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html_14.3.13.html
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<html lang="en">
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<col/>
<col/>
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<thead class="gt_header">
<tr>
<th colspan="6" class="gt_heading gt_title gt_font_normal" style>Table 14.3.13</th>
</tr>
<tr>
<th colspan="6" class="gt_heading gt_subtitle gt_font_normal gt_bottom_border" style>CIBIC+ - Categorical Analysis - LOCF</th>
</tr>
</thead>
<thead class="gt_col_headings">
<tr>
<th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1"></th>
<th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1">Assessment</th>
<th class="gt_col_heading gt_columns_bottom_border gt_right" rowspan="1" colspan="1">Placebo<br />
(N=79)</th>
<th class="gt_col_heading gt_columns_bottom_border gt_right" rowspan="1" colspan="1">Xanomeline<br />
Low Dose<br />
(N=81)</th>
<th class="gt_col_heading gt_columns_bottom_border gt_right" rowspan="1" colspan="1">Xanomeline<br />
High Dose<br />
(N=74)</th>
<th class="gt_col_heading gt_columns_bottom_border gt_right" rowspan="1" colspan="1">p-value<sup class="gt_footnote_marks">1</sup></th>
</tr>
</thead>
<tbody class="gt_table_body">
<tr><td class="gt_row gt_left">Week 8</td>
<td class="gt_row gt_left">n</td>
<td class="gt_row gt_right">77</td>
<td class="gt_row gt_right">81</td>
<td class="gt_row gt_right">73</td>
<td class="gt_row gt_right">0.2727</td></tr>
<tr><td class="gt_row gt_left"></td>
<td class="gt_row gt_left">Marked improvement</td>
<td class="gt_row gt_right">0</td>
<td class="gt_row gt_right">0</td>
<td class="gt_row gt_right">0</td>
<td class="gt_row gt_right"></td></tr>
<tr><td class="gt_row gt_left"></td>
<td class="gt_row gt_left">Moderate improvement</td>
<td class="gt_row gt_right">1 (1%)</td>
<td class="gt_row gt_right">2 (2%)</td>
<td class="gt_row gt_right">1 (1%)</td>
<td class="gt_row gt_right"></td></tr>
<tr><td class="gt_row gt_left"></td>
<td class="gt_row gt_left">Minimal improvement</td>
<td class="gt_row gt_right">19 (25%)</td>
<td class="gt_row gt_right">16 (20%)</td>
<td class="gt_row gt_right">13 (18%)</td>
<td class="gt_row gt_right"></td></tr>
<tr><td class="gt_row gt_left"></td>
<td class="gt_row gt_left">No Change</td>
<td class="gt_row gt_right">45 (58%)</td>
<td class="gt_row gt_right">48 (59%)</td>
<td class="gt_row gt_right">38 (52%)</td>
<td class="gt_row gt_right"></td></tr>
<tr><td class="gt_row gt_left"></td>
<td class="gt_row gt_left">Minimal worsening</td>
<td class="gt_row gt_right">10 (13%)</td>
<td class="gt_row gt_right">14 (17%)</td>
<td class="gt_row gt_right">20 (27%)</td>
<td class="gt_row gt_right"></td></tr>
<tr><td class="gt_row gt_left"></td>
<td class="gt_row gt_left">Moderate worsening</td>
<td class="gt_row gt_right">2 (3%)</td>
<td class="gt_row gt_right">1 (1%)</td>
<td class="gt_row gt_right">1 (1%)</td>
<td class="gt_row gt_right"></td></tr>
<tr><td class="gt_row gt_left"></td>
<td class="gt_row gt_left">Marked worsening</td>
<td class="gt_row gt_right">0</td>
<td class="gt_row gt_right">0</td>
<td class="gt_row gt_right">0</td>
<td class="gt_row gt_right"></td></tr>
<tr><td class="gt_row gt_left"></td>
<td class="gt_row gt_left"></td>
<td class="gt_row gt_right"></td>
<td class="gt_row gt_right"></td>
<td class="gt_row gt_right"></td>
<td class="gt_row gt_right"></td></tr>
<tr><td class="gt_row gt_left">Week 16</td>
<td class="gt_row gt_left">n</td>
<td class="gt_row gt_right">79</td>
<td class="gt_row gt_right">81</td>
<td class="gt_row gt_right">74</td>
<td class="gt_row gt_right">0.4003</td></tr>
<tr><td class="gt_row gt_left"></td>
<td class="gt_row gt_left">Marked improvement</td>
<td class="gt_row gt_right">0</td>
<td class="gt_row gt_right">0</td>
<td class="gt_row gt_right">0</td>
<td class="gt_row gt_right"></td></tr>
<tr><td class="gt_row gt_left"></td>
<td class="gt_row gt_left">Moderate improvement</td>
