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1001.xml
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1001.xml
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<?xml version="1.0" encoding="ASCII"?>
<!DOCTYPE nm:output SYSTEM "output.dtd">
<nm:output
xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
xsi:schemaLocation="http://namespaces.oreilly.com/xmlnut/address output.xsd"
xmlns:nm="http://namespaces.oreilly.com/xmlnut/address"
>
<nm:start_datetime>2023-08-26T04:38:18.296</nm:start_datetime>
<nm:control_stream><![CDATA[
$PROB RUN# 101
$INPUT C ID TIME EVID AMT CMT SS II ADDL RATE LAGT MODE DUR2 RAT2 BIOAV DV
$DATA data/1001.csv IGNORE=C
$SUBROUTINES ADVAN2 TRANS2
$PK
TVCL=THETA(1)
CL=TVCL*EXP(ETA(1))
TVV2=THETA(2)
V=TVV2*EXP(ETA(2))
TVKA=THETA(3)
KA=TVKA*EXP(ETA(3))
ALAG2 = LAGT
F2 = BIOAV
IF(MODE.EQ.1) R2 = RAT2
IF(MODE.EQ.2) D2 = DUR2
$ERROR
IPRED=A(2)/(V/1000)
Y=IPRED*EXP(ERR(1))
CP = IPRED
$THETA
(1.1, FIX) ;; CL
(20, FIX) ;; V
(1.5, FIX) ;; KA
$OMEGA
0.0 FIX
0.0 FIX
0.0 FIX
$SIGMA
0.00 FIX
$TABLE FILE=TAB ID TIME CP NOPRINT ONEHEADER NOAPPEND
$SIMULATION (2674474) ONLYSIMULATION
]]></nm:control_stream>
<nm:nmtran><![CDATA[
WARNINGS AND ERRORS (IF ANY) FOR PROBLEM 1
(WARNING 2) NM-TRAN INFERS THAT THE DATA ARE POPULATION.
]]></nm:nmtran>
<nm:nonmem nm:version='7.4.3'>
<nm:license_information><![CDATA[
License Registered to: Novartis
Expiration Date: 14 JAN 2024
Current Date: 26 AUG 2023
Days until program expires : 143
]]></nm:license_information>
<nm:program_information><![CDATA[
1NONLINEAR MIXED EFFECTS MODEL PROGRAM (NONMEM) VERSION 7.4.3
ORIGINALLY DEVELOPED BY STUART BEAL, LEWIS SHEINER, AND ALISON BOECKMANN
CURRENT DEVELOPERS ARE ROBERT BAUER, ICON DEVELOPMENT SOLUTIONS,
AND ALISON BOECKMANN. IMPLEMENTATION, EFFICIENCY, AND STANDARDIZATION
PERFORMED BY NOUS INFOSYSTEMS.
]]></nm:program_information>
<nm:theta_lb>
<nm:val nm:name='1'>1.10000000000000</nm:val>
<nm:val nm:name='2'>20.0000000000000</nm:val>
<nm:val nm:name='3'>1.50000000000000</nm:val>
</nm:theta_lb>
<nm:theta_in>
<nm:val nm:name='1'>1.10000000000000</nm:val>
<nm:val nm:name='2'>20.0000000000000</nm:val>
<nm:val nm:name='3'>1.50000000000000</nm:val>
</nm:theta_in>
<nm:theta_ub>
<nm:val nm:name='1'>1.10000000000000</nm:val>
<nm:val nm:name='2'>20.0000000000000</nm:val>
<nm:val nm:name='3'>1.50000000000000</nm:val>
</nm:theta_ub>
<nm:problem nm:number='1' nm:subproblem='0' nm:superproblem1='0' nm:iteration1='0' nm:superproblem2='0' nm:iteration2='0'>
<nm:problem_title>RUN# 101</nm:problem_title>
<nm:problem_information><![CDATA[
PROBLEM NO.: 1
RUN# 101
0DATA CHECKOUT RUN: NO
DATA SET LOCATED ON UNIT NO.: 2
THIS UNIT TO BE REWOUND: NO
NO. OF DATA RECS IN DATA SET: 7157
NO. OF DATA ITEMS IN DATA SET: 17
ID DATA ITEM IS DATA ITEM NO.: 2
DEP VARIABLE IS DATA ITEM NO.: 16
MDV DATA ITEM IS DATA ITEM NO.: 17
