338437,-0.20186,1.8,7,Med
+2,21,0.249791,-0.00300078,1.8,7,Med
+3,21,0.350137,-0.178163,1.8,7,Med
+4,21,0.30679,-0.00598944,1.8,7,Med
+5,21,0.162389,-0.00256262,1.8,7,Med
+6,21,0.395908,-0.11406,1.8,7,Med
+7,21,0.0615355,0.242578,1.8,7,Med
+8,21,0.251462,-0.138957,1.8,7,Med
+9,21,0.231841,0.128821,1.8,7,Med
+10,21,0.3604,-0.225421,1.8,7,Med
+1,22,-0.111104,-0.165696,1.5,8,High
+2,22,-0.0529749,0.188044,1.5,8,High
+3,22,-0.141864,0.109802,1.5,8,High
+4,22,-0.208643,-0.093946,1.5,8,High
+5,22,-0.20409,-0.295265,1.5,8,High
+6,22,-0.232227,-0.109512,1.5,8,High
+7,22,-0.148289,0.248904,1.5,8,High
+8,22,-0.20554,0.247875,1.5,8,High
+9,22,-0.277627,0.42555,1.5,8,High
+10,22,-0.229646,0.0653531,1.5,8,High
+1,23,0.646194,0.0734,3.1,3,Low
+2,23,0.520262,0.116027,3.1,3,Low
+3,23,0.69223,0.114491,3.1,3,Low
+4,23,0.743547,0.0394899,3.1,3,Low
+5,23,0.725304,0.080903,3.1,3,Low
+6,23,0.627177,0.2835,3.1,3,Low
+7,23,0.523253,0.535588,3.1,3,Low
+8,23,0.635436,0.27169,3.1,3,Low
+9,23,0.642226,0.193266,3.1,3,Low
+10,23,0.590999,0.35117,3.1,3,Low
+1,24,0.988865,0.217844,3.2,2,Low
+2,24,0.899553,0.2558,3.2,2,Low
+3,24,0.776255,0.110394,3.2,2,Low
+4,24,0.874696,0.109217,3.2,2,Low
+5,24,0.806759,0.245259,3.2,2,Low
+6,24,0.844679,0.213449,3.2,2,Low
+7,24,0.938416,0.0846153,3.2,2,Low
+8,24,0.847145,0.0134047,3.2,2,Low
+9,24,0.81684,0.371901,3.2,2,Low
+10,24,0.874915,0.276215,3.2,2,Low
+1,25,-0.269727,0.0435623,0.7,1,Low
+2,25,-0.342293,-0.152914,0.7,1,Low
+3,25,-0.27117,-0.0842544,0.7,1,Low
+4,25,-0.280975,-0.180147,0.7,1,Low
+5,25,-0.286329,-0.445532,0.7,1,Low
+6,25,-0.287591,-0.28335,0.7,1,Low
+7,25,-0.38988,-0.005251,0.7,1,Low
+8,25,-0.347684,0.0437332,0.7,1,Low
+9,25,-0.30801,-0.0777448,0.7,1,Low
+10,25,-0.244271,-0.409541,0.7,1,Low
+1,26,0.638887,0.180212,3.5,9,High
+2,26,0.525907,0.100204,3.5,9,High
+3,26,0.54911,0.134118,3.5,9,High
+4,26,0.57624,-0.0521155,3.5,9,High
+5,26,0.611387,-0.122081,3.5,9,High
+6,26,0.629608,-0.202427,3.5,9,High
+7,26,0.446852,0.112524,3.5,9,High
+8,26,0.439704,0.209981,3.5,9,High
+9,26,0.528545,-0.0180094,3.5,9,High
+10,26,0.631009,-0.311161,3.5,9,High
+1,27,0.162167,-0.0958016,1.9,5,Med
+2,27,0.0787025,0.0932204,1.9,5,Med
+3,27,0.117069,-0.160053,1.9,5,Med
+4,27,0.0113247,0.186754,1.9,5,Med
+5,27,0.0861515,0.102767,1.9,5,Med
+6,27,0.317257,-0.13819,1.9,5,Med
+7,27,0.130633,-0.0255092,1.9,5,Med
+8,27,0.18179,-0.141951,1.9,5,Med
+9,27,-0.0274382,0.447484,1.9,5,Med
+10,27,0.113917,-0.0379473,1.9,5,Med
+1,28,0.554701,0.146686,3.2,9,High
+2,28,0.766801,0.0161286,3.2,9,High
+3,28,0.84969,0.0806813,3.2,9,High
+4,28,0.866046,-0.239468,3.2,9,High
+5,28,0.770994,-0.109539,3.2,9,High
+6,28,0.541837,0.314696,3.2,9,High
+7,28,0.770604,0.121854,3.2,9,High
+8,28,0.756563,0.266844,3.2,9,High
+9,28,0.693347,0.0820208,3.2,9,High
+10,28,0.754269,0.254766,3.2,9,High
+1,29,-0.171556,-0.3547,1,7,Med
+2,29,-0.238237,0.0384585,1,7,Med
+3,29,-0.262777,-0.13818,1,7,Med
+4,29,-0.285121,-0.0568859,1,7,Med
+5,29,-0.393828,0.12451,1,7,Med
+6,29,-0.1922,0.0923129,1,7,Med
+7,29,-0.229367,0.265313,1,7,Med
+8,29,-0.169217,-0.0881114,1,7,Med
+9,29,-0.259616,-0.0787152,1,7,Med
+10,29,-0.128672,-0.0143082,1,7,Med
+1,30,0.186368,0.0476256,1.8,8,High
+2,30,-0.0474289,0.0346489,1.8,8,High
+3,30,-0.0266669,0.067091,1.8,8,High
+4,30,0.177012,-0.0110925,1.8,8,High
+5,30,0.227342,0.0818901,1.8,8,High
+6,30,0.0377611,0.0267769,1.8,8,High
+7,30,0.13594,0.137668,1.8,8,High
+8,30,0.172173,0.0408713,1.8,8,High
+9,30,-0.00471074,0.2862,1.8,8,High
+10,30,0.276484,0.0177835,1.8,8,High
+1,31,-0.188504,0.210759,1.4,8,High
+2,31,-0.153012,-0.207736,1.4,8,High
+3,31,-0.308945,0.320745,1.4,8,High
+4,31,-0.365309,0.00111153,1.4,8,High
+5,31,-0.461038,0.137214,1.4,8,High
+6,31,-0.202491,0.115491,1.4,8,High
+7,31,-0.457705,-0.118412,1.4,8,High
+8,31,-0.239965,0.0938028,1.4,8,High
+9,31,-0.259354,-0.109843,1.4,8,High
+10,31,-0.221919,0.158589,1.4,8,High
+1,32,1.03644,-0.199172,3.6,9,High
+2,32,1.11368,-0.0852332,3.6,9,High
+3,32,1.10694,-0.1593,3.6,9,High
+4,32,0.981893,0.0413554,3.6,9,High
+5,32,1.23685,-0.0279424,3.6,9,High
+6,32,1.07579,0.13108,3.6,9,High
+7,32,1.08687,0.0353055,3.6,9,High
+8,32,1.07583,0.307968,3.6,9,High
+9,32,1.12258,0.167112,3.6,9,High
+10,32,1.16987,-0.19036,3.6,9,High
+1,33,0.11177,-0.171585,1.7,8,High
+2,33,-0.06202,-0.152259,1.7,8,High
+3,33,-0.103558,0.0669338,1.7,8,High
+4,33,-0.069311,0.0977812,1.7,8,High
+5,33,-0.0596333,-0.0675712,1.7,8,High
+6,33,-0.130345,0.188343,1.7,8,High
+7,33,-0.196144,0.486829,1.7,8,High
+8,33,0.0270275,-0.137923,1.7,8,High
+9,33,-0.223766,0.112591,1.7,8,High
+10,33,0.0521415,-0.337229,1.7,8,High
+1,34,0.118553,-0.0872703,1.7,4,Med
+2,34,0.25558,0.259812,1.7,4,Med
+3,34,0.0874655,0.208507,1.7,4,Med
+4,34,0.145169,-0.144438,1.7,4,Med
+5,34,0.344882,-0.0885131,1.7,4,Med
+6,34,0.187013,-0.00514047,1.7,4,Med
+7,34,0.2862,-0.201267,1.7,4,Med
+8,34,0.314537,-0.0643681,1.7,4,Med
+9,34,0.291119,-0.309616,1.7,4,Med
+10,34,0.022284,-0.294229,1.7,4,Med
+1,35,0.326716,0.0105906,2.5,5,Med
+2,35,0.331971,0.143153,2.5,5,Med
+3,35,0.556821,-0.132173,2.5,5,Med
+4,35,0.341089,0.131859,2.5,5,Med
+5,35,0.405182,-0.0446749,2.5,5,Med
+6,35,0.487417,-0.139467,2.5,5,Med
+7,35,0.38274,-0.0778519,2.5,5,Med
+8,35,0.458862,0.184353,2.5,5,Med
+9,35,0.367289,-0.241679,2.5,5,Med
+10,35,0.415849,-0.178476,2.5,5,Med
+1,36,0.0485103,0.209285,1.5,5,Med
+2,36,0.266749,-0.111764,1.5,5,Med
+3,36,0.151488,0.150355,1.5,5,Med
+4,36,0.131564,0.0792959,1.5,5,Med
+5,36,0.145316,0.112716,1.5,5,Med
+6,36,0.176989,0.0732933,1.5,5,Med
+7,36,0.0222737,0.189017,1.5,5,Med
+8,36,0.0699114,0.160276,1.5,5,Med
+9,36,0.142206,0.17796,1.5,5,Med
+10,36,0.10641,0.127713,1.5,5,Med
+1,37,-0.347424,-0.154009,1.2,9,High
+2,37,-0.277452,0.0397908,1.2,9,High
+3,37,-0.255946,-0.0342977,1.2,9,High
+4,37,-0.298365,-0.119134,1.2,9,High
+5,37,-0.356002,0.0622056,1.2,9,High
+6,37,-0.305886,-0.253465,1.2,9,High
+7,37,-0.258402,-0.0337963,1.2,9,High
+8,37,-0.256877,-0.0155448,1.2,9,High
+9,37,-0.227217,-0.136044,1.2,9,High
+10,37,-0.166992,-0.275366,1.2,9,High
+1,38,-0.153268,0.135616,1.3,8,High
+2,38,-0.0335557,-0.0167563,1.3,8,High
+3,38,-0.0706443,0.0665206,1.3,8,High
+4,38,-0.229553,0.181516,1.3,8,High
+5,38,-0.143915,0.104524,1.3,8,High
+6,38,-0.0944818,-0.0222043,1.3,8,High
+7,38,-0.185232,0.17465,1.3,8,High
+8,38,-0.132686,0.0809348,1.3,8,High
+9,38,-0.241087,0.193004,1.3,8,High
+10,38,-0.0372413,-0.0175929,1.3,8,High
+1,39,0.0985548,0.147044,1.9,10,High
+2,39,0.122859,0.019958,1.9,10,High
+3,39,0.105598,0.103038,1.9,10,High
+4,39,0.242464,-0.0126429,1.9,10,High
+5,39,0.0959258,0.234317,1.9,10,High
+6,39,-0.0511532,0.330514,1.9,10,High
+7,39,0.0208295,0.142676,1.9,10,High
+8,39,0.0833025,0.169684,1.9,10,High
+9,39,0.192775,0.095161,1.9,10,High
+10,39,0.244153,-0.0166941,1.9,10,High
+1,40,0.0100915,0.0661888,1.1,3,Low
+2,40,-0.197459,-0.12693,1.1,3,Low
+3,40,-0.109732,-0.0302519,1.1,3,Low
+4,40,-0.0724988,-0.241833,1.1,3,Low
+5,40,-0.0948123,-0.0289822,1.1,3,Low
+6,40,0.00172769,0.00379876,1.1,3,Low
+7,40,-0.0161887,0.0579898,1.1,3,Low
+8,40,0.133941,-0.260897,1.1,3,Low
+9,40,0.0237676,0.136193,1.1,3,Low
+10,40,-0.0613061,0.104604,1.1,3,Low
+1,41,0.4327,-0.346002,1.7,7,Med
+2,41,0.459965,0.334187,1.7,7,Med
+3,41,0.415365,-0.211809,1.7,7,Med
+4,41,0.335039,-0.10582,1.7,7,Med
+5,41,0.457009,0.0585887,1.7,7,Med
+6,41,0.483406,-0.00170986,1.7,7,Med
+7,41,0.460094,0.13367,1.7,7,Med
+8,41,0.338155,0.0578441,1.7,7,Med
+9,41,0.307748,0.017137,1.7,7,Med
+10,41,0.361876,0.186872,1.7,7,Med
+1,42,0.862519,0.351587,2.8,9,High
+2,42,0.940057,0.0308325,2.8,9,High
+3,42,0.902911,-0.0874328,2.8,9,High
+4,42,1.03031,0.209342,2.8,9,High
+5,42,0.92216,0.179696,2.8,9,High
+6,42,0.991557,0.380849,2.8,9,High
+7,42,0.925849,0.226198,2.8,9,High
+8,42,0.843388,0.374592,2.8,9,High
+9,42,1.03222,-0.285509,2.8,9,High
+10,42,0.977696,-0.00277977,2.8,9,High
+1,43,-0.599578,-0.325117,0.9,1,Low
+2,43,-0.593314,0.0835907,0.9,1,Low
+3,43,-0.584739,-0.0408503,0.9,1,Low
+4,43,-0.514688,0.0781357,0.9,1,Low
+5,43,-0.433266,0.0924454,0.9,1,Low
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+9,43,-0.641923,0.254877,0.9,1,Low
+10,43,-0.535111,0.203305,0.9,1,Low
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+5,44,0.21595,-0.0603871,1.4,7,Med
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+9,44,0.175159,-0.00428484,1.4,7,Med
+10,44,0.201413,-0.0393062,1.4,7,Med
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+2,45,-0.551153,0.00768193,0.8,2,Low
+3,45,-0.491405,0.0462889,0.8,2,Low
+4,45,-0.275053,-0.194245,0.8,2,Low
+5,45,-0.410402,-0.0508534,0.8,2,Low
+6,45,-0.476764,0.105213,0.8,2,Low
+7,45,-0.397202,0.0593555,0.8,2,Low
+8,45,-0.457577,0.143538,0.8,2,Low
+9,45,-0.478577,-0.187876,0.8,2,Low
+10,45,-0.38926,-0.101014,0.8,2,Low
+1,46,-0.326952,-0.0422892,1.1,8,High
+2,46,-0.337224,-0.301942,1.1,8,High
+3,46,-0.288482,-0.203644,1.1,8,High
+4,46,-0.558379,-0.157201,1.1,8,High
+5,46,-0.386959,0.178723,1.1,8,High
+6,46,-0.479574,-0.0476935,1.1,8,High
+7,46,-0.383154,-0.179782,1.1,8,High
+8,46,-0.290916,-0.0726251,1.1,8,High
+9,46,-0.585533,-0.348399,1.1,8,High
+10,46,-0.470909,0.086825,1.1,8,High
+1,47,0.32036,0.0112134,2.6,9,High
+2,47,0.323813,0.0997514,2.6,9,High
+3,47,0.414566,0.0746967,2.6,9,High
+4,47,0.128089,0.170566,2.6,9,High
+5,47,0.32041,0.125141,2.6,9,High
+6,47,0.397211,-0.174662,2.6,9,High
+7,47,0.307294,0.443441,2.6,9,High
+8,47,0.332506,-0.00101175,2.6,9,High
+9,47,0.354183,-0.20185,2.6,9,High
+10,47,0.44669,0.108297,2.6,9,High
+1,48,-0.908062,-0.290253,0.7,8,High
+2,48,-0.734264,-0.424242,0.7,8,High
+3,48,-0.82625,-0.214124,0.7,8,High
+4,48,-0.739721,-0.365309,0.7,8,High
+5,48,-0.791183,-0.367667,0.7,8,High
+6,48,-0.765947,-0.39027,0.7,8,High
+7,48,-0.796947,-0.300998,0.7,8,High
+8,48,-0.729858,-0.413923,0.7,8,High
+9,48,-1.01692,-0.13237,0.7,8,High
+10,48,-0.759875,-0.426942,0.7,8,High
+1,49,-0.0628758,-0.097237,1.3,8,High
+2,49,-0.140957,-0.0484816,1.3,8,High
+3,49,-0.140957,-0.080803,1.3,8,High
+4,49,-0.138799,-0.0733917,1.3,8,High
+5,49,-0.152013,0.136544,1.3,8,High
+6,49,-0.236356,-0.000381245,1.3,8,High
+7,49,-0.154397,0.183845,1.3,8,High
+8,49,-0.0960965,0.0144076,1.3,8,High
+9,49,-0.112092,-0.017116,1.3,8,High
+10,49,-0.155251,0.0478461,1.3,8,High
+1,50,-0.318374,0.147058,1.1,6,Med
+2,50,-0.32143,0.0917665,1.1,6,Med
+3,50,-0.39919,0.143155,1.1,6,Med
+4,50,-0.350893,-0.0365875,1.1,6,Med
+5,50,-0.316507,-0.192851,1.1,6,Med
+6,50,-0.328823,-0.372554,1.1,6,Med
+7,50,-0.447237,0.0524855,1.1,6,Med
+8,50,-0.399346,-0.0505557,1.1,6,Med
+9,50,-0.425355,0.448049,1.1,6,Med
+10,50,-0.275497,0.0473747,1.1,6,Med
+1,51,-0.322373,-0.534593,0.9,9,High
+2,51,-0.302639,-0.299123,0.9,9,High
+3,51,-0.378918,-0.149613,0.9,9,High
+4,51,-0.394596,-0.172964,0.9,9,High
+5,51,-0.345971,0.0428436,0.9,9,High
+6,51,-0.47201,0.197681,0.9,9,High
+7,51,-0.245731,-0.251099,0.9,9,High
+8,51,-0.273188,-0.238371,0.9,9,High
+9,51,-0.33006,-0.206154,0.9,9,High
+10,51,-0.337522,-0.0264285,0.9,9,High
+1,52,-0.458583,-0.0502383,0.9,7,Med
+2,52,-0.623445,0.304555,0.9,7,Med
+3,52,-0.589102,0.108896,0.9,7,Med
+4,52,-0.530874,0.177862,0.9,7,Med
+5,52,-0.419091,0.0467908,0.9,7,Med
+6,52,-0.384597,-0.167604,0.9,7,Med
+7,52,-0.481216,-0.00553882,0.9,7,Med
+8,52,-0.482118,0.206826,0.9,7,Med
+9,52,-0.534683,0.165714,0.9,7,Med
+10,52,-0.512094,0.222262,0.9,7,Med
+1,53,-0.00487589,0.147138,1.7,8,High
+2,53,-0.157542,-0.311154,1.7,8,High
+3,53,-0.0804343,-0.0243048,1.7,8,High
+4,53,-0.120131,0.034994,1.7,8,High
+5,53,-0.138644,-0.109511,1.7,8,High
+6,53,-0.140645,-0.172468,1.7,8,High
+7,53,-0.197199,-0.063412,1.7,8,High
+8,53,-0.0411252,0.14902,1.7,8,High
+9,53,-0.178482,0.0614777,1.7,8,High
+10,53,-0.154824,-0.155687,1.7,8,High
+1,54,-0.241807,0.0500709,1.8,8,High
+2,54,-0.164468,-0.130648,1.8,8,High
+3,54,-0.151976,-0.0263203,1.8,8,High
+4,54,-0.106857,-0.204413,1.8,8,High
+5,54,-0.133245,-0.173199,1.8,8,High
+6,54,-0.251808,-0.010678,1.8,8,High
+7,54,-0.135463,-0.160222,1.8,8,High
+8,54,-0.209643,0.0874988,1.8,8,High
+9,54,-0.210595,-0.0425401,1.8,8,High
+10,54,-0.0799842,-0.0704222,1.8,8,High
+1,55,0.259238,-0.228109,1.1,4,Med
+2,55,0.399518,0.0432731,1.1,4,Med
+3,55,0.300351,0.161447,1.1,4,Med
+4,55,0.341523,0.259288,1.1,4,Med
+5,55,0.241033,-0.19051,1.1,4,Med
+6,55,0.0669837,-0.200942,1.1,4,Med
+7,55,0.000664061,0.179892,1.1,4,Med
+8,55,0.358985,-0.163131,1.1,4,Med
+9,55,0.334625,-0.400069,1.1,4,Med
+10,55,0.197964,0.12633,1.1,4,Med
+1,56,-0.555877,0.016443,0.6,4,Med
+2,56,-0.613174,0.153063,0.6,4,Med
+3,56,-0.566576,-0.24097,0.6,4,Med
+4,56,-0.594643,0.00256941,0.6,4,Med
+5,56,-0.4695,0.0212283,0.6,4,Med
+6,56,-0.674796,0.41962,0.6,4,Med
+7,56,-0.569928,-0.150798,0.6,4,Med
+8,56,-0.570916,-0.239251,0.6,4,Med
+9,56,-0.587928,-0.36067,0.6,4,Med
+10,56,-0.695169,0.0671762,0.6,4,Med
+1,57,0.49891,0.0545027,2.1,6,Med
+2,57,0.364392,0.304635,2.1,6,Med
+3,57,0.413698,0.168382,2.1,6,Med
+4,57,0.616553,-0.0399455,2.1,6,Med
+5,57,0.446434,-0.203121,2.1,6,Med
+6,57,0.477589,0.0851517,2.1,6,Med
+7,57,0.466672,-0.038202,2.1,6,Med
+8,57,0.394513,-0.17152,2.1,6,Med
+9,57,0.451409,0.0926502,2.1,6,Med
+10,57,0.420431,0.123094,2.1,6,Med
+1,58,-0.255283,-0.219556,1.4,8,High
+2,58,-0.361199,0.18905,1.4,8,High
+3,58,-0.18767,0.135283,1.4,8,High
+4,58,-0.333013,0.138935,1.4,8,High
+5,58,-0.284549,-0.230409,1.4,8,High
+6,58,-0.354414,-0.00068261,1.4,8,High
+7,58,-0.28369,0.0988129,1.4,8,High
+8,58,-0.300933,-0.148113,1.4,8,High
+9,58,-0.278195,0.0602767,1.4,8,High
+10,58,-0.137601,-0.000663216,1.4,8,High
+1,59,-0.253246,0.0925931,1.1,6,Med
+2,59,-0.25373,-0.0363344,1.1,6,Med
+3,59,-0.299725,-0.145403,1.1,6,Med
+4,59,-0.198161,-0.138717,1.1,6,Med
+5,59,-0.305127,0.0591285,1.1,6,Med
+6,59,-0.431902,0.360016,1.1,6,Med
+7,59,-0.224005,0.0907291,1.1,6,Med
+8,59,-0.311774,-0.414857,1.1,6,Med
+9,59,-0.239633,-0.249703,1.1,6,Med
+10,59,-0.20128,-0.0827986,1.1,6,Med
diff --git a/inst/cov/pb/LogLikelihood/individualLL.txt b/inst/cov/pb/LogLikelihood/individualLL.txt
new file mode 100644
index 0000000..de785e9
--- /dev/null
+++ b/inst/cov/pb/LogLikelihood/individualLL.txt
@@ -0,0 +1,60 @@
+id,importanceSampling
+1,11.475185
+2,18.971397
+3,16.520245
+4,16.429188
+5,14.665217
+6,21.091019
+7,15.315011
+8,18.047036
+9,22.262168
+10,15.756994
+11,7.390797
+12,17.166874
+13,12.610348
+14,25.476819
+15,11.082461
+16,18.473734
+17,17.616722
+18,28.782907
+19,17.030148
+20,16.529172
+21,16.304953
+22,10.977681
+23,20.424011
+24,24.342631
