diff --git a/CMakeLists.txt b/CMakeLists.txt
index 54aa3a78043b..a7e829de5b3c 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -950,8 +950,8 @@ if(IREE_ENABLE_CLANG_TIDY)
 endif()
 
 if(IREE_BUILD_TRACY)
-  if(NOT CMAKE_SYSTEM_NAME MATCHES "Linux")
-    message(WARNING "Building Tracy (IREE_BUILD_TRACY) on non-Linux is unsupported and may fail below.")
+  if(NOT CMAKE_SYSTEM_NAME MATCHES "Darwin|Linux")
+    message(WARNING "Building Tracy (IREE_BUILD_TRACY) on non-Darwin/Linux is unsupported and may fail below.")
   endif()
   add_subdirectory(build_tools/third_party/tracy ${CMAKE_CURRENT_BINARY_DIR}/tracy)
   if(NOT TARGET IREETracyCaptureServer)
diff --git a/build_tools/third_party/tracy/CMakeLists.txt b/build_tools/third_party/tracy/CMakeLists.txt
index 3ca9023c9735..7efc9592994f 100644
--- a/build_tools/third_party/tracy/CMakeLists.txt
+++ b/build_tools/third_party/tracy/CMakeLists.txt
@@ -19,9 +19,13 @@ find_package(Threads REQUIRED)
 message(STATUS "Checking for Tracy dependencies...")
 find_program(PKGCONFIG pkg-config)
 if(NOT PKGCONFIG)
-  message(STATUS "Could not find pkg-config (on Ubuntu/Debian, 'apt install pkg-config')")
+  message(STATUS "Could not find pkg-config to get dependencies; you need to specify them manually or use pkg-config")
+  message(STATUS "  Ubuntu/Debian: `apt install pkg-config`")
+  message(STATUS "  MacOS: `brew install pkg-config`")
 else()
   include(FindPkgConfig)
+
+  # Deps slightly differ by platform but some are common.
   pkg_check_modules(TRACY_DEPS
     tbb
     libzstd
@@ -29,31 +33,41 @@ else()
   pkg_check_modules(TRACY_CAPSTONE_DEPS
     capstone
   )
-  pkg_check_modules(TRACY_GTK_DEPS
-    freetype2
-    glfw3
-    gtk+-3.0
-    dbus-1
-  )
-endif()
-
-
-if(NOT TRACY_DEPS_FOUND)
-  message(STATUS "Could not find Tracy dependencies (Tracy server will not be built).")
-  message(STATUS "To build Tracy, install packages libzstd, and tbb (on Ubuntu/Debian, 'apt install libcapstone-dev libtbb-dev libzstd-dev')")
-  return()
-endif()
-
-if(NOT TRACY_CAPSTONE_DEPS_FOUND)
-  message(STATUS "Could not find capstone, a Tracy dependency (Tracy server will not be built).")
-  message(STATUS "To build Tracy, install capstone (on Ubuntu/Debian, 'apt install libcapstone-dev')")
-  return()
-endif()
-
-if(NOT TRACY_GTK_DEPS_FOUND)
-  message(STATUS
-    "Could not find deps required to build graphical programs: "
-    "Tracy graphical profiler will not be built (on Ubuntu/Debian, 'apt install libglfw3-dev libfreetype-dev libgtk-3-dev libdbus-1-dev')")
+  if(APPLE)
+    pkg_check_modules(TRACY_GUI_DEPS
+      freetype2
+      glfw3
+    )
+  else()
+    pkg_check_modules(TRACY_GUI_DEPS
+      freetype2
+      glfw3
+      gtk+-3.0
+      dbus-1
+    )
+  endif()
+
+  if(NOT TRACY_DEPS_FOUND)
+    message(STATUS "Could not find Tracy dependencies (Tracy server will not be built).")
+    message(STATUS "To build Tracy, install packages libzstd, and tbb:")
+    message(STATUS "  Ubuntu/Debian: `apt install libcapstone-dev libtbb-dev libzstd-dev`")
+    message(STATUS "  MacOS: `brew install capstone tbb zstd`")
+    return()
+  endif()
+
+  if(NOT TRACY_CAPSTONE_DEPS_FOUND)
+    message(STATUS "Could not find capstone, a Tracy dependency (Tracy server will not be built).")
+    message(STATUS "To build Tracy, install capstone or build from source:")
+    message(STATUS "  Ubuntu/Debian: `apt install libcapstone-dev`")
+    message(STATUS "  MacOS: `brew install capstone`")
+    return()
+  endif()
+
+  if(NOT TRACY_GUI_DEPS_FOUND)
+    message(STATUS "Could not find deps required to build graphical programs (Tracy graphical profiler will not be built).")
+    message(STATUS "  Ubuntu/Debian: `apt install libglfw3-dev libfreetype-dev libgtk-3-dev libdbus-1-dev`")
+    message(STATUS "  MacOS: `brew install glfw freetype`")
+  endif()
 endif()
 