0INDICES PASSED TO SUBROUTINE PRED:
4 3 5 10 7 8 6 0 0 0 9
0LABELS FOR DATA ITEMS:
C ID TIME EVID AMT CMT SS II ADDL RATE LAGT MODE DUR2 RAT2 BIOAV DV MDV
0(NONBLANK) LABELS FOR PRED-DEFINED ITEMS:
CP
0FORMAT FOR DATA:
(E2.0,E5.0,E4.0,E2.0,E4.0,2E2.0,2E3.0,E17.0,E6.0,E2.0,4E6.0/1F2.0)
TOT. NO. OF OBS RECS: 7074
TOT. NO. OF INDIVIDUALS: 54
0LENGTH OF THETA: 3
0DEFAULT THETA BOUNDARY TEST OMITTED: NO
0OMEGA HAS SIMPLE DIAGONAL FORM WITH DIMENSION: 3
0DEFAULT OMEGA BOUNDARY TEST OMITTED: NO
0SIGMA HAS SIMPLE DIAGONAL FORM WITH DIMENSION: 1
0DEFAULT SIGMA BOUNDARY TEST OMITTED: NO
0INITIAL ESTIMATE OF THETA:
LOWER BOUND INITIAL EST UPPER BOUND
0.1100E+01 0.1100E+01 0.1100E+01
0.2000E+02 0.2000E+02 0.2000E+02
0.1500E+01 0.1500E+01 0.1500E+01
0INITIAL ESTIMATE OF OMEGA:
0.0000E+00
0.0000E+00 0.0000E+00
0.0000E+00 0.0000E+00 0.0000E+00
0OMEGA CONSTRAINED TO BE THIS INITIAL ESTIMATE
0INITIAL ESTIMATE OF SIGMA:
0.0000E+00
0SIGMA CONSTRAINED TO BE THIS INITIAL ESTIMATE
0SIMULATION STEP OMITTED: NO
OBJ FUNC EVALUATED: NO
ORIGINAL DATA USED ON EACH NEW SIMULATION: NO
SEEDS RESET ON EACH NEW SUPERSET ITERATION: YES
0SIMULATION RANDOM METHOD SELECTED (RANMETHOD): 4U
SEED 1 RESET TO INITIAL: YES
SOURCE 1:
SEED1: 2674474 SEED2: 0 PSEUDO-NORMAL
0WARNING: NO. OF OBS RECS IN INDIVIDUAL REC NO. 1 (IN INDIVIDUAL
REC ORDERING) EXCEEDS ONE WHILE INITIAL ESTIMATE OF WITHIN INDIVIDUAL VARIANCE IS ZERO
0WARNING: NO. OF OBS RECS IN INDIVIDUAL REC NO. 2 (IN INDIVIDUAL
REC ORDERING) EXCEEDS ONE WHILE INITIAL ESTIMATE OF WITHIN INDIVIDUAL VARIANCE IS ZERO
0WARNING: NO. OF OBS RECS IN INDIVIDUAL REC NO. 3 (IN INDIVIDUAL
REC ORDERING) EXCEEDS ONE WHILE INITIAL ESTIMATE OF WITHIN INDIVIDUAL VARIANCE IS ZERO
0WARNING: NO. OF OBS RECS IN INDIVIDUAL REC NO. 4 (IN INDIVIDUAL
REC ORDERING) EXCEEDS ONE WHILE INITIAL ESTIMATE OF WITHIN INDIVIDUAL VARIANCE IS ZERO
0WARNING: NO. OF OBS RECS IN INDIVIDUAL REC NO. 5 (IN INDIVIDUAL
REC ORDERING) EXCEEDS ONE WHILE INITIAL ESTIMATE OF WITHIN INDIVIDUAL VARIANCE IS ZERO
0TABLES STEP OMITTED: NO
NO. OF TABLES: 1
SEED NUMBER (SEED): 11456
RANMETHOD: 3U
MC SAMPLES (ESAMPLE): 300
WRES SQUARE ROOT TYPE (WRESCHOL): EIGENVALUE
0-- TABLE 1 --
0RECORDS ONLY: ALL
04 COLUMNS APPENDED: NO
PRINTED: NO
HEADERS: ONE
FILE TO BE FORWARDED: NO
FORMAT: S1PE11.4
LFORMAT:
RFORMAT:
FIXED_EFFECT_ETAS:
0USER-CHOSEN ITEMS:
ID TIME CP
1DOUBLE PRECISION PREDPP VERSION 7.4.3
ONE COMPARTMENT MODEL WITH FIRST-ORDER ABSORPTION (ADVAN2)
0MAXIMUM NO. OF BASIC PK PARAMETERS: 3
0BASIC PK PARAMETERS (AFTER TRANSLATION):
ELIMINATION RATE (K) IS BASIC PK PARAMETER NO.: 1
ABSORPTION RATE (KA) IS BASIC PK PARAMETER NO.: 3
TRANSLATOR WILL CONVERT PARAMETERS
CLEARANCE (CL) AND VOLUME (V) TO K (TRANS2)
0COMPARTMENT ATTRIBUTES
COMPT. NO. FUNCTION INITIAL ON/OFF DOSE DEFAULT DEFAULT
STATUS ALLOWED ALLOWED FOR DOSE FOR OBS.
