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This seems like it would be a simpler fit within nlmixr2lib where we have some way to add a Markov model by implied matrix operations. It would really just need a cumulative logit function to get each transition probability (maybe with a special case for binomial, single-transition models).
That makes sense. I guess my thought was that both estimation and simulation could occur by helpers. Having them directly in the DSL would be easier (though harder to maintain the DSL).
This has some example NONMEM models that could be used to create test cases:
https://ascpt.onlinelibrary.wiley.com/doi/full/10.1002/psp4.13278
And possibly
https://pubmed.ncbi.nlm.nih.gov/9819830/
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