+25,40.653020
+26,14.249376
+27,12.195059
+28,9.161014
+29,6.675102
+30,10.443557
+31,7.150686
+32,22.052543
+33,11.233980
+34,11.407326
+35,14.376590
+36,18.266538
+37,11.993682
+38,22.433107
+39,17.454243
+40,9.855745
+41,16.646260
+42,16.674542
+43,8.225448
+44,14.895918
+45,15.375531
+46,7.028963
+47,7.261535
+48,44.843945
+49,17.537611
+50,25.021518
+51,22.063701
+52,23.993910
+53,13.732008
+54,21.691504
+55,6.477952
+56,8.382310
+57,12.412103
+58,17.242933
+59,17.575928
diff --git a/inst/cov/pb/LogLikelihood/logLikelihood.txt b/inst/cov/pb/LogLikelihood/logLikelihood.txt
new file mode 100644
index 0000000..236ee12
--- /dev/null
+++ b/inst/cov/pb/LogLikelihood/logLikelihood.txt
@@ -0,0 +1,6 @@
+criteria,importanceSampling
+OFV,971.427906
+AIC,985.427906
+BIC,999.970668
+BICc,1002.868331
+standardError,0.069867
diff --git a/inst/cov/pb/Tests/correlationIndividualParametersCovariates.txt b/inst/cov/pb/Tests/correlationIndividualParametersCovariates.txt
new file mode 100644
index 0000000..38b7efe
--- /dev/null
+++ b/inst/cov/pb/Tests/correlationIndividualParametersCovariates.txt
@@ -0,0 +1,3 @@
+parameter,covariate,statistics,p-value,test
+V,beta_V_tAPGAR_High,2.14297,0.0364754,t-Test
+V,beta_V_tAPGAR_Low,0.621568,0.536748,t-Test
diff --git a/inst/cov/pb/Tests/correlationRandomEffects.txt b/inst/cov/pb/Tests/correlationRandomEffects.txt
new file mode 100644
index 0000000..29cdacb
--- /dev/null
+++ b/inst/cov/pb/Tests/correlationRandomEffects.txt
@@ -0,0 +1,2 @@
+eta1,eta2,coeff,statistics,p-value
+eta_V,eta_k,0,1.90179,0.0621694
diff --git a/inst/cov/pb/Tests/correlationRandomEffectsCovariates.txt b/inst/cov/pb/Tests/correlationRandomEffectsCovariates.txt
new file mode 100644
index 0000000..958d661
--- /dev/null
+++ b/inst/cov/pb/Tests/correlationRandomEffectsCovariates.txt
@@ -0,0 +1,7 @@
+eta,covariate,statistics,p-value,test
+eta_V,APGAR,1.65527,0.125934,Anova
+eta_V,tAPGAR,0.0184744,0.981701,Anova
+eta_V,WEIGHT,12.0595,<2.2e-16,Pearson
+eta_k,APGAR,0.992395,0.458555,Anova
+eta_k,tAPGAR,0.912807,0.407284,Anova
+eta_k,WEIGHT,3.18816,0.00232602,Pearson
diff --git a/inst/cov/pb/Tests/fixedEffects.txt b/inst/cov/pb/Tests/fixedEffects.txt
new file mode 100644
index 0000000..81927d9
--- /dev/null
+++ b/inst/cov/pb/Tests/fixedEffects.txt
@@ -0,0 +1,3 @@
+parameter,statistics(sa),p-value(sa)
+beta_V_tAPGAR_High,2.26508,0.0235
+beta_V_tAPGAR_Low,0.744812,0.456
diff --git a/inst/cov/pb/Tests/normalityIndividualParameters.txt b/inst/cov/pb/Tests/normalityIndividualParameters.txt
new file mode 100644
index 0000000..ffe564c
--- /dev/null
+++ b/inst/cov/pb/Tests/normalityIndividualParameters.txt
@@ -0,0 +1,3 @@
+parameter,statistics,p-value,test
+V,0.115658,0.0172607,Kolmogorov-Smirnov
+k,0.980138,0.672503,Shapiro-Wilk
diff --git a/inst/cov/pb/Tests/normalityRandomEffects.txt b/inst/cov/pb/Tests/normalityRandomEffects.txt
new file mode 100644
index 0000000..1b20300
--- /dev/null
+++ b/inst/cov/pb/Tests/normalityRandomEffects.txt
@@ -0,0 +1,3 @@
+eta,statistics,p-value
+eta_V,0.95443,0.018648
+eta_k,0.980138,0.672503
diff --git a/inst/cov/pb/Tests/normalityResiduals.txt b/inst/cov/pb/Tests/normalityResiduals.txt
new file mode 100644
index 0000000..ae548f5
--- /dev/null
+++ b/inst/cov/pb/Tests/normalityResiduals.txt
@@ -0,0 +1,4 @@
+residuals,statistics,p-value,test
+IWRES_CONC,0.985979,0.0178589,Shapiro-Wilk
+PWRES_CONC,0.917991,1.07147e-07,Shapiro-Wilk
+NPDE_CONC,0.9481,1.68054e-05,Shapiro-Wilk
diff --git a/inst/cov/pb/Tests/symmetryResiduals.txt b/inst/cov/pb/Tests/symmetryResiduals.txt
new file mode 100644
index 0000000..d512a1c
--- /dev/null
+++ b/inst/cov/pb/Tests/symmetryResiduals.txt
@@ -0,0 +1,4 @@
+residuals,statistics,p-value,test
+IWRES_CONC,-0.855394,0.392333,Symmetry
+PWRES_CONC,-1.06601,0.28642,Symmetry
+NPDE_CONC,-4.22966,2.34047e-05,Symmetry
diff --git a/inst/cov/pb/populationParameters.txt b/inst/cov/pb/populationParameters.txt
new file mode 100644
index 0000000..bf4d263
--- /dev/null
+++ b/inst/cov/pb/populationParameters.txt
@@ -0,0 +1,8 @@
+parameter,value,CV,se_sa,rse_sa
+V_pop,1.24689732935331,,0.0936975242081976,7.51445383693242
+beta_V_tAPGAR_High,0.260578209875729,,0.115041637466471,44.1486022646848
+beta_V_tAPGAR_Low,0.127948846160619,,0.17178681111809,134.262102608131
+k_pop,0.00479852739901777,,0.000243812155121,5.08097870131797
+omega_V,0.401481325663058,41.8216397185517,0.0390637761053152,9.72991110876708
+omega_k,0.186667045786903,18.8304995915346,0.069019120270078,36.9744536209511
+b,0.108861379047358,,0.00845666526279147,7.76828783246683
\ No newline at end of file
diff --git a/inst/cov/pb/predictions.txt b/inst/cov/pb/predictions.txt
new file mode 100644
index 0000000..45089cb
--- /dev/null
+++ b/inst/cov/pb/predictions.txt
@@ -0,0 +1,156 @@
+id,time,CONC,popPred_medianCOV,popPred,indivPred_SAEM,indivPred_mean,indivPred_mode,indWRes_SAEM,indWRes_mean,indWRes_mode
+1,2,17.3,19.8583,19.8583,18.1499,18.4203,18.1411,-0.430129,-0.558667,-0.425887
+1,112.5,31,31.5973,31.5973,29.4802,29.5874,29.3038,0.473565,0.438566,0.53171
+2,2,9.7,11.915,9.18174,12.0044,12.0672,11.7268,-1.76339,-1.802,-1.58769
+2,63.5,24.6,21.7614,16.7695,22.3403,22.2316,21.925,0.929176,0.978594,1.12074
+2,135.5,33,30.4605,23.4731,31.7183,31.323,31.2393,0.371182,0.491794,0.517731
+3,1.5,18,23.8872,23.8872,17.7002,17.312,17.5958,0.155615,0.365041,0.21099
+3,83.5,23.8,30.7594,30.7594,22.4387,21.8698,22.2581,0.557302,0.810754,0.636351
+3,134.3,24.3,37.2386,37.2386,27.0312,26.317,26.7955,-0.928152,-0.70405,-0.855506
+4,1.8,20.8,14.7887,14.7887,20.7154,20.2505,20.3217,0.0375133,0.24926,0.216209
+4,59.3,23.9,17.6482,17.6482,24.7704,24.4428,24.411,-0.322793,-0.203994,-0.192299
+4,130.8,31.7,21.6575,21.6575,30.4473,30.2755,30.1175,0.37793,0.432219,0.482677
+5,2,14.2,21.4469,21.4469,14.5194,14.2101,14.4449,-0.202069,-0.00653295,-0.155713
+5,59.5,18.2,25.7626,25.7626,17.2294,16.9493,17.2463,0.517502,0.677841,0.507957
+5,132,20.3,31.632,31.632,20.9426,20.6895,21.0693,-0.281881,-0.172951,-0.335395
+6,1.8,19,19.0822,19.0822,18.3006,18.7034,18.2871,0.351052,0.145681,0.358081
+6,59.3,17.3,22.852,22.852,22.3506,22.5985,22.2183,-2.07577,-2.15377,-2.03344
+6,142.8,32.5,28.8415,28.8415,28.7267,28.7566,28.4186,1.2066,1.1958,1.31927
+7,2,17.9,15.0923,15.0923,17.9951,17.6077,17.8073,-0.0485482,0.152515,0.0478457
+7,73.8,23.4,18.7459,18.7459,22.2871,22.0182,22.0769,0.458688,0.576489,0.550521
+7,165.3,25.8,22.4242,22.4242,26.5949,26.4908,26.3669,-0.274575,-0.23953,-0.197509
+8,1.7,25.8,19.0914,19.0914,24.5193,24.5017,24.408,0.479805,0.486767,0.523882
+8,73.7,34.2,25.956,25.956,32.7544,32.7251,32.7193,0.405419,0.414008,0.4157
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diff --git a/inst/cov/pb/summary.txt b/inst/cov/pb/summary.txt
new file mode 100644
index 0000000..8feba16
--- /dev/null
+++ b/inst/cov/pb/summary.txt
@@ -0,0 +1,110 @@
+********************************************************************************
+*                        phenobarbital_project.mlxtran                         *
+*                        May 09, 2024 at 20:48:29                              *
+*                        Monolix version : 2023R1                              *
+********************************************************************************
+
+
+ESTIMATION OF THE POPULATION PARAMETERS ________________________________________
+
+Fixed Effects ----------------------------     se_sa    rse(%)
+V_pop              :                  1.25    0.0937      7.51
+beta_V_tAPGAR_High :                 0.261     0.115      44.1
+beta_V_tAPGAR_Low  :                 0.128     0.172       134
+k_pop              :                0.0048  0.000244      5.08
+
+Standard Deviation of the Random Effects -
+omega_V            :                 0.401    0.0391      9.73
+omega_k            :                 0.187     0.069        37
+
+Error Model Parameters -------------------
+b                  :                 0.109   0.00846      7.77
+
+Elapsed time (seconds):      2.5
+CPU time     (seconds):        2
+Exploratory phase iterations:      194 (Autostop)
+Smoothing phase iterations:         89 (Autostop)
+
+ _______________________________________________________________________________
+
+
+
+ESTIMATION OF THE INDIVIDUAL PARAMETERS ________________________________________
+
+
+Estimation of the individual parameters by Conditional Distribution ------------
+          min        Q1    median        Q3       max
+V :     0.695      1.07      1.37       1.7      4.88
+k :   0.00344   0.00466   0.00485   0.00505    0.0063
+
+Elapsed time (seconds):     0.67
+CPU time     (seconds):     0.82
+Iterations:       78 (Autostop)
+
+ -------------------------------------------------------------------------------
+
+
+Estimation of the individual parameters by Conditional Mode --------------------
+          min        Q1    median        Q3       max
+V :     0.692      1.06      1.37      1.68      4.94
+k :   0.00364   0.00464    0.0048   0.00498   0.00629
+
+Elapsed time (seconds):     0.06
+CPU time     (seconds):        0
+
+ -------------------------------------------------------------------------------
+
+ _______________________________________________________________________________
+
+
+
+ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________
+
+
+Estimation of the Fisher information matrix by Stochastic Approximation --------
+
+Correlation Matrix :
+             V_pop         1
+beta_V_tAPGAR_High  -0.64791         1
+ beta_V_tAPGAR_Low  -0.43591   0.28245         1
+             k_pop -0.099287 0.0079791  0.032804         1
+           omega_V -0.012152  0.013185  0.016219  0.022327         1
+           omega_k  0.031777  0.020461  -0.03771  -0.43918 -0.075066         1
+                 b 0.0023841 -0.013771  0.018361   0.08753 -0.014211  -0.16785         1
+
+                               min       max   max/min
+Eigen values           :      0.32       1.9         6
+
+Elapsed time (seconds):     0.37
+CPU time     (seconds):      0.4
+Iterations:       50 (Autostop)
+
+ -------------------------------------------------------------------------------
+
+ _______________________________________________________________________________
+
+
+
+ESTIMATION OF THE LOG-LIKELIHOOD _______________________________________________
+
+                                                            (is)
+-2 x log-likelihood                       (OFV) :         971.43
+Akaike Information Criteria               (AIC) :         985.43
+Corrected Bayesian Information Criteria  (BICc) :        1002.87
+Bayesian Information Criteria             (BIC) :         999.97
+
+Elapsed time                          (seconds) :           7.56
+CPU time                              (seconds) :          10.00
+MonteCarlo size (is):    10000 (Fixed number of iterations)
+
+
+[Importance Sampling] Standard error        : 0.070
+                      Sampling distribution : T-distribution with 5 degrees of freedom
+
+ _______________________________________________________________________________
+
+DATASET INFORMATION
+Number of individuals: 59
+Number of observations (CONC): 155
+Number of doses: 589
+
diff --git a/inst/cov/phenobarbital_project.mlxtran b/inst/cov/phenobarbital_project.mlxtran
new file mode 100644
index 0000000..a12f485
--- /dev/null
+++ b/inst/cov/phenobarbital_project.mlxtran
@@ -0,0 +1,75 @@
+<DATAFILE>
+
+[FILEINFO]
+file='data/phenobarbital_data.csv'
+delimiter = semicolon
+header = {ID, TIME, DOSE, WEIGHT, APGAR, CONC}
+
+[CONTENT]
+ID = {use=identifier}
+TIME = {use=time}
+DOSE = {use=amount}
+WEIGHT = {use=covariate, type=continuous}
+APGAR = {use=covariate, type=categorical}
+CONC = {use=observation, name=CONC, type=continuous}
+
+<MODEL>
+
+[COVARIATE]
+input = APGAR
+
+APGAR = {type=categorical, categories={1, 10, 2, 3, 4, 5, 6, 7, 8, 9}}
+
+DEFINITION:
+tAPGAR =
+{
+  transform = APGAR,
+  categories = {
+  High = {10, 8, 9},
+  Low = {1, 2, 3},
+  Med = {4, 5, 6, 7}  },
+  reference = Med
+}
+
+[INDIVIDUAL]
+input = {V_pop, omega_V, k_pop, omega_k, tAPGAR, beta_V_tAPGAR_High, beta_V_tAPGAR_Low}
+
+tAPGAR = {type=categorical, categories={High, Low, Med}}
+
+DEFINITION:
+V = {distribution=logNormal, typical=V_pop, covariate=tAPGAR, coefficient={beta_V_tAPGAR_High, beta_V_tAPGAR_Low, 0}, sd=omega_V}
+k = {distribution=logNormal, typical=k_pop, sd=omega_k}
+
+[LONGITUDINAL]
+input = {b}
+
+file = 'lib:bolus_1cpt_Vk.txt'
+
+DEFINITION:
+CONC = {distribution=normal, prediction=Cc, errorModel=proportional(b)}
+
+<FIT>
+data = CONC
+model = CONC
+
+<PARAMETER>
+V_pop = {value=1, method=MLE}
+b = {value=0.3, method=MLE}
+beta_V_tAPGAR_High = {value=0, method=MLE}
+beta_V_tAPGAR_Low = {value=0, method=MLE}
+k_pop = {value=0.01, method=MLE}
+omega_V = {value=1, method=MLE}
+omega_k = {value=1, method=MLE}
+
+<MONOLIX>
+
+[TASKS]
+populationParameters()
+individualParameters(method = {conditionalMean, conditionalMode })
+fim(method = StochasticApproximation)
+logLikelihood(run = false,method = ImportanceSampling)
+plotResult(method = {indfits, parameterdistribution, covariancemodeldiagnosis, covariatemodeldiagnosis, obspred, vpc, residualsscatter, residualsdistribution, randomeffects, saemresults })
+
+[SETTINGS]
+GLOBAL:
+exportpath = 'pb'
diff --git a/inst/cov/w1/FisherInformation/correlationEstimatesSA.txt b/inst/cov/w1/FisherInformation/correlationEstimatesSA.txt
new file mode 100644
index 0000000..7ce7086
--- /dev/null
+++ b/inst/cov/w1/FisherInformation/correlationEstimatesSA.txt
@@ -0,0 +1,10 @@
+Tlag_pop,1,0.469324,0.0421566,-0.0484674,-0.899455,-0.503396,-0.035675,0.0622168,0.0881963,0.0661154
+ka_pop,0.469324,1,-0.0271025,-0.0833874,-0.448425,-0.110068,-0.041523,0.0368971,0.0368257,0.0576569
+V_pop,0.0421566,-0.0271025,1,0.00222496,-0.0200579,-0.026566,0.0376404,0.00307112,-0.0259787,0.0275584
+Cl_pop,-0.0484674,-0.0833874,0.00222496,1,0.0575445,0.0705647,-0.000467052,-0.00929513,0.0221508,-0.0328802
+omega_Tlag,-0.899455,-0.448425,-0.0200579,0.0575445,1,0.487733,0.0460069,-0.060085,-0.0929014,-0.065018
+omega_ka,-0.503396,-0.110068,-0.026566,0.0705647,0.487733,1,0.0263861,-0.0738753,-0.0702378,-0.0807465
+omega_V,-0.035675,-0.041523,0.0376404,-0.000467052,0.0460069,0.0263861,1,-0.00254901,-0.0231658,-0.00658089
+omega_Cl,0.0622168,0.0368971,0.00307112,-0.00929513,-0.060085,-0.0738753,-0.00254901,1,0.0416041,-0.033796