<td class="gt_row gt_right">0</td>
<td class="gt_row gt_right">3 (4%)</td>
<td class="gt_row gt_right">2 (3%)</td>
<td class="gt_row gt_right"></td></tr>
<tr><td class="gt_row gt_left"></td>
<td class="gt_row gt_left">Minimal improvement</td>
<td class="gt_row gt_right">12 (15%)</td>
<td class="gt_row gt_right">12 (15%)</td>
<td class="gt_row gt_right">13 (18%)</td>
<td class="gt_row gt_right"></td></tr>
<tr><td class="gt_row gt_left"></td>
<td class="gt_row gt_left">No Change</td>
<td class="gt_row gt_right">41 (52%)</td>
<td class="gt_row gt_right">46 (57%)</td>
<td class="gt_row gt_right">39 (53%)</td>
<td class="gt_row gt_right"></td></tr>
<tr><td class="gt_row gt_left"></td>
<td class="gt_row gt_left">Minimal worsening</td>
<td class="gt_row gt_right">25 (32%)</td>
<td class="gt_row gt_right">19 (23%)</td>
<td class="gt_row gt_right">20 (27%)</td>
<td class="gt_row gt_right"></td></tr>
<tr><td class="gt_row gt_left"></td>
<td class="gt_row gt_left">Moderate worsening</td>
<td class="gt_row gt_right">1 (1%)</td>
<td class="gt_row gt_right">1 (1%)</td>
<td class="gt_row gt_right">0</td>
<td class="gt_row gt_right"></td></tr>
<tr><td class="gt_row gt_left"></td>
<td class="gt_row gt_left">Marked worsening</td>
<td class="gt_row gt_right">0</td>
<td class="gt_row gt_right">0</td>
<td class="gt_row gt_right">0</td>
<td class="gt_row gt_right"></td></tr>
<tr><td class="gt_row gt_left"></td>
<td class="gt_row gt_left"></td>
<td class="gt_row gt_right"></td>
<td class="gt_row gt_right"></td>
<td class="gt_row gt_right"></td>
<td class="gt_row gt_right"></td></tr>
<tr><td class="gt_row gt_left">Week 24</td>
<td class="gt_row gt_left">n</td>
<td class="gt_row gt_right">79</td>
<td class="gt_row gt_right">81</td>
<td class="gt_row gt_right">74</td>
<td class="gt_row gt_right">0.6183</td></tr>
<tr><td class="gt_row gt_left"></td>
<td class="gt_row gt_left">Marked improvement</td>
<td class="gt_row gt_right">0</td>
<td class="gt_row gt_right">0</td>
<td class="gt_row gt_right">0</td>
<td class="gt_row gt_right"></td></tr>
<tr><td class="gt_row gt_left"></td>
<td class="gt_row gt_left">Moderate improvement</td>
<td class="gt_row gt_right">1 (1%)</td>
<td class="gt_row gt_right">1 (1%)</td>
<td class="gt_row gt_right">0</td>
<td class="gt_row gt_right"></td></tr>
<tr><td class="gt_row gt_left"></td>
<td class="gt_row gt_left">Minimal improvement</td>
<td class="gt_row gt_right">9 (11%)</td>
<td class="gt_row gt_right">14 (17%)</td>
<td class="gt_row gt_right">11 (15%)</td>
<td class="gt_row gt_right"></td></tr>
<tr><td class="gt_row gt_left"></td>
<td class="gt_row gt_left">No Change</td>
<td class="gt_row gt_right">38 (48%)</td>
<td class="gt_row gt_right">37 (46%)</td>
<td class="gt_row gt_right">33 (45%)</td>
<td class="gt_row gt_right"></td></tr>
<tr><td class="gt_row gt_left"></td>
<td class="gt_row gt_left">Minimal worsening</td>
<td class="gt_row gt_right">28 (35%)</td>
<td class="gt_row gt_right">27 (33%)</td>
<td class="gt_row gt_right">25 (34%)</td>
<td class="gt_row gt_right"></td></tr>
<tr><td class="gt_row gt_left"></td>
<td class="gt_row gt_left">Moderate worsening</td>
<td class="gt_row gt_right">3 (4%)</td>
<td class="gt_row gt_right">2 (2%)</td>
<td class="gt_row gt_right">5 (7%)</td>
<td class="gt_row gt_right"></td></tr>
<tr><td class="gt_row gt_left"></td>
<td class="gt_row gt_left">Marked worsening</td>
<td class="gt_row gt_right">0</td>
<td class="gt_row gt_right">0</td>
<td class="gt_row gt_right">0</td>
<td class="gt_row gt_right"></td></tr>
</tbody>
<tfoot class="gt_sourcenotes">
<tr>
<td class="gt_sourcenote" colspan="6">2022-05-21</td>
</tr>
</tfoot>
<tfoot class="gt_footnotes">
<tr>
<td class="gt_footnote" colspan="6"><sup class="gt_footnote_marks">1</sup> Overall comparison of treatments using CMH test (Pearson Chi-Square), controlling for site group.</td>
</tr>
</tfoot>
</table>
</div>
</body>
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