1 DEPOT OFF YES YES YES NO
2 CENTRAL ON NO YES NO YES
3 OUTPUT OFF YES NO NO NO
1
ADDITIONAL PK PARAMETERS - ASSIGNMENT OF ROWS IN GG
COMPT. NO. INDICES
SCALE BIOAVAIL. ZERO-ORDER ZERO-ORDER ABSORB
FRACTION RATE DURATION LAG
1 * * * * *
2 * 5 6 7 4
3 * - - - -
- PARAMETER IS NOT ALLOWED FOR THIS MODEL
* PARAMETER IS NOT SUPPLIED BY PK SUBROUTINE;
WILL DEFAULT TO ONE IF APPLICABLE
0DATA ITEM INDICES USED BY PRED ARE:
EVENT ID DATA ITEM IS DATA ITEM NO.: 4
TIME DATA ITEM IS DATA ITEM NO.: 3
DOSE AMOUNT DATA ITEM IS DATA ITEM NO.: 5
DOSE RATE DATA ITEM IS DATA ITEM NO.: 10
STEADY STATE DATA ITEM IS DATA ITEM NO.: 7
INTERVAL DATA ITEM IS DATA ITEM NO.: 8
ADDL. DOSES DATA ITEM IS DATA ITEM NO.: 9
COMPT. NO. DATA ITEM IS DATA ITEM NO.: 6
0PK SUBROUTINE CALLED WITH EVERY EVENT RECORD.
PK SUBROUTINE NOT CALLED AT NONEVENT (ADDITIONAL OR LAGGED) DOSE TIMES.
0ERROR SUBROUTINE CALLED WITH EVERY EVENT RECORD.
0ERROR SUBROUTINE INDICATES THAT DERIVATIVES OF COMPARTMENT AMOUNTS ARE USED.
]]></nm:problem_information>
<nm:problem_options
nm:data_checkout_run='no' nm:data_unit='2' nm:data_rewind='no' nm:data_nrec='7157' nm:data_nitems='17' nm:data_id='2'
nm:data_l2='0' nm:data_dv='16' nm:data_mdv='17' nm:data_mrg='0' nm:data_raw='0' nm:data_rpt='0' nm:data_sub_array1='0'
nm:data_sub_array2='0' nm:data_sub_array3='0' nm:data_pred_indices='4,3,5,10,7,8,6,0,0,0,9'
nm:data_format='(e2.0,e5.0,e4.0,e2.0,e4.0,2e2.0,2e3.0,e17.0,e6.0,e2.0,4e6.0/1f2.0)' nm:data_nobs='7074'
nm:data_nind='54' nm:data_mdv100='0' nm:nthetat='3' nm:theta_bound_test_omitted='no' nm:omega_diagdim='3'
nm:omega_bound_test_omitted='no' nm:sigma_diagdim='1' nm:sigma_bound_test_omitted='no' nm:sim_omitted='no'
nm:sim_obj_evaluated='no' nm:sim_rewind='no' nm:sim_supreset='yes' nm:sim_ranmethod='4u' nm:sim_seed1_01='2674474'
nm:sim_seed2_01='0' nm:sim_dist_01='pseudo-normal' nm:sim_newran='0' nm:sim_etader_order_max='0'
nm:tab_omitted='no' nm:tab_number='1' nm:tab_seed='11456' nm:tab_ranmethod='3u' nm:tab_esample='300'
nm:tab_wres='eigenvalue' nm:tab_fixedetas_01='BLANK' nm:pred_advan='2' nm:pred_evid='4' nm:pred_time='3'
nm:pred_amt='5' nm:pred_rate='10' nm:pred_ss='7' nm:pred_ii='8' nm:pred_addl='9' nm:pred_cmt='6'
/>
<nm:simulation_information><![CDATA[
1
SIMULATION STEP PERFORMED
SOURCE 1:
SEED1: 518363105 SEED2: 1042641217
]]></nm:simulation_information>
<nm:sim_info
nm:sim_bootstrap='0' nm:sim_seed1_01='518363105' nm:sim_seed2_01='1042641217'
/>
<nm:sim_elapsed_time>0.03</nm:sim_elapsed_time>
<nm:estimation nm:number='1' nm:type='1'>
<nm:table_series>0</nm:table_series>
<nm:estimation_information><![CDATA[
ESTIMATION STEP OMITTED: YES
]]></nm:estimation_information>
<nm:estimation_options
nm:estim_omitted='yes'
/>
</nm:estimation>
<nm:post_process_times>
<nm:post_elapsed_time>0.00</nm:post_elapsed_time>
<nm:finaloutput_elapsed_time>0.25</nm:finaloutput_elapsed_time>
</nm:post_process_times>
</nm:problem>
</nm:nonmem>
<nm:stop_datetime>2023-08-26T04:38:18.718</nm:stop_datetime>
<nm:total_cputime>0.269</nm:total_cputime>
</nm:output>