+a,0.0881963,0.0368257,-0.0259787,0.0221508,-0.0929014,-0.0702378,-0.0231658,0.0416041,1,-0.745283
+b,0.0661154,0.0576569,0.0275584,-0.0328802,-0.065018,-0.0807465,-0.00658089,-0.033796,-0.745283,1
diff --git a/inst/cov/w1/FisherInformation/covarianceEstimatesSA.txt b/inst/cov/w1/FisherInformation/covarianceEstimatesSA.txt
new file mode 100644
index 0000000..902e9f1
--- /dev/null
+++ b/inst/cov/w1/FisherInformation/covarianceEstimatesSA.txt
@@ -0,0 +1,10 @@
+Tlag_pop,0.302671,0.101209,0.000960627,-0.00138107,-0.212874,-0.105277,-0.000601203,0.00126216,0.00192737,0.000282151
+ka_pop,0.101209,0.153645,-0.00044002,-0.00169293,-0.0756147,-0.0164006,-0.000498562,0.0005333,0.000573375,0.000175309
+V_pop,0.000960627,-0.00044002,0.00171557,4.77317e-06,-0.000357393,-0.000418281,4.77562e-05,4.69051e-06,-4.27414e-05,8.85426e-06
+Cl_pop,-0.00138107,-0.00169293,4.77317e-06,0.00268263,0.00128216,0.00138933,-7.40999e-07,-1.77524e-05,4.5572e-05,-1.32102e-05
+omega_Tlag,-0.212874,-0.0756147,-0.000357393,0.00128216,0.185061,0.0797587,0.000606251,-0.000953111,-0.00158748,-0.000216962
+omega_ka,-0.105277,-0.0164006,-0.000418281,0.00138933,0.0797587,0.144503,0.000307246,-0.00103552,-0.00106057,-0.000238098
+omega_V,-0.000601203,-0.000498562,4.77562e-05,-7.40999e-07,0.000606251,0.000307246,0.000938304,-2.87914e-06,-2.8187e-05,-1.56369e-06
+omega_Cl,0.00126216,0.0005333,4.69051e-06,-1.77524e-05,-0.000953111,-0.00103552,-2.87914e-06,0.00135969,6.09375e-05,-9.66671e-06
+a,0.00192737,0.000573375,-4.27414e-05,4.5572e-05,-0.00158748,-0.00106057,-2.8187e-05,6.09375e-05,0.00157782,-0.000229638
+b,0.000282151,0.000175309,8.85426e-06,-1.32102e-05,-0.000216962,-0.000238098,-1.56369e-06,-9.66671e-06,-0.000229638,6.0171e-05
diff --git a/inst/cov/w1/IndividualParameters/estimatedIndividualParameters.txt b/inst/cov/w1/IndividualParameters/estimatedIndividualParameters.txt
new file mode 100644
index 0000000..ffd3201
--- /dev/null
+++ b/inst/cov/w1/IndividualParameters/estimatedIndividualParameters.txt
@@ -0,0 +1,33 @@
+id,Tlag_SAEM,ka_SAEM,V_SAEM,Cl_SAEM,Tlag_mean,ka_mean,V_mean,Cl_mean,Tlag_mode,ka_mode,V_mode,Cl_mode,Tlag_sd,ka_sd,V_sd,Cl_sd,wt,sex
+1,0.89699,3.18356,7.7155,0.112121,0.831868,2.41434,7.70341,0.112094,0.773357,1.40624,7.66977,0.111513,0.52759,3.08441,0.602986,0.00632447,66.7,1
+2,0.718624,1.09983,8.49245,0.126091,0.773265,1.00002,8.39486,0.128054,0.608268,0.81841,8.31658,0.128488,0.185372,0.244834,0.419389,0.00555544,66.7,1
+3,0.984988,2.03157,8.50447,0.112731,0.761624,1.59214,8.54439,0.111233,0.809916,0.910516,8.45366,0.11257,0.377348,1.86541,0.359115,0.00487807,80,1
+4,0.789551,3.34704,5.09239,0.0717225,0.771295,3.38799,5.10436,0.0720395,0.807632,1.42138,5.08214,0.0724521,0.407529,3.34102,0.193445,0.00394699,40,0
+5,0.849642,2.84494,11.5478,0.17568,0.896895,2.67963,11.531,0.17574,0.731764,1.60891,11.533,0.175433,0.634691,3.82244,0.614687,0.00938912,75.3,1
+6,0.789369,4.95747,6.08682,0.230467,0.784412,3.15321,6.14972,0.231735,0.750412,1.56017,6.14308,0.231256,0.408823,2.76461,0.262255,0.0115726,60,0
+7,0.669423,5.98744,8.01958,0.1729,0.662361,6.42669,8.0165,0.172829,0.656685,3.65313,8.04694,0.173331,0.294273,5.06416,0.267207,0.00769139,90,1
+8,0.784203,0.387644,5.44763,0.110445,0.774173,0.364448,5.35042,0.110015,0.814392,0.37778,5.39832,0.110298,0.0662312,0.0511951,0.292947,0.00495156,50,0
+9,0.894139,2.37582,9.1685,0.116174,0.905689,2.96737,9.24133,0.115096,0.761808,1.4701,9.05823,0.115424,0.687818,4.44893,0.686241,0.00648725,70,1
+10,0.542691,0.292946,7.76953,0.283227,0.556388,0.29148,7.63686,0.287852,0.542705,0.285168,7.64338,0.28781,0.0785802,0.0425225,0.548988,0.0151928,66.7,1
+11,0.725429,1.93177,7.42821,0.130959,0.657124,1.66154,7.49539,0.132084,0.732436,1.54459,7.47479,0.130959,0.246634,0.68085,0.27629,0.00519396,82,1
+12,2.69552,0.678576,6.98318,0.134732,2.67233,0.673418,7.02019,0.134619,2.73951,0.742729,7.08755,0.134276,0.0977399,0.256928,0.329077,0.00488903,75.3,1
+13,1.38581,3.28407,8.91167,0.174143,1.41545,5.39446,8.87483,0.174636,1.37454,2.66191,8.92175,0.175493,0.0493199,3.03096,0.341627,0.00688878,75.3,1
+14,0.908167,3.32645,6.15584,0.156251,0.881501,2.76814,6.17709,0.155329,0.910186,2.79762,6.19507,0.155544,0.0514872,1.3331,0.247068,0.00807439,50,0
+15,0.490368,1.60658,6.74353,0.0984567,0.571118,2.34251,6.68033,0.0984256,0.605588,1.86275,6.74678,0.0978812,0.202167,1.5899,0.270946,0.00473518,56.7,0
+16,1.03506,2.86031,6.1256,0.0963757,0.947918,2.21712,6.04457,0.0971727,0.799485,1.26017,6.01044,0.0955013,0.637549,3.87122,0.395147,0.00480569,58,1
+17,0.938068,3.33694,10.98,0.150213,0.882651,3.54153,10.9094,0.15089,0.74268,1.57618,10.7469,0.149922,0.606295,5.31235,0.927394,0.00782076,78,1
+18,0.880379,4.04618,8.31304,0.178915,0.829533,3.02623,8.30686,0.180838,0.745832,1.55914,8.15841,0.178086,0.594091,6.87215,0.783178,0.0111682,74.7,1
+19,0.89667,2.68572,9.34696,0.186912,0.925721,2.82649,9.24069,0.185935,0.736833,1.60942,9.06206,0.184568,0.620313,3.82052,0.967679,0.0113016,63.7,1
+20,0.999854,2.64371,7.02631,0.0947927,0.948032,2.54399,7.06788,0.0949473,0.785931,1.33653,6.8836,0.0945344,0.584857,4.2717,0.516938,0.00539537,59,1
+21,0.896795,3.18374,9.26396,0.144427,0.803529,2.96767,9.39823,0.144016,0.751656,1.52637,9.18412,0.143698,0.51418,3.62801,0.821599,0.00763581,62,1
+22,0.951871,2.69349,6.25364,0.102201,0.953749,2.0604,6.27339,0.102062,0.79568,1.28166,6.19064,0.0991127,0.714921,2.99999,0.481204,0.00745272,58,1
+23,0.880795,3.34667,7.99161,0.121707,0.950224,2.33765,8.14574,0.121398,0.767536,1.43844,7.99575,0.121328,0.586107,2.5274,0.619004,0.00547593,73.3,1
+24,0.961497,2.74858,11.2917,0.100185,0.900174,2.59829,11.2092,0.100697,0.757958,1.49128,11.0201,0.101199,0.492825,3.67473,0.910411,0.00804115,76.7,1
+25,1.00068,2.78941,7.01094,0.106688,0.92582,2.77232,7.10979,0.105892,0.782521,1.35539,6.9917,0.104836,0.541809,7.38673,0.513233,0.00567891,74.7,1
+26,0.887096,2.25443,8.59214,0.120906,0.949906,2.49728,8.57758,0.120801,0.763912,1.45848,8.49185,0.120372,0.629813,2.87972,0.648597,0.0059813,80,1
+27,0.94825,2.62007,7.53019,0.120152,0.966167,2.50562,7.49266,0.119791,0.77412,1.40195,7.38258,0.119552,0.641222,3.35661,0.552298,0.00587993,80,1
+28,0.850525,3.09641,8.72736,0.136204,0.852082,2.35011,8.69357,0.135593,0.758055,1.4909,8.61028,0.135735,0.541682,2.50866,0.653251,0.00595286,80,1
+29,0.966343,3.25803,13.0392,0.19027,0.879134,3.53519,13.0183,0.188611,0.723561,1.68366,12.8412,0.189429,0.581992,4.30496,1.0522,0.00959723,102,1
+30,0.975018,2.46634,7.90191,0.124848,0.961371,2.55287,7.93656,0.124637,0.768677,1.43211,7.76235,0.124596,0.634069,3.2076,0.633199,0.00604733,70,1
+31,0.880023,2.71029,9.70788,0.142236,0.904689,2.83422,9.72763,0.140687,0.750911,1.53046,9.61591,0.13943,0.577043,3.98827,0.737774,0.00751188,83.3,1
+32,1.0722,2.21539,7.74678,0.103952,1.04024,2.67922,7.77839,0.103892,0.775671,1.39347,7.64066,0.103626,0.675845,3.33138,0.656326,0.00552527,62,1
diff --git a/inst/cov/w1/IndividualParameters/estimatedRandomEffects.txt b/inst/cov/w1/IndividualParameters/estimatedRandomEffects.txt
new file mode 100644
index 0000000..b8fd942
--- /dev/null
+++ b/inst/cov/w1/IndividualParameters/estimatedRandomEffects.txt
@@ -0,0 +1,33 @@
+id,eta_Tlag_SAEM,eta_ka_SAEM,eta_V_SAEM,eta_Cl_SAEM,eta_Tlag_mean,eta_ka_mean,eta_V_mean,eta_Cl_mean,eta_Tlag_mode,eta_ka_mode,eta_V_mode,eta_Cl_mode,eta_Tlag_sd,eta_ka_sd,eta_V_sd,eta_Cl_sd,wt,sex
+1,-0.0423976,0.138832,-0.0334843,-0.167792,-0.0841675,-0.0519486,-0.0358612,-0.168675,0.0117504,-0.0349136,-0.0371672,-0.172306,0.576789,1.06665,0.0784459,0.0557831,66.7,1
+2,-0.12308,-0.441893,0.0641598,-0.0500691,-0.0170326,-0.401013,0.0518995,-0.034933,-0.228374,-0.576227,0.0437969,-0.0306042,0.24037,0.218483,0.0505266,0.0434066,66.7,1
+3,0.089448,-0.0363632,0.0659581,-0.162062,-0.135233,-0.166529,0.0699274,-0.175786,0.0579405,-0.469579,0.0601456,-0.16287,0.535865,0.603511,0.0424146,0.044036,80,1
+4,-0.135122,0.527519,-0.446738,-0.614696,-0.130632,0.539812,-0.445073,-0.610738,0.0551164,-0.0242074,-0.448722,-0.603518,0.538759,0.732103,0.03778,0.0550395,40,0
+5,-0.0464695,0.163338,0.3714,0.280932,-0.0563485,0.167684,0.369174,0.281129,-0.0435325,0.0997246,0.37076,0.280815,0.654693,0.886564,0.053078,0.0536652,75.3,1
+6,-0.121686,0.715043,-0.268717,0.552646,-0.110782,0.509526,-0.258953,0.5579,-0.018367,0.0689578,-0.259128,0.557083,0.534505,0.687656,0.0424966,0.0500352,60,0
+7,-0.248703,1.13275,0.00754358,0.265814,-0.244731,1.2681,0.00649324,0.264866,-0.151786,0.919748,0.0108388,0.26876,0.464015,0.619283,0.0333058,0.0445482,90,1
+8,-0.00992857,-1.40242,-0.380001,-0.182441,0.00900094,-1.39509,-0.398779,-0.186836,0.0634519,-1.34928,-0.388365,-0.183255,0.0881974,0.140901,0.0547936,0.0448713,50,0
+9,-0.0713535,-0.0983725,0.139288,-0.132717,-0.0428305,0.0452232,0.14652,-0.142261,-0.0032951,0.00949229,0.12922,-0.137828,0.640772,1.13149,0.0734019,0.0562519,70,1
+10,-0.384967,-1.67674,-0.0258859,0.758889,-0.327841,-1.61887,-0.0440503,0.774606,-0.342425,-1.63051,-0.0406138,0.775857,0.145143,0.142342,0.0719214,0.0529258,66.7,1
+11,-0.19478,0.0788956,-0.0694581,-0.0118525,-0.226356,0.0606266,-0.0608486,-0.00378104,-0.0426144,0.0589204,-0.062918,-0.0115624,0.399284,0.365671,0.0370167,0.0395355,82,1
+12,1.23122,-0.859558,-0.131851,0.016287,1.25105,-0.823313,-0.126762,0.0153474,1.27655,-0.673259,-0.116114,0.0134523,0.0365015,0.301302,0.0469025,0.036289,75.3,1
+13,0.565792,0.712547,0.112784,0.272598,0.615597,1.13795,0.108027,0.275481,0.586885,0.603209,0.114038,0.281156,0.0352243,0.599763,0.0383946,0.0394183,75.3,1
+14,0.142233,0.66714,-0.257482,0.164184,0.140895,0.543573,-0.25441,0.157743,0.174659,0.652934,-0.250701,0.160485,0.0593563,0.428565,0.0401131,0.0521329,50,0
+15,-0.526244,-0.0157238,-0.166219,-0.297852,-0.369771,0.294488,-0.176112,-0.298303,-0.232789,0.246217,-0.165389,-0.302689,0.426136,0.576755,0.0406657,0.0482339,56.7,0
+16,0.0880557,-0.151358,-0.264599,-0.319131,0.0334823,-0.264662,-0.27745,-0.311156,0.0449779,-0.144586,-0.280956,-0.327304,0.603074,1.10313,0.0658471,0.0488354,58,1
+17,-0.00405931,0.183656,0.319637,0.124441,-0.042845,0.284667,0.311555,0.128747,-0.0287242,0.07917,0.300166,0.123669,0.5986,1.07661,0.0851751,0.0524197,78,1
+18,-0.0722117,0.277776,0.0399518,0.29976,-0.105689,0.0375265,0.0381674,0.309305,-0.0244892,0.0683011,0.0245952,0.295824,0.592603,1.15473,0.0946399,0.0604579,74.7,1
+19,-0.0359147,-0.0901984,0.155465,0.342505,-0.0101461,0.230922,0.143754,0.337109,-0.0366292,0.100041,0.129643,0.331573,0.637181,0.892086,0.103829,0.0607056,63.7,1
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+21,-0.0633001,0.187645,0.149244,0.0851475,-0.119746,0.177627,0.162253,0.0820817,-0.0167107,0.0470604,0.143023,0.0812682,0.572139,1.0464,0.0873872,0.0527685,62,1
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diff --git a/inst/cov/w1/IndividualParameters/simulatedIndividualParameters.txt b/inst/cov/w1/IndividualParameters/simulatedIndividualParameters.txt
new file mode 100644
index 0000000..e63b1ec
--- /dev/null
+++ b/inst/cov/w1/IndividualParameters/simulatedIndividualParameters.txt
@@ -0,0 +1,321 @@
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diff --git a/inst/cov/w1/IndividualParameters/simulatedRandomEffects.txt b/inst/cov/w1/IndividualParameters/simulatedRandomEffects.txt
new file mode 100644
index 0000000..8a81f91
--- /dev/null
+++ b/inst/cov/w1/IndividualParameters/simulatedRandomEffects.txt
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diff --git a/inst/cov/w1/LogLikelihood/individualLL.txt b/inst/cov/w1/LogLikelihood/individualLL.txt
new file mode 100644
index 0000000..37fb48b
--- /dev/null
+++ b/inst/cov/w1/LogLikelihood/individualLL.txt
@@ -0,0 +1,33 @@
+id,importanceSampling
+1,11.007136
+2,27.436454
+3,25.387680
+4,30.947486
+5,14.486862
+6,37.241838
+7,45.636552
+8,33.787292
+9,11.512947
+10,38.486309
+11,41.211130
+12,37.113185
+13,39.462364
+14,26.140391
+15,29.644207
+16,13.682642
+17,11.085054
+18,14.372758
+19,9.236523
+20,13.554236
+21,9.974623
+22,19.309946
+23,9.724362
+24,12.554324
+25,13.095378
+26,10.378976
+27,11.971067
+28,11.941267
+29,15.515808
+30,10.486635
+31,10.410935
+32,10.561945
diff --git a/inst/cov/w1/LogLikelihood/logLikelihood.txt b/inst/cov/w1/LogLikelihood/logLikelihood.txt
new file mode 100644
index 0000000..5480e1a
--- /dev/null
+++ b/inst/cov/w1/LogLikelihood/logLikelihood.txt
@@ -0,0 +1,6 @@
+criteria,importanceSampling
+OFV,657.358312
+AIC,677.358312
+BIC,692.015671
+BICc,704.277586
+standardError,0.131188
diff --git a/inst/cov/w1/Tests/correlationRandomEffects.txt b/inst/cov/w1/Tests/correlationRandomEffects.txt
new file mode 100644
index 0000000..3bad5d3
--- /dev/null
+++ b/inst/cov/w1/Tests/correlationRandomEffects.txt
@@ -0,0 +1,7 @@
+eta1,eta2,coeff,statistics,p-value
+eta_Tlag,eta_ka,0,0.637709,0.528346
+eta_Tlag,eta_V,0,0.524268,0.603821
+eta_Tlag,eta_Cl,0,1.0463,0.303512
+eta_ka,eta_V,0,0.361813,0.719946
+eta_ka,eta_Cl,0,-0.581732,0.564954
+eta_V,eta_Cl,0,1.83107,0.0767172
diff --git a/inst/cov/w1/Tests/correlationRandomEffectsCovariates.txt b/inst/cov/w1/Tests/correlationRandomEffectsCovariates.txt
new file mode 100644
index 0000000..05b0ffb
--- /dev/null
+++ b/inst/cov/w1/Tests/correlationRandomEffectsCovariates.txt
@@ -0,0 +1,9 @@
+eta,covariate,statistics,p-value,test
+eta_Tlag,sex,0.946024,0.338511,Anova
+eta_Tlag,wt,1.12216,0.270697,Pearson
+eta_ka,sex,0.151167,0.700168,Anova
+eta_ka,wt,0.994976,0.327706,Pearson
+eta_V,sex,18.1732,0.000184502,Anova
+eta_V,wt,6.37812,4.87001e-07,Pearson
+eta_Cl,sex,0.390628,0.536695,Anova
+eta_Cl,wt,2.13068,0.041428,Pearson
diff --git a/inst/cov/w1/Tests/normalityIndividualParameters.txt b/inst/cov/w1/Tests/normalityIndividualParameters.txt
new file mode 100644
index 0000000..37a9c78
--- /dev/null
+++ b/inst/cov/w1/Tests/normalityIndividualParameters.txt
@@ -0,0 +1,5 @@
+parameter,statistics,p-value,test
+Tlag,0.968623,0.529672,Shapiro-Wilk
+ka,0.969788,0.797625,Shapiro-Wilk
+V,0.978879,0.997045,Shapiro-Wilk
+Cl,0.970709,0.765264,Shapiro-Wilk
diff --git a/inst/cov/w1/Tests/normalityRandomEffects.txt b/inst/cov/w1/Tests/normalityRandomEffects.txt
new file mode 100644
index 0000000..fb33f60
--- /dev/null
+++ b/inst/cov/w1/Tests/normalityRandomEffects.txt
@@ -0,0 +1,5 @@
+eta,statistics,p-value
+eta_Tlag,0.968623,0.529672
+eta_ka,0.969788,0.797625
+eta_V,0.978879,0.997045
+eta_Cl,0.970709,0.765264
diff --git a/inst/cov/w1/Tests/normalityResiduals.txt b/inst/cov/w1/Tests/normalityResiduals.txt
new file mode 100644
index 0000000..eb01539
--- /dev/null
+++ b/inst/cov/w1/Tests/normalityResiduals.txt
@@ -0,0 +1,4 @@
+residuals,statistics,p-value,test
+IWRES_concentration,0.992359,0.103604,Shapiro-Wilk
+PWRES_concentration,0.99082,0.122869,Shapiro-Wilk
+NPDE_concentration,0.994731,0.551884,Shapiro-Wilk
diff --git a/inst/cov/w1/Tests/symmetryResiduals.txt b/inst/cov/w1/Tests/symmetryResiduals.txt
new file mode 100644
index 0000000..dcedf60
--- /dev/null
+++ b/inst/cov/w1/Tests/symmetryResiduals.txt
@@ -0,0 +1,4 @@
+residuals,statistics,p-value,test
+IWRES_concentration,-0.206632,0.836297,Symmetry
+PWRES_concentration,-0.510315,0.609831,Symmetry
+NPDE_concentration,-2.2896,0.0220443,Symmetry
diff --git a/inst/cov/w1/populationParameters.txt b/inst/cov/w1/populationParameters.txt
new file mode 100644
index 0000000..9112f35
--- /dev/null
+++ b/inst/cov/w1/populationParameters.txt
@@ -0,0 +1,11 @@
+parameter,value,CV,se_sa,rse_sa
+Tlag_pop,0.764322535850091,,0.420496337644856,55.0155618762665
+ka_pop,1.45620698534217,,0.570797523525994,39.1975542811912
+V_pop,7.96019644663432,,0.329706577234286,4.14194020769036
+Cl_pop,0.132481552644036,,0.00686176474906852,5.17941148191807
+omega_Tlag,0.605115662973185,66.4976041111586,0.430186959202578,71.091691312185
+omega_ka,1.08210228973354,149.165681014931,0.380135650264131,35.1293638199154
+omega_V,0.222522809015499,22.530606992046,0.0306317450105289,13.7656652574413
+omega_Cl,0.286211422517007,29.2174087265823,0.0368739656541468,12.8834710123967
+a,0.247145876284213,,0.0397217695323461,16.072195955504
+b,0.0503195895352995,,0.00775699508916458,15.4154577984445
\ No newline at end of file
diff --git a/inst/cov/w1/predictions.txt b/inst/cov/w1/predictions.txt
new file mode 100644
index 0000000..326fa85
--- /dev/null
+++ b/inst/cov/w1/predictions.txt
@@ -0,0 +1,248 @@
+id,time,concentration,popPred_medianCOV,popPred,indivPred_SAEM,indivPred_mean,indivPred_mode,indWRes_SAEM,indWRes_mean,indWRes_mode
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+1,36,8.5,7.06946,7.06946,7.81776,7.82884,7.89404,1.06511,1.0469,0.940389
+1,48,6.4,5.78963,5.78963,6.56672,6.57451,6.63022,-0.288658,-0.301941,-0.396394
+1,72,4.8,3.88311,3.88311,4.6332,4.63656,4.67718,0.347294,0.340181,0.254545
+1,96,3.1,2.6044,2.6044,3.26899,3.26985,3.29944,-0.410523,-0.412574,-0.482715
+1,120,2.5,1.74678,1.74678,2.30646,2.306,2.32754,0.532872,0.534157,0.47344
+2,0.5,0.02,0,0,0,0,0,0.0809239,0.0809239,0.0809239
+2,2,8.4,10.3472,10.3472,8.79514,8.32508,8.07139,-0.572903,0.112476,0.50301
+2,3,9.7,11.7536,11.7536,10.5679,10.3877,10.0802,-1.1142,-0.893239,-0.503967
+2,6,9.8,11.6411,11.6411,11.0003,11.1046,11.1274,-1.49905,-1.61878,-1.64475
+2,12,11,10.5404,10.5404,10.0954,10.1925,10.2766,1.19791,1.06242,0.946494
+2,24,8.3,8.6322,8.6322,8.44789,8.48776,8.53848,-0.220002,-0.278467,-0.352362
+2,36,7.7,7.06946,7.06946,7.06921,7.06801,7.09355,1.04632,1.04842,1.0039
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+3,6,13.2,13.9693,13.9693,13.2889,13.2233,13.316,-0.0970693,-0.0254858,-0.126509
+3,9,14.4,13.2959,13.2959,12.7713,12.72,12.909,1.83039,1.89357,1.66278
+3,24,9.6,10.3586,10.3586,10.4685,10.4636,10.5785,-1.1222,-1.11627,-1.25537
+3,36,8.2,8.48335,8.48335,8.92899,8.95029,9.01627,-1.04672,-1.07566,-1.1647
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+3,120,3,2.09613,2.09613,2.93245,2.99863,2.94608,0.171153,0.00343767,0.136359
+4,3,11.1,7.05217,7.05217,11.4621,11.4321,11.0301,-0.439543,-0.403835,0.0871627
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diff --git a/inst/cov/w1/summary.txt b/inst/cov/w1/summary.txt
new file mode 100644
index 0000000..318909f
--- /dev/null
+++ b/inst/cov/w1/summary.txt
@@ -0,0 +1,121 @@
+********************************************************************************
+*                     warfarin_covariate1_project.mlxtran                      *
+*                     May 09, 2024 at 20:53:44                                 *
+*                     Monolix version : 2023R1                                 *
+********************************************************************************
+
+
+ESTIMATION OF THE POPULATION PARAMETERS ________________________________________
+
+Fixed Effects ----------------------------     se_sa    rse(%)
+Tlag_pop   :                         0.764      0.42        55
+ka_pop     :                          1.46     0.571      39.2
+V_pop      :                          7.96      0.33      4.14
+Cl_pop     :                         0.132   0.00686      5.18
+
+Standard Deviation of the Random Effects -
+omega_Tlag :                         0.605      0.43      71.1
+omega_ka   :                          1.08      0.38      35.1
+omega_V    :                         0.223    0.0306      13.8
+omega_Cl   :                         0.286    0.0369      12.9
+
+Error Model Parameters -------------------
+a          :                         0.247    0.0397      16.1
+b          :                        0.0503   0.00776      15.4
+
+Elapsed time (seconds):      3.9
+CPU time     (seconds):        5
+Exploratory phase iterations:      210 (Autostop)
+Smoothing phase iterations:         95 (Autostop)
+
+ _______________________________________________________________________________
+
+
+
+ESTIMATION OF THE INDIVIDUAL PARAMETERS ________________________________________
+
+
+Estimation of the individual parameters by Conditional Distribution ------------
+             min        Q1    median        Q3       max
+Tlag :     0.556     0.779      0.89     0.949      2.67
+ka   :     0.291      2.28      2.58      2.97      6.43
+V    :       5.1      7.04      7.98      9.06        13
+Cl   :     0.072     0.108     0.126     0.164     0.288
+
+Elapsed time (seconds):      1.1
+CPU time     (seconds):      1.4
+Iterations:      121 (Autostop)
+
+ -------------------------------------------------------------------------------
+
+
+Estimation of the individual parameters by Conditional Mode --------------------
+             min        Q1    median        Q3       max
+Tlag :     0.543      0.74     0.763     0.791      2.74
+ka   :     0.285      1.35      1.46      1.57      3.65
+V    :      5.08      6.94      7.88      8.99      12.8
+Cl   :    0.0725     0.108     0.127     0.164     0.288
+
+Elapsed time (seconds):    0.076
+CPU time     (seconds):        0
+
+ -------------------------------------------------------------------------------
+
+ _______________________________________________________________________________
+
+
+
+ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________
+
+
+Estimation of the Fisher information matrix by Stochastic Approximation --------
+
+Correlation Matrix :
+  Tlag_pop         1
+    ka_pop   0.46932         1
+     V_pop  0.042157 -0.027102         1
+    Cl_pop -0.048467 -0.083387  0.002225         1
+omega_Tlag  -0.89945  -0.44843 -0.020058  0.057544         1
+  omega_ka   -0.5034  -0.11007 -0.026566  0.070565   0.48773         1
+   omega_V -0.035675 -0.041523   0.03764-0.00046705  0.046007  0.026386         1
+  omega_Cl  0.062217  0.036897 0.0030711-0.0092951 -0.060085 -0.073875 -0.002549         1
+         a  0.088196  0.036826 -0.025979  0.022151 -0.092901 -0.070238 -0.023166  0.041604         1
+         b  0.066115  0.057657  0.027558  -0.03288 -0.065018 -0.080747-0.0065809 -0.033796  -0.74528         1
+
+                               min       max   max/min
+Eigen values           :     0.099       2.6        26
+
+Elapsed time (seconds):     0.52
+CPU time     (seconds):     0.67
+Iterations:       50 (Autostop)
+
+ -------------------------------------------------------------------------------
+
+ _______________________________________________________________________________
+
+
+
+ESTIMATION OF THE LOG-LIKELIHOOD _______________________________________________
+
+                                                            (is)
+-2 x log-likelihood                       (OFV) :         657.36
+Akaike Information Criteria               (AIC) :         677.36
+Corrected Bayesian Information Criteria  (BICc) :         704.28
+Bayesian Information Criteria             (BIC) :         692.02
+
+Elapsed time                          (seconds) :           4.03
+CPU time                              (seconds) :           5.00
+MonteCarlo size (is):    10000 (Fixed number of iterations)
+
+
+[Importance Sampling] Standard error        : 0.131
+                      Sampling distribution : T-distribution with 5 degrees of freedom
+
+ _______________________________________________________________________________
+
+DATASET INFORMATION
+Number of individuals: 32
+Number of observations (obsid 1): 247
+Number of observations (obsid 2): 232
+Number of doses: 32
+
diff --git a/inst/cov/w2/FisherInformation/correlationEstimatesLin.txt b/inst/cov/w2/FisherInformation/correlationEstimatesLin.txt
new file mode 100644
index 0000000..82dd876
--- /dev/null
+++ b/inst/cov/w2/FisherInformation/correlationEstimatesLin.txt
@@ -0,0 +1,12 @@
+Tlag_pop,1,0.261827,0.0757948,0.000481349,0.0299138,0.00309266,0,0,0,0,0,0
+ka_pop,0.261827,1,-0.00812771,-0.0267474,-0.038648,-0.00495228,0,0,0,0,0,0
+V_pop,0.0757948,-0.00812771,1,0.108334,0.00287378,-0.000556425,0,0,0,0,0,0
+beta_V_lw70,0.000481349,-0.0267474,0.108334,1,0.00045024,-0.00281897,0,0,0,0,0,0
+Cl_pop,0.0299138,-0.038648,0.00287378,0.00045024,1,0.089524,0,0,0,0,0,0
+beta_Cl_lw70,0.00309266,-0.00495228,-0.000556425,-0.00281897,0.089524,1,0,0,0,0,0,0
+omega_Tlag,0,0,0,0,0,0,1,-0.0846999,-0.00177071,-0.000843516,-0.00239085,-0.00539952
+omega_ka,0,0,0,0,0,0,-0.0846999,1,-0.00249154,-0.00149518,0.0326994,-0.0590895
+omega_V,0,0,0,0,0,0,-0.00177071,-0.00249154,1,0.000697915,0.0062361,-0.0583388
+omega_Cl,0,0,0,0,0,0,-0.000843516,-0.00149518,0.000697915,1,-0.0100303,0.0013487
+a,0,0,0,0,0,0,-0.00239085,0.0326994,0.0062361,-0.0100303,1,-0.796461
+b,0,0,0,0,0,0,-0.00539952,-0.0590895,-0.0583388,0.0013487,-0.796461,1
diff --git a/inst/cov/w2/FisherInformation/covarianceEstimatesLin.txt b/inst/cov/w2/FisherInformation/covarianceEstimatesLin.txt
new file mode 100644
index 0000000..dfcb716
--- /dev/null
+++ b/inst/cov/w2/FisherInformation/covarianceEstimatesLin.txt
@@ -0,0 +1,12 @@
+Tlag_pop,0.0522925,0.0180935,0.000473914,1.54432e-05,0.000326,0.000178914,0,0,0,0,0,0
+ka_pop,0.0180935,0.0913226,-6.7158e-05,-0.00113404,-0.0005566,-0.000378606,0,0,0,0,0,0
+V_pop,0.000473914,-6.7158e-05,0.000747619,0.000415589,3.74473e-06,-3.84893e-06,0,0,0,0,0,0
+beta_V_lw70,1.54432e-05,-0.00113404,0.000415589,0.0196842,3.01043e-06,-0.000100056,0,0,0,0,0,0
+Cl_pop,0.000326,-0.0005566,3.74473e-06,3.01043e-06,0.00227119,0.00107934,0,0,0,0,0,0
+beta_Cl_lw70,0.000178914,-0.000378606,-3.84893e-06,-0.000100056,0.00107934,0.0640008,0,0,0,0,0,0
+omega_Tlag,0,0,0,0,0,0,0.0291894,-0.00343737,-6.48704e-06,-4.91057e-06,-1.74064e-05,-8.02968e-06
+omega_ka,0,0,0,0,0,0,-0.00343737,0.0564237,-1.26907e-05,-1.21018e-05,0.00033099,-0.000122172
+omega_V,0,0,0,0,0,0,-6.48704e-06,-1.26907e-05,0.000459806,5.09936e-07,5.69829e-06,-1.08887e-05
+omega_Cl,0,0,0,0,0,0,-4.91057e-06,-1.21018e-05,5.09936e-07,0.00116105,-1.45641e-05,4.00012e-07
+a,0,0,0,0,0,0,-1.74064e-05,0.00033099,5.69829e-06,-1.45641e-05,0.00181589,-0.00029542
+b,0,0,0,0,0,0,-8.02968e-06,-0.000122172,-1.08887e-05,4.00012e-07,-0.00029542,7.57636e-05
diff --git a/inst/cov/w2/IndividualParameters/estimatedIndividualParameters.txt b/inst/cov/w2/IndividualParameters/estimatedIndividualParameters.txt
new file mode 100644
index 0000000..faff301
--- /dev/null
+++ b/inst/cov/w2/IndividualParameters/estimatedIndividualParameters.txt
@@ -0,0 +1,33 @@
+id,Tlag_SAEM,ka_SAEM,V_SAEM,Cl_SAEM,Tlag_mean,ka_mean,V_mean,Cl_mean,Tlag_mode,ka_mode,V_mode,Cl_mode,Tlag_sd,ka_sd,V_sd,Cl_sd,wt,lw70,sex
+1,0.894318,2.00846,7.68724,0.1121,0.852572,1.85731,7.73021,0.112232,0.78676,1.33175,7.66249,0.111648,0.520593,2.04211,0.523183,0.00540649,66.7,-0.048290289127781,1
+2,0.73402,0.995412,8.40026,0.128283,0.781474,0.966512,8.28379,0.12831,0.646496,0.831658,8.27001,0.128692,0.222959,0.292555,0.385693,0.00650258,66.7,-0.048290289127781,1
+3,0.871729,1.78155,8.57915,0.11213,0.874504,1.6932,8.60462,0.111619,0.838104,0.954601,8.53476,0.112757,0.424311,2.12775,0.321348,0.00548048,80,0.1335313926245226,1
+4,0.762989,2.47099,5.01674,0.0715048,0.733781,2.2144,5.01988,0.0716595,0.790545,1.3296,5.01088,0.0720812,0.329198,1.32278,0.196684,0.00373134,40,-0.5596157879354228,0
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+18,0.903242,1.9432,8.47546,0.1806,0.817919,1.9359,8.4113,0.18054,0.771854,1.39298,8.30923,0.179122,0.465673,1.61,0.631396,0.00913523,74.7,0.0649848500894127,1
+19,0.90429,2.10205,8.66206,0.184114,0.921649,2.28936,8.71639,0.183226,0.734972,1.54885,8.53414,0.182554,0.563668,1.75691,0.789907,0.0102373,63.7,-0.0943106794712413,1
+20,0.925361,1.96894,6.93217,0.0951867,0.951411,1.87428,6.91584,0.0950784,0.79113,1.31399,6.8006,0.0945609,0.540956,1.82776,0.48248,0.00546994,59,-0.1709577981436395,1
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+31,0.890204,1.78887,9.74655,0.140819,0.879047,1.82509,9.88145,0.141797,0.777414,1.36994,9.75418,0.140003,0.548397,2.26706,0.728458,0.00743931,83.3,0.173953307123438,1
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diff --git a/inst/cov/w2/IndividualParameters/estimatedRandomEffects.txt b/inst/cov/w2/IndividualParameters/estimatedRandomEffects.txt
new file mode 100644
index 0000000..5c361ef
--- /dev/null
+++ b/inst/cov/w2/IndividualParameters/estimatedRandomEffects.txt
@@ -0,0 +1,33 @@
+id,eta_Tlag_SAEM,eta_ka_SAEM,eta_V_SAEM,eta_Cl_SAEM,eta_Tlag_mean,eta_ka_mean,eta_V_mean,eta_Cl_mean,eta_Tlag_mode,eta_ka_mode,eta_V_mode,eta_Cl_mode,eta_Tlag_sd,eta_ka_sd,eta_V_sd,eta_Cl_sd,wt,lw70,sex
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diff --git a/inst/cov/w2/IndividualParameters/simulatedIndividualParameters.txt b/inst/cov/w2/IndividualParameters/simulatedIndividualParameters.txt
new file mode 100644
index 0000000..fd19122
--- /dev/null
+++ b/inst/cov/w2/IndividualParameters/simulatedIndividualParameters.txt
@@ -0,0 +1,321 @@
+rep,id,Tlag,ka,V,Cl,wt,lw70,sex
+1,1,1.07069,0.631494,8.38046,0.114781,66.7,-0.048290289127781,1
+2,1,0.954213,0.823106,7.55206,0.108375,66.7,-0.048290289127781,1
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+6,1,2.41082,0.363265,7.51919,0.11732,66.7,-0.048290289127781,1