 #-------------------------------------------------------------------------------
@@ -94,20 +108,20 @@ endfunction()
 
 function(setup_graphics_deps name)
   target_compile_definitions(${name}
-  PRIVATE
-    DISPLAY_SERVER_X11
+    PRIVATE
+      DISPLAY_SERVER_X11
   )
   target_include_directories(${name}
     PUBLIC
-      ${TRACY_GTK_DEPS_INCLUDE_DIRS}
+      ${TRACY_GUI_DEPS_INCLUDE_DIRS}
   )
   target_link_libraries(${name}
     PRIVATE
-      ${TRACY_GTK_DEPS_LIBRARIES}
+      ${TRACY_GUI_DEPS_LIBRARIES}
   )
   target_link_directories(${name}
     PRIVATE
-      ${TRACY_GTK_DEPS_LIBRARY_DIRS}
+      ${TRACY_GUI_DEPS_LIBRARY_DIRS}
   )
 endfunction()
 
@@ -175,7 +189,7 @@ target_link_libraries(IREETracyCSVExport
 # Graphical frontends
 #-------------------------------------------------------------------------------
 
-if(TRACY_GTK_DEPS_FOUND)
+if(TRACY_GUI_DEPS_FOUND)
   #-----------------------------------------------------------------------------
   # IMGUI library
   #-----------------------------------------------------------------------------
@@ -188,17 +202,18 @@ if(TRACY_GTK_DEPS_FOUND)
     ${IMGUI_SOURCES}
   )
   setup_cxx_options(IREETracyIMGUI)
+  setup_graphics_deps(IREETracyIMGUI)
 
   #-----------------------------------------------------------------------------
   # NFD library
   #-----------------------------------------------------------------------------
 
-  set(NFD_SOURCES
-    ${TRACY_SOURCE_DIR}/nfd/nfd_portal.cpp
-  )
-  add_library(IREETracyNFD
-    ${NFD_SOURCES}
-  )
+  if(APPLE)
+    set(NFD_SOURCES ${TRACY_SOURCE_DIR}/nfd/nfd_cocoa.m)
+  else()
+    set(NFD_SOURCES ${TRACY_SOURCE_DIR}/nfd/nfd_portal.cpp)
+  endif()
+  add_library(IREETracyNFD ${NFD_SOURCES})
   setup_cxx_options(IREETracyNFD)
   setup_graphics_deps(IREETracyNFD)
 
