Error simulating multiple endpoints

[tmss1]

See this error when simulating a model with 2 endpoints:

It was okay with either of the endpoint alone, e.g., if I comment out the line with the other endpoint as below:

Not sure why?

[mattfidler]

I need more information to answer exactly why. However, the nlmixr2 description of multiple endpoints may be helpful and could possibly answer your question if you are not sure you can share the model or data.

[tmss1]

Thanks @mattfidler,
To test this out, I used the example model shown in nlmixr2 description of multiple endpoints as suggested, but have the same error:

pk.turnover.emax <- function() {
  ini({
    tktr <- log(1)
    tka <- log(1)
    tcl <- log(0.1)
    tv <- log(10)
    ##
    eta.ktr ~ 1
    eta.ka ~ 1
    eta.cl ~ 2
    eta.v ~ 1
    prop.err <- 0.1
    pkadd.err <- 0.1
    ##
    temax <- logit(0.8)
    #temax <- 7.5
    tec50 <- log(0.5)
    tkout <- log(0.05)
    te0 <- log(100)
    ##
    eta.emax ~ .5
    eta.ec50  ~ .5
    eta.kout ~ .5
    eta.e0 ~ .5
    ##
    pdadd.err <- 10
  })
  model({
    ktr <- exp(tktr + eta.ktr)
    ka <- exp(tka + eta.ka)
    cl <- exp(tcl + eta.cl)
    v <- exp(tv + eta.v)
    ##
    #poplogit = log(temax/(1-temax))
    emax=expit(temax+eta.emax)
    #logit=temax+eta.emax
    ec50 =  exp(tec50 + eta.ec50)
    kout = exp(tkout + eta.kout)
    e0 = exp(te0 + eta.e0)
    ##
    DCP = center/v
    PD=1-emax*DCP/(ec50+DCP)
    ##
    effect(0) = e0
    kin = e0*kout
    ##
    d/dt(depot) = -ktr * depot
    d/dt(gut) =  ktr * depot -ka * gut
    d/dt(center) =  ka * gut - cl / v * center
    d/dt(effect) = kin*PD -kout*effect
    ##
    cp = center / v
    cp ~ prop(prop.err) + add(pkadd.err)
    effect ~ add(pdadd.err)
  })
}
m1 = nlmixr2(pk.turnover.emax)
ev = et(amt=150000, until=48, ii=24, cmt=1) 
sim = m1 %>% rxSolve(events=ev,nSub=1)