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+8,1,0.666293,2.93206,6.77009,0.116231,66.7,-0.048290289127781,1
+9,1,1.4967,1.20639,8.06675,0.127493,66.7,-0.048290289127781,1
+10,1,0.255177,1.71599,6.64034,0.106396,66.7,-0.048290289127781,1
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diff --git a/inst/cov/w2/IndividualParameters/simulatedRandomEffects.txt b/inst/cov/w2/IndividualParameters/simulatedRandomEffects.txt
new file mode 100644
index 0000000..90f7f69
--- /dev/null
+++ b/inst/cov/w2/IndividualParameters/simulatedRandomEffects.txt
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+4,28,-0.567064,0.458335,0.0649352,0.0054472,80,0.1335313926245226,1
+5,28,0.040144,-0.204218,0.00510182,-0.066748,80,0.1335313926245226,1
+6,28,-0.00920913,0.747784,-0.0287276,-0.0411955,80,0.1335313926245226,1
+7,28,0.110756,-0.279932,0.0622654,-0.0266725,80,0.1335313926245226,1
+8,28,0.230335,0.657646,0.0148706,-0.0487559,80,0.1335313926245226,1
+9,28,-0.3776,-0.159549,-0.0606906,0.0397378,80,0.1335313926245226,1
+10,28,0.0070032,-0.814794,-0.115189,-0.0670912,80,0.1335313926245226,1
+1,29,0.0705182,0.216956,0.113667,0.12763,102,0.376477571234912,1
+2,29,0.372014,0.0377306,0.112845,0.0180967,102,0.376477571234912,1
+3,29,0.415727,-0.277494,0.143999,0.145512,102,0.376477571234912,1
+4,29,0.45818,0.587142,0.135629,0.145365,102,0.376477571234912,1
+5,29,-0.491046,0.825568,0.195564,0.0709096,102,0.376477571234912,1
+6,29,-0.743708,0.713502,0.178574,0.0890766,102,0.376477571234912,1
+7,29,-0.85657,-1.19571,0.320939,0.0887734,102,0.376477571234912,1
+8,29,-0.570464,0.17825,0.248765,0.135531,102,0.376477571234912,1
+9,29,-0.380732,1.99304,0.237814,0.102938,102,0.376477571234912,1
+10,29,-0.115224,-0.988961,0.149595,0.144793,102,0.376477571234912,1
+1,30,0.657604,0.701421,0.0191732,-0.0297894,70,0,1
+2,30,0.335907,-0.647622,0.0162082,-0.174312,70,0,1
+3,30,0.332873,0.075166,-0.0930779,-0.0139123,70,0,1
+4,30,-0.525708,0.233473,-0.131934,-0.0862331,70,0,1
+5,30,0.805208,-0.214848,0.00294079,-0.0615019,70,0,1
+6,30,0.235608,0.248431,-0.0735323,-0.0900084,70,0,1
+7,30,-0.39697,-0.245604,0.0781214,-0.0785495,70,0,1
+8,30,0.272146,-1.58973,-0.0658926,-0.00534099,70,0,1
+9,30,0.915317,-0.319961,-0.0161664,-0.0834405,70,0,1
+10,30,-0.799582,-0.066456,-0.0646038,-0.09332,70,0,1
+1,31,0.317066,-1.17424,0.0564764,0.0351786,83.3,0.173953307123438,1
+2,31,-0.488808,0.663349,0.175785,-0.112935,83.3,0.173953307123438,1
+3,31,-0.581544,1.85109,0.0459868,-0.142161,83.3,0.173953307123438,1
+4,31,0.353581,-1.90067,0.144095,0.0532159,83.3,0.173953307123438,1
+5,31,0.703705,0.135293,0.0611618,-0.0342347,83.3,0.173953307123438,1
+6,31,-0.694727,0.557091,-0.0802575,-0.0524605,83.3,0.173953307123438,1
+7,31,-1.41351,-0.383109,0.0762769,-0.0690502,83.3,0.173953307123438,1
+8,31,0.271656,-0.101989,-0.055275,-0.140255,83.3,0.173953307123438,1
+9,31,-0.147722,-0.463851,0.0484996,0.0246371,83.3,0.173953307123438,1
+10,31,-0.205449,-0.995633,0.103073,-0.0755618,83.3,0.173953307123438,1
+1,32,-0.418853,2.32919,0.036615,-0.148455,62,-0.1213608570042675,1
+2,32,0.25178,-0.985682,0.104182,-0.173013,62,-0.1213608570042675,1
+3,32,-0.0124952,1.27908,-0.0836453,-0.127455,62,-0.1213608570042675,1
+4,32,-0.495639,-1.40609,0.131642,-0.174712,62,-0.1213608570042675,1
+5,32,0.304362,-2.57681,-0.0714898,-0.0255452,62,-0.1213608570042675,1
+6,32,0.024881,-0.516274,0.0950118,-0.205584,62,-0.1213608570042675,1
+7,32,-0.322468,1.91803,0.169039,-0.1744,62,-0.1213608570042675,1
+8,32,-0.117559,0.484531,0.0519504,-0.1814,62,-0.1213608570042675,1
+9,32,-0.373043,-0.194652,0.0909151,-0.252161,62,-0.1213608570042675,1
+10,32,0.952961,0.753635,0.0314078,-0.157864,62,-0.1213608570042675,1
diff --git a/inst/cov/w2/LogLikelihood/individualLL.txt b/inst/cov/w2/LogLikelihood/individualLL.txt
new file mode 100644
index 0000000..27e59e8
--- /dev/null
+++ b/inst/cov/w2/LogLikelihood/individualLL.txt
@@ -0,0 +1,33 @@
+id,linearization
+1,10.023007
+2,25.399805
+3,25.074543
+4,22.552924
+5,14.929574
+6,38.001445
+7,45.299347
+8,29.851534
+9,10.944949
+10,39.134500
+11,41.554462
+12,38.470126
+13,36.598471
+14,24.694871
+15,26.880481
+16,11.464666
+17,10.019696
+18,13.360782
+19,10.410076
+20,11.710218
+21,11.437087
+22,17.336472
+23,8.987713
+24,12.882689
+25,14.198689
+26,9.812692
+27,13.117082
+28,10.854955
+29,9.318614
+30,9.575680
+31,8.658680
+32,9.475203
diff --git a/inst/cov/w2/LogLikelihood/logLikelihood.txt b/inst/cov/w2/LogLikelihood/logLikelihood.txt
new file mode 100644
index 0000000..de8b3cf
--- /dev/null
+++ b/inst/cov/w2/LogLikelihood/logLikelihood.txt
@@ -0,0 +1,6 @@
+criteria,linearization
+OFV,622.031033
+AIC,646.031033
+BIC,663.619863
+BICc,675.881778
+standardError,
diff --git a/inst/cov/w2/Tests/correlationIndividualParametersCovariates.txt b/inst/cov/w2/Tests/correlationIndividualParametersCovariates.txt
new file mode 100644
index 0000000..a5b34ff
--- /dev/null
+++ b/inst/cov/w2/Tests/correlationIndividualParametersCovariates.txt
@@ -0,0 +1,3 @@
+parameter,covariate,statistics,p-value,test
+V,beta_V_lw70,7.29371,4.02359e-08,t-Test
+Cl,beta_Cl_lw70,2.38242,0.0237378,t-Test
diff --git a/inst/cov/w2/Tests/correlationRandomEffects.txt b/inst/cov/w2/Tests/correlationRandomEffects.txt
new file mode 100644
index 0000000..685fdaa
--- /dev/null
+++ b/inst/cov/w2/Tests/correlationRandomEffects.txt
@@ -0,0 +1,7 @@
+eta1,eta2,coeff,statistics,p-value
+eta_Tlag,eta_ka,0,-0.641528,0.525895
+eta_Tlag,eta_V,0,-0.573634,0.570354
+eta_Tlag,eta_Cl,0,-0.191715,0.849216
+eta_ka,eta_V,0,0.699169,0.489659
+eta_ka,eta_Cl,0,-0.158768,0.874881
+eta_V,eta_Cl,0,0.81866,0.419229
diff --git a/inst/cov/w2/Tests/correlationRandomEffectsCovariates.txt b/inst/cov/w2/Tests/correlationRandomEffectsCovariates.txt
new file mode 100644
index 0000000..b090079
--- /dev/null
+++ b/inst/cov/w2/Tests/correlationRandomEffectsCovariates.txt
@@ -0,0 +1,13 @@
+eta,covariate,statistics,p-value,test
+eta_Tlag,sex,0.453562,0.505804,Anova
+eta_Tlag,lw70,-0.242794,0.809817,Pearson
+eta_Tlag,wt,-0.391216,0.698402,Pearson
+eta_ka,sex,0.0280049,0.86822,Anova
+eta_ka,lw70,0.87679,0.387568,Pearson
+eta_ka,wt,1.08569,0.286264,Pearson
+eta_V,sex,0.401503,0.531116,Anova
+eta_V,lw70,0.178538,0.859501,Pearson
+eta_V,wt,0.196944,0.8452,Pearson
+eta_Cl,sex,0.634432,0.431993,Anova
+eta_Cl,lw70,0.0323859,0.974379,Pearson
+eta_Cl,wt,-0.0465223,0.963202,Pearson
diff --git a/inst/cov/w2/Tests/fixedEffects.txt b/inst/cov/w2/Tests/fixedEffects.txt
new file mode 100644
index 0000000..e1c98e8
--- /dev/null
+++ b/inst/cov/w2/Tests/fixedEffects.txt
@@ -0,0 +1,3 @@
+parameter,statistics(lin),p-value(lin)
+beta_V_lw70,6.40734,1.48e-10
+beta_Cl_lw70,2.35281,0.0186
diff --git a/inst/cov/w2/Tests/normalityIndividualParameters.txt b/inst/cov/w2/Tests/normalityIndividualParameters.txt
new file mode 100644
index 0000000..554ce19
--- /dev/null
+++ b/inst/cov/w2/Tests/normalityIndividualParameters.txt
@@ -0,0 +1,5 @@
+parameter,statistics,p-value,test
+Tlag,0.977027,0.959754,Shapiro-Wilk
+ka,0.977932,0.998599,Shapiro-Wilk
+V,0.0936126,0.0795308,Kolmogorov-Smirnov
+Cl,0.0998117,0.319972,Kolmogorov-Smirnov
diff --git a/inst/cov/w2/Tests/normalityRandomEffects.txt b/inst/cov/w2/Tests/normalityRandomEffects.txt
new file mode 100644
index 0000000..54cbc63
--- /dev/null
+++ b/inst/cov/w2/Tests/normalityRandomEffects.txt
@@ -0,0 +1,5 @@
+eta,statistics,p-value
+eta_Tlag,0.977027,0.959754
+eta_ka,0.977932,0.998599
+eta_V,0.965041,0.665704
+eta_Cl,0.89831,0.00611602
diff --git a/inst/cov/w2/Tests/normalityResiduals.txt b/inst/cov/w2/Tests/normalityResiduals.txt
new file mode 100644
index 0000000..290abd8
--- /dev/null
+++ b/inst/cov/w2/Tests/normalityResiduals.txt
@@ -0,0 +1,4 @@
+residuals,statistics,p-value,test
+IWRES_concentration,0.990539,0.0710422,Shapiro-Wilk
+PWRES_concentration,0.979495,0.00122581,Shapiro-Wilk
+NPDE_concentration,0.973912,0.000165811,Shapiro-Wilk
diff --git a/inst/cov/w2/Tests/symmetryResiduals.txt b/inst/cov/w2/Tests/symmetryResiduals.txt
new file mode 100644
index 0000000..65b3682
--- /dev/null
+++ b/inst/cov/w2/Tests/symmetryResiduals.txt
@@ -0,0 +1,4 @@
+residuals,statistics,p-value,test
+IWRES_concentration,0.179912,0.857222,Symmetry
+PWRES_concentration,-4.65912,3.17561e-06,Symmetry
+NPDE_concentration,-4.46463,8.02065e-06,Symmetry
diff --git a/inst/cov/w2/populationParameters.txt b/inst/cov/w2/populationParameters.txt
new file mode 100644
index 0000000..d13bc63
--- /dev/null
+++ b/inst/cov/w2/populationParameters.txt
@@ -0,0 +1,13 @@
+parameter,value,CV,se_lin,rse_lin
+Tlag_pop,0.780016055663023,,0.17837065691411,22.8675622276124
+ka_pop,1.35928759069304,,0.410771702678662,30.2196316284495
+V_pop,8.0607521386391,,0.22040205773655,2.73426169104066
+beta_V_lw70,0.898951301623242,,0.140300259496287,15.6071034374104
+Cl_pop,0.133622588749826,,0.00636805640551266,4.76570351247663
+beta_Cl_lw70,0.595223300469559,,0.252983840620238,42.5023416288751
+omega_Tlag,0.541595485175291,58.3848784310045,0.170849072479768,31.5455126854448
+omega_ka,0.850145400049819,102.960425004182,0.237536679119416,27.9407121541204
+omega_V,0.136594432002439,13.7234061647908,0.0214430916253883,15.6983643557341
+omega_Cl,0.263663140318272,26.8312553840452,0.0340742392287991,12.9233988443237
+a,0.238670616593435,,0.0426132443515246,17.8544158303803
+b,0.0526737305673756,,0.00870422703536792,16.5247969749062
\ No newline at end of file
diff --git a/inst/cov/w2/predictions.txt b/inst/cov/w2/predictions.txt
new file mode 100644
index 0000000..12e299a
--- /dev/null
+++ b/inst/cov/w2/predictions.txt
@@ -0,0 +1,248 @@
+id,time,concentration,popPred_medianCOV,popPred,indivPred_SAEM,indivPred_mean,indivPred_mode,indWRes_SAEM,indWRes_mean,indWRes_mode
+1,24,9.2,8.3931,8.87664,9.3554,9.31675,9.40839,-0.212447,-0.160063,-0.283814
+1,36,8.5,6.88863,7.25406,7.85351,7.82709,7.89914,0.991019,1.03372,0.917704
+1,48,6.4,5.65385,5.92807,6.59274,6.57562,6.63199,-0.328944,-0.300184,-0.39454
+1,72,4.8,3.80861,3.95893,4.6459,4.64097,4.6749,0.318796,0.329172,0.25798
+1,96,3.1,2.56559,2.64388,3.27396,3.27552,3.29535,-0.423136,-0.426849,-0.473856
+1,120,2.5,1.72826,1.76566,2.30716,2.31181,2.3229,0.53538,0.522103,0.490558
+2,0.5,0.02,0,0,0,0,0,0.0837975,0.0837975,0.0837975
+2,2,8.4,9.7132,10.3535,8.42963,8.26058,8.06772,-0.0434014,0.20692,0.500707
+2,3,9.7,11.2574,11.9959,10.4115,10.4166,10.1389,-0.903966,-0.910164,-0.56802
+2,6,9.8,11.2775,12.0049,11.0917,11.2366,11.1939,-1.5697,-1.72972,-1.68287
+2,12,11,10.2261,10.8622,10.1788,10.3112,10.3259,1.05987,0.880982,0.861427
+2,24,8.3,8.3931,8.87664,8.47454,8.56246,8.5678,-0.254785,-0.380544,-0.388135
+2,36,7.7,6.88863,7.25406,7.05553,7.1101,7.10839,1.05597,0.962032,0.964963
+2,48,6.3,5.65385,5.92807,5.87412,5.90408,5.89756,0.77704,0.720291,0.732614
+2,72,4.1,3.80861,3.95893,4.07164,4.07105,4.05953,0.0625917,0.063886,0.0894373
+2,96,3,2.56559,2.64388,2.82225,2.80712,2.79434,0.458912,0.499002,0.532999
+2,120,1.4,1.72826,1.76566,1.95624,1.9356,1.92346,-1.6278,-1.57239,-1.53964
+3,3,12,13.5089,12.2421,13.3863,13.287,12.0456,-1.46893,-1.37131,-0.052275
+3,6,13.2,13.533,12.2832,13.1758,13.1473,13.2143,0.0259928,0.056646,-0.0152941
+3,9,14.4,12.8924,11.7208,12.6706,12.6477,12.7942,1.90868,1.93649,1.75964
+3,24,9.6,10.0717,9.23138,10.4149,10.4114,10.499,-1.03505,-1.03086,-1.13551
+3,36,8.2,8.26636,7.62622,8.90304,8.91053,8.95972,-0.993519,-1.00354,-1.06911
+3,48,7.8,6.78462,6.30016,7.61068,7.62604,7.64614,0.296018,0.271651,0.239876
+3,72,5.8,4.57033,4.29968,5.56152,5.58587,5.56849,0.448588,0.401817,0.43518
+3,96,4.3,3.07871,2.93441,4.0641,4.0915,4.05539,0.521056,0.459063,0.540828
+3,120,3,2.07392,2.00265,2.96985,2.99691,2.95344,0.0763146,0.00778329,0.118099
+4,3,11.1,6.75444,11.3463,11.604,11.5675,11.0848,-0.593046,-0.551307,0.0184484
+4,6,11.9,6.76651,11.2626,11.1641,11.1587,11.2191,0.890147,0.89696,0.820766
+4,9,9.8,6.44618,10.6275,10.6968,10.691,10.7564,-1.11806,-1.11127,-1.18767
+4,12,11,6.13567,10.0193,10.2491,10.2428,10.3023,0.964569,0.972961,0.893012
+4,24,8.5,5.03586,7.91481,8.63779,8.63028,8.66892,-0.198642,-0.187929,-0.242952
+4,36,7.6,4.13318,6.25235,7.27983,7.27159,7.29453,0.514636,0.528245,0.490395
+4,48,5.4,3.39231,4.93908,6.13536,6.12681,6.13804,-1.30883,-1.29465,-1.31328
+4,72,4.5,2.28516,3.08214,4.3579,4.34954,4.34605,0.303489,0.321649,0.329245
+4,96,3.3,1.53936,1.92335,3.09539,3.08782,3.07722,0.50935,0.5287,0.555885
+4,120,2.3,1.03696,1.20023,2.19863,2.19211,2.17883,0.285967,0.304667,0.342828
+5,6,8.6,12.7436,12.1975,9.29154,9.30985,9.30593,-0.949801,-0.973657,-0.968554
+5,12,8.6,11.5555,11.0768,8.46031,8.46886,8.47856,0.204136,0.191518,0.17721
+5,24,7,9.4842,9.11839,7.01412,7.0073,7.0327,-0.0232145,-0.0120162,-0.0536768
+5,36,5.7,7.78416,7.50621,5.81514,5.79798,5.83339,-0.211268,-0.180094,-0.244338
+5,48,4.7,6.38885,6.17908,4.82111,4.79737,4.83861,-0.245844,-0.198161,-0.280852
+5,72,3.3,4.30373,4.18725,3.31376,3.2844,3.32905,-0.0332881,0.0379055,-0.0701534
+5,96,2.3,2.89912,2.83749,2.27769,2.24858,2.29044,0.0622135,0.143998,0.0266102
+5,120,1.7,1.95294,1.92283,1.56555,1.53943,1.57586,0.418662,0.502161,0.385915
+6,3,13.4,10.1317,11.8638,13.6784,13.5865,13.2759,-0.290271,-0.195435,0.132267
+6,6,12.4,10.1498,11.8538,12.2612,12.2027,12.2715,0.156895,0.223846,0.145172
+6,9,12.7,9.66928,11.2619,10.9592,10.9158,10.9825,2.13353,2.19288,2.10179
+6,12,8.8,9.20351,10.6902,9.79541,9.76455,9.82569,-1.31907,-1.28093,-1.35633
+6,24,6.1,7.55379,8.67871,6.25172,6.25235,6.29513,-0.267121,-0.268226,-0.342185
+6,36,3.5,6.19977,7.04568,3.99003,4.00345,4.03317,-1.09177,-1.11991,-1.18191
+6,48,1.8,5.08846,5.71993,2.54655,2.56346,2.58398,-2.00252,-2.04298,-2.09184
+6,72,1.5,3.42775,3.76987,1.0373,1.05101,1.06065,1.5775,1.527,1.49165
+6,96,1,2.30904,2.48463,0.422532,0.430915,0.435368,2.21314,2.17733,2.15836
+7,2,17.6,13.1128,10.6891,16.1118,16.2046,16.0081,1.36863,1.2776,1.47143
+7,3,17.3,15.1975,12.3997,15.8132,15.9027,15.857,1.3874,1.2982,1.34366
+7,6,15,15.2246,12.4615,14.8437,14.9242,14.8828,0.153105,0.0739809,0.114611
+7,9,15,14.5039,11.9108,13.9333,14.0055,13.9623,1.09671,1.01855,1.06526
+7,12,12.4,13.8053,11.3747,13.0788,13.1434,13.0987,-0.731772,-0.798464,-0.75245
+7,24,7.9,11.3307,9.4601,10.1535,10.1938,10.1466,-2.91336,-2.95742,-2.90584
+7,36,7.9,9.29966,7.86781,7.88245,7.90621,7.85978,0.0268417,-0.00948169,0.0616216
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+28,72,4.9,4.57033,4.29968,4.54465,4.59158,4.57687,0.74332,0.641828,0.673532
