unhandled error message: EE:[lsoda] 70000 steps taken before reaching tout @(lsoda.c:754

[rebekazakelj]

I've been running some models with IIV and IOV and with some seeds I keep getting this error. Consequently, some subjects don't have results:
#> unhandled error message: EE:[lsoda] 70000 steps taken before reaching tout
#> @(lsoda.c:754
#> Warning: some ID(s) could not solve the ODEs correctly; These values are
#> replaced with 'NA'

I see we get the same error in: vignettes/rxode2-nesting.Rmd
Any solution to this?

[mattfidler]

The solution I have used is to re-simulate and replace the IDs that have NA with the new values.

Currently that is the only way, but it is a bit complicated if you are simulating with parameter uncertainty since that would require keeping the same omega block that you have for each "study." (as well as any sampled thetas).