@@ -210,9 +225,7 @@ if(TRACY_GTK_DEPS_FOUND)
   # Remove the source files for Wayland backend; right now we just use GLFW.
   list(REMOVE_ITEM PROFILER_SRCS
        "${TRACY_SOURCE_DIR}/profiler/src/BackendWayland.cpp")
-  add_executable(IREETracyProfiler
-    ${PROFILER_SRCS}
-  )
+  add_executable(IREETracyProfiler ${PROFILER_SRCS})
   set_target_properties(IREETracyProfiler
     PROPERTIES
       OUTPUT_NAME "iree-tracy-profiler"
@@ -227,4 +240,12 @@ if(TRACY_GTK_DEPS_FOUND)
       IREETracyServer
       ${CMAKE_THREAD_LIBS_INIT}
   )
+  if(APPLE)
+    target_link_libraries(IREETracyProfiler
+      PRIVATE
+        "-framework Foundation"
+        "-framework AppKit"
+        "-framework UniformTypeIdentifiers"
+    )
+  endif()
 endif()
diff --git a/docs/developers/developing_iree/profiling_with_tracy.md b/docs/developers/developing_iree/profiling_with_tracy.md
index 8d42b1737824..22c5e4dd8bd7 100644
--- a/docs/developers/developing_iree/profiling_with_tracy.md
+++ b/docs/developers/developing_iree/profiling_with_tracy.md
@@ -99,7 +99,7 @@ brew install capstone
 Install other dependencies:
 
 ```shell
-brew install glfw freetype
+brew install pkg-config glfw freetype tbb zstd
 ```
 
 ## Build the Tracy tools
diff --git a/runtime/src/iree/base/tracing/tracy.cc b/runtime/src/iree/base/tracing/tracy.cc
index d500a5ca9fd7..722ade897b70 100644
--- a/runtime/src/iree/base/tracing/tracy.cc
+++ b/runtime/src/iree/base/tracing/tracy.cc
@@ -30,6 +30,24 @@ void IREEDbgHelpUnlock(void) { ReleaseMutex(iree_dbghelp_mutex); }
 
 #if IREE_TRACING_FEATURES != 0
 
+void iree_tracing_tracy_initialize() {
+  // No-op.
+}
+
+void iree_tracing_tracy_deinitialize() {
+#if defined(IREE_PLATFORM_APPLE)
+  // Synchronously shut down the profiler service.
+  // This is required on some platforms to support TRACY_NO_EXIT=1 such as
+  // MacOS and iOS. It should be harmless on other platforms as it returns
+  // quickly if TRACY_NO_EXIT=1 is not set.
+  // See: https://github.com/wolfpld/tracy/issues/8
+  tracy::GetProfiler().RequestShutdown();
+  while (!tracy::GetProfiler().HasShutdownFinished()) {
+    std::this_thread::sleep_for(std::chrono::milliseconds(10));
+  }
+#endif  // IREE_PLATFORM_*
+}
+
 iree_zone_id_t iree_tracing_zone_begin_impl(
     const iree_tracing_location_t* src_loc, const char* name,
     size_t name_length) {
diff --git a/runtime/src/iree/base/tracing/tracy.h b/runtime/src/iree/base/tracing/tracy.h
index ffe410c83fd8..fcc15854a5b7 100644
--- a/runtime/src/iree/base/tracing/tracy.h
+++ b/runtime/src/iree/base/tracing/tracy.h
@@ -104,6 +104,9 @@ typedef struct ___tracy_source_location_data iree_tracing_location_t;
   (TracyCZoneCtx) { zone_id, 1 }
 #endif  // __cplusplus
 
+void iree_tracing_tracy_initialize();
+void iree_tracing_tracy_deinitialize();
+
 IREE_MUST_USE_RESULT iree_zone_id_t
 iree_tracing_zone_begin_impl(const iree_tracing_location_t* src_loc,
                              const char* name, size_t name_length);
@@ -185,8 +188,8 @@ void* iree_tracing_obscure_ptr(void* ptr);
 
 #define IREE_TRACE(expr) expr
 
-#define IREE_TRACE_APP_ENTER()
-#define IREE_TRACE_APP_EXIT(exit_code)
+#define IREE_TRACE_APP_ENTER() iree_tracing_tracy_initialize()
+#define IREE_TRACE_APP_EXIT(exit_code) iree_tracing_tracy_deinitialize()
 #define IREE_TRACE_SET_APP_INFO(value, value_length) \
   ___tracy_emit_message_appinfo(value, value_length)
 #define IREE_TRACE_SET_THREAD_NAME(name) ___tracy_set_thread_name(name)