+28,96,3.4,3.07871,2.93441,3.13765,3.19409,3.1565,0.649476,0.506026,0.601331
+28,120,2,2.07392,2.00265,2.16625,2.22194,2.17692,-0.471256,-0.623931,-0.500716
+29,24,8.3,12.8414,9.70468,8.36908,8.3578,8.4347,-0.101663,-0.0851422,-0.197226
+29,36,7,10.5396,8.12689,7.03744,7.02219,7.07704,-0.0614489,-0.0364694,-0.125996
+29,48,5.6,8.65039,6.80562,5.91769,5.90002,5.93791,-0.577222,-0.546039,-0.612779
+29,72,4.1,5.82717,4.7726,4.18434,4.165,4.18021,-0.183712,-0.141898,-0.174803
+29,96,3.1,3.92536,3.34689,2.9587,2.94019,2.94281,0.358155,0.406071,0.399283
+29,120,2.2,2.64424,2.34708,2.09207,2.07557,2.0717,0.309379,0.35756,0.368899
+30,24,9.9,8.81275,8.97378,9.27959,9.2211,9.37071,0.852849,0.93722,0.722821
+30,36,7.5,7.23307,7.35503,7.68501,7.64123,7.74025,-0.287521,-0.220264,-0.371688
+30,48,6.5,5.93654,6.02828,6.36444,6.33204,6.39349,0.2362,0.293538,0.185099
+30,72,4.1,3.99904,4.04959,4.36508,4.34815,4.36218,-0.56569,-0.530565,-0.559676
+30,96,2.9,2.69387,2.72037,2.99381,2.98583,2.97624,-0.236671,-0.216773,-0.19281
+30,120,2.3,1.81468,1.82745,2.05332,2.05034,2.03065,0.711261,0.720166,0.77931
+31,24,9.5,10.4914,9.31345,9.2592,9.15012,9.27974,0.331504,0.485514,0.302777
+31,36,7.8,8.61079,7.71197,7.78533,7.70269,7.81149,0.0226153,0.151012,-0.0176729
+31,48,6.4,7.06731,6.38587,6.54607,6.48422,6.57555,-0.250338,-0.145156,-0.300068
+31,72,4.5,4.76076,4.37854,4.62794,4.59504,4.65938,-0.265184,-0.197703,-0.329232
+31,96,3.4,3.20699,3.00219,3.27186,3.25627,3.3016,0.311776,0.350401,0.238501
+31,120,2.5,2.16033,2.05849,2.31314,2.30755,2.33949,0.518329,0.534256,0.443529
+32,24,8.9,7.80558,8.74126,8.99799,8.9388,9.07907,-0.137501,-0.0546787,-0.249783
+32,36,7.7,6.40643,7.11114,7.6333,7.59257,7.69221,0.10409,0.168222,0.0120924
+32,48,6.9,5.25808,5.78501,6.4756,6.4491,6.51721,0.732026,0.779609,0.657772
+32,72,4.4,3.542,3.82854,4.6603,4.65285,4.67823,-0.537657,-0.522683,-0.573562
+32,96,3.5,2.386,2.53375,3.35389,3.3569,3.35816,0.351791,0.3444,0.341321
+32,120,2.5,1.60729,1.67685,2.4137,2.42192,2.41058,0.235916,0.213204,0.244553
diff --git a/inst/cov/w2/summary.txt b/inst/cov/w2/summary.txt
new file mode 100644
index 0000000..a1413f9
--- /dev/null
+++ b/inst/cov/w2/summary.txt
@@ -0,0 +1,119 @@
+********************************************************************************
+*                     warfarin_covariate2_project.mlxtran                      *
+*                     May 09, 2024 at 20:54:57                                 *
+*                     Monolix version : 2023R1                                 *
+********************************************************************************
+
+
+ESTIMATION OF THE POPULATION PARAMETERS ________________________________________
+
+Fixed Effects ----------------------------    se_lin    rse(%)
+Tlag_pop     :                        0.78     0.178      22.9
+ka_pop       :                        1.36     0.411      30.2
+V_pop        :                        8.06      0.22      2.73
+beta_V_lw70  :                       0.899      0.14      15.6
+Cl_pop       :                       0.134   0.00637      4.77
+beta_Cl_lw70 :                       0.595     0.253      42.5
+
+Standard Deviation of the Random Effects -
+omega_Tlag   :                       0.542     0.171      31.5
+omega_ka     :                        0.85     0.238      27.9
+omega_V      :                       0.137    0.0214      15.7
+omega_Cl     :                       0.264    0.0341      12.9
+
+Error Model Parameters -------------------
+a            :                       0.239    0.0426      17.9
+b            :                      0.0527    0.0087      16.5
+
+Elapsed time (seconds):      4.1
+CPU time     (seconds):        5
+Exploratory phase iterations:      212 (Autostop)
+Smoothing phase iterations:         97 (Autostop)
+
+ _______________________________________________________________________________
+
+
+
+ESTIMATION OF THE INDIVIDUAL PARAMETERS ________________________________________
+
+
+Estimation of the individual parameters by Conditional Distribution ------------
+             min        Q1    median        Q3       max
+Tlag :     0.555     0.821     0.882     0.933      2.77
+ka   :     0.305      1.75      1.91      2.14      4.53
+V    :      5.02       7.1      8.06      8.82      13.2
+Cl   :    0.0717     0.108     0.127     0.163     0.282
+
+Elapsed time (seconds):     0.74
+CPU time     (seconds):     0.92
+Iterations:       77 (Autostop)
+
+ -------------------------------------------------------------------------------
+
+
+Estimation of the individual parameters by Conditional Mode --------------------
+             min        Q1    median        Q3       max
+Tlag :     0.551     0.753     0.784     0.806      2.76
+ka   :     0.291      1.25      1.34       1.5      3.34
+V    :      5.01      7.02      7.97      8.75        13
+Cl   :    0.0721     0.108     0.127     0.164     0.286
+
+Elapsed time (seconds):    0.057
+CPU time     (seconds):        0
+
+ -------------------------------------------------------------------------------
+
+ _______________________________________________________________________________
+
+
+
+ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________
+
+
+Estimation of the Fisher information matrix by Linearization -------------------
+
+Correlation Matrix :
+    Tlag_pop         1
+      ka_pop   0.26183         1
+       V_pop  0.075795-0.0081277         1
+ beta_V_lw700.00048135 -0.026747   0.10833         1
+      Cl_pop  0.029914 -0.038648 0.00287380.00045024         1
+beta_Cl_lw70 0.0030927-0.0049523-0.00055643 -0.002819  0.089524         1
+  omega_Tlag         0         0         0         0         0         0         1
+    omega_ka         0         0         0         0         0         0   -0.0847         1
+     omega_V         0         0         0         0         0         0-0.0017707-0.0024915         1
+    omega_Cl         0         0         0         0         0         0-0.00084352-0.00149520.00069791         1
+           a         0         0         0         0         0         0-0.0023909  0.032699 0.0062361  -0.01003         1
+           b         0         0         0         0         0         0-0.0053995 -0.059089 -0.058339 0.0013487  -0.79646         1
+
+                               min       max   max/min
+Eigen values           :       0.2       1.8         9
+
+Elapsed time (seconds):    0.005
+CPU time     (seconds):        0
+
+ -------------------------------------------------------------------------------
+
+ _______________________________________________________________________________
+
+
+
+ESTIMATION OF THE LOG-LIKELIHOOD _______________________________________________
+
+                                                           (lin)
+-2 x log-likelihood                       (OFV) :         622.03
+Akaike Information Criteria               (AIC) :         646.03
+Corrected Bayesian Information Criteria  (BICc) :         675.88
+Bayesian Information Criteria             (BIC) :         663.62
+
+Elapsed time                          (seconds) :           0.00
+CPU time                              (seconds) :           0.00
+
+ _______________________________________________________________________________
+
+DATASET INFORMATION
+Number of individuals: 32
+Number of observations (obsid 1): 247
+Number of observations (obsid 2): 232
+Number of doses: 32
+
diff --git a/inst/cov/w3/FisherInformation/correlationEstimatesSA.txt b/inst/cov/w3/FisherInformation/correlationEstimatesSA.txt
new file mode 100644
index 0000000..0375137
--- /dev/null
+++ b/inst/cov/w3/FisherInformation/correlationEstimatesSA.txt
@@ -0,0 +1,12 @@
+Tlag_pop,1,0.0360747,-0.000248501,0.0299896,0.0167871,0.00133725,-0.74399,-0.191912,-0.0228334,-0.0216767,0.045628,-0.0222808
+ka_pop,0.0360747,1,-0.0699077,0.0388781,-0.059607,0.018762,0.0378008,0.148057,0.0265794,0.0126461,-0.0238185,0.0202836
+V_pop,-0.000248501,-0.0699077,1,-0.416163,0.00729685,-0.00300831,0.029266,0.0217827,0.00610173,-0.00388959,-0.0312685,0.0454156
+beta_V_tSex_F,0.0299896,0.0388781,-0.416163,1,-0.00394288,-0.000107724,-0.0410955,-0.0197238,-0.000791073,0.00325253,-0.00017444,-0.00756661
+Cl_pop,0.0167871,-0.059607,0.00729685,-0.00394288,1,-0.396499,0.000789918,0.0372423,-0.01383,-0.00155349,0.0171267,-0.013832
+beta_Cl_tSex_F,0.00133725,0.018762,-0.00300831,-0.000107724,-0.396499,1,-0.00715013,-0.0195038,0.00584487,-0.0060485,0.0096107,-0.00437649
+omega_Tlag,-0.74399,0.0378008,0.029266,-0.0410955,0.000789918,-0.00715013,1,0.155201,0.0338494,0.0152551,-0.0587083,0.0220399
+omega_ka,-0.191912,0.148057,0.0217827,-0.0197238,0.0372423,-0.0195038,0.155201,1,-0.0375831,-0.0203223,-0.039965,0.0205156
+omega_V,-0.0228334,0.0265794,0.00610173,-0.000791073,-0.01383,0.00584487,0.0338494,-0.0375831,1,0.00332933,-0.0364158,-0.022802
+omega_Cl,-0.0216767,0.0126461,-0.00388959,0.00325253,-0.00155349,-0.0060485,0.0152551,-0.0203223,0.00332933,1,0.0413831,-0.047834
+a,0.045628,-0.0238185,-0.0312685,-0.00017444,0.0171267,0.0096107,-0.0587083,-0.039965,-0.0364158,0.0413831,1,-0.746091
+b,-0.0222808,0.0202836,0.0454156,-0.00756661,-0.013832,-0.00437649,0.0220399,0.0205156,-0.022802,-0.047834,-0.746091,1
diff --git a/inst/cov/w3/FisherInformation/covarianceEstimatesSA.txt b/inst/cov/w3/FisherInformation/covarianceEstimatesSA.txt
new file mode 100644
index 0000000..f9b33a0
--- /dev/null
+++ b/inst/cov/w3/FisherInformation/covarianceEstimatesSA.txt
@@ -0,0 +1,12 @@
+Tlag_pop,0.116829,0.00381408,-3.00146e-06,0.00087222,0.000321585,6.45183e-05,-0.0869622,-0.0172905,-0.000199902,-0.00027062,0.000596188,-5.73116e-05
+ka_pop,0.00381408,0.0956804,-0.000764125,0.00102328,-0.00103337,0.000819193,0.00399853,0.0120718,0.000210585,0.000142875,-0.000281646,4.72163e-05
+V_pop,-3.00146e-06,-0.000764125,0.00124869,-0.00125133,1.44514e-05,-1.50053e-05,0.000353655,0.000202894,5.5227e-06,-5.0202e-06,-4.22388e-05,1.20773e-05
+beta_V_tSex_F,0.00087222,0.00102328,-0.00125133,0.00724034,-1.88035e-05,-1.29385e-06,-0.00119581,-0.000442385,-1.72411e-06,1.01086e-05,-5.67417e-07,-4.84525e-06
+Cl_pop,0.000321585,-0.00103337,1.44514e-05,-1.88035e-05,0.00314118,-0.00313677,1.51396e-05,0.000550191,-1.98536e-05,-3.18012e-06,3.6694e-05,-5.83399e-06
+beta_Cl_tSex_F,6.45183e-05,0.000819193,-1.50053e-05,-1.29385e-06,-0.00313677,0.0199246,-0.00034514,-0.000725679,2.11319e-05,-3.1184e-05,5.18592e-05,-4.64896e-06
+omega_Tlag,-0.0869622,0.00399853,0.000353655,-0.00119581,1.51396e-05,-0.00034514,0.116943,0.0139898,0.000296489,0.000190543,-0.000767474,5.67197e-05
+omega_ka,-0.0172905,0.0120718,0.000202894,-0.000442385,0.000550191,-0.000725679,0.0139898,0.0694802,-0.000253742,-0.000195656,-0.000402704,4.06959e-05
+omega_V,-0.000199902,0.000210585,5.5227e-06,-1.72411e-06,-1.98536e-05,2.11319e-05,0.000296489,-0.000253742,0.000656055,3.1147e-06,-3.56563e-05,-4.39519e-06
+omega_Cl,-0.00027062,0.000142875,-5.0202e-06,1.01086e-05,-3.18012e-06,-3.1184e-05,0.000190543,-0.000195656,3.1147e-06,0.00133407,5.77815e-05,-1.31481e-05
+a,0.000596188,-0.000281646,-4.22388e-05,-5.67417e-07,3.6694e-05,5.18592e-05,-0.000767474,-0.000402704,-3.56563e-05,5.77815e-05,0.00146135,-0.000214637
+b,-5.73116e-05,4.72163e-05,1.20773e-05,-4.84525e-06,-5.83399e-06,-4.64896e-06,5.67197e-05,4.06959e-05,-4.39519e-06,-1.31481e-05,-0.000214637,5.66332e-05
diff --git a/inst/cov/w3/IndividualParameters/estimatedIndividualParameters.txt b/inst/cov/w3/IndividualParameters/estimatedIndividualParameters.txt
new file mode 100644
index 0000000..5b39f29
--- /dev/null
+++ b/inst/cov/w3/IndividualParameters/estimatedIndividualParameters.txt
@@ -0,0 +1,33 @@
+id,Tlag_SAEM,ka_SAEM,V_SAEM,Cl_SAEM,Tlag_mean,ka_mean,V_mean,Cl_mean,Tlag_mode,ka_mode,V_mode,Cl_mode,Tlag_sd,ka_sd,V_sd,Cl_sd,wt,lw70,sex,tSex
+1,0.971633,2.28578,7.82804,0.111806,0.839088,1.96192,7.77659,0.111857,0.789401,1.34988,7.78501,0.111583,0.588187,1.90053,0.572476,0.00608059,66.7,-0.048290289127781,1,M
+2,0.671624,0.936021,8.47443,0.127869,0.781163,0.997549,8.44499,0.128245,0.619934,0.833541,8.35059,0.128493,0.223854,0.278555,0.357605,0.00598566,66.7,-0.048290289127781,1,M
+3,0.85069,1.79501,8.50568,0.111792,0.834251,1.38663,8.52901,0.111943,0.828733,0.927394,8.47582,0.112589,0.397999,0.949563,0.320265,0.0047526,80,0.1335313926245226,1,M
+4,0.778449,2.75515,5.03865,0.0718163,0.755947,2.99901,5.07042,0.0720163,0.805679,1.38621,5.0533,0.072404,0.379125,2.35608,0.196917,0.0038729,40,-0.5596157879354228,0,F
+5,0.827832,3.22821,11.3671,0.175986,0.912052,2.27744,11.4829,0.176078,0.727142,1.59807,11.4208,0.175734,0.601848,3.22193,0.633993,0.00966389,75.3,0.0729848927564888,1,M
+6,0.752092,3.17929,6.02021,0.229588,0.734495,2.65254,6.04562,0.23065,0.716221,1.47726,6.05747,0.230799,0.359004,2.57782,0.258366,0.0109512,60,-0.1541506798272584,0,F
+7,0.619981,5.01792,8.03838,0.173655,0.657116,5.4813,8.04113,0.172733,0.650705,3.50889,8.06128,0.173357,0.283608,4.14027,0.273029,0.00697905,90,0.2513144282809062,1,M
+8,0.792805,0.366252,5.31422,0.110151,0.746472,0.331966,5.19205,0.109575,0.812501,0.370538,5.33659,0.11019,0.0672778,0.0355609,0.267365,0.00483206,50,-0.3364722366212129,0,F
+9,0.813086,2.29764,9.1669,0.116106,0.853767,2.39116,9.18823,0.115828,0.769698,1.43535,9.06667,0.115523,0.550643,2.69205,0.593895,0.00643023,70,0,1,M
+10,0.558917,0.31944,8.06365,0.281822,0.575575,0.312777,7.88946,0.286719,0.549333,0.293372,7.75972,0.287468,0.0763297,0.0453429,0.524314,0.0145221,66.7,-0.048290289127781,1,M
+11,0.541644,1.36832,7.46532,0.130607,0.648396,1.67121,7.56013,0.132039,0.739158,1.57117,7.50922,0.130999,0.247564,0.70455,0.26492,0.00558288,82,0.1582240052148942,1,M
+12,2.74059,0.839726,7.08671,0.134337,2.76851,0.939647,7.22208,0.134242,2.75114,0.785957,7.16639,0.134307,0.0836046,0.35135,0.378103,0.00593067,75.3,0.0729848927564888,1,M
+13,1.37422,3.96316,8.9394,0.176242,1.36316,3.17177,8.81099,0.174318,1.37025,2.57475,8.92399,0.17555,0.0704343,1.58559,0.368219,0.00787979,75.3,0.0729848927564888,1,M
+14,0.866819,2.14045,6.02181,0.155264,0.894248,2.57692,6.13491,0.155612,0.904358,2.5895,6.11399,0.155214,0.0235914,0.639676,0.24301,0.00845889,50,-0.3364722366212129,0,F
+15,0.571757,2.38397,6.65693,0.0978751,0.457315,1.48012,6.64763,0.0975357,0.582977,1.72407,6.65413,0.0978712,0.148424,0.47259,0.27892,0.00453569,56.7,-0.2107210313156525,0,F
+16,1.14756,1.99061,6.37749,0.0967258,1.2463,2.24386,6.29121,0.0972671,0.831576,1.16741,6.21542,0.0957398,1.26224,4.08745,0.425147,0.00470685,58,-0.1880522315029396,1,M
+17,0.946215,2.66252,10.8406,0.150627,0.8873,2.85414,10.6561,0.151867,0.742756,1.55456,10.5789,0.15018,0.643336,3.43419,0.852308,0.00903295,78,0.1082135846402328,1,M
+18,0.886745,2.30652,8.59763,0.18306,0.788474,2.34783,8.42656,0.180687,0.758591,1.48437,8.27389,0.178717,0.488869,3.75923,0.720361,0.00936811,74.7,0.0649848500894127,1,M
+19,0.887572,2.41258,9.38326,0.186135,1.02993,2.59229,9.21403,0.186549,0.743264,1.55276,9.07755,0.184754,0.642164,2.47935,0.793411,0.0101088,63.7,-0.0943106794712413,1,M
+20,1.08621,1.91585,7.16191,0.0956646,1.07765,2.45902,7.1324,0.0944548,0.807325,1.27279,7.04329,0.0945054,0.681406,3.23958,0.544525,0.00525653,59,-0.1709577981436395,1,M
+21,0.888737,2.52694,9.21693,0.144046,0.930985,2.56266,9.40142,0.144123,0.758365,1.48515,9.18335,0.143824,0.623723,2.64736,0.801701,0.00781051,62,-0.1213608570042675,1,M
+22,1.06761,1.89596,6.62721,0.101064,0.920476,1.53927,6.4494,0.101615,0.825279,1.19484,6.40547,0.0993547,0.552618,1.74715,0.421806,0.0068453,58,-0.1880522315029396,1,M
+23,0.83368,2.11147,8.05636,0.121992,1.05343,2.14084,8.1382,0.122953,0.781543,1.38383,8.0878,0.121454,0.664223,2.06066,0.623764,0.00553802,73.3,0.0460653668432468,1,M
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diff --git a/inst/cov/w3/IndividualParameters/estimatedRandomEffects.txt b/inst/cov/w3/IndividualParameters/estimatedRandomEffects.txt
new file mode 100644
index 0000000..3eafa54
--- /dev/null
+++ b/inst/cov/w3/IndividualParameters/estimatedRandomEffects.txt
@@ -0,0 +1,33 @@
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diff --git a/inst/cov/w3/IndividualParameters/simulatedIndividualParameters.txt b/inst/cov/w3/IndividualParameters/simulatedIndividualParameters.txt
new file mode 100644
index 0000000..d9d29f5
--- /dev/null
+++ b/inst/cov/w3/IndividualParameters/simulatedIndividualParameters.txt
@@ -0,0 +1,321 @@
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diff --git a/inst/cov/w3/IndividualParameters/simulatedRandomEffects.txt b/inst/cov/w3/IndividualParameters/simulatedRandomEffects.txt
new file mode 100644
index 0000000..426f29c
--- /dev/null
+++ b/inst/cov/w3/IndividualParameters/simulatedRandomEffects.txt
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+10,31,-0.135779,-0.682877,0.216555,0.00224456,83.3,0.173953307123438,1,M
+1,32,-0.665586,2.47524,-0.075249,-0.229246,62,-0.1213608570042675,1,M
+2,32,0.384154,-0.814667,-0.0949824,-0.211305,62,-0.1213608570042675,1,M
+3,32,-0.00279636,0.458949,-0.254337,-0.174473,62,-0.1213608570042675,1,M
+4,32,0.083831,-2.11771,-0.0480063,-0.140504,62,-0.1213608570042675,1,M
+5,32,0.328214,-1.11119,-0.270946,-0.172653,62,-0.1213608570042675,1,M
+6,32,-0.435942,-0.459041,-0.0673053,-0.287381,62,-0.1213608570042675,1,M
+7,32,-0.215817,2.36805,0.0391504,-0.313762,62,-0.1213608570042675,1,M
+8,32,0.247892,0.160853,0.025724,-0.301238,62,-0.1213608570042675,1,M
+9,32,-0.628597,0.219608,-0.099575,-0.330438,62,-0.1213608570042675,1,M
+10,32,0.760497,0.407706,-0.097495,-0.232856,62,-0.1213608570042675,1,M
diff --git a/inst/cov/w3/LogLikelihood/individualLL.txt b/inst/cov/w3/LogLikelihood/individualLL.txt
new file mode 100644
index 0000000..1435d8f
--- /dev/null
+++ b/inst/cov/w3/LogLikelihood/individualLL.txt
@@ -0,0 +1,33 @@
+id,importanceSampling
+1,10.837151
+2,26.687592
+3,24.705213
+4,25.831011
+5,14.522919
+6,36.320657
+7,45.049469
+8,30.124861
+9,10.913020
+10,38.209190
+11,40.845405
+12,36.929049
+13,38.296788
+14,24.869719
+15,28.862496
+16,15.604586
+17,10.840437
+18,13.776348
+19,8.527822
+20,14.130230
+21,9.305481
+22,20.843286
+23,9.381334
+24,12.581540
+25,13.551815
+26,9.865159
+27,11.983694
+28,11.312150
+29,16.490579
+30,10.212287
+31,9.814127
+32,10.457273
diff --git a/inst/cov/w3/LogLikelihood/logLikelihood.txt b/inst/cov/w3/LogLikelihood/logLikelihood.txt
new file mode 100644
index 0000000..146e381
--- /dev/null
+++ b/inst/cov/w3/LogLikelihood/logLikelihood.txt
@@ -0,0 +1,6 @@
+criteria,importanceSampling
+OFV,641.682690
+AIC,665.682690
+BIC,683.271520
+BICc,695.533435
+standardError,0.097109
diff --git a/inst/cov/w3/Tests/correlationIndividualParametersCovariates.txt b/inst/cov/w3/Tests/correlationIndividualParametersCovariates.txt
new file mode 100644
index 0000000..69a7a83
--- /dev/null
+++ b/inst/cov/w3/Tests/correlationIndividualParametersCovariates.txt
@@ -0,0 +1,3 @@
+parameter,covariate,statistics,p-value,test
+V,beta_V_tSex_F,-4.6112,6.96781e-05,t-Test
+Cl,beta_Cl_tSex_F,-0.709272,0.483632,t-Test
diff --git a/inst/cov/w3/Tests/correlationRandomEffects.txt b/inst/cov/w3/Tests/correlationRandomEffects.txt
new file mode 100644
index 0000000..daa19aa
--- /dev/null
+++ b/inst/cov/w3/Tests/correlationRandomEffects.txt
@@ -0,0 +1,7 @@
+eta1,eta2,coeff,statistics,p-value
+eta_Tlag,eta_ka,0,0.0267898,0.978799
+eta_Tlag,eta_V,0,-1.18134,0.246453
+eta_Tlag,eta_Cl,0,0.385404,0.70257
+eta_ka,eta_V,0,1.95311,0.0598845
+eta_ka,eta_Cl,0,0.155127,0.877727
+eta_V,eta_Cl,0,2.27774,0.0297911
diff --git a/inst/cov/w3/Tests/correlationRandomEffectsCovariates.txt b/inst/cov/w3/Tests/correlationRandomEffectsCovariates.txt
new file mode 100644
index 0000000..720696e
--- /dev/null
+++ b/inst/cov/w3/Tests/correlationRandomEffectsCovariates.txt
@@ -0,0 +1,17 @@
+eta,covariate,statistics,p-value,test
+eta_Tlag,sex,0.831564,0.369091,Anova
+eta_Tlag,tSex,0.831564,0.369091,Anova
+eta_Tlag,lw70,-0.00221955,0.998244,Pearson
+eta_Tlag,wt,-0.113675,0.910253,Pearson
+eta_ka,sex,0.00643776,0.936583,Anova
+eta_ka,tSex,0.00643776,0.936583,Anova
+eta_ka,lw70,0.839816,0.407655,Pearson
+eta_ka,wt,1.00595,0.322484,Pearson
+eta_V,sex,0.00303627,0.956422,Anova
+eta_V,tSex,0.00303627,0.956422,Anova
+eta_V,lw70,2.41485,0.0220458,Pearson
+eta_V,wt,2.62629,0.0134608,Pearson
+eta_Cl,sex,0.00275292,0.958503,Anova
+eta_Cl,tSex,0.00275292,0.958503,Anova
+eta_Cl,lw70,1.73205,0.0935372,Pearson
+eta_Cl,wt,1.66017,0.107299,Pearson
diff --git a/inst/cov/w3/Tests/fixedEffects.txt b/inst/cov/w3/Tests/fixedEffects.txt
new file mode 100644
index 0000000..65feedf
--- /dev/null
+++ b/inst/cov/w3/Tests/fixedEffects.txt
@@ -0,0 +1,3 @@
+parameter,statistics(sa),p-value(sa)
+beta_V_tSex_F,4.49263,7.03e-06
+beta_Cl_tSex_F,0.664779,0.506
diff --git a/inst/cov/w3/Tests/normalityIndividualParameters.txt b/inst/cov/w3/Tests/normalityIndividualParameters.txt
new file mode 100644
index 0000000..065cb79
--- /dev/null
+++ b/inst/cov/w3/Tests/normalityIndividualParameters.txt
@@ -0,0 +1,5 @@
+parameter,statistics,p-value,test
+Tlag,0.972932,0.668331,Shapiro-Wilk
+ka,0.974204,0.866384,Shapiro-Wilk
+V,0.0954507,0.299865,Kolmogorov-Smirnov
+Cl,0.10989,0.220282,Kolmogorov-Smirnov
diff --git a/inst/cov/w3/Tests/normalityRandomEffects.txt b/inst/cov/w3/Tests/normalityRandomEffects.txt
new file mode 100644
index 0000000..67a2df1
--- /dev/null
+++ b/inst/cov/w3/Tests/normalityRandomEffects.txt
@@ -0,0 +1,5 @@
+eta,statistics,p-value
+eta_Tlag,0.972932,0.668331
+eta_ka,0.974204,0.866384
+eta_V,0.96511,0.619619
+eta_Cl,0.950778,0.257498
diff --git a/inst/cov/w3/Tests/normalityResiduals.txt b/inst/cov/w3/Tests/normalityResiduals.txt
new file mode 100644
index 0000000..5955e4f
--- /dev/null
+++ b/inst/cov/w3/Tests/normalityResiduals.txt
@@ -0,0 +1,4 @@
+residuals,statistics,p-value,test
+IWRES_concentration,0.990847,0.0290732,Shapiro-Wilk
+PWRES_concentration,0.994961,0.592559,Shapiro-Wilk
+NPDE_concentration,0.992062,0.205396,Shapiro-Wilk
diff --git a/inst/cov/w3/Tests/symmetryResiduals.txt b/inst/cov/w3/Tests/symmetryResiduals.txt
new file mode 100644
index 0000000..6d9f397
--- /dev/null
+++ b/inst/cov/w3/Tests/symmetryResiduals.txt
@@ -0,0 +1,4 @@
+residuals,statistics,p-value,test
+IWRES_concentration,0.0824229,0.93431,Symmetry
+PWRES_concentration,-1.44732,0.147808,Symmetry
+NPDE_concentration,-2.52424,0.0115948,Symmetry
diff --git a/inst/cov/w3/populationParameters.txt b/inst/cov/w3/populationParameters.txt
new file mode 100644
index 0000000..d2df296
--- /dev/null
+++ b/inst/cov/w3/populationParameters.txt
@@ -0,0 +1,13 @@
+parameter,value,CV,se_sa,rse_sa
+Tlag_pop,0.771438750805779,,0.263679942425076,34.1802822517872
+ka_pop,1.42775873640368,,0.441637834721607,30.9322453059561
+V_pop,8.46609504205801,,0.299165215219173,3.5336859996607
+beta_V_tSex_F,-0.382278567256413,,0.0850901726087562,22.2586825150681
+Cl_pop,0.134437806143132,,0.00753472722343848,5.60461929542086
+beta_Cl_tSex_F,-0.0938365059053137,,0.141154435818998,150.425929074374
+omega_Tlag,0.61940678586983,68.385184978931,0.34196954759751,55.2092026433459
+omega_ka,0.992834041241909,129.604748563596,0.26359089754432,26.5493412388038
+omega_V,0.166818280322244,16.7985605874085,0.025613564608197,15.3541713526355
+omega_Cl,0.285345299602576,29.1253382073524,0.0365249350085803,12.8002581642143
+a,0.24818990819019,,0.0382275439573807,15.402537611677
+b,0.0508665778176092,,0.00752550584274643,14.7945982718366
\ No newline at end of file
diff --git a/inst/cov/w3/predictions.txt b/inst/cov/w3/predictions.txt
new file mode 100644
index 0000000..3f727e5
--- /dev/null
+++ b/inst/cov/w3/predictions.txt
@@ -0,0 +1,248 @@
+id,time,concentration,popPred_medianCOV,popPred,indivPred_SAEM,indivPred_mean,indivPred_mode,indWRes_SAEM,indWRes_mean,indWRes_mode
+1,24,9.2,8.26001,8.26001,9.25179,9.28379,9.30886,-0.0720454,-0.116308,-0.150843
+1,36,8.5,6.8269,6.8269,7.79454,7.81203,7.8379,1.0943,1.06569,1.02354
+1,48,6.4,5.64244,5.64244,6.56682,6.57359,6.59937,-0.286527,-0.297974,-0.34146
+1,72,4.8,3.85437,3.85437,4.66106,4.65457,4.67852,0.286302,0.29988,0.249872
+1,96,3.1,2.63293,2.63293,3.30837,3.29577,3.31676,-0.500327,-0.470791,-0.519935
+1,120,2.5,1.79856,1.79856,2.34825,2.33364,2.35137,0.412772,0.453422,0.404121
+2,0.5,0.02,0,0,0,0,0,0.0805835,0.0805835,0.0805835
+2,2,8.4,9.6467,9.6467,8.29654,8.23915,8.08229,0.154377,0.241047,0.481876
+2,3,9.7,11.0335,11.0335,10.2229,10.3114,10.0837,-0.680717,-0.791223,-0.504158
+2,6,9.8,10.9862,10.9862,10.9852,11.0423,11.0934,-1.46869,-1.53392,-1.59198
+2,12,11,9.99396,9.99396,10.1088,10.1407,10.2397,1.16895,1.12478,0.988626
+2,24,8.3,8.26001,8.26001,8.43484,8.45145,8.51403,-0.199103,-0.223345,-0.314162
+2,36,7.7,6.8269,6.8269,7.03787,7.04351,7.07854,1.0923,1.08248,1.02171
+2,48,6.3,5.64244,5.64244,5.87226,5.87012,5.88508,0.782131,0.786198,0.757782
+2,72,4.1,3.85437,3.85437,4.08821,4.07721,4.0679,0.0258398,0.0500266,0.0705426
+2,96,3,2.63293,2.63293,2.84618,2.83191,2.81182,0.391442,0.428549,0.481018
+2,120,1.4,1.79856,1.79856,1.98148,1.96696,1.94359,-1.66623,-1.62805,-1.5663
+3,3,12,13.2403,13.2403,13.5164,13.101,12.0377,-1.62057,-1.20382,-0.0437901
+3,6,13.2,13.1834,13.1834,13.2809,13.2619,13.2914,-0.0875371,-0.0671334,-0.0988846
+3,9,14.4,12.5778,12.5778,12.7687,12.7603,12.8789,1.81721,1.82743,1.68399
+3,24,9.6,9.91201,9.91201,10.484,10.4801,10.5582,-1.13118,-1.1265,-1.22026
+3,36,8.2,8.19229,8.19229,8.95427,8.95292,9.00249,-1.07192,-1.0701,-1.13648
+3,48,7.8,6.77093,6.77093,7.64775,7.64827,7.676,0.238933,0.238105,0.194169
+3,72,5.8,4.62524,4.62524,5.5788,5.58163,5.58058,0.415815,0.41039,0.412409
+3,96,4.3,3.15952,3.15952,4.06957,4.07341,4.05717,0.506233,0.497565,0.534201
+3,120,3,2.15828,2.15828,2.96862,2.97273,2.94963,0.078599,0.0682666,0.126483
+4,3,11.1,6.62013,9.61951,11.5705,11.5025,11.0532,-0.56229,-0.482999,0.0577022
+4,6,11.9,6.59169,9.43172,11.1114,11.0363,11.128,0.969571,1.06691,0.948134
+4,9,9.8,6.28889,8.85642,10.6463,10.5759,10.6682,-1.0716,-0.986949,-1.09786
+4,12,11,5.99637,8.31104,10.2006,10.1347,10.2195,1.04211,1.133,1.01622
+4,24,8.5,4.95601,6.4451,8.597,8.54656,8.60517,-0.141508,-0.0681717,-0.153334
+4,36,7.6,4.09614,4.99808,7.24547,7.20727,7.24584,0.574841,0.638801,0.574234
+4,48,5.4,3.38546,3.87594,6.10641,6.07785,6.10123,-1.26416,-1.2162,-1.25547
+4,72,4.5,2.31262,2.3309,4.33736,4.32224,4.32589,0.346916,0.379793,0.371854
+4,96,3.3,1.57976,1.40175,3.08081,3.07374,3.06713,0.541348,0.559294,0.57611
+4,120,2.3,1.07914,0.842983,2.18828,2.18588,2.17466,0.310751,0.317548,0.349337
+5,6,8.6,12.4144,12.4144,9.22023,9.16379,9.20969,-0.864807,-0.789269,-0.850746
+5,12,8.6,11.2932,11.2932,8.40232,8.35839,8.39949,0.292607,0.358811,0.296859
+5,24,7,9.33381,9.33381,6.97772,6.95359,6.98332,0.0369368,0.0770996,0.0276408
+5,36,5.7,7.7144,7.7144,5.79466,5.7849,5.80592,-0.174353,-0.156513,-0.194882
+5,48,4.7,6.37596,6.37596,4.81219,4.81263,4.82703,-0.227581,-0.22846,-0.257297
+5,72,3.3,4.35544,4.35544,3.31873,3.33085,3.33656,-0.0449151,-0.0738782,-0.0874786
+5,96,2.3,2.97521,2.97521,2.28876,2.30531,2.30631,0.0308169,-0.0145181,-0.0172543
+5,120,1.7,2.03238,2.03238,1.57845,1.59552,1.59417,0.370046,0.31724,0.32139
+6,3,13.4,9.93019,14.4293,13.8761,13.8163,13.4575,-0.49909,-0.437773,-0.0616973
+6,6,12.4,9.88754,14.1476,12.3867,12.3552,12.4638,0.0151795,0.0511295,-0.0723364
+6,9,12.7,9.43334,13.2846,11.0476,11.019,11.123,2.03965,2.07867,1.93738
+6,12,8.8,8.99456,12.4666,9.85328,9.82733,9.92164,-1.40551,-1.3733,-1.48982
+6,24,6.1,7.43401,9.66764,6.23495,6.21738,6.28081,-0.2387,-0.207948,-0.318507
+6,36,3.5,6.14421,7.49712,3.94534,3.9335,3.97601,-0.992131,-0.967038,-1.05678
+6,48,1.8,5.0782,5.81391,2.49653,2.48857,2.51698,-1.85653,-1.8373,-1.90574
+6,72,1.5,3.46893,3.49635,0.999635,0.99608,1.00866,1.67325,1.68616,1.64056
+6,96,1,2.36964,2.10263,0.400263,0.398692,0.404211,2.23324,2.23976,2.21688
+7,2,17.6,13.023,13.023,16.355,16.3648,16.22,1.15262,1.14308,1.28578
+7,3,17.3,14.8953,14.8953,16.0216,16.0274,16.0154,1.20244,1.19664,1.20862
+7,6,15,14.8313,14.8313,15.0163,15.0272,15.019,-0.0161068,-0.0268447,-0.0187483
+7,9,15,14.15,14.15,14.074,14.0893,14.0806,0.960534,0.943841,0.953289
+7,12,12.4,13.4918,13.4918,13.1908,13.21,13.2009,-0.860313,-0.880294,-0.870853
+7,24,7.9,11.151,11.151,10.1785,10.2083,10.1984,-2.9748,-3.00772,-2.99676
+7,36,7.9,9.21632,9.21632,7.85413,7.88865,7.87874,0.0708214,0.0174823,0.0327654
+7,48,5.1,7.61729,7.61729,6.06055,6.0961,6.08672,-1.72615,-1.78425,-1.76894
+7,72,3.6,5.2034,5.2034,3.60861,3.64043,3.63275,-0.0199452,-0.0932867,-0.0756507
+7,96,2.4,3.55446,3.55446,2.14866,2.17396,2.16815,0.703072,0.630028,0.646768
+7,120,2,2.42806,2.42806,1.27937,1.29823,1.29402,2.30037,2.23332,2.24824
+8,0.5,0.01,0,0,0,0,0,0.0402917,0.0402917,0.0402917
+8,1,1,2.46189,3.60589,1.02912,1.16283,0.941413,-0.0968768,-0.529803,0.197878
+8,2,4.6,7.23502,10.5598,4.97601,4.84829,4.93755,-0.75006,-0.501785,-0.67598
+8,3,8,8.27516,12.0244,7.62505,7.40882,7.60871,0.58949,0.945809,0.615999
+8,6,11.5,8.23961,11.7896,11.2076,11.1102,11.1943,0.357357,0.479288,0.373958
+8,9,11.4,7.86111,11.0705,11.8791,11.9637,11.852,-0.56204,-0.657981,-0.531082
+8,12,11,7.49547,10.3888,11.6119,11.7968,11.5777,-0.729493,-0.939358,-0.690159
+8,24,9.1,6.19501,8.05637,9.24425,9.43633,9.21803,-0.200791,-0.461876,-0.164602
+8,36,8.2,5.12018,6.2476,7.21091,7.33035,7.19711,1.60832,1.40027,1.63262
+8,48,5.9,4.23183,4.84492,5.62302,5.69044,5.61761,0.518479,0.389776,0.528876
+8,72,3.6,2.89078,2.91363,3.4192,3.42905,3.42244,0.428315,0.404509,0.420492
+8,96,1.7,1.9747,1.75219,2.07912,2.06634,2.08506,-1.07112,-1.03691,-1.08698
+8,120,1.1,1.34892,1.05373,1.26426,1.24517,1.27029,-0.525621,-0.465997,-0.54439
+9,24,8.6,8.67301,8.67301,8.58665,8.5809,8.69097,0.0194862,0.0278951,-0.131782
+9,36,8,7.16825,7.16825,7.37591,7.37625,7.45874,1.00114,1.00056,0.862445
+9,48,6,5.92456,5.92456,6.33589,6.34072,6.40122,-0.58879,-0.597004,-0.699234
+9,72,4.4,4.04709,4.04709,4.6751,4.68538,4.71474,-0.566063,-0.586571,-0.644935
+9,96,3.6,2.76458,2.76458,3.44965,3.46219,3.47258,0.354882,0.324801,0.299936
+9,120,2.8,1.88849,1.88849,2.54542,2.55833,2.55768,0.674097,0.638795,0.640556
+10,0.5,0.01,0,0,0,0,0,0.0402917,0.0402917,0.0402917
+10,1,1.9,3.28252,3.28252,1.61703,1.56337,1.58247,0.856325,1.02722,0.966072
+10,2,3.3,9.6467,9.6467,4.45333,4.43244,4.34065,-2.42952,-2.39086,-2.21895
+10,3,6.6,11.0335,11.0335,6.40146,6.41353,6.28261,0.346003,0.324621,0.559018
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+32,120,2.5,1.67267,1.67267,2.47979,2.4526,2.46373,0.0539968,0.127085,0.0971117
diff --git a/inst/cov/w3/summary.txt b/inst/cov/w3/summary.txt
new file mode 100644
index 0000000..f35ffe7
--- /dev/null
+++ b/inst/cov/w3/summary.txt
@@ -0,0 +1,125 @@
+********************************************************************************
+*                     warfarin_covariate3_project.mlxtran                      *
+*                     May 09, 2024 at 20:57:01                                 *
+*                     Monolix version : 2023R1                                 *
+********************************************************************************
+
+
+ESTIMATION OF THE POPULATION PARAMETERS ________________________________________
+
+Fixed Effects ----------------------------     se_sa    rse(%)
+Tlag_pop       :                     0.771     0.264      34.2
+ka_pop         :                      1.43     0.442      30.9
+V_pop          :                      8.47     0.299      3.53
+beta_V_tSex_F  :                    -0.382    0.0851      22.3
+Cl_pop         :                     0.134   0.00753       5.6
+beta_Cl_tSex_F :                   -0.0938     0.141       150
+
+Standard Deviation of the Random Effects -
+omega_Tlag     :                     0.619     0.342      55.2
+omega_ka       :                     0.993     0.264      26.5
+omega_V        :                     0.167    0.0256      15.4
+omega_Cl       :                     0.285    0.0365      12.8
+
+Error Model Parameters -------------------
+a              :                     0.248    0.0382      15.4
+b              :                    0.0509   0.00753      14.8
+
+Elapsed time (seconds):      3.9
+CPU time     (seconds):        5
+Exploratory phase iterations:      194 (Autostop)
+Smoothing phase iterations:         94 (Autostop)
+
+ _______________________________________________________________________________
+
+
+
+ESTIMATION OF THE INDIVIDUAL PARAMETERS ________________________________________
+
+
+Estimation of the individual parameters by Conditional Distribution ------------
+             min        Q1    median        Q3       max
+Tlag :     0.457     0.785     0.897     0.999      2.77
+ka   :     0.313      1.82      2.28      2.57      5.48
+V    :      5.07      7.16      8.05         9      12.5
+Cl   :     0.072     0.108     0.127     0.164     0.287
+
+Elapsed time (seconds):      0.7
+CPU time     (seconds):     0.89
+Iterations:       78 (Autostop)
+
+ -------------------------------------------------------------------------------
+
+
+Estimation of the individual parameters by Conditional Mode --------------------
+             min        Q1    median        Q3       max
+Tlag :     0.549     0.741     0.772     0.807      2.75
+ka   :     0.293      1.28      1.42      1.55      3.51
+V    :      5.05      7.09      7.97         9      12.4
+Cl   :    0.0724     0.108     0.127     0.164     0.287
+
+Elapsed time (seconds):    0.061
+CPU time     (seconds):        0
+
+ -------------------------------------------------------------------------------
+
+ _______________________________________________________________________________
+
+
+
+ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________
+
+
+Estimation of the Fisher information matrix by Stochastic Approximation --------
+
+Correlation Matrix :
+      Tlag_pop         1
+        ka_pop  0.036075         1
+         V_pop-0.0002485 -0.069908         1
+ beta_V_tSex_F   0.02999  0.038878  -0.41616         1
+        Cl_pop  0.016787 -0.059607 0.0072968-0.0039429         1
+beta_Cl_tSex_F 0.0013373  0.018762-0.0030083-0.00010772   -0.3965         1
+    omega_Tlag  -0.74399  0.037801  0.029266 -0.0410960.00078992-0.0071501         1
+      omega_ka  -0.19191   0.14806  0.021783 -0.019724  0.037242 -0.019504    0.1552         1
+       omega_V -0.022833  0.026579 0.0061017-0.00079107  -0.01383 0.0058449  0.033849 -0.037583         1
+      omega_Cl -0.021677  0.012646-0.0038896 0.0032525-0.0015535-0.0060485  0.015255 -0.020322 0.0033293         1
+             a  0.045628 -0.023819 -0.031269-0.00017444  0.017127 0.0096107 -0.058708 -0.039965 -0.036416  0.041383         1
+             b -0.022281  0.020284  0.045416-0.0075666 -0.013832-0.0043765   0.02204  0.020516 -0.022802 -0.047834  -0.74609         1
+
+                               min       max   max/min
+Eigen values           :      0.24       1.9       7.8
+
+Elapsed time (seconds):     0.66
+CPU time     (seconds):     0.85
+Iterations:       50 (Autostop)
+
+ -------------------------------------------------------------------------------
+
+ _______________________________________________________________________________
+
+
+
+ESTIMATION OF THE LOG-LIKELIHOOD _______________________________________________
+
+                                                            (is)
+-2 x log-likelihood                       (OFV) :         641.68
+Akaike Information Criteria               (AIC) :         665.68
+Corrected Bayesian Information Criteria  (BICc) :         695.53
+Bayesian Information Criteria             (BIC) :         683.27
+
+Elapsed time                          (seconds) :           4.67
+CPU time                              (seconds) :           7.00
+MonteCarlo size (is):    10000 (Fixed number of iterations)
+
+
+[Importance Sampling] Standard error        : 0.097
+                      Sampling distribution : T-distribution with 5 degrees of freedom
+
+ _______________________________________________________________________________
+
+DATASET INFORMATION
+Number of individuals: 32
+Number of observations (obsid 1): 247
+Number of observations (obsid 2): 232
+Number of doses: 32
+
diff --git a/inst/cov/warfarin_covariate1_project.mlxtran b/inst/cov/warfarin_covariate1_project.mlxtran
new file mode 100644
index 0000000..ff2410d
--- /dev/null
+++ b/inst/cov/warfarin_covariate1_project.mlxtran
@@ -0,0 +1,72 @@
+<DATAFILE>
+
+[FILEINFO]
+file='data/warfarin_data.csv'
+delimiter = comma
+header={id, time, amt, dv, dvid, wt, sex, age}
+
+[CONTENT]
+id = {use=identifier}
+time = {use=time}
+amt = {use=amount}
+dv = {use=observation, yname={'1', '2'}, type={continuous, continuous}}
+dvid = {use=observationtype}
+wt = {use=covariate, type=continuous}
+sex = {use=covariate, type=categorical}
+
+[SETTINGS]
+dataType = {'1'=plasma, '2'=plasma}
+
+<MODEL>
+
+[COVARIATE]
+input = {wt, sex}
+
+sex = {type=categorical, categories={'0', '1'}}
+
+[INDIVIDUAL]
+input = {Tlag_pop, omega_Tlag, ka_pop, omega_ka, V_pop, omega_V, Cl_pop, omega_Cl}
+
+DEFINITION:
+Tlag = {distribution=logNormal, typical=Tlag_pop, sd=omega_Tlag}
+ka = {distribution=logNormal, typical=ka_pop, sd=omega_ka}
+V = {distribution=logNormal, typical=V_pop, sd=omega_V}
+Cl = {distribution=logNormal, typical=Cl_pop, sd=omega_Cl}
+
+[LONGITUDINAL]
+input = {a, b}
+
+file = 'lib:oral1_1cpt_TlagkaVCl.txt'
+
+DEFINITION:
+concentration = {distribution=normal, prediction=Cc, errorModel=combined1(a, b)}
+
+<FIT>
+data = '1'
+model = concentration
+
+<PARAMETER>
+Cl_pop = {value=0.1, method=MLE}
+Tlag_pop = {value=1, method=MLE}
+V_pop = {value=5, method=MLE}
+a = {value=1, method=MLE}
+b = {value=0.3, method=MLE}
+c = {value=1, method=FIXED}
+ka_pop = {value=1, method=MLE}
+omega_Cl = {value=1, method=MLE}
+omega_Tlag = {value=1, method=MLE}
+omega_V = {value=1, method=MLE}
+omega_ka = {value=1, method=MLE}
+
+<MONOLIX>
+
+[TASKS]
+populationParameters()
+individualParameters(method = {conditionalMean, conditionalMode })
+fim(run = false,method = StochasticApproximation)
+logLikelihood(run = false,method = ImportanceSampling)
+plotResult(method = {indfits, parameterdistribution, covariancemodeldiagnosis, covariatemodeldiagnosis, obspred, vpc, residualsscatter, residualsdistribution, randomeffects, saemresults })
+
+[SETTINGS]
+GLOBAL:
+exportpath = 'w1'
diff --git a/inst/cov/warfarin_covariate2_project.mlxtran b/inst/cov/warfarin_covariate2_project.mlxtran
new file mode 100644
index 0000000..44d86e8
--- /dev/null
+++ b/inst/cov/warfarin_covariate2_project.mlxtran
@@ -0,0 +1,77 @@
+<DATAFILE>
+
+[FILEINFO]
+file='data/warfarin_data.csv'
+delimiter = comma
+header={id, time, amt, dv, dvid, wt, sex, age}
+
+[CONTENT]
+id = {use=identifier}
+time = {use=time}
+amt = {use=amount}
+dv = {use=observation, yname={'1', '2'}, type={continuous, continuous}}
+dvid = {use=observationtype}
+wt = {use=covariate, type=continuous}
+sex = {use=covariate, type=categorical}
+
+[SETTINGS]
+dataType = {'1'=plasma, '2'=plasma}
+
+<MODEL>
+
+[COVARIATE]
+input = {wt, sex}
+
+sex = {type=categorical, categories={'0', '1'}}
+
+EQUATION:
+lw70 = log(wt/70)
+
+[INDIVIDUAL]
+input = {Tlag_pop, omega_Tlag, ka_pop, omega_ka, V_pop, omega_V, Cl_pop, omega_Cl, lw70, beta_V_lw70, beta_Cl_lw70}
+
+DEFINITION:
+Tlag = {distribution=logNormal, typical=Tlag_pop, sd=omega_Tlag}
+ka = {distribution=logNormal, typical=ka_pop, sd=omega_ka}
+V = {distribution=logNormal, typical=V_pop, covariate=lw70, coefficient=beta_V_lw70, sd=omega_V}
+Cl = {distribution=logNormal, typical=Cl_pop, covariate=lw70, coefficient=beta_Cl_lw70, sd=omega_Cl}
+
+[LONGITUDINAL]
+input = {a, b}
+
+file = 'lib:oral1_1cpt_TlagkaVCl.txt'
+
+DEFINITION:
+concentration = {distribution=normal, prediction=Cc, errorModel=combined1(a, b)}
+
+<FIT>
+data = '1'
+model = concentration
+
+<PARAMETER>
+Cl_pop = {value=0.1, method=MLE}
+Tlag_pop = {value=1, method=MLE}
+V_pop = {value=5, method=MLE}
+a = {value=1, method=MLE}
+b = {value=0.3, method=MLE}
+beta_Cl_lw70 = {value=0, method=MLE}
+beta_V_lw70 = {value=0, method=MLE}
+c = {value=1, method=FIXED}
+ka_pop = {value=1, method=MLE}
+omega_Cl = {value=1, method=MLE}
+omega_Tlag = {value=1, method=MLE}
+omega_V = {value=1, method=MLE}
+omega_ka = {value=1, method=MLE}
+
+<MONOLIX>
+
+[TASKS]
+populationParameters()
+individualParameters(method = {conditionalMean, conditionalMode })
+fim(method = Linearization)
+logLikelihood(method = Linearization)
+plotResult(method = {indfits, parameterdistribution, covariancemodeldiagnosis, covariatemodeldiagnosis, obspred, vpc, residualsscatter, residualsdistribution, randomeffects, saemresults })
+
+[SETTINGS]
+GLOBAL:
+exportpath = 'w2'
diff --git a/inst/cov/warfarin_covariate3_project.mlxtran b/inst/cov/warfarin_covariate3_project.mlxtran
new file mode 100644
index 0000000..4af5eed
--- /dev/null
+++ b/inst/cov/warfarin_covariate3_project.mlxtran
@@ -0,0 +1,89 @@
+<DATAFILE>
+
+[FILEINFO]
+file='data/warfarin_data.csv'
+delimiter = comma
+header={id, time, amt, dv, dvid, wt, sex, age}
+
+[CONTENT]
+id = {use=identifier}
+time = {use=time}
+amt = {use=amount}
+dv = {use=observation, yname={'1', '2'}, type={continuous, continuous}}
+dvid = {use=observationtype}
+wt = {use=covariate, type=continuous}
+sex = {use=covariate, type=categorical}
+
+[SETTINGS]
+dataType = {'1'=plasma, '2'=plasma}
+
+<MODEL>
+
+[COVARIATE]
+input = {wt, sex}
+
+sex = {type=categorical, categories={'0', '1'}}
+
+EQUATION:
+lw70 = log(wt/70)
+
+DEFINITION:
+tSex =
+{
+  transform = sex,
+  categories = {
+  'F' = {'0'},
+  'M' = {'1'}  },
+  reference = 'M'
+}
+
+[INDIVIDUAL]
+input = {Tlag_pop, omega_Tlag, ka_pop, omega_ka, V_pop, omega_V, Cl_pop, omega_Cl, tSex, beta_V_tSex_F, beta_Cl_tSex_F}
+
+tSex = {type=categorical, categories={'F', 'M'}}
+
+DEFINITION:
+Tlag = {distribution=logNormal, typical=Tlag_pop, sd=omega_Tlag}
+ka = {distribution=logNormal, typical=ka_pop, sd=omega_ka}
+V = {distribution=logNormal, typical=V_pop, covariate=tSex, coefficient={beta_V_tSex_F, 0}, sd=omega_V}
+Cl = {distribution=logNormal, typical=Cl_pop, covariate=tSex, coefficient={beta_Cl_tSex_F, 0}, sd=omega_Cl}
+
+[LONGITUDINAL]
+input = {a, b}
+
+file = 'lib:oral1_1cpt_TlagkaVCl.txt'
+
+DEFINITION:
+concentration = {distribution=normal, prediction=Cc, errorModel=combined1(a, b)}
+
+<FIT>
+data = '1'
+model = concentration
+
+<PARAMETER>
+Cl_pop = {value=0.1, method=MLE}
+Tlag_pop = {value=1, method=MLE}
+V_pop = {value=5, method=MLE}
+a = {value=1, method=MLE}
+b = {value=0.3, method=MLE}
+beta_Cl_tSex_F = {value=0, method=MLE}
+beta_V_tSex_F = {value=0, method=MLE}
+c = {value=1, method=FIXED}
+ka_pop = {value=1, method=MLE}
+omega_Cl = {value=1, method=MLE}
+omega_Tlag = {value=1, method=MLE}
+omega_V = {value=1, method=MLE}
+omega_ka = {value=1, method=MLE}
+
+<MONOLIX>
+
+[TASKS]
+populationParameters()
+individualParameters(method = {conditionalMean, conditionalMode })
+fim(method = StochasticApproximation)
+logLikelihood(method = ImportanceSampling)
+plotResult(method = {indfits, parameterdistribution, covariancemodeldiagnosis, covariatemodeldiagnosis, obspred, vpc, residualsscatter, residualsdistribution, randomeffects, saemresults })
+
+[SETTINGS]
+GLOBAL:
+exportpath